Psychopharmacology in Psychodermatology

Background: The management of psychodermatologic disease often involves the use of psychotropics by dermatologists. A general approach to the psychopharmacologic management of psychodermatological disease may be of assistance to the dermatologist. Objective: We review and provide a current psychopharmacologically based approach to management of common psychopathologies associated with psychodermatologic disorders, common side effects, and potential drug interactions that may occur with selected psychotropics. Methods: Using relevant MeSH terms, we performed a review of the literature from 1980 to 2006. Results and Conclusions: Effective psychopharmacologic management of psychodermatologic disease involves identifying and basing treatment on the associated psychopathology; familiarity with a variety of psychotropic agents, including antidepressants, anxiolytics, and antipsychotics; and the involvement of a psychiatrist when possible.

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Emerging and experimental treatments for COVID-19 and drug interactions with psychotropic agents

Therapeutic Advances in Psychopharmacology ◽

10.1177/2045125320935306 ◽

2020 ◽

Vol 10 ◽

pp. 204512532093530 ◽

Cited By ~ 6

Author(s):

Delia Bishara ◽

Chris Kalafatis ◽

David Taylor

Keyword(s):

Drug Interaction ◽

Adverse Effects ◽

Drug Interactions ◽

Clinical Trial Data ◽

Potential Drug ◽

Qtc Prolongation ◽

Experimental Drugs ◽

Psychotropic Agents ◽

The Common ◽

Experimental Treatments

As yet, no agents have been approved for the treatment of COVID-19, although several experimental drugs are being used off licence. These may have serious adverse effects and potential drug interactions with psychotropic agents. We reviewed the common agents being used across the world for the treatment of COVID-19 and investigated their drug interaction potential with psychotropic agents using several drug interaction databases and resources. A preliminary search identified the following drugs as being used to treat COVID-19 symptoms: atazanavir (ATV), azithromycin (AZI), chloroquine (CLQ)/hydroxychloroquine (HCLQ), dipyridamole, famotidine (FAM), favipiravir, lopinavir/ritonavir (LPV/r), nitazoxanide, remdesivir, ribavirin and tocilizumab. Many serious adverse effects and potential drug interactions with psychotropic agents were identified. The most problematic agents were found to be ATV, AZI, CLQ, HCLQ, FAM and LPV/r in terms of both pharmacokinetic as well as serious pharmacodynamic drug interactions, including QTc prolongation and neutropenia. Significant caution should be exercised if using any of the medications being trialled for the treatment of COVID-19 until robust clinical trial data are available. An even higher threshold of vigilance should be maintained for patients with pre-existing conditions and older adults due to added toxicity and drug interactions, especially with psychotropic agents.

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Safety and Efficacy of Weight‐Loss Pharmacotherapy in Persons Living with HIV: A Review of the Literature and Potential Drug‐Drug Interactions with Antiretroviral Therapy

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy ◽

10.1002/phar.2342 ◽

2019 ◽

Vol 39 (12) ◽

pp. 1204-1215 ◽

Cited By ~ 2

Author(s):

Rebecca J. Cope ◽

Briann S. Fischetti ◽

Rebecca K. Kavanagh ◽

Trisha M. Lepa ◽

Maria A. Sorbera

Keyword(s):

Weight Loss ◽

Antiretroviral Therapy ◽

Drug Interactions ◽

Potential Drug ◽

Review Of The Literature ◽

Safety And Efficacy ◽

Persons Living With Hiv ◽

Living With Hiv

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Potential drug interactions and side effects in an outpatient oncology clinic: a retrospective descriptive study

European Journal of Hospital Pharmacy ◽

10.1136/ejhpharm-2014-000449 ◽

2014 ◽

Vol 21 (4) ◽

pp. 216-221 ◽

Cited By ~ 6

Author(s):

Aygin Bayraktar-Ekincioglu ◽

Kutay Demirkan ◽

Burcu Keskin ◽

Oktay Aslantas ◽

Evren Ozdemir

Keyword(s):

Side Effects ◽

Drug Interactions ◽

Descriptive Study ◽

Potential Drug

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Management of drug interactions

Batna Journal of Medical Sciences (BJMS) ◽

10.48087/bjmstf.2014.1214 ◽

2014 ◽

Vol 1 (2) ◽

pp. 116-120

Author(s):

Houari Toumi ◽

◽

Fatima Boudia ◽

Fatima Zohra Nadjet Mekaouche ◽

Habiba Fetati ◽

...

Keyword(s):

Side Effects ◽

Drug Interactions ◽

Clinical Relevance ◽

Therapeutic Efficacy ◽

Potential Drug

The risk of drug interactions in patients increases with the increasing number of drugs in the therapeutic regimens. To avoid or reduce them, management of these interactions is imperative. This management is to identify potential drug interactions by using the appropriate resources, to judge the clinical relevance, and to act accordingly with the prescriber. This article discusses the levels of severity of drug interactions and highlights the need for their management by presenting a part of the experience of the department of Pharmacovigilance EHU Oran. The intervention of the pharmacologist turns out beneficial by helping the clinician to manage risk associations in favor of better therapeutic efficacy and minimal side effects.

