EFFECTS OF EXERCISE AND A CHOLESTEROL-FREE DIET ON HUMAN SERUM LIPIDS

1966 ◽  
Vol 44 (4) ◽  
pp. 575-580 ◽  
Author(s):  
R. C. Goode ◽  
J. B. Firstbrook ◽  
R. J. Shephard
Keyword(s):  
Serum Cholesterol ◽  
Serum Triglycerides ◽  
Animal Fats ◽  
Cholesterol Levels ◽  
Daily Energy ◽  
Exercise Period ◽  
Small Rise ◽  
And Control ◽  
Caloric Balance ◽  
Male Subjects

Six male subjects were maintained on a diet free of all animal fats for 54 days; carbohydrate intake was increased to maintain an approximate caloric balance. Serum cholesterol decreased progressively to a low plateau over the first 3 weeks, and thereafter showed a small rise, suggesting increased synthesis. Treadmill exercise sufficient to increase daily energy expenditure by a sixth was carried out for 14 days during the phase of increased synthesis. Serum cholesterol levels did not differ significantly between exercised and control subjects, but serum triglycerides decreased significantly (P < 0.05) over the exercise period.

scholarly journals Anthropometric measurements and amounts of body fat and serum cholesterol in samples of three Nigerian populations

1975 ◽  
Vol 33 (2) ◽  
pp. 141-148 ◽  
Author(s):  
R. S. Watson ◽  
K. M. Etta
Keyword(s):  
Body Weight ◽  
University Students ◽  
Body Fat ◽  
Serum Cholesterol ◽  
Skinfold Thickness ◽  
Mean Values ◽  
Cholesterol Levels ◽  
The Mean ◽  
Male Subjects ◽  
Triceps Skinfold Thickness

1. Skinfold thicknesses, arm circumferences, heights, weights and serum cholesterol levels were determined in ninety-one university students, 207 soldiers and 102 out-patients, all male subjects. Some of these measurements were used to determine the amount of body fat, Quetelet's index and mid-arm muscle circumference2. Quetelet's indices and body-fat values obtained were similar to previously reported values for lean or moderately built males3. Serum cholesterol levels were generally low, with means ranging from 3·98 mmol/1 for 18- to 29-year-old students to 5·19 mmol/l for 40- to 69-year-old out-patients4. The mean values for triceps skinfold thickness, the amount of body fat and serum cholesterol levels for healthy adults obtained in this study are probably normal for northern Nigerian populations5. There was a significant correlation between the amount of body fat and values for triceps and subscapular skinfold thicknesses, Quetelet's index and body-weight for all adults. The correlation between muscle circumference and the amount of body fat was significant for all subjects except adult soldiers.

Fat Metabolism in Experimental Obesities

1956 ◽  
Vol 187 (2) ◽  
pp. 365-368 ◽  
Author(s):  
Claire Zomzely ◽  
J. Mayer
Keyword(s):  
Fatty Acids ◽  
Serum Cholesterol ◽  
Cholesterol Content ◽  
Liver Cholesterol ◽  
Tumor Bearing ◽  
Cholesterol Levels ◽  
Body Weights ◽  
And Control ◽  
Normal Controls

In vivo incorporation of acetate-1-C14 into fatty acids and cholesterol by carcass and liver was determined 30 minutes after injection of the labeled acetate in mice grafted with adrenocorticotropin-secreting tumors. Serum cholesterol levels were also determined. Lipogenesis is elevated under fed and fasted conditions in mice bearing adrenocorticotropin-secreting tumors as compared with normal controls or tumor-bearing adrenalectomized mice. Cholesterologenesis was not significantly different in fed tumor-bearing and control mice. When fasted, however, the tumor-bearing mice exhibited greater incorporation of C14 than that of their controls. Fasting did not decrease cholesterologenesis in the former group. Serum cholesterol levels of the adrenocorticotropic mice were found to be twice as high as those of controls. In addition, the amounts of carcass and liver fatty acids were three times as great for the ACTH mice as compared with controls, although their body weights did not differ significantly. Carcass and liver cholesterol content of adrenocorticotropic mice was also elevated. The results of this experiment indicate that mice bearing adrenocorticotropin-secreting tumors exhibit a ‘metabolic’ type of obesity.

scholarly journals Effects on liver and serum lipids of dietary supplements of methionine and excess lysine given to previously-starved rats

1983 ◽  
Vol 50 (3) ◽  
pp. 627-636 ◽  
Author(s):  
Yoritaka Aoyama ◽  
Kazuhiro Sakaida ◽  
Akira Yoshida ◽  
Kiyoshi Ashida
Keyword(s):  
Serum Cholesterol ◽  
Lipid Accumulation ◽  
Serum Lipids ◽  
Liver Lipid ◽  
Serum Triglyceride ◽  
Sprague Dawley ◽  
Serum Triglycerides ◽  
Hepatic Lipid Accumulation ◽  
Cholesterol Levels ◽  
Maize Oil

