scholarly journals 223 Clinicopathological features and prognostic factors for patients with recurrent cervical cancer treated with secondary surgical resection plus radiotherapy

2019 ◽  
Author(s):  
Z Shao ◽  
W Qiang ◽  
T Zhu
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Surgical Resection ◽  
Clinicopathological Features ◽  
Recurrent Cervical Cancer

Reirradiation Using High-Dose-Rate Interstitial Brachytherapy for Locally Recurrent Cervical Cancer: A Single Institutional Experience

2014 ◽  
Vol 24 (1) ◽  
pp. 141-148 ◽  
Author(s):  
Seiji Mabuchi ◽  
Ryoko Takahashi ◽  
Fumiaki Isohashi ◽  
Takeshi Yokoi ◽  
Mika Okazawa ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Dose Rate ◽  
Palliative Therapy ◽  
High Dose Rate ◽  
Interstitial Brachytherapy ◽  
Clinical Variable ◽  
High Dose ◽  
Recurrent Cervical Cancer

ObjectivesThis study aimed to evaluate the effectiveness and feasibility of reirradiation using high-dose-rate interstitial brachytherapy (HDR-ISBT) in patients with recurrent cervical cancer.MethodsThe records of 52 consecutive women with central pelvic recurrence who were salvaged with HDR-ISBT–based reirradiation were retrospectively reviewed. Data regarding the primary disease, follow-up findings, recurrence, the treatment outcome, and toxicities were collected. Multivariate analysis was performed using the Cox proportional hazards regression model to identify predictors of the response to HDR-ISBT. Survival rate was calculated using the Kaplan-Meier method and compared using the log-rank test.ResultsA total of 52 patients who had been treated with HDR-ISBT–based reirradiation were included in our database. The local control rate was 76.9% (40/52), and the median postrecurrence survival period was 32 months. Grade 3 or 4 late toxicities were observed in 13 patients (25%). Multivariate analysis revealed that tumor size and the treatment-free interval were significant poor prognostic factors of postrecurrence survival. In a comparison between the patients who were salvaged with HDR-ISBT–based reirradiation (ISBT group) and those who were treated with palliative therapy alone (palliative group), we found that among the patients who displayed 0 or 1 poor prognostic factors, the patients in the ISBT group survived significantly longer than those in the palliative group. In contrast, similar survival rates were seen in both groups among the patients with 2 or more poor prognostic factors.ConclusionsReirradiation using HDR-ISBT is effective and feasible in patients with recurrent cervical cancer. Our 2-clinical variable prognostic model might enable physicians to identify patients who would not derive clinical benefit from HDR-ISBT and offer them the opportunity to receive other types of treatment.

Surgical resection of locally recurrent cervical cancer: a single institutional 70 patient series

2004 ◽  
Vol 14 (5) ◽  
pp. 846-851 ◽  
Author(s):  
V. Moutardier ◽  
G. Houvenaeghel ◽  
M. Martino ◽  
B. Lelong ◽  
V. J. Bardou ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Surgical Resection ◽  
Recurrent Cervical Cancer ◽  
Patient Series ◽  
Locally Recurrent

Secondary platinum therapy in patients with uterine cervical cancer previously treated with platinum chemotherapy

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 5588-5588
Author(s):  
M. Tanioka ◽  
N. Katsumata ◽  
T. Hirata ◽  
M. Yunokawa ◽  
K. Yonemori ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Regression Model ◽  
Response Rate ◽  
Cox Regression ◽  
Multivariate Analyses ◽  
Secondary Response ◽  
Front Line ◽  
Recurrent Cervical Cancer ◽  
Free Interval

5588 Background: Second-line chemotherapy after the front-line platinum based regimens including concurrent chemoradiation (CCRT) has not been established for patients with advanced or recurrent cervical cancer. Platinum based regimens are often selected, but the predictive and prognostic factors of secondary platinum therapy are unclear. We therefore evaluated the relative influence of platinum free interval ( PFI ) between the completion of front-line regimen and the institution of second-line regimen. Methods: This retrospective review was undertaken of 65 patients who received ≥ 2 platinum-based regimens and were assessable for secondary response in National Cancer Center Hospital between 1996 and 2008. We analyzed independent predictive factors associated with secondary response by logistic regression model and prognostic factors associated with subsequent survival by Cox regression model. Results: The median age was 54 years old (range, 28 to 73). The median follow-up of subsequent survival was 11.0 months (1.1 to 66.6). The median PFI was 11.1 months (0.7 to 77.6). Overall secondary response rate was 40%, while response rate for 36 patients after CCRT was 36%. The response increases in frequency with longer PFI ( Table ). Univariate and multivariate analyses using logistic regression model showed PFI for ≥ 9 months (odds ratio [OR] = 0.28; P =.04), PS 0 (OR = 0.19; P =.006) and maximum tumor diameter ≥ 30 mm (OR = 0.23; P =.02) were independent predictive factors of secondary response. Univariate and multivariate analyses using Cox regression model revealed PFI for ≥ 9 months (hazard ratio [HR] = 0.44; P =.005), PS 0 (HR = 0.30; P =.000) and histology of squamous cell carcinoma (HR = 2.20; P =.02) were independent prognostic factors of subsequent survival. Conclusions: Our exploratory study demonstrates that platinum free interval has both predictive and prognostic value for secondary platinum-based treatment for patients with advanced or recurrent cervical cancer. [Table: see text] [Table: see text]

