Resuscitation room blood alcohol concentrations: one-year cohort study

Abstract Background Recent studies are lacking reports on mortality after non-hip fractures in adults aged > 65. Methods This retrospective, matched-cohort study used de-identified health services data from the publicly funded healthcare system in Ontario, Canada, contained in the ICES Data Repository. Patients aged 66 years and older with an index fragility fracture occurring at any osteoporotic site between 2011 and 2015 were identified from acute hospital admissions, emergency and ambulatory care using International Classification of Diseases (ICD)-10 codes and data were analyzed until 2017. Thus, follow-up ranged from 2 years to 6 years. Patients were excluded if they presented with an index fracture occurring at a non-osteoporotic fracture site, their index fracture was associated with a trauma code, or they experienced a previous fracture within 5 years prior to their index fracture. This fracture cohort was matched 1:1 to controls within a non-fracture cohort by date, sex, age, geography and comorbidities. All-cause mortality risk was assessed. Results The survival probability for up to 6 years post-fracture was significantly reduced for the fracture cohort vs matched non-fracture controls (p < 0.0001; n = 101,773 per cohort), with the sharpest decline occurring within the first-year post-fracture. Crude relative risk of mortality (95% confidence interval) within 1-year post-fracture was 2.47 (2.38–2.56) in women and 3.22 (3.06–3.40) in men. In the fracture vs non-fracture cohort, the absolute mortality risk within one year after a fragility fracture occurring at any site was 12.5% vs 5.1% in women and 19.5% vs 6.0% in men. The absolute mortality risk within one year after a fragility fracture occurring at a non-hip vs hip site was 9.4% vs 21.5% in women and 14.4% vs 32.3% in men. Conclusions In this real-world cohort aged > 65 years, a fragility fracture occurring at any site was associated with reduced survival for up to 6 years post-fracture. The greatest reduction in survival occurred within the first-year post-fracture, where mortality risk more than doubled and deaths were observed in 1 in 11 women and 1 in 7 men following a non-hip fracture and in 1 in 5 women and 1 in 3 men following a hip fracture.

Download Full-text

Asymmetry in gait pattern following bicondylar tibial plateau fractures—A prospective one-year cohort study

Injury ◽

10.1016/j.injury.2017.04.045 ◽

2017 ◽

Vol 48 (7) ◽

pp. 1657-1661 ◽

Cited By ~ 7

Author(s):

Rasmus Elsoe ◽

Peter Larsen

Keyword(s):

Cohort Study ◽

Tibial Plateau ◽

Gait Pattern ◽

Tibial Plateau Fractures ◽

One Year ◽

Bicondylar Tibial Plateau

Download Full-text

A cohort study of male subjects attending an alcoholics anonymous program in India: one-year follow-up for sobriety.

Journal of Studies on Alcohol ◽

10.15288/jsa.2004.65.546 ◽

2004 ◽

Vol 65 (4) ◽

pp. 546-549 ◽

Cited By ~ 7

Author(s):

P K Kuruvilla ◽

N Vijayakumar ◽

K S Jacob

Keyword(s):

Cohort Study ◽

Alcoholics Anonymous ◽

One Year ◽

Male Subjects

Download Full-text

Pre-test probability risk scores and their use in contemporary management of patients with chest pain: One year stress echo cohort study

JRSM Open ◽

10.1177/2054270415611295 ◽

2015 ◽

Vol 6 (11) ◽

pp. 205427041561129

Author(s):

Daniela Cassar Demarco ◽

Alexandros Papachristidis ◽

Damian Roper ◽

Ioannis Tsironis ◽

Jonathan Byrne ◽

...

Keyword(s):

Cohort Study ◽

Chest Pain ◽

Risk Scores ◽

Stress Echo ◽

Contemporary Management ◽

One Year ◽

Test Probability

Download Full-text

Divergent patterns of anti-fracture medication use following fracture on therapy: A population-based cohort study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab696 ◽

2021 ◽

Author(s):

Gregory A Kline ◽

Suzanne N Morin ◽

Lisa M Lix ◽

William D Leslie

Keyword(s):