1. The addition of lysine hydrochloride (50 g/kg) to a diet supplemented with methionine (3 g/kg) had no effect on liver lipids when rats (Wistar and Sprague-Dawley) were fed ad lib. for 14 d. However, refeeding a diet supplemented with methionine and excess lysine hydrochloride to previously-starved rats (Wistar) for 6, 7 or 9 d, but not 3 or 4 d, resulted in liver lipid accumulation, mainly triglycerides, which was prevented by the addition of arginine, citrulline, ornithine, adenine, allopurinol or maize oil, but not by guanine, cytosine, thymine or uracil.2. The addition of lysine hydrochloride to a methionine-supplemented diet resulted in reduced serum triglyceride levels after refeeding for 3 or 4 d and reduced serum cholesterol levels after refeeding for 3, 4 or 6 d. Serum lipids were unaffected by refeeding the diets for 7 or 9 d.3. Since hepatic lipid accumulation was preceded by the decline in the level of serum triglycerides, one of the factors responsible for lipid accumulation in the liver might be reduced transport of triglycerides from the liver into the blood.4. When adenine and allopurinol were added to the diet supplemented with methionine and lysine hydrochloride refed for 4 d, there was an increase in serum triglycerides. However, when this diet was refed for 7 d, with the addition of arginine, citrulline, guanine, pyrimidine bases, allopurinol or maize oil, no effects on serum cholesterol and triglyceride levels were observed.

scholarly journals Serum cholesterol and serum triglycerides in mental retardation

1974 ◽  
Vol 50 (581) ◽  
pp. 140-144 ◽  
Author(s):  
T. Lawlor ◽  
F. O'Hara ◽  
D. T. Birtwistle
Keyword(s):  
Mental Retardation ◽  
Serum Cholesterol ◽  
Serum Triglycerides

scholarly journals High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

1998 ◽  
pp. 141-145 ◽  
Author(s):  
G Michalopoulou ◽  
M Alevizaki ◽  
G Piperingos ◽  
D Mitsibounas ◽  
E Mantzos ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Cholesterol Levels ◽  
Group D ◽  
Tsh Levels

OBJECTIVE: The association between established hypothyroidism and high cholesterol levels is well known. The aim of the present study was to investigate the effect of thyroxine (T4) administration on cholesterol levels in hypercholesterolemic subjects with TSH levels within the normal range ('high-normal' TSH compared with 'low-normal' TSH). DESIGN AND METHODS: We determined TSH levels in 110 consecutive patients referred for hypercholesterolemia (serum cholesterol >7.5 mmol/l). Those with 'high-normal' TSH (2.0-4.0 microU/ml) as well as those with 'low-normal' TSH (0.40-1.99 microU/ml) were randomly assigned to receive either 25 or 50 microg T4 daily for two months. Thus, groups A and B (low-normal TSH) received 25 and 50 microg T4 respectively and groups C and D (high-normal TSH) received 25 and 50 microg T4 respectively. Serum T4, tri-iodothyronine (T3), TSH, free thyroxine index, resin T3 uptake and thyroid autoantibodies (ThAab) as well as total cholesterol, high and low density lipoprotein cholesterol (HDL, LDL), and triglycerides were determined before and at the end of the two-month treatment period. RESULTS: TSH levels were reduced in all groups. The most striking effect was observed in group D (TSH levels before: 2.77+/-0.55, after: 1.41+/-0.85 microU/ml, P < 0.01). Subjects in groups C and D had a higher probability of having positive ThAabs. A significant reduction in total cholesterol (P < 0.01) and LDL (P < 0.01) was observed after treatment only in group D. In those subjects in group D who were ThAab negative, there was no significant effect of thyroxine on cholesterol levels. CONCLUSIONS: Subjects with high-normal TSH levels combined with ThAabs may, in fact, have subclinical hypothyroidism presenting with elevated cholesterol levels. It is possible that these patients might benefit from thyroxine administration.

Longitudinal associations between serum cholesterol levels and suicidal ideation in an older Korean population

2014 ◽  
Vol 152-154 ◽  
pp. 517-521 ◽  
Author(s):  
Jae-Min Kim ◽  
Robert Stewart ◽  
Hee-Ju Kang ◽  
Bo-ok Jeong ◽  
Seon-Young Kim ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Serum Cholesterol ◽  
Korean Population ◽  
Cholesterol Levels ◽  
Longitudinal Associations
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