The sonolysis of cytosine and thymine

1987 ◽  
Vol 65 (6) ◽  
pp. 1162-1164 ◽  
Author(s):  
Tain-Jen Yu ◽  
Ronald G. Sutherland ◽  
Ronald E. Verrall
Keyword(s):  
Spectral Analysis ◽  
Degradation Products ◽  
Mass Spectral Analysis ◽  
Mass Spectral ◽  
Ms Analysis ◽  
Alloxan Monohydrate ◽  
Sonolytic Degradation ◽  
Oxaluric Acid ◽  
Chromatographic Mass

Sonolysis of cytosine has been studied at 630 kHz in the presence of air and nitrogen. The degradation products were identified by gas chromatographic – mass spectral analysis. Under aerated conditions the following products were found: urea, formyl urea, parabanic acid, isobarbituric acid, oxaluric acid, alloxan monohydrate, alloxantin, dialuric acid, and uracil glycols. Under nitrogen the degradation products were isobarbituric acid, alloxan monohydrate, and uracil glycols. The observed products have been used to develop a possible mechanism for the sonolytic degradation. There appears to be some similarity with the products reported from radiolysis studies of this compound. Sonolysis of thymine in the presence of air was reinvestigated and the gc–ms analysis shows that a previously reported, unidentified, product may be 5-hydroxy-5-methylbarbituric acid.

The sonolysis of uracil

1980 ◽  
Vol 58 (18) ◽  
pp. 1909-1915 ◽  
Author(s):  
Tain-Jen Yu ◽  
Ronald G. Sutherland ◽  
Ronald E. Verrall
Keyword(s):  
Degradation Products ◽  
Ms Analysis ◽  
Alloxan Monohydrate ◽  
Sonolytic Degradation ◽  
Oxaluric Acid

The sonolysis of uracil (1) has been studied at 630 kHz in the presence of air, oxygen, nitrogen, and argon. The degradation products were identified by gc–ms analysis. Under aerated conditions the following products were found: uracil glycols (7), isobarbituric acid (8), N-formyl-N′-glyoxylurea (6), 5-hydroxyhydantoin (9), dialuric acid (10), alloxan monohydrate (12), parabanic acid (13), and oxaluric acid (14). In deaerated solutions 6, 13, and 14 were not observed but either 6-hydroxy-5,6-dihydrouracil(17) or its isomer (18) were detected in addition to 7, 8, 9, 10, and 12. The observed products have been used to develop a possible mechanism for the sonolytic degradation and the results are similar to those obtained in radiolysis.The sonolytic degradation of 5-bromouracil (19) is also reported; the products observed were 5-bromobarbituric acid (20), 12, 13, 14, and 9 and these can be rationalized by a similar mechanistic scheme.

Micro-Synthesis and Electron Ionization Mass Spectral Analysis of O-Alkyl N,N-Dialkylphosphoramidocyanidates

2005 ◽  
Vol 11 (3) ◽  
pp. 309-318 ◽  
Author(s):  
Arvind. K. Gupta ◽  
Meehir Palit ◽  
Deepak Pardasani ◽  
Purushottam Shakya ◽  
Rajendra K. Srivastava ◽  
...  
Keyword(s):  
Mass Spectra ◽  
Chemical Warfare Agent ◽  
Chemical Warfare ◽  
Toxic Chemicals ◽  
Ionization Mass ◽  
Mass Spectral Analysis ◽  
Mass Spectral ◽  
Ms Analysis ◽  
Chemical Weapons Convention ◽  
Chromatographic Mass

This communication describes the microsynthesis and gas chromatographic/mass spectrometric (GC/MS) analysis of O-alkyl N,N-dialkylphosphoramidocyanidates (ADAPCs), which are analogs of the chemical warfare agent, Tabun. The study was undertaken with a view to develop a spectral database of ADAPCs for verification purposes of the Chemical Weapons Convention (CWC). Reported microsynthetic approaches have advantages over traditional synthesis in terms of efficiency, synthetic waste and exposure to toxic chemicals. GC/MS analysis of a variety of these compounds (ADAPCs) was performed. Based on the obtained mass spectra of structurally diverse ADAPCs, the fragmentation routes are proposed, which explains most of the characteristic ions.

scholarly journals SYNTHESIS, CHARACTERIZATION, AND ANTHELMINTIC ACTIVITY OF NOVEL BENZOTHIAZOLE DERIVATIVES CONTAINING INDOLE MOIETIES

2019 ◽  
pp. 321-325
Author(s):  
ALETI RAJAREDDY ◽  
SRINIVAS MURTHY M
Keyword(s):  
Spectral Analysis ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Magnetic Resonance ◽  
Fourier Transform Infrared Spectroscopy ◽  
Anthelmintic Activity ◽  
Mass Spectral Analysis ◽  
Standard Drug ◽  
Mass Spectral ◽  
Benzothiazole Derivatives

Objective: The objective of this study was to synthesize and evaluate the anthelmintic activity (AA) of novel benzothiazole derivatives containing indole moieties (BDIM). Methods: The present works which involve the substituted isatin Schiff bases undergo acetylating and reacting with 2-aminobenzothiazole to give novel BDIM. Results: All the newly synthesized molecules (5a-5o) were characterized by Fourier-transform infrared spectroscopy, H_nuclear magnetic resonance, and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their AA using an Indian earthworm (Pheretima posthuma), and albendazole was used as standard drug. Conclusion: The synthesized compound 5f, 5n, and 5o showed good AA, whereas others exhibited significant activities.

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