scholarly journals Propriospinal myoclonus with life threatening tonic spasms as paraneoplastic presentation of breast cancer

2005 ◽  
Vol 77 (3) ◽  
pp. 422-424 ◽  
Author(s):  
E Salsano
Keyword(s):  
Breast Cancer ◽  
Life Threatening ◽  
Tonic Spasms ◽  
Propriospinal Myoclonus

A Multicentric non-interventional observational study to determine treatment patterns and response of drugs in various stages of breast cancer along with epidemiology

2020 ◽  
Vol 8 (2) ◽  
pp. 71-81
Author(s):  
Mukkamala Durga Niharika ◽  
Shaik Kulsumbi ◽  
Devagiri Anupama ◽  
Tadigiri Vineela Supriya ◽  
Kotari Navya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Observational Study ◽  
Receptor Expression ◽  
Breast Cancer Patients ◽  
Female Patients ◽  
Life Threatening ◽  
Guntur District ◽  
Study Population ◽  
Hormone Receptor Expression

Cancer is a life-threatening disease which causes to lose cohesiveness and orderliness of normal tissue. These malignant cells can spread to any other organ through blood flow or lymphatic flow and develop malignancy over there; this phenomenon is called metastasis. The aim is to focus on treatment pattern and response of drugs in various stages of breast cancer along with epidemiology. It is a non- interventional multicentric observational study. Female patients confirmed with Breast cancer are included in the study. All the relevant data were collected on a patient demographic form after obtaining informed consent from individual patients. In our study, the mean age of presentation in breast cancer patients was 41.35 years. Further it was found that 40.5% (n = 81) majority-female patients with Breast cancer are from Guntur District and 21.5% (n= 43). The majority of women with Breast cancer have hormone receptor expression of ER+/PR+HER2- was found to be 33% (n= 50). In the study on analyzing comorbidities of the study population, it was noted that 28.5% of women were affected with Diabetes mellitus. In our study, it was found that most of the patients with Breast cancer have been most often prescribed with Adriamycin 27.86%. From these observations, we conclude that late menarche may be one of the etiological causes of breast cancer in women, Invasive carcinoma in situ is the most commonly reported breast cancer in the study. Patients have been diagnosed with breast cancer at their stage 3 of progression, which may be the reason for making it mandatory for more than 50% of patients to undergo 6 to 8 cycles of chemotherapy. Coming to the patterns of drug use, ADRIAMYCIN, CYCLOPHOSPHAMIDE and DOCETAXEL are the three most commonly used single drug and combinational drug therapies among the study population.

scholarly journals Assessment of Breast Cancer Detection and Implementation

2019 ◽  
Vol 8 (11) ◽  
pp. 323-330
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Median Filter ◽  
Breast Cancer Detection ◽  
Statistical Parameters ◽  
Cause Of Deaths ◽  
Life Threatening ◽  
Mammogram Image ◽  
Mean Variance ◽  
Progressive Algorithms

Breast Cancer is the most dangerous and life threatening disease. Of all kinds of cancers, Breast cancer is the second major cause of deaths and especially the first major cause of deaths in women. In this project, images are taken from medical representativess in order to implement a real time project. This methodology aims at diagnosing Breast Cancer at an earlier stage by considering progressive algorithms. In this methodology, a mammogram image is considered. To this image sample, image segmentation technique is applied which separates fore-ground regions from the background regions. Later, Binarization technique is used to enrich the contrast of the image in order to make it more desirable for finding the tumour cell location within the affected area. Median filter is used for removing noise within the image. To the noise free images, some statistical parameters viz., mean, variance, Standard deviation, Mean Square error and entropy are calculated to analyze the performance

scholarly journals Natural product like “shikonin” might be a hope for Breast cancer cure

2019 ◽  
Vol 2 (2) ◽  
pp. 14-18
Author(s):  
Md. Niuz Morshed Khan ◽  
Maidul Islam
Keyword(s):  
Breast Cancer ◽  
Effective Treatment ◽  
Estrogen Therapy ◽  
Future Research ◽  
Breast Cancer Patients ◽  
Developed Country ◽  
Estrogen Receptor Signaling ◽  
Life Threatening ◽  
Effective Treatment Regimen ◽  
Less Developed Country