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Potential Drug Interactions with Coumadin (Warfarin) and Prozac (Fluoxetine): A Brief Report and Review of the Literature

Jefferson Journal of Psychiatry ◽

10.29046/jjp.009.2.006 ◽

1991 ◽

Vol 9 (2) ◽

Author(s):

Robert Claire ◽

Mark Servis ◽

David Cram, Jr.

Keyword(s):

Drug Interactions ◽

Potential Drug ◽

Review Of The Literature

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Profile of studies of potential drug interactions in Brazilian hospitals: an integrative review of the literature

Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde ◽

10.30968/rbfhss.2018.094.003 ◽

2019 ◽

Vol 9 (4) ◽

Author(s):

Adriana Tiemi Yamagata ◽

Roberto Mauro Coelho Barcelos Júnior ◽

Dayani Galato ◽

Micheline Marie Milward De Azevedo Meiners ◽

Emília Vitória Da Silva

Keyword(s):

Drug Interactions ◽

Hospital Setting ◽

Potential Drug ◽

Review Of The Literature ◽

Cross Sectional ◽

Futures Research ◽

Bibliographic Search ◽

Publication Time ◽

Cross Sectional Studies ◽

Patient Studies

The risk of drug interaction (DI), especially in the hospital setting, increases along with the number of drugs used by the patient. Studies that evaluate drug interactions based on patient prescriptions are therefore useful to know this risk and guide strategies to improve drug use. The present study is aimed to identify studies that evaluated DI in patients of Brazilian hospitals. As of bibliographic search in several databases, we collected articles describing prescribing evaluations which focused on the analysis and identification of drug interactions in Brazilian hospitals. The search was conducted in 2017 and there was no restriction of publication time. Of a total of 273 articles retrieved, 23 were included for analysis. Most was published after 2010, and the predominant design was cross-sectional studies. The Micromedex® database was the most used to categorize the interactions, and midazolam and fentanyl was the most commonly reported potential DI in the studies. The results may guide futures research which should assess the real harm of IMP in patients and, then, promote the rational use of drugs.

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Lithium Side Effects in the Medically Ill

The International Journal of Psychiatry in Medicine ◽

10.2190/vdll-d9lh-eve9-d1k2 ◽

1993 ◽

Vol 23 (4) ◽

pp. 357-382 ◽

Cited By ~ 8

Author(s):

W. Alexander Morton ◽

Susan C. Sonne ◽

R. Bruce Lydiard

Keyword(s):

Side Effects ◽

Literature Review ◽

Drug Interactions ◽

Drug Monitoring ◽

Geriatric Patient ◽

Potential Drug ◽

Medical Problems ◽

Medically Ill ◽

Organ Systems ◽

General Pharmacology

Objective: This review will include the general pharmacology of lithium and discuss its effects on various organ systems, with emphasis on the medically ill patient as well as the geriatric patient with multiple medical problems. Methods: A full literature review on the side effects of lithium was performed. Attention is focused on the medically ill and possible drug interactions. Results: This review points to the numerous problems which can result in toxicity in the medically ill or the geriatric patient. Conclusion: Serious side effects can be avoided with proper drug monitoring and knowledge of potential drug interactions.

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Depression in Temporal Lobe Epilepsy: A Review of Prevalence, Clinical Features, and Management Considerations

Epilepsy Research and Treatment ◽

10.1155/2012/809843 ◽

2012 ◽

Vol 2012 ◽

pp. 1-12 ◽

Cited By ~ 9

Author(s):

C. S. Garcia

Keyword(s):

Depressive Symptoms ◽

Temporal Lobe Epilepsy ◽

Drug Interactions ◽

Antiepileptic Drugs ◽

Temporal Lobe ◽

Treatment Strategies ◽

Potential Drug ◽

Review Of The Literature ◽

Clinical Phenomenology ◽

Significant Effort

Depression in temporal lobe epilepsy has been established as a frequent occurrence, and various possible mechanisms for this significant comorbidity have been posited. However, there is still little to guide a clinician in the recognition and management of depression in patients with temporal lobe epilepsy. This is in part due to the lack of consistent findings in earlier studies, which was likely partly due to variabilities in methodology, sampling, and diagnosis of both temporal lobe epilepsy and depression. However, in recent years, significant effort has been made to address these issues and provide a framework for diagnosis and management of depression in this population. The following is a review of the literature, with special emphasis on clinical phenomenology of depressive symptoms, described bidirectional risk between depression and temporal lobe epilepsy, and treatment strategies in the context of potential drug interactions with antiepileptic drugs.

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