scholarly journals Gymnasium-based unsupervised exercise maintains benefits in oxygen uptake kinetics obtained following supervised training in type 2 diabetes

2012 ◽  
Vol 37 (4) ◽  
pp. 599-609 ◽  
Author(s):  
Oscar MacAnaney ◽  
Donal O’Shea ◽  
Stuart A. Warmington ◽  
Simon Green ◽  
Mikel Egaña
Keyword(s):  
Type 2 Diabetes ◽  
Heart Rate ◽  
Oxygen Uptake ◽  
Ventilatory Threshold ◽  
Constant Load ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Supervised Exercise ◽  
Rate Kinetics

Supervised exercise (SE) in patients with type 2 diabetes improves oxygen uptake kinetics at the onset of exercise. Maintenance of these improvements, however, has not been examined when supervision is removed. We explored if potential improvements in oxygen uptake kinetics following a 12-week SE that combined aerobic and resistance training were maintained after a subsequent 12-week unsupervised exercise (UE). The involvement of cardiac output (CO) in these improvements was also tested. Nineteen volunteers with type 2 diabetes were recruited. Oxygen uptake kinetics and CO (inert gas rebreathing) responses to constant-load cycling at 50% ventilatory threshold (VT), 80% VT, and mid-point between VT and peak workload (50% Δ) were examined at baseline (on 2 occasions) and following each 12-week training period. Participants decided to exercise at a local gymnasium during the UE. Thirteen subjects completed all the interventions. The time constant of phase 2 of oxygen uptake was significantly faster (p < 0.05) post-SE and post-UE compared with baseline at 50% VT (17.3 ± 10.7 s and 17.5 ± 5.9 s vs. 29.9 ± 10.7 s), 80% VT (18.9 ± 4.7 and 20.9 ± 8.4 vs. 34.3 ± 12.7s), and 50% Δ (20.4 ± 8.2 s and 20.2 ± 6.0 s vs. 27.6 ± 3.7 s). SE also induced faster heart rate kinetics at all 3 intensities and a larger increase in CO at 30 s in relation to 240 s at 80% VT; and these responses were maintained post-UE. Unsupervised exercise maintained benefits in oxygen uptake kinetics obtained during a supervised exercise in subjects with diabetes, and these benefits were associated with a faster dynamic response of heart rate after training.

Influence of menopause and Type 2 diabetes on pulmonary oxygen uptake kinetics and peak exercise performance during cycling

2015 ◽  
Vol 309 (8) ◽  
pp. R875-R883 ◽  
Author(s):  
Catherine Kiely ◽  
Joel Rocha ◽  
Eamonn O'Connor ◽  
Donal O'Shea ◽  
Simon Green ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Oxygen Uptake ◽  
Ventilatory Threshold ◽  
Menopausal Status ◽  
Constant Load ◽  
Peak Oxygen Uptake ◽  
Oxygen Uptake Kinetics ◽  
Peak Exercise ◽  
Age Range

We investigated if the magnitude of the Type 2 diabetes (T2D)-induced impairments in peak oxygen uptake (V̇o2) and V̇o2 kinetics was affected by menopausal status. Twenty-two women with T2D (8 premenopausal, 14 postmenopausal), and 22 nondiabetic (ND) women (11 premenopausal, 11 postmenopausal) matched by age (range = 30–59 yr) were recruited. Participants completed four bouts of constant-load cycling at 80% of their ventilatory threshold for the determination of V̇o2 kinetics. Cardiac output (CO) (inert gas rebreathing) was recorded at rest and at 30 s and 240 s during two additional bouts. Peak V̇o2 was significantly ( P < 0.05) reduced in both groups with T2D compared with ND counterparts (premenopausal, 1.79 ± 0.16 vs. 1.55 ± 0.32 l/min; postmenopausal, 1.60 ± 0.30 vs. 1.45 ± 0.24 l/min). The time constant of phase II of the V̇o2 response was slowed ( P < 0.05) in both groups with T2D compared with healthy counterparts (premenopausal, 29.1 ± 11.2 vs. 43.0 ± 12.2 s; postmenopausal, 33.0 ± 9.1 vs. 41.8 ± 17.7 s). At rest and during submaximal exercise absolute CO responses were lower, but the “gains” in CO larger (both P < 0.05) in both groups with T2D. Our results suggest that the magnitude of T2D-induced impairments in peak V̇o2 and V̇o2 kinetics is not affected by menopausal status in participants younger than 60 yr of age.

