The prognostic value of histopathologic grading parameters and microvessel density in patients with early squamous cell carcinoma of the uterine cervix.

2002 ◽  
Vol 12 (1) ◽  
pp. 32-41 ◽  
Author(s):  
M Graflund ◽  
B Sorbe ◽  
A Hussein ◽  
M Bryne ◽  
M Karlsson
Keyword(s):  
Lymph Node ◽  
Prognostic Factor ◽  
Squamous Cell ◽  
Microvessel Density ◽  
Lymph Node Metastases ◽  
Disease Free Survival ◽  
Lymph Node Status ◽  
Free Survival ◽  
Node Metastases ◽  
Disease Free

Abstract.Graflund M, Sorbe B, Hussein A, Bryne M, Karlsson M.The purpose of this study was to investigate the prognostic importance of clinical and histopathologic factors, including malignancy grading systems (MGS), partial index (PI), invasive front grading (IFG), and microvessel density. A complete geographic series of 172 early stage (FIGO I–II) cervical carcinomas treated by Wertheim-Meigs surgery during the period 1965–1990 was studied. The patients were followed up for at least 10 years. Significant prognostic factors for disease-free survival were lymph node status (P < 0.0000001), radical surgical margins (P = 0.00003), and tumor size (P = 0.008). In a multivariate Cox analysis it was shown that lymph node status was the single most important prognostic factor with regard to disease-free survival. The total MGS and the PI scores were highly significantly (P = 0.0001) associated with pelvic lymph node metastases and disease-free survival rate in squamous cell carcinomas. The MGS and the PI systems were superior to the IFG system in predicting lymph node metastases. The total IFG score was also a statistically highly significant (P = 0.003) prognostic factor with regard to disease-free survival in both univariate and multivariate analyses. Microvessel density was a nonsignificant prognostic factor. There was a highly significant (P = 0.002) association between vascular space invasion of tumor cells and the presence of lymph node metastases. In conclusion, histopathologic malignancy grading systems provide valuable prognostic information in patients with early stage squamous cell carcinomas of the uterine cervix.

Prognostic Role of Lymph Node Metastases in Vulvar Cancer and Implications for Adjuvant Treatment

2012 ◽  
Vol 22 (3) ◽  
pp. 503-508 ◽  
Author(s):  
Linn Woelber ◽  
Christine Eulenburg ◽  
Matthias Choschzick ◽  
Andreas Kruell ◽  
Cordula Petersen ◽  
...  
Keyword(s):  
Lymph Node ◽  
Adjuvant Treatment ◽  
Lymph Node Metastases ◽  
Adjuvant Radiotherapy ◽  
Vulvar Cancer ◽  
Disease Free Survival ◽  
Free Survival ◽  
Node Negative ◽  
Node Metastases ◽  
Disease Free

ObjectiveLymph node metastases are the most important prognostic factor for recurrence and survival in vulvar cancer. However, information regarding the impact of the number of positive nodes in vulvar cancer is inconsistent, and so are recommendations when to apply adjuvant radiotherapy.MethodsOne hundred fifty-seven consecutive patients with primary squamous cell cancer of the vulva treated at our center were analyzed. All patients underwent primary surgery by triple incision resulting in complete tumor resection.ResultsMedian age was 61 years; 49 patients (31%) had lymph node metastases; 21 patients had 1, 13 had 2, and 15 had more than 2 positive lymph nodes. Thirty-two percent of the patients received adjuvant radiotherapy. The risk of lymph node metastases increased with age, greater tumor size, deeper invasion, and higher tumor grade. Median follow-up was 36 months; 23 patients (14.6%) developed disease recurrence (61% vulva, 35% groins, and 4% both). Compared with node-negative patients, survival in all node-positive patients was significantly impaired (P < 0.001; disease-free patients after 2 years: 88% in node-negative patients; 60%, 43%, and 29% in patients with 1, 2, and >2 affected nodes, respectively), whereas no significant difference between the node-positive subgroups could be demonstrated regarding disease-free survival. In multivariate analysis, lymph node status remained the most important prognostic factor regarding disease-free survival, but the effect of positive nodes differed significantly dependent on adjuvant treatment (P = 0.001). In patients without adjuvant radiotherapy to the groins/pelvis, the number of metastatic nodes was highly relevant for prognosis (hazard ratio, 1.752; P < 0.001), whereas this effect disappeared in patients who were treated with adjuvant radiotherapy (hazard ratio, 0.972; P = 0.828).ConclusionsThe negative impact of lymph node metastases is already evident in patients with only 1 affected lymph node. In patients receiving adjuvant radiotherapy, the negative effect of additional lymph node metastases is reduced; adjuvant treatment might therefore be beneficial in patients with only 1 positive node.

