scholarly journals Electrochemotherapy in Breast Cancer - Discussion of the Method and Literature Review

Breast Care ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. 409-414 ◽  
Author(s):  
Mateusz Wichtowski ◽  
Dawid Murawa ◽  
Katarzyna Kulcenty ◽  
Karolina Zaleska
Keyword(s):  
Breast Cancer ◽  
Cancer Recurrence ◽  
Locoregional Treatment ◽  
Electric Pulses ◽  
Non Invasive ◽  
Life Threatening ◽  
Late Stages ◽  
Methods Of Treatment ◽  
Cause Of Pain

Breast cancer is the most common cause of skin metastases in women. The probability of their occurrence ranges from about 5% in the entire population to as much as 30% in the late stages of the disease. Although rarely life-threatening, they have a major impact on the quality of life of patients with this diagnosis, being the cause of pain, effusion, ulceration, infection, and psychological discomfort. Available methods of treatment, both local and systemic, often fail to provide adequate control of the disease. A particular challenge seems to be the treatment of those patients with cutaneous metastases who, due to the extent of their metastases, are not eligible for resection, in whom the possibility of radiation therapy has already been used, and in whom systemic therapy is ineffective or contraindicated. A new method providing the opportunity for effective treatment is electrochemotherapy (ECT). ECT combines electropulsation of tumor cells (by local application of electric pulses) and administration of antineoplastic drugs such as cisplatin or bleomycin (either intravenous or intratumoral). Several clinical studies have demonstrated that ECT provides safe, efficient, and non-invasive locoregional treatment for chest wall breast cancer recurrence.

scholarly journals Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Andrea DeCensi ◽  
Harriet Johansson ◽  
Thomas Helland ◽  
Matteo Puntoni ◽  
Debora Macis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Low Dose ◽  
Cancer Recurrence ◽  
Phase Iii ◽  
Cyp2d6 Genotype ◽  
Phase Iii Trial ◽  
Reactive Protein ◽  
Non Invasive ◽  
Tamoxifen Metabolites ◽  
Dose Trial

AbstractLow-dose tamoxifen halves recurrence in non-invasive breast cancer without significant adverse events. Some adjuvant trials with tamoxifen 20 mg/day had shown an association between low endoxifen levels (9–16 nM) and recurrence, but no association with CYP2D6 was shown in the NSABP P1 and P2 prevention trials. We studied the association of CYP2D6 genotype and tamoxifen metabolites with tumor biomarkers and recurrence in a randomized phase III trial of low-dose tamoxifen. Median (IQR) endoxifen levels at year 1 were 8.4 (5.3–11.4) in patients who recurred vs 7.5 (5.1–10.2) in those who did not recur (p = 0.60). Tamoxifen and metabolites significantly decreased C-reactive protein (CRP, p < 0.05), and a CRP increase after 3 years was associated with higher risk of recurrence (HR = 4.37, 95% CI, 1.14–16.73, P = 0.03). In conclusion, endoxifen is below 9 nM in most subjects treated with 5 mg/day despite strong efficacy and there is no association with recurrence, suggesting that the reason for tamoxifen failure is not poor drug metabolism. Trial registration: ClinicalTrials.gov, Identifier: NCT01357772.

Effectiveness and safety of modern treatment against nausea and vomiting induced by chemotherapy and radiotherapy

2021 ◽  
Vol 14 (1) ◽  
pp. 11-15
Author(s):  
Łukasz Hajac ◽  
Martyna Hajac ◽  
Adam Maciejczyk
Keyword(s):  
Side Effects ◽  
Serotonin Syndrome ◽  
Nausea And Vomiting ◽  
Effective Prevention ◽  
Important Group ◽  
Life Threatening ◽  
Treatment Changes ◽  
Long Acting ◽  
Methods Of Treatment

Nausea and vomiting are one of most frequent side effects of chemotherapy and radiotherapy. Effective prevention and treatment of these symptoms is essential for better quality of life for patients undergoing oncological therapies. Nausea and vomiting can be acute, delayed or anticipatory. Leading mechanisms and methods of treatment are different for each of those. Most often used groups of drugs are: 5-HT3-antagonists, glucocorticosteroids, NK1-antagonists. Another important group are neuroleptics, which are therapy of choice for anticipatory vomiting. Modern antiemetic medications are in most cases safe and effective. But as every treatment it causes risks of adverse events which may be serious and difficult to manage. It applies in particular to long-acting drugs. Most common side effects are headache, constipation and sedation. But more severe or life-threatening symptoms may appear, like intestinal obstruction and serotonin syndrome. Some of the drugs also come with risk of interacting with other treatment. Changes in pharmacokinetics may lead to additional toxicities. In elderly, especially with cardiac disease, in risk of ileus or cachexia these drugs shall be used with caution.