Heart Rate and Oxygen Uptake Kinetics in Type 2 Diabetes Patients – A Pilot Study on the Influence of Cardiovascular Medication on Regulatory Processes

2017 ◽  
Vol 125 (05) ◽  
pp. 275-281 ◽  
Author(s):  
Jessica Koschate ◽  
Uwe Drescher ◽  
Klaus Baum ◽  
Christian Brinkmann ◽  
Thorsten Schiffer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Oxygen Uptake ◽  
Cross Correlation ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Cardiovascular Medication ◽  
Regulatory Processes ◽  
Rate Kinetics ◽  
Heart Rate Kinetics

AbstractThe aim of this pilot study was to investigate whether there are differences in heart rate and oxygen uptake kinetics in type 2 diabetes patients, considering their cardiovascular medication. It was hypothesized that cardiovascular medication would affect heart rate and oxygen uptake kinetics and that this could be detected using a standardized exercise test. 18 subjects were tested for maximal oxygen uptake. Kinetics were measured in a single test session with standardized, randomized moderate-intensity work rate changes. Time series analysis was used to estimate kinetics. Greater maxima in cross-correlation functions indicate faster kinetics. 6 patients did not take any cardiovascular medication, 6 subjects took peripherally acting medication and 6 patients were treated with centrally acting medication. Maximum oxygen uptake was not significantly different between groups. Significant main effects were identified regarding differences in muscular oxygen uptake kinetics and heart rate kinetics. Muscular oxygen uptake kinetics were significantly faster than heart rate kinetics in the group with no cardiovascular medication (maximum in cross-correlation function of muscular oxygen uptake vs. heart rate; 0.32±0.08 vs. 0.25±0.06; p=0.001) and in the group taking peripherally acting medication (0.34±0.05 vs. 0.28±0.05; p=0.009) but not in the patients taking centrally acting medication (0.28±0.05 vs. 0.30±0.07; n.s.). It can be concluded that regulatory processes for the achievement of a similar maximal oxygen uptake are different between the groups. The used standardized test provided plausible results for heart rate and oxygen uptake kinetics in a single measurement session in this patient group.

Similar level of impairment in exercise performance and oxygen uptake kinetics in middle-aged men and women with type 2 diabetes

2012 ◽  
Vol 303 (1) ◽  
pp. R70-R76 ◽  
Author(s):  
Eamonn O'Connor ◽  
Catherine Kiely ◽  
Donal O'Shea ◽  
Simon Green ◽  
Mikel Egaña
Keyword(s):  
Type 2 Diabetes ◽  
Oxygen Uptake ◽  
Ventilatory Threshold ◽  
Constant Load ◽  
Peak Oxygen Uptake ◽  
Oxygen Uptake Kinetics ◽  
Dynamic Responses ◽  
Middle Aged ◽  
Men And Women

The present study tested the hypothesis that the magnitude of the type 2 diabetes-induced impairments in peak oxygen uptake (V̇o2) and V̇o2 kinetics would be greater in females than males in middle-aged participants. Thirty-two individuals with type 2 diabetes (16 male, 16 female), and 32 age- and body mass index (BMI)-matched healthy individuals (16 male, 16 female) were recruited. Initially, the ventilatory threshold (VT) and peak V̇o2 were determined. On a separate day, subjects completed four 6-min bouts of constant-load cycling at 80% VT for the determination of V̇o2 kinetics using standard procedures. Cardiac output (CO) (inert gas rebreathing) was recorded at rest, 30, and 240 s during two additional bouts. Peak V̇o2 (ml·kg−1·min−1) was significantly reduced in men and women with type 2 diabetes compared with their respective nondiabetic counterparts (men, 27.8 ± 4.4 vs. 31.1 ± 6.2 ml·kg−1·min−1; women, 19.4 ± 4.1 vs. 21.4 ± 2.9 ml·kg−1·min−1). The time constant (s) of phase 2 (τ2) and mean response time (s) of the V̇o2 response (MRT) were slowed in women with type 2 diabetes compared with healthy women (τ2, 43.3 ± 9.8 vs. 33.6 ± 10.0 s; MRT, 51.7 ± 9.4 vs. 43.5 ± 11.4s) and in men with type 2 diabetes compared with nondiabetic men (τ2, 43.8 ± 12.0 vs. 35.3 ± 9.5 s; MRT, 57.6 ± 8.3 vs. 47.3 ± 9.3 s). The magnitude of these impairments was not different between males and females. The steady-state CO responses or the dynamic responses of CO were not affected by type 2 diabetes among men or women. The results suggest that the type 2 diabetes-induced impairments in peak V̇o2 and V̇o2 kinetics are not affected by sex in middle aged participants.

