THE EFFECT OF REPEATED ALCOHOLIC INTOXICATION ON ADRENAL ASCORBIC ACID AND CHOLESTEROL IN THE RAT

1962 ◽  
Vol 40 (8) ◽  
pp. 975-981 ◽  
Author(s):  
H. Kalant ◽  
Caroline Czaja
Keyword(s):  
Ascorbic Acid ◽  
Relative Weight ◽  
Ascorbic Acid Content ◽  
Female Rats ◽  
Male Rats ◽  
Albino Rats ◽  
Chronic Alcoholic ◽  
Alcoholic Intoxication ◽  
Chronic Alcoholic Intoxication ◽  
Inclined Plane Test

Groups of adult male and female albino rats received daily gavage of 1.25 ml of water or of 20% ethanol per 100 g body weight for a period of 1 month, and were killed either 1.5 hours or 24 hours after the last dose. Such daily treatment with either water or alcohol, ending 24 hours before death, did not result in any significant change from control values in the relative weight of the adrenal glands, or their ascorbic acid and cholesterol contents. No changes in these values were found in animals which received an additional dose of water or alcohol 1.5 hours before death. The female rats showed lower values for adrenal ascorbic acid content than the males in corresponding groups, but did not differ from the males with respect to the effects of the various treatments. A similar experiment with male rats only, carried on for 2 months, also showed no significant differences among any of the treatment groups.Measurements of the degree of intoxication produced by single doses of ethanol were carried out by means of the inclined-plane test. Intraperitoneal injection of 2 g/kg produced much more rapid and marked intoxication than did gavage with either 2 or 4 g/kg.It was concluded that daily gavage for 1-2 months with ethanol in a moderately intoxicating dose (2 g/kg) does not constitute a stimulus to adrenal cortical activity or result in exhaustion atrophy of the adrenal cortex, and that adrenal cortical stimulation is not an invariable accompaniment of acute or chronic alcoholic intoxication.

THE EFFECT OF REPEATED ALCOHOLIC INTOXICATION ON ADRENAL ASCORBIC ACID AND CHOLESTEROL IN THE RAT

1962 ◽  
Vol 40 (1) ◽  
pp. 975-981 ◽  
Author(s):  
H. Kalant ◽  
Caroline Czaja
Keyword(s):  
Ascorbic Acid ◽  
Relative Weight ◽  
Ascorbic Acid Content ◽  
Female Rats ◽  
Male Rats ◽  
Albino Rats ◽  
Chronic Alcoholic ◽  
Alcoholic Intoxication ◽  
Chronic Alcoholic Intoxication ◽  
Inclined Plane Test

Groups of adult male and female albino rats received daily gavage of 1.25 ml of water or of 20% ethanol per 100 g body weight for a period of 1 month, and were killed either 1.5 hours or 24 hours after the last dose. Such daily treatment with either water or alcohol, ending 24 hours before death, did not result in any significant change from control values in the relative weight of the adrenal glands, or their ascorbic acid and cholesterol contents. No changes in these values were found in animals which received an additional dose of water or alcohol 1.5 hours before death. The female rats showed lower values for adrenal ascorbic acid content than the males in corresponding groups, but did not differ from the males with respect to the effects of the various treatments. A similar experiment with male rats only, carried on for 2 months, also showed no significant differences among any of the treatment groups.Measurements of the degree of intoxication produced by single doses of ethanol were carried out by means of the inclined-plane test. Intraperitoneal injection of 2 g/kg produced much more rapid and marked intoxication than did gavage with either 2 or 4 g/kg.It was concluded that daily gavage for 1-2 months with ethanol in a moderately intoxicating dose (2 g/kg) does not constitute a stimulus to adrenal cortical activity or result in exhaustion atrophy of the adrenal cortex, and that adrenal cortical stimulation is not an invariable accompaniment of acute or chronic alcoholic intoxication.

Acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii (Miq.) Miq. stem bark in rats

2021 ◽  
Vol 10 (2) ◽  
pp. 89-97
Author(s):  
EL Lappa ◽  
◽  
C Bogning Zangueu ◽  
EL Nguemfo ◽  
JJ Kojom Wanche ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Chronic Toxicity ◽  
Hematological Parameters ◽  
Lethal Dose ◽  
Relative Weight ◽  
Stem Bark ◽  
The Body ◽  
Female Rats ◽  
Male Rats

Ficus vogelii is a medicinal plant mainly found in tropical Africa and reported to treat inflammatory complaints. This study aims to evaluate the acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii stem bark in wistar rats. For acute study, aqueous extract at a single dose of 5000 mg/kg body weight was administered to female rats and observed for 14 days. In the sub-chronic study, the extract was administered daily to both sex rats at the doses of 100, 200, 400, and 600 mg/kg body weight for 28 consecutive days. Body weight was measured weekly, while hematological, biochemical, and histopathological parameters were analyzed after euthanize. Aqueous extract of Ficus vogelii at all tested doses didn’t produced any mortality or significant change on the body weight and relative weight of rats on acute and sub-chronic studies. The lethal dose 50 was estimated greater than 5000 mg/kg (DL50˃5000 mg/kg). Hematological parameters were recorded non-significant in all treated rats. Aqueous extract at 600 mg/kg significantly changed transaminases and alkaline phosphatase activities, these changes were reversible in satellites. The concentrations of bilirubin was increased at 200 and 600 mg/kg in male rats, at 100, 400 mg/kg in female rats. The levels of lipids markers didn’t changed, except the significant decrease of LDL-cholesterol. Histological examination didn’t showed any change in the architecture of the liver and kidney of rats treated compared to control. Thus aqueous extract of Ficus vogelii stem bark didn’t produced adverse effects in rats after oral acute and sub-chronic treatment.

THE EFFECT OF VARIOUS ACTH EXTRACTS ON THE GONADS

1954 ◽  
Vol 10 (4) ◽  
pp. 291-301 ◽  
Author(s):  
R. W. BRIMBLECOMBE ◽  
I. D. K. HALKERSTON ◽  
M. REISS
Keyword(s):  
Ascorbic Acid ◽  
Female Rats ◽  
Male Rats ◽  
Stimulatory Action ◽  
Follicular Maturation ◽  
Accessory Sex Organs ◽  
Stimulation Of

SUMMARY ACTH extracts showing inhibition of the stimulatory action of PMS on follicular maturation in infantile female rats and slight stimulation of the growth of the testes and accessory sex organs in infantile male rats and day-old chicks have been investigated. The action of these extracts on the gonads was found to be independent of the adrenal ascorbic acid depleting principle, as ACTH fractions free from inhibitory or stimulatory influence on the gonads could be prepared. The nature of the factor described is discussed.

Effects of sex hormone manipulation on audiogenic seizures

1961 ◽  
Vol 201 (5) ◽  
pp. 830-832 ◽  
Author(s):  
Jack Werboff ◽  
John B. Corcoran
Keyword(s):  
Audiogenic Seizures ◽  
Audiogenic Seizure ◽  
Sex Hormone ◽  
Female Rats ◽  
Male Rats ◽  
Albino Rats ◽  
Sprague Dawley ◽  
Hormone Balance ◽  
Threshold Conditions ◽  
Testosterone Administration

Albino rats of the Sprague-Dawley strain exhibited an unusual sex incidence to audiogenic seizures, with females more susceptible than males. It was predicted that altering the sex hormone balance by means of surgical intervention or hormonal injection would alter their seizure susceptibility. Male rats were castrated and then received injections of estradiol (100 RU) and progesterone (0.5 mg). Female rats received testosterone (1.0 and 2.0 mg) and were later ovariectomized. Audiogenic seizure tests under two threshold conditions were conducted prior to and during the respective hormonal treatments. Each group was used as its own control. The results indicated that castration of the males had little effect on seizure responses. Estradiol administration resulted in an increase in seizure responses. In the females, testosterone administration and ovariectomy resulted in a decrease in seizure responses. It was concluded that sex hormones either exert a direct effect or mediate the control of audiogenic seizure responses in rats of the Sprague-Dawley strain.

Sign in / Sign up

Export Citation Format

Share Document