AbstractAmong all cancers, breast cancer is the most commonly occurring cancer in women and the second most common cancer overall, both in the developed and less developed country. It is a matter of concern worldwide, that there is no effective drug is available for cancer treatment. Although, Surgery, radiation, hormonal (anti-estrogen) therapy, and chemotherapy are being used for treatment of breast cancer in recent years, due to life threatening side effects, these treatment approaches becoming more vulnerable. However, researchers from across the world searching a safe and effective treatment approach that can be a breakthrough for this situation, as it is evident that natural compounds like shikonin from Lithospermum erythrorhizon can fight against aggressiveness of breast cancer by regulating apoptosis, necroptosis and estrogen receptor signaling pathway. In this review, we discussed about potential green chemical compounds with their mechanisms of actions, which can be very effective treatment regimen for breast cancer and can be more potent by their proper modifications and further molecular research. Hopefully in future, research focusing on the “shikonin” will open a new door for increasing the survival rate of breast cancer patients as well as cancer cure.

Layer-Wise Tumor Segmentation of Breast Images Using Convolutional Neural Networks

2021 ◽  
pp. 70-84
Author(s):  
Nishanth Krishnaraj ◽  
A. Mary Mekala ◽  
Bhaskar M. ◽  
Ruban Nersisson ◽  
Alex Noel Joseph Raj
Keyword(s):  
Breast Cancer ◽  
Neural Network ◽  
Network Architecture ◽  
Breast Imaging ◽  
Breast Tissue ◽  
Imaging Techniques ◽  
Tumor Segmentation ◽  
Cancer Type ◽  
The Neural Network ◽  
Life Threatening

Early prediction of cancer type has become very crucial. Breast cancer is common to women and it leads to life threatening. Several imaging techniques have been suggested for timely detection and treatment of breast cancer. More research findings have been done to accurately detect the breast cancer. Automated whole breast ultrasound (AWBUS) is a new breast imaging technology that can render the entire breast anatomy in 3-D volume. The tissue layers in the breast are segmented and the type of lesion in the breast tissue can be identified which is essential for cancer detection. In this chapter, a u-net convolutional neural network architecture is used to implement the segmentation of breast tissues from AWBUS images into the different layers, that is, epidermis, subcutaneous, and muscular layer. The architecture was trained and tested with the AWBUS dataset images. The performance of the proposed scheme was based on accuracy, loss and the F1 score of the neural network that was calculated for each layer of the breast tissue.

Post IORT seroma complication in breast cancer surgery

2020 ◽  
pp. 1-7
Author(s):  
Maha Abdel Hadi ◽  
Afnan Al-Muhanna ◽  
Lina Abu Arida ◽  
Dina Lutfi
Keyword(s):  
Breast Cancer ◽  
Lymphovascular Invasion ◽  
Tumour Size ◽  
Nodal Status ◽  
Histological Diagnosis ◽  
Tumour Grade ◽  
Receptor Status ◽  
Life Threatening ◽  
Radiotherapy Treatment

Abstract Background: Intraoperative radiotherapy (IORT) has gained popularity over recent years due to its impact on shortening the radiotherapy treatment time for early breast cancer. It has certainly proven effective as an exclusive treatment or when combined with whole breast irradiation (WBIR). Seroma is a common non-life-threatening complication that may delay treatment and impose challenges on radiological diagnostic follow-up. Aim: To review and compare the occurrence of seroma in patients who received exclusive IORT or when combined with WBIR and to outline the diagnostic challenges encountered during radiological follow-up. Materials and methods: Based on strict selection criteria, all eligible patients who received IORT ± WBIR treatment between 2012 and 2019 in a university hospital setting were included. Demographic data, histological diagnosis, tumour size, tumour grade, lymphovascular invasion, nodal status, receptor status, treatment with neoadjuvant hormonal chemotherapy, applicator size, dose used, duration of radiotherapy treatment, timing of seroma development and duration of seroma were documented. Both clinical and radiological follow-up were exercised in all patients. Results: The total number of patients treated with breast conserving surgery (BCS) and IORT was 86. Age ranged between 31 and 75 years with the median age of 51 years. Patients treated exclusively with IORT were 39 (45%) while those who received the IORT as a boost were 47 (55%). Seroma was observed in 39(45%) of both IORT and IORT\WBIR patients. Those included 15(38%) of the exclusive IORT treated patients and 24 (62%) of those treated as a boost. Duration of asymptomatic seroma ranged from 6 months to 6 years. Repeated aspiration was performed in 2 (5%) patients. Postoperative seroma occurred independent of age histological diagnosis, tumour size, tumour grade, lymphovascular invasion, nodal status, receptor status, treatment with neoadjuvant hormonal\chemotherapy, applicator size, dose used or duration of radiotherapy treatment. All reviewed patients have shown increased risk of developing seroma; however, an increased incidence of seroma in the IORT + WBIR treated patients was higher than those who received exclusive IORT treatment. Conclusion: Postoperative seroma is a common non-life-threatening entity that occasionally may lead to delay in the subsequent treatment plan. IORT is a safe modality with many benefits; however, it may increase the risk of seroma formation independent of the clinical parameters. Promoting the expertise in post IORT breast imaging aids in overcoming diagnostic challenges.