Prognostic factors for stage IVB persistent or recurrent cervical cancer (from the results of the JCOG0505 Trial)

2013 ◽  
Vol 130 (1) ◽  
pp. e2-e3
Author(s):  
S. Nishio ◽  
R. Kitagawa ◽  
T. Shibata ◽  
K. Ushijima ◽  
H. Yoshikawa ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Recurrent Cervical Cancer ◽  
Stage Ivb

Prognostic Factors for Survival in Patients With Recurrent Cervical Cancer Previously Treated With Radiotherapy

2010 ◽  
Vol 20 (5) ◽  
pp. 834-840 ◽  
Author(s):  
Seiji Mabuchi ◽  
Fumiaki Isohashi ◽  
Yasuo Yoshioka ◽  
Kumiko Temma ◽  
Takashi Takeda ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cervical Cancer ◽  
Prognostic Factors ◽  
High Risk ◽  
Treatment Modality ◽  
High Risk Group ◽  
Poor Prognostic Factor ◽  
Recurrent Cervical Cancer ◽  
Risk Patients ◽  
Symptom Status

Introduction:The aim of this study was to identify the prognostic factors and to establish a model for the prediction of life expectancy in patients with recurrent cervical cancer that had previously been treated with radiotherapy.Methods:The records of consecutive women with recurrent cervical cancer after radiotherapy were retrospectively reviewed. Primary disease, follow-up, and recurrence data were collected. Univariate and multivariate analyses of prognostic factors of survival were performed.Results:A total of 162 patients were included in our database. The median survival after recurrence was 15 months. Multivariate analysis revealed that symptom status, the site of relapse, prior chemoradiotherapy, and treatment modality were significant prognostic factors in terms of survival after recurrence. Patient survival was inversely correlated with the number of these prognostic factors. When the patients were divided into 3 prognostic groups, (low risk: patients with no poor prognostic factors; intermediate: patients with one poor prognostic factor; and high-risk: patients with more than 2 poor prognostic factors), the patients in the high-risk group had a significantly shorter survival (median, 10 months) than those with one risk factor (median, 20 months) or no risk factors (median, 36 months).Conclusions:Symptom status, the site of relapse, prior chemoradiotherapy, and treatment modality are significant prognostic factors in patients with recurrent cervical cancer that had previously been treated with radiotherapy. Our prognostic model, composed of 4 clinical variables, may enable physicians to predict survival more accurately.Abbreviations:CT - Computed tomography, PET-CT - Positron emission tomography in combination with computed tomography, ISBT - Interstitial brachytherapy, DFI - Disease-free interval

Clinical Aspects and Prognostic Factors for Survival in Patients with Recurrent Cervical Cancer after Radical Hysterectomy

2016 ◽  
Vol 39 (11) ◽  
pp. 704-711 ◽  
Author(s):  
Jitti Hanprasertpong ◽  
Ingporn Jiamset ◽  
Alan Geater ◽  
Athithan Rattanaburi ◽  
Sarayut Thannil
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Radical Hysterectomy ◽  
Clinical Aspects ◽  
Recurrent Cervical Cancer

scholarly journals Clinical Aspects and Prognostic Factors for Survival in Patients with Recurrent Cervical Cancer after Radical Hysterectomy and Adjuvant Radiochemotherapy

2021 ◽  
Author(s):  
Huiting Zhu ◽  
Wenjuan Yan ◽  
Yuhua Gao
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Survival Rate ◽  
Resection Margin ◽  
Disease Relapse ◽  
Early Disease ◽  
Recurrent Cervical Cancer ◽  
Node Metastasis ◽  
Margin Involvement

Abstract Purpose To investigate the recurrence patterns and prognostic factors of patients with recurrent cervical cancer after radical hysterectomy with node dissection (RHND) followed by adjuvant radiotherapy (RT)/concurrent radiochemotherapy (CCRT). Methods Between January 1, 2012 and May 31, 2018, the medical records of 153 patients with pre-operative FIGO stage IB-IIA disease treated with RHND followed by adjuvant RT/CCRT in Liaoning Cancer Hospital were retrospectively analyzed. Results The median disease progression-free survival (PFS) time was 16 months. 75.2% (115/153) patients had disease relapse within 2 years. The survival of patients with recurrences in multiple organs was signifificantly lower in comparison to those with recurrences in single organ ( P <0.001). The survival rate of patients with distant metastasis (DM) and distant metastasis with local recurrence (LR) was significantly lower than that of patients with simple LR ( P =0.006, P <0.001). Furthermore, the survival rate of patients with LR+DM was significantly lower than that of patients with simple DM ( P =0.046).The multivariate analysis showed that resection margin involvement, para-aortic and common iliac lymph node metastasis, DM, no treatment after disease relapse and early disease relapse were independent prognostic fators asscociated with poor survivals. Conclusion Most cervical cancer patients who received initial RHND followed by adjuvant RT/CCRT occurred disease relapse within 2 years. Resection margin involvement, para-aortic and common iliac lymph node metastasis, DM, no treatment after recurrence and early disease relapse were found to be prognostic factors in patients with recurrent cervical cancer after RHND followed by adjuvant RT/CCRT.

Galectin-8 and -9 as prognostic factors for cervical cancer

2020 ◽  
Author(s):  
M Wehrmann ◽  
S Beyer ◽  
S Meister ◽  
TM Kolben ◽  
E Schmoeckel ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors
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