Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy
Keyword(s):
The synthesis of three potential boron neutron capture therapy agents (68) is reported. The compounds synthesized are comprised of ortho-carborane covalently attached to L-fucose via C-6. Incorporation of the carborane moiety was achieved either through the reaction of an L-fucose-derived alkyne with decaborane or by the coupling of a 6-amino-L-galactopyranose derivative with carborane carboxylic acid chloride (18).Key words: L-fucose, fucosyltransferase, boron neutron capture therapy, ortho-carborane.
Modular triazine-based carborane-containing carboxylic acids – synthesis and characterisation of potential boron neutron capture therapy agents made of readily accessible building blocks