scholarly journals Electrochemotherapy in the Treatment of Massive, Multisite Breast Cancer Metastasis to the Skin and Subcutaneous Tissue: A Case Report

Breast Care ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. 353-355 ◽  
Author(s):  
Mateusz Wichtowski ◽  
Paweł Potocki ◽  
Joanna Kufel-Grabowska ◽  
Joanna Streb ◽  
Dawid Murawa
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Cancer Metastasis ◽  
Subcutaneous Tissue ◽  
Cancer Recurrence ◽  
Breast Cancer Metastasis ◽  
Locoregional Therapy ◽  
Non Invasive ◽  
Chest Wall Recurrence ◽  
Complete Clinical Remission

Background: Chest wall recurrence (CWR) from breast cancer after mastectomy is a difficult to treat disease. Electrochemotherapy (ECT) provides a safe, efficient, and non-invasive locoregional treatment approach in this setting. Case Report: A 61-year-old woman presented with unresectable breast cancer recurrence to the skin and subcutaneous tissue for which numerous lines of treatment were unsuccessful. Between February 2015 and May 2015, the patient underwent 3 courses of ECT after which a spectacular regression of the cutaneous metastatic foci was observed. After an overall observation period of 12 weeks, complete clinical remission was achieved. Conclusion: ECT can be proposed as an effective and safe locoregional therapy for breast cancer CWR and provides an alternative treatment modality to conventional therapies, especially in the case of multiple cutaneous and subcutaneous lesions.

scholarly journals Health variations among breast-cancer patients from different disease states: evidence from China

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Qing Yang ◽  
Xuexin Yu ◽  
Wei Zhang
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Cancer Recurrence ◽  
Mapping Function ◽  
Health Utility ◽  
Breast Cancer Patients ◽  
Utility Values ◽  
Disease States

Abstract Background This study aimed to obtain health utility parameters among Chinese breast cancer patients in different disease states for subsequent health economics model. In addition, we aimed to explore the feasibility of establishing a breast cancer health utility mapping model in China. Methods Multiple patient-reported health attributes were assessed, including quality of life, which was measured by the Functional Assessment of Cancer Therapy-Breast (FACT-B) instrument; health utility and self-rated health, which were measured by the EuroQol-5 Dimension-5 Level (EQ-5D-5L) questionnaire. Multivariate regression models, including a linear regression model, an ordinal logistic regression model and a Tobit model, were employed to analyze health differences among 446 breast cancer patients. Subgroup analyses were performed to examine differences in multiple dimensions of health derived from the FACT-B and EQ-5D-5L instruments. A mapping function was used to estimate health utility from quality of life. Rank correlation analyses were employed to examine the correlation between estimated and observed health utility values. Results A total of 446 breast cancer patients with different disease states were analyzed. The health utility values of breast cancer patients in the P state (without cancer recurrence and metastasis), R state (with cancer recurrence within a year), S state (with primary and recurrent breast cancer for the second year and above), and M state (metastatic cancer) were 0.81 (SD ± 0.23), 0.90 (SD ± 0.12), 0.78 (SD ± 0.31), and 0.74 (SD ± 0.27), respectively. There were positive correlations between all scores, including every domain of the FACT-B instrument (p < 0.001). Results from multivariate analysis suggested that patients in the R and M states had lower scores for overall quality of life (R, β = − 9.45, p < 0.01; M, β = − 6.72, p < 0.05). Patients in the M state had lower health utility values than patients in the P state (β = − 0.11, p < 0.05). Estimated health utility values, which were derived from quality of life by using a mapping function, were significantly correlated with directly measured health utility values (p < 0.001). Conclusions We obtained the health utility and health-related quality of life (HRQoL) scores of Chinese breast cancer patients in different disease states. Mapping health utility values from quality of life using four disease states could be feasible in health economic modelling, but the mapping function may need further revision.

