The sonolysis of uracil

1980 ◽  
Vol 58 (18) ◽  
pp. 1909-1915 ◽  
Author(s):  
Tain-Jen Yu ◽  
Ronald G. Sutherland ◽  
Ronald E. Verrall
Keyword(s):  
Degradation Products ◽  
Ms Analysis ◽  
Alloxan Monohydrate ◽  
Sonolytic Degradation ◽  
Oxaluric Acid

The sonolysis of uracil (1) has been studied at 630 kHz in the presence of air, oxygen, nitrogen, and argon. The degradation products were identified by gc–ms analysis. Under aerated conditions the following products were found: uracil glycols (7), isobarbituric acid (8), N-formyl-N′-glyoxylurea (6), 5-hydroxyhydantoin (9), dialuric acid (10), alloxan monohydrate (12), parabanic acid (13), and oxaluric acid (14). In deaerated solutions 6, 13, and 14 were not observed but either 6-hydroxy-5,6-dihydrouracil(17) or its isomer (18) were detected in addition to 7, 8, 9, 10, and 12. The observed products have been used to develop a possible mechanism for the sonolytic degradation and the results are similar to those obtained in radiolysis.The sonolytic degradation of 5-bromouracil (19) is also reported; the products observed were 5-bromobarbituric acid (20), 12, 13, 14, and 9 and these can be rationalized by a similar mechanistic scheme.

The sonolysis of cytosine and thymine

1987 ◽  
Vol 65 (6) ◽  
pp. 1162-1164 ◽  
Author(s):  
Tain-Jen Yu ◽  
Ronald G. Sutherland ◽  
Ronald E. Verrall
Keyword(s):  
Spectral Analysis ◽  
Degradation Products ◽  
Mass Spectral Analysis ◽  
Mass Spectral ◽  
Ms Analysis ◽  
Alloxan Monohydrate ◽  
Sonolytic Degradation ◽  
Oxaluric Acid ◽  
Chromatographic Mass

Sonolysis of cytosine has been studied at 630 kHz in the presence of air and nitrogen. The degradation products were identified by gas chromatographic – mass spectral analysis. Under aerated conditions the following products were found: urea, formyl urea, parabanic acid, isobarbituric acid, oxaluric acid, alloxan monohydrate, alloxantin, dialuric acid, and uracil glycols. Under nitrogen the degradation products were isobarbituric acid, alloxan monohydrate, and uracil glycols. The observed products have been used to develop a possible mechanism for the sonolytic degradation. There appears to be some similarity with the products reported from radiolysis studies of this compound. Sonolysis of thymine in the presence of air was reinvestigated and the gc–ms analysis shows that a previously reported, unidentified, product may be 5-hydroxy-5-methylbarbituric acid.

HS-SPME-GC-MS analysis of antioxidant degradation products migrating to drinking water from PE materials and PEX pipes

2013 ◽  
Vol 93 (6) ◽  
pp. 593-612 ◽  
Author(s):  
Hans-Christian Holten Lützhøft ◽  
Christopher Kevin Waul ◽  
Henrik Rasmus Andersen ◽  
Bozena Seredynska-Sobecka ◽  
Hans Mosbæk ◽  
...  
Keyword(s):  
Drinking Water ◽  
Degradation Products ◽  
Ms Analysis

Bacteria-based polythene degradation products: GC-MS analysis and toxicity testing

2016 ◽  
Vol 23 (11) ◽  
pp. 10733-10741 ◽  
Author(s):  
Mohd. Shahnawaz ◽  
Manisha K. Sangale ◽  
Avinash B. Ade
Keyword(s):  
Degradation Products ◽  
Toxicity Testing ◽  
Ms Analysis

scholarly journals The limitations and capabilities of wipe samples analysis in control of contamination of facilities with highly toxic organic compounds

2021 ◽  
Author(s):  
MD Shachneva ◽  
MA Leninskii ◽  
EI Savelieva
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Sulfur Mustard ◽  
Degradation Products ◽  
Tandem Mass ◽  
Toxic Substances ◽  
Building Structures ◽  
Engineering Structures ◽  
Ms Analysis ◽  
The Matrix

Wipe sampling is widely used for microbiological control purposes. Sanitary and chemical studies also include analysis of samples wiped from the work surfaces during routine and periodic working conditions safety inspections at chemical facilities. The analysis also allows assessing the toxicity and hazard of items/structures that could be in contact with highly toxic substances. This study aimed to investigate the capabilities and limitations of the surface wipe sample analysis method in control of residual contamination of equipment and building structures of a former chemical weapons destruction facilities (CWDF) with sulfur mustard and O-isobutyl-S(2-diethylaminoethyl) methylphosphonothioate (VR), as well as their degradation products. Gas chromatography with tandem mass spectrometry (GC-MS/MS) enabled identification of the sulfur mustard markers, high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) allowed identifying VR markers. An assessment of the matrix influence on the results of GC-MS/MS and HPLC-MS/MS analysis was carried out. The matrix effect was established to affect the results the most in case of HPLC-MS/MS analysis: for GC-MS/MS analysis of target substances, the matrix factor averaged at 60–80%, for HPLC-MS/ MS it was less than 40%. The average percent sulfur mustard recoveries from three types of surfaces (PVC tiles, laminate and metal plates) was 9 ± 2%, 0.13 ± 0.02% and 0.10 ± 0.03%; in case of VR, the recoveries was 2.7 ± 0.5%, 11.8 ± 0.3% and 0.8 ± 0.1%, respectively. The limits of detection for sulfur mustard by GC-MS/MS and VR by HPLC-MS/MS were established at 0.001 MPL and 0.02 MPL, respectively. The developed approaches were applied to the analysis of wipe samples from the surfaces of the equipment and engineering structures of the former CWDF.

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