scholarly journals Electrochemotherapy in Breast Cancer - Discussion of the Method and Literature Review

Breast Care ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. 409-414 ◽  
Author(s):  
Mateusz Wichtowski ◽  
Dawid Murawa ◽  
Katarzyna Kulcenty ◽  
Karolina Zaleska
Keyword(s):  
Breast Cancer ◽  
Cancer Recurrence ◽  
Locoregional Treatment ◽  
Electric Pulses ◽  
Non Invasive ◽  
Life Threatening ◽  
Late Stages ◽  
Methods Of Treatment ◽  
Cause Of Pain

Breast cancer is the most common cause of skin metastases in women. The probability of their occurrence ranges from about 5% in the entire population to as much as 30% in the late stages of the disease. Although rarely life-threatening, they have a major impact on the quality of life of patients with this diagnosis, being the cause of pain, effusion, ulceration, infection, and psychological discomfort. Available methods of treatment, both local and systemic, often fail to provide adequate control of the disease. A particular challenge seems to be the treatment of those patients with cutaneous metastases who, due to the extent of their metastases, are not eligible for resection, in whom the possibility of radiation therapy has already been used, and in whom systemic therapy is ineffective or contraindicated. A new method providing the opportunity for effective treatment is electrochemotherapy (ECT). ECT combines electropulsation of tumor cells (by local application of electric pulses) and administration of antineoplastic drugs such as cisplatin or bleomycin (either intravenous or intratumoral). Several clinical studies have demonstrated that ECT provides safe, efficient, and non-invasive locoregional treatment for chest wall breast cancer recurrence.

A life-threatening drug-drug interaction between capecitabine and brivudine in a patient with metastatic breast cancer

2019 ◽  
Vol 31 (7-8) ◽  
pp. 424-427 ◽  
Author(s):  
Angeliki Tsifi ◽  
George Papaxoinis ◽  
Panagiotis Diamantopoulos ◽  
Marina Mantzourani ◽  
Vasiliki Antoniadou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Interaction ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
Life Threatening ◽  
Drug Drug Interaction

scholarly journals Interfering MSN-NONO complex–activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer

2020 ◽  
Vol 6 (8) ◽  
pp. eaaw9960 ◽  
Author(s):  
Yuanyuan Qin ◽  
Weilong Chen ◽  
Guojuan Jiang ◽  
Lei Zhou ◽  
Xiaoli Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Cell Proliferation ◽  
Poor Overall Survival ◽  
Kinase C ◽  
Life Threatening

Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, little is known about the regulatory mechanisms of MSN in TNBC. We found that MSN significantly stimulated breast cancer cell proliferation and invasion in vitro and tumor growth in vivo, requiring the phosphorylation of MSN and a nucleoprotein NONO-assisted nuclear localization of phosphorylated MSN with protein kinase C (PKC) and then the phosphorylation activation of CREB signaling by PKC. Our study also demonstrated that targeting MSN, NONO, or CREB significantly inhibited breast tumor growth in vivo. These results introduce a new understanding of MSN function in breast cancer and provide favorable evidence that MSN or its downstream molecules might serve as new targets for TNBC treatment.

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