To the Question of Comprehensive Treatment in the Patients with Ovarian Cancer III-IV Stages by Autohemochemotherapy Associated with the «Melaxen»

10.12737/5917 ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 126-131
Author(s):  
Козырева ◽  
S. Kozyreva ◽  
Козырев ◽  
K. Kozyrev ◽  
Карсанов ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Malignant Tumors ◽  
Cancer Recurrence ◽  
Biological Rhythms ◽  
Comprehensive Treatment ◽  
Synthetic Analogue ◽  
Complex Treatment ◽  
Methods Of Treatment ◽  
Positive Effect

This paper presents the positive characteristics of preoperative autohemochemotherapy associated with the drug &#34;Melaxen” as a synthetic analogue of the epiphysial hormone melatonin, produced by Unipharm-USA in the complex treatment of patients with ovarian cancer on the stage III-IV. The authors emphasize that the &#34;Melaxen&#34; has a powerful antioxidant, anticarcinogenic and adaptogenic action, reduces stress response and regulates neuroendocrine function and biological rhythms. The authors believe that neoadjuvant autohemotherapy by the &#34;Melaxen&#34; with a powerful immunomodulatory and lipoic effects, improves general non-specific resistance of the organism, has a positive effect on the immediate and remote results of complex treatment of patients. In comparison with polychemotherapy, the autohemotherapy in combination with the “Melaxen&#34; has the advantages. This therapy is significant in several basic methods of treatment of malignant tumors of the localization. It was found that with autohemochemotherapy by the &#34;Melaxen&#34; improves efficiency polychemotherapy, reduces its toxicity, consequently, clinically warranted and expedient in this connection, can be used as subsidiary means complex treatment of ovarian cancer recurrence in the spread process. The drug allows to improve the quality of life, to increase its duration in critically ill patients.

scholarly journals Stress and Quality of Life in Breast Cancer Recurrence: Moderation or Mediation of Coping?

2008 ◽  
Vol 35 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Hae-Chung Yang ◽  
Brittany M. Brothers ◽  
Barbara L. Andersen
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence

scholarly journals Health variations among breast-cancer patients from different disease states: Evidence from China

2020 ◽  
Author(s):  
Qing Yang ◽  
Xuexin Yu ◽  
Wei Zhang
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Cancer Recurrence ◽  
Mapping Function ◽  
Health Utility ◽  
Breast Cancer Patients ◽  
Utility Values ◽  
Disease States

Abstract Background: The aim of this study was to obtain health utility data for Chinese breast cancer patients in different disease states to obtain important parameters for health economics modelling and to explore the feasibility of establishing a breast cancer health utility mapping model in China.Methods: Multiple patient-reported health attributes were assessed, including quality of life, which was measured by the Functional Assessment of Cancer Therapy-Breast (FACT-B) instrument; health utility and self-rated health, which were measured by the EuroQol-5 Dimension-5 Level (EQ-5D-5L) questionnaire. Multivariate regression models, including a linear regression model, an ordinal logistic regression model and a Tobit model, were employed to analyse health differences among 446 breast cancer patients. Subgroup analyses were performed to analyse differences in the dimensions of health derived from the FACT-B and EQ-5D-5L instruments. A mapping function was used to estimate health utility from quality of life. Rank correlation analyses were employed to examine the correlation between estimated and observed health utility values.Results: A total of 446 breast cancer patients with different disease states were analysed. The health utility values of breast cancer patients in the P state (without cancer recurrence and metastasis), R state (with cancer recurrence within a year), S state (with primary and recurrent breast cancer for the second year and above), and M state (metastatic cancer) were 0.81 (SD±0.23), 0.90 (SD±0.12), 0.78 (SD±0.31), and 0.74 (SD±0.27), respectively. There were positive correlations between all scores, including each domain of the FACT-B instrument (p<0.001). Multivariate analysis suggested that patients in the R and M states had lower scores for overall quality of life (R, β = -9.45, p< 0.01; M, β = -6.72, p<0.05). Patients in the M state had lower health utility values than patients in the P state (β = -0.11, p< 0.05). Estimated health utility values, which were derived from quality of life using a mapping function, were significantly correlated with directly measured health utility values (p<0.001).Conclusions: We obtained the health utility and health-related quality of life (HRQoL) scores of Chinese breast cancer patients with different disease states. Mapping health utility values from quality of life using four disease states could be feasible in health economic modelling, but the mapping function may need further revision.