Cohort Study ◽

Medication Adherence ◽

Vertebral Fracture ◽

Drug Efficacy ◽

Population Based ◽

Duration Of Treatment ◽

Traumatic Fracture ◽

Before And After ◽

One Year

Abstract Context Fracture-on-therapy should motivate better anti-fracture medication adherence. Objective Describe osteoporosis medication adherence in women before and following a fracture. Design Retrospective cohort study. Setting Manitoba BMD Registry (1996-2013). Patients Women who started anti-fracture drug therapy after a DXA-BMD with follow-up for 5 years during which a non-traumatic fracture occurred at least one year after starting treatment. Main Outcome Linked prescription records determined medication adherence (estimated by medication possession ratios, MPR) in one-year intervals. The variable of interest was MPR in the year before and after the year in which the fracture occurred with subgroup analyses according to duration of treatment pre-fracture. We chose an MPR of ≥0.50 to indicate minimum adherence needed for drug efficacy. Results There were 585 women with fracture-on-therapy, 193(33%) had hip or vertebral fracture. Bisphosphonates accounted for 82.2% of therapies. Median MPR the year prior to fracture was 0.89(IQR 0.49-1.0) and 0.69(IQR 0.07-0.96) the year following the year of fracture(p< 0.0001). The percentage of women with MPR ≥ 0.5 pre-fracture was 73.8%, dropping to 57.3% post-fracture(p<0.0001); restricted to hip/vertebral fracture results were similar (58.2% to 33.3%, p <0.002). Among those with pre-fracture MPR <0.5, only 21.7% achieved a post-fracture MPR ≥ 0.5. Conclusions Although fracture-on-therapy may motivate sustained/improved adherence, MPR remains low or even declines after fracture in many. This could reflect natural decline in MPR with time but is paradoxical to expectations. Fracture-on-therapy represents an important opportunity for clinicians to re-emphasize treatment adherence.

Download Full-text

Functional impairment prior to major non-cardiac surgery is associated with mortality within one year in elderly patients with gastrointestinal, gynaecological and urogenital cancer: A prospective observational cohort study

Journal of Geriatric Oncology ◽

10.1016/j.jgo.2017.07.011 ◽

2018 ◽

Vol 9 (1) ◽

pp. 53-59 ◽

Cited By ~ 10

Author(s):

Maren Schmidt ◽

Rahel Eckardt ◽

Sarah Altmeppen ◽

Klaus-Dieter Wernecke ◽

Claudia Spies

Keyword(s):

Cardiac Surgery ◽

Cohort Study ◽

Elderly Patients ◽

Functional Impairment ◽

Observational Cohort Study ◽

Prospective Observational Cohort Study ◽

Observational Cohort ◽

Urogenital Cancer ◽

One Year

Download Full-text

Sleep problems increase the risk of musculoskeletal pain in boys but not girls: a prospective cohort study

European Journal of Pediatrics ◽

10.1007/s00431-020-03667-8 ◽

2020 ◽

Vol 179 (11) ◽

pp. 1711-1719

Author(s):

Alessandro Andreucci ◽

Paul Campbell ◽

Lisa K Mundy ◽

Susan M Sawyer ◽

Silja Kosola ◽

...

Keyword(s):

Cohort Study ◽

Musculoskeletal Pain ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Sleep Problems ◽

Large Population ◽

Population Based ◽

School Aged Children ◽

Increased Risk ◽

One Year

Abstract Adults with sleep problems are at higher risk for onset of musculoskeletal pain, but the evidence is less clear for children. This prospective cohort study investigated whether children with sleep problems are at higher risk for onset of musculoskeletal pain and explored whether sex is a modifier of this association. In a prospective cohort study of Australian schoolchildren (n = 1239, mean age 9 years), the associations between sleep problems at baseline and new onset of both musculoskeletal pain and persistent musculoskeletal pain (pain lasting > 3 months) 1 year later were investigated using logistic regression. The potential modifying effect of sex was also assessed. One-year incidence proportion for musculoskeletal pain onset is 43% and 7% for persistent musculoskeletal pain. Sleep problems were associated with musculoskeletal pain onset and persistent musculoskeletal pain onset in boys, odds ratio 2.80 (95% CI 1.39, 5.62) and OR 3.70 (1.30, 10.54), respectively, but not girls OR 0.58 (0.28, 1.19) and OR 1.43 (0.41, 4.95), respectively. Conclusions: Rates of musculoskeletal pain are high in children. Boys with sleep problems are at greater risk of onset of musculoskeletal pain, but girls do not appear to have higher risk. Consideration of sleep health may help prevent persistent musculoskeletal pain in children. What is Known:• Sleep problems are associated with the onset of musculoskeletal pain in adults.• It is not clear if the association between sleep problems and the onset of musculoskeletal pain is present also in children and if sex plays a role in this association. What is New:• This is the first large population-based study that has prospectively investigated the relationship between sleep problems and onset of musculoskeletal pain in school-aged children.• Children, especially boys with sleep problems, were at increased risk for the development of persistent musculoskeletal pain.

Download Full-text