118 ASPIRE-2-PREVENT: lifestyle and risk factor management in people at high risk of developing cardiovascular disease in the UK

Heart ◽  
2010 ◽  
Vol 96 (Suppl 1) ◽  
pp. A69.1-A69
Author(s):  
K Kotseva ◽  
C Jennings ◽  
E Turner ◽  
D Wood
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
High Risk ◽  
Risk Factor Management ◽  
The Uk

Is weekend surgery a risk factor for post-tonsillectomy haemorrhage?

2016 ◽  
Vol 130 (8) ◽  
pp. 763-767 ◽  
Author(s):  
A Patel ◽  
N Foden ◽  
A Rachmanidou
Keyword(s):  
Risk Factor ◽  
High Risk ◽  
General Hospital ◽  
General Surgery ◽  
District General Hospital ◽  
Low Risk ◽  
Morbidity And Mortality ◽  
The Uk

AbstractBackground:Tonsillectomy is a common, low-risk procedure. Post-tonsillectomy haemorrhage remains the most serious complication. Recent nationwide studies in the UK have identified an increased morbidity and mortality for both high-risk and low-risk elective general surgery performed at the weekend.Methods:Data for tonsillectomies performed at a district general hospital over a three-year period were retrospectively reviewed. The same group of surgeons performed elective tonsillectomies on both weekends and weekdays. All patients who developed a post-tonsillectomy haemorrhage were identified and the day of original operation was noted.Results:Between 2010 and 2013, 2208 (94.00 per cent) elective tonsillectomies were performed on a weekday and 141 (6.00 per cent) were performed on the weekend. Post-tonsillectomy haemorrhages occurred in 104 patients (4.71 per cent) who underwent their procedure on a weekday and in 10 patients (7.09 per cent) who had their surgery at the weekend (p = 0.20).Conclusion:There is no difference in the rate of post-tonsillectomy haemorrhage for procedures performed on a weekday or weekend.

scholarly journals ApoE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

2020 ◽  
Author(s):  
Chia-Ling Kuo ◽  
Luke C Pilling ◽  
Janice L Atkins ◽  
Jane AH Masoli ◽  
João Delgado ◽  
...  
Keyword(s):  
Older Adults ◽  
Risk Factor ◽  
High Risk ◽  
The Novel ◽  
Shortness Of Breath ◽  
Uk Biobank ◽  
Impaired Consciousness ◽  
Homozygous Genotype ◽  
The Common ◽  
The Uk

The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, we found that pre-existing dementia is a major risk factor (OR = 3.07, 95% CI: 1.71 to 5.50) for COVID-19 hospitalization in the UK Biobank (UKB). In another UK study of 16,749 patients hospitalized for COVID-19, dementia was among the common comorbidities and was associated with higher mortality. Additionally, impaired consciousness, including delirium, is common in severe cases. The ApoE e4 genotype is associated with both dementia and delirium, with the e4e4 (homozygous) genotype associated with high risk of dementia. We therefore aimed to test associations between ApoE e4 alleles and COVID-19 severity, using the UKB data.

scholarly journals The Management of Aspirin in Transurethral Prostatectomy: Current Practice in the UK

2006 ◽  
Vol 88 (3) ◽  
pp. 280-283 ◽  
Author(s):  
Mohamed Khalid Enver ◽  
Ivan Hoh ◽  
Frank I Chinegwundoh
Keyword(s):  
Cardiovascular Disease ◽  
High Risk ◽  
Blood Loss ◽  
Cardiovascular Event ◽  
Current Practice ◽  
Operative Management ◽  
British Association ◽  
Operative Blood Loss ◽  
Transurethral Prostatectomy ◽  
The Uk

INTRODUCTION Stopping aspirin prior to transurethral prostatectomy (TURP) may minimise peri-operative blood loss, but it may also increase the risk of a significant cardiovascular event. There are no guidelines on the management of aspirin in TURP. This study sought to determine the variation in the peri-operative management of transurethral prostatectomy (TURP) patients that are taking aspirin. MATERIALS AND METHODS A questionnaire was sent to 444 consultant urologists in the UK from a list obtained from the British Association of Urologists. This resulted in 290 anonymous replies (65%), of which 287 were suitable for analysis. RESULTS Of these 287 urologists, 178 (62%) ask patients to stop aspirin prior to TURP. Aspirin is stopped 9.8 days (median, 10 days; range, 2–30 days) prior to surgery, and recommenced 8.8 days (median, 7 days; range, 1–42 days) after surgery. In those that stop aspirin, 62% will stop aspirin in all patients, regardless of the indication, and 40% will cancel a TURP if aspirin use has inadvertently continued. Of the 287 urologists, 109 (38%) do not stop aspirin. CONCLUSIONS There is a wide variation in the management of aspirin in TURP patients in the UK. Aspirin is being stopped in patients at high risk of serious cardiovascular disease, often for longer than necessary. There is a need for multidisciplinary guidelines to reduce variation in practice.

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