scholarly journals The development of a lifestyle modification mobile application, “Health for You” for overweight and obese breast cancer survivors in Korea

2021 ◽  
Vol 27 (3) ◽  
pp. 243-255
Author(s):  
Su-Jin Seo ◽  
Ju-Hee Nho ◽  
Youngsam Park
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Mobile Application ◽  
Breast Cancer Survivors ◽  
Lifestyle Modification ◽  
Healthy Lifestyle ◽  
Cancer Recurrence ◽  
Bulletin Board ◽  
Design Development

Purpose: This study aimed to develop a lifestyle modification (LSM) mobile application based on the Android operating system for overweight and obese breast cancer survivors (BCS) in Korea and evaluate its usability.Methods: The content analysis, design, development, implementation, and evaluation of the LSM intervention mobile application for overweight and obese BCS was conducted by identifying survivors’ needs, searching the literature, and reviewing existing mobile applications. The survey was conducted from June 1 to December 28, 2020 at Jeonju city, Korea.Results: The mobile application for BCS included dietary and exercise information, weight logs, as well as distress and daily achievement check. It also included information and videos on the prevention of breast cancer recurrence and used a communication bulletin board. Expert and user usability evaluation of its content and functions confirmed that it was appropriate and satisfactory for overweight and obese BCS.Conclusion: This LSM mobile application developed for overweight and obese BCS was found to be appropriate for use. It can be applied for further study of effectiveness on improving their health and maintaining a healthy lifestyle, to ultimately improve quality of life.

scholarly journals Hepatic Metastasis from Breast Cancer

2020 ◽  
Vol 37 (05) ◽  
pp. 518-526
Author(s):  
Ariel N. Liberchuk ◽  
Amy R. Deipolyi
Keyword(s):  
Breast Cancer ◽  
Liver Metastasis ◽  
Locoregional Treatment ◽  
Preserve Liver Function ◽  
Potential Benefits ◽  
Hospital Stays ◽  
Poor Outcomes ◽  
Breast Cancer Liver Metastasis ◽  
Outpatient Settings

AbstractBreast cancer is the most common cancer in women and breast cancer liver metastasis may be associated with poor outcomes. Emerging locoregional therapies can be given in outpatient settings or with short hospital stays, to provide local control, support quality of life, preserve liver function, and potentially prolong survival. This review discusses retrospective studies suggesting potential benefits of locoregional treatment of breast cancer liver metastasis. Future prospective studies are needed to demonstrate efficacy and optimize patient selection.

Comprehensive rehabilitation of lymphatic oedema in women after mastectomy.

2018 ◽  
Vol 1 (4) ◽  
pp. 27-34
Author(s):  
Anna MARGOL ◽  
Adrian KUŻDŻAŁ ◽  
Grzegorz MAGOŃ
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Lymphatic Drainage ◽  
Cancer Disease ◽  
Female Population ◽  
Holistic Treatment ◽  
Research Outcomes ◽  
Comprehensive Rehabilitation ◽  
Methods Of Treatment

Breast cancer is the most frequently occurring type of cancer among the female population. As a result, it poses a serious social problem, being subject to various scientific research and analysis. The topic of this thesis is an assessment o f a c o m p l e x r e h a b i l i t a t i o n o f lymphedema that occurs among females after mastectomy, which is the most frequent postoperative complication in this group of patients. The purpose of this thesis is an assessment of the quality of rehabilitation of patients and its effectiveness but also a recognition of the preferences concerning types of treatment. The analysis was divided into two parts: theoretical and explanatory. The research was conducted among m e m b e r s o f “ B i ł g o r a j s k i e Stowarzyszenie Amazonek” (The Amazons' Association in Biłgoraj) and Stowarzyszenie “Rzeszowski Klub Amazonek” (The Amazons' Club in Rzeszów). The first part includes an outline of cancer disease, its risk factors and methods of treatment. The explanatory part includes an answer to the hypothesis concerning the level of complex rehabilitation, its accessibility and effectiveness. The research shows that complex rehabilitation is a crucial element of the holistic treatment of cancer patients because it reduces the risk of complications, improves psychophysical conditions of patients and increases the chances of full recovery. The research outcomes demonstrate that the most frequently used treatment in the therapy of lymphedema is lymphatic drainage but also physiotherapy and kinesiotherapy treatments.

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