Is Well-Controlled Type 2 Diabetes Affects Oxygen Uptake Kinetics in Male Subjects? A Pilot Study

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 456-457
Author(s):  
Patrice Brassard ◽  
Joanie Caron ◽  
Gregory R. duManoir ◽  
Claudine Pelletier ◽  
Guillaume Salamin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pilot Study ◽  
Oxygen Uptake ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Male Subjects

scholarly journals A Single Bout of Constant-Load Exercise Test for Estimating the Time Constant of Oxygen Uptake Kinetics in Individuals With Stroke

2021 ◽  
Vol 45 (4) ◽  
pp. 304-313
Author(s):  
Kazuaki Oyake ◽  
Yasuto Baba ◽  
Yuki Suda ◽  
Jun Murayama ◽  
Ayumi Mochida ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Time Constant ◽  
Ventilatory Threshold ◽  
Exercise Bout ◽  
Relative Difference ◽  
Constant Load ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Single Bout ◽  
The Relationship

Objective To examine the relationship between the time constant of oxygen uptake kinetics during the onset of exercise (τVO2) estimated from a single exercise bout and that obtained from three averaged exercise bouts in individuals with stroke.Methods Twenty participants with stroke performed three bouts of a constant-load pedaling exercise at approximately 80% of the workload corresponding to the ventilatory threshold to estimate τVO2. The VO2 data from the first trial of three bouts were used to estimate τVO2 for a single bout. Additionally, data collected from three bouts were ensemble-averaged to obtain τVO2 for three averaged bouts as the criterion.Results There was a very high correlation between τVO2 for a single bout (34.8±14.0 seconds) and τVO2 for three averaged bouts (38.5±13.4 seconds) (r=0.926, p<0.001). However, τVO2 for a single bout was smaller than that for three averaged bouts (p=0.006).Conclusion τVO2 for a single bout could reflect the relative difference in τVO2 for three averaged bouts among individuals with stroke. However, it should be noted that τVO2 for a single bout may be underestimated compared to τVO2 for three averaged bouts.

scholarly journals Physical Fitness and Exercise Endurance Measured by Oxygen Uptake Kinetics in Patients with Type 2 Diabetes Mellitus.

2001 ◽  
Vol 13 (2) ◽  
pp. 83-85 ◽  
Author(s):  
Junichi Katoh ◽  
Masao Hirayama ◽  
Masahito Murakami ◽  
Junko Nakato ◽  
Akiyo Hosokawa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Oxygen Uptake ◽  
Physical Fitness ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Exercise Endurance

Effects of 2 Models of Aquatic Exercise Training on Cardiorespiratory Responses of Patients With Type 2 Diabetes: The Diabetes and Aquatic Training Study—A Randomized Controlled Trial

2020 ◽  
Vol 17 (11) ◽  
pp. 1091-1099
Author(s):  
Rodrigo Sudatti Delevatti ◽  
Ana Carolina Kanitz ◽  
Cláudia Gomes Bracht ◽  
Salime Donida Chedid Lisboa ◽  
Elisa Corrêa Marson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Heart Rate ◽  
Exercise Training ◽  
Oxygen Uptake ◽  
Ventilatory Threshold ◽  
Training Group ◽  
Aquatic Exercise ◽  
Maximal Velocity ◽  
Aquatic Training

Background: There are a lack of clinical trials with suitable methodological quality that compare aquatic exercise training types in type 2 diabetes (T2D) treatment. This study aimed to compare the effects of aerobic and combined aquatic training on cardiorespiratory outcomes in patients with T2D. Methods: Untrained patients with T2D were randomized to receive an aerobic aquatic training, a combined aquatic training, or a procedure control in 3 weekly sessions for 15 weeks. The sessions were 50 minutes long. The intensities were from 85% to 100% of heart rate of anaerobic threshold and at maximal velocity for aerobic and resistance parts, respectively. Resting heart rate, peak oxygen uptake (VO2peak), and oxygen uptake corresponding to second ventilatory threshold and its relation with VO2peak were evaluated. Results: Participants were 59.0 (8.2) years old and 51% women. Intervention groups increased in VO2peak (aerobic aquatic training group: 4.48 mL·kg−1·min−1, P = .004; combined aquatic training group: 5.27 mL·kg−1·min−1; P = .006) and oxygen uptake corresponding to second ventilatory threshold, whereas the control group presented an increase in oxygen uptake corresponding to second ventilatory threshold and minimal change in VO2peak. Conclusions: Aerobic and combined aquatic exercise interventions improve the cardiorespiratory fitness of patients with T2D.

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