Analysis of lymphangiogenetic factors in invasive bladder cancer—A tissue microarray analysis

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 15530-15530
Author(s):  
C. Wulfing ◽  
E. Herrmann ◽  
T. Kopke ◽  
E. Eltze ◽  
J. Neumann ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Tissue Microarray ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Disease Free Survival ◽  
Free Survival ◽  
Tumor Stages ◽  
Node Metastases ◽  
Disease Free

15530 Introduction: Vascular endothelial growth factors (VEGF) -C, -D and their receptor Flt-4 play an emerging role in lymphangiogenesis of different tumor types. Our aim was to determine the role of VEGF-C, VEGF-D and Flt-4 in invasive transitional cell carcinoma of the bladder. Material and Methods: Archival tumor tissue of 286 patients, who had previously undergone radical cystectomy at our institution, was reviewed and representative tumor blocks were selected for constructing a tissue microarray (TMA). Paraffin sections were assessed immunohistochemically using mono- and polyclonal antibodies against VEGF-C, VEGF-D and Flt-4. Staining results were analysed semiquantitatively and correlated with various clinicopathological factors. Results: Overexpression of VEGF-C, VEGF-D and Flt-4 was found in 24.1%, 37.4% and 46.3% of cases, respectively. While there was no association of VEGF-C to histopathological parameters and clinical outcome, patients with VEGF-D overexpression had higher pathological tumor stages (p=0.021) and regional lymph node metastases (p=0.016). Furthermore, they had significantly worse disease-free survival (p=0.042). Overexpression of Flt-4 was found in the subgroup of G3- and G4-tumors (p=0.001) and correlated with a shorter period of disease- free survival (p=0.033). Conclusion: VEGF-C, VEGF-D and Flt-4 are overexpressed in bladder cancer. VEGF-D predicts higher tumor stages and regional lymph node metastases. It is associated with a worse disease-free survival as well as Flt-4 in the subgroup of high-grade tumors. Further studies should be initiated to evaluate VEGF-D and Flt-4 as potential targets in bladder cancer. No significant financial relationships to disclose.

scholarly journals The Multidisciplinary Treatment of Advanced Gallbladder Cancer to Disease-Free Survival: A Case Report

2021 ◽  
Author(s):  
Biao Zhang ◽  
Shuang Li ◽  
Zhaoyi Liu ◽  
Karieshinie Ghandalie Kalandika Peiris ◽  
Lifu Song ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gallbladder Cancer ◽  
Lymph Node Metastases ◽  
Radical Surgery ◽  
Multidisciplinary Treatment ◽  
Disease Free Survival ◽  
Free Survival ◽  
Node Metastases ◽  
Advanced Gallbladder Cancer ◽  
Disease Free

Abstract Background: Gallbladder cancer is the most common malignant tumor in the biliary system and is characterized by strong aggressiveness and an extremely poor prognosis. Current treatment for advanced gallbladder cancer remains unsatisfactory. Here we reported a patient with stage IV gallbladder cancer who achieved disease-free survival by multidisciplinary treatment.Case presentation: A 73-year-old man presented to our hospital with right abdominal pain for 3 days and was diagnosed with advanced gallbladder cancer with multiple intrahepatic metastases and distant lymph node metastases. The patient initially received chemotherapy, targeted therapy, radioactive seed implantation, and immunotherapy as there was no specific indications for radical surgery. With the progression of these adjuvant therapies, the patient’s tumor makers gradually decreased but remained higher than normal, lymph node metastases gradually disappeared, and intrahepatic metastases were gradually limited to the left liver. Finally, the patient received a radical surgery of left hepatectomy with partial diaphragmatic resection and radical lymphadenectomy. To date, the patient has survived for more than six years post-treatment, and the level of tumor markers is normal and the imaging examination shows no signs of disease recurrence.Conclusion: The treatment of advanced gallbladder cancer remains pessimistic in the current medical arena. This successful case is an inspiration and we believe that multidisciplinary treatment can benefit patients with advanced gallbladder cancer and help them achieve long-term survival or even disease-free survival.

P-34 Insulin resistance as a prognostic factor for disease-free survival in patients with Squamous Cell Carcinomas of the Head and Neck

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 15
Author(s):  
Nesly Gonzalez Sanchez ◽  
Joan Remacha ◽  
Mireia Quer-Castells ◽  
Isabel Vilaseca Gonzalez ◽  
Ximena Terra ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Prognostic Factor ◽  
Head And Neck ◽  
Squamous Cell ◽  
Disease Free Survival ◽  
Squamous Cell Carcinomas ◽  
Free Survival ◽  
Disease Free

Front pattern of invasion in squamous cell carcinoma of the penis: New prognostic factor for predicting risk of lymph node metastases

Urology ◽  
2006 ◽  
Vol 68 (1) ◽  
pp. 148-153 ◽  
Author(s):  
Gustavo Cardoso Guimarães ◽  
Ademar Lopes ◽  
Rodrigo Sousa Madeira Campos ◽  
Stenio de Cássio Zequi ◽  
Marcos Lima de Oliveira Leal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Node Metastases ◽  
Pattern Of Invasion

Surgery Plus Chemotherapy Compared With Surgery Alone for Localized Squamous Cell Carcinoma of the Thoracic Esophagus: A Japan Clinical Oncology Group Study—JCOG9204

2003 ◽  
Vol 21 (24) ◽  
pp. 4592-4596 ◽  
Author(s):  
Nobutoshi Ando ◽  
Toshifumi Iizuka ◽  
Hiroko Ide ◽  
Kaoru Ishida ◽  
Masayuki Shinoda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Survival Rate ◽  
Adjuvant Chemotherapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Disease Free Survival ◽  
Postoperative Adjuvant Chemotherapy ◽  
Free Survival ◽  
Disease Free

Purpose: We performed a multicenter randomized controlled trial to determine whether postoperative adjuvant chemotherapy improves outcome in patients with esophageal squamous cell carcinoma undergoing radical surgery. Patients and Methods: Patients undergoing transthoracic esophagectomy with lymphadenectomy between July 1992 and January 1997 at 17 institutions were randomly assigned to receive surgery alone or surgery plus chemotherapy including two courses of cisplatin (80 mg/m2 of body-surface area × 1 day) and fluorouracil (800 mg/m2 × 5 days) within 2 months after surgery. Adaptive stratification factors were institution and lymph node status (pN0 versus pN1). The primary end point was disease-free survival. Results: Of the 242 patients, 122 were assigned to surgery alone, and 120 to surgery plus chemotherapy. In the surgery plus chemotherapy group, 91 patients (75%) received both full courses of chemotherapy; grade 3 or 4 hematologic or nonhematologic toxicities were limited. The 5-year disease-free survival rate was 45% with surgery alone, and 55% with surgery plus chemotherapy (one-sided log-rank, P = .037). The 5-year overall survival rate was 52% and 61%, respectively (P = .13). Risk reduction by postoperative chemotherapy was remarkable in the subgroup with lymph node metastasis. Conclusion: Postoperative adjuvant chemotherapy with cisplatin and fluorouracil is better able to prevent relapse in patients with esophageal cancer than surgery alone.

scholarly journals Disease-free Survival of Patients with Differentiated Thyroid Cancer: A Study from a Tertiary Center in Oman

2021 ◽  
Vol 36 (2) ◽  
pp. e246-e246
Author(s):  
Fathimabeebi P. Kunjumohamed ◽  
Abdulhakeem Al Rawahi ◽  
Noor B. Al Busaidi ◽  
Hilal N. Al Musalhi
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Distant Metastasis ◽  
Differentiated Thyroid Cancer ◽  
Disease Free Survival ◽  
Lymph Node Status ◽  
Free Survival ◽  
Disease Free

Objectives: As with global trends, the prevalence of differentiated thyroid cancer (DTC) has increased in recent years in Oman. However, to the best of our knowledge, no local studies have yet been published evaluating the prognosis of DTC cases in Oman. This study aimed to assess disease-free survival (DFS) and prognostic factors related to DTC among Omani patients attending a tertiary care center. Methods: This retrospective, observational cohort study was conducted between January 2006 and May 2016 at the National Diabetes and Endocrine Center in Oman. Data related to DFS and prognostic factors were obtained from the electronic medical records of all ≥ 18-year-old patients diagnosed with DTC during the study period. Results: A total of 346 DTC cases were identified. Overall, 82.7% of patients were disease-free at their last follow-up appointment. Univariate analysis indicated that various tumor characteristics including histological subtype (i.e., papillary carcinoma, Hurthle cell cancer, and minimally invasive follicular thyroid carcinoma), lymph node status, number of lymph node metastases, distant metastasis status, and TNM status (primary tumor (T), regional lymph node (N), distant metastasis (M) stage) were strong prognostic factors for DFS (p < 0.050). According to multivariate regression analysis, lymph node status, extrathyroidal extension, and angiovascular invasion were independent predictors of DFS (p < 0.050). Conclusions: The overall prognosis of DTC among Omani patients was excellent. Treatment and follow-up strategies for patients with DTC should be tailored based on the individual’s risk factor profile.

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