scholarly journals Study of cosmogenic activation in copper for rare event search experiments

2021 ◽  
Vol 81 (11) ◽  
Author(s):  
Ze She ◽  
Zhi Zeng ◽  
Hao Ma ◽  
Qian Yue ◽  
Mingkun Jing ◽  
...  

AbstractRare event search experiments using germanium detectors are performed in underground laboratories to minimize the background induced by cosmic rays. However, the cosmogenic activation of cupreous detector components on the ground generates long half-life radioisotopes and contributes to the background level. We measured cosmogenic activation with 142.50 kg of copper bricks after 504 days of exposure at an altitude of 2469.4 m outside the China Jinping Underground Laboratory (CJPL). The specific activities of the cosmogenic nuclides produced in the copper bricks were measured using a low-background germanium gamma-ray spectrometer at CJPL. The production rates at sea level, in units of nuclei/kg/day, were $${18.6 \pm 2.0}$$ 18.6 ± 2.0 for $${^{54}}$$ 54 Mn, $${9.9 \pm 1.3}$$ 9.9 ± 1.3 for $${^{56}}$$ 56 Co, $${48.3 \pm 5.5}$$ 48.3 ± 5.5 for $${^{57}}$$ 57 Co, $${51.8 \pm 2.5}$$ 51.8 ± 2.5 for $${^{58}}$$ 58 Co, and $${39.7 \pm 5.7}$$ 39.7 ± 5.7 for $${^{60}}$$ 60 Co. The measurement will help to constrain cosmogenic background estimation for rare event searches using copper as a detector structure and shielding material. Based on the measured production rates, the impact of the cosmogenic background in cupreous components of germanium detectors on the next generation CDEX-100 experiment was assessed with the expected exposure history above ground.

2016 ◽  
Vol 5 (03) ◽  
pp. 4892 ◽  
Author(s):  
Ratna Raju M.* ◽  
Madhusudhana Rao P. V. ◽  
Seshi Reddy T. ◽  
Raju M. K. ◽  
Brahmaji Rao J. S. ◽  
...  

A study was undertaken to evaluate the inorganic elements for humans in two Indian medicinal plants leaves, namely Sphaeranthus indicus, and Cassia fistula by Instrumental Neutron Activation Analysis (INAA). INAA experiment was performed by using 20 kW KAMINI Reactor at Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam. The emitted gamma rays were measured using gamma ray spectrometer. The concentrations of Al, Br, Ca, Fe, K, La, Mg, Mn, Na, Sc, V and Zn were determined in the selected medicinal plants. The medicinal leaves are using in treatment of various important ailments. The elemental content in selected medicinal leaves is various proportions depending on the soil composition, location of plant specimen and the climate in which the plant grows.


2020 ◽  
Vol 91 (10) ◽  
pp. 104707
Author(s):  
Yinyu Liu ◽  
Hao Xiong ◽  
Chunhui Dong ◽  
Chaoyang Zhao ◽  
Quanfeng Zhou ◽  
...  

2021 ◽  
Vol 92 (4) ◽  
pp. 043537
Author(s):  
M. Nocente ◽  
T. Craciunescu ◽  
G. Gorini ◽  
V. Kiptily ◽  
M. Tardocchi ◽  
...  

1977 ◽  
Vol 24 (1) ◽  
pp. 673-677 ◽  
Author(s):  
J. J. Lipsett ◽  
I. L. Fowler ◽  
R. J. Dinger ◽  
H. L. Malm

2021 ◽  
Vol 22 (12) ◽  
pp. 6258
Author(s):  
Rossana Domenis ◽  
Adriana Cifù ◽  
Catia Mio ◽  
Martina Fabris ◽  
Francesco Curcio

Exosomes released from tumor cells are instrumental in shaping the local tumor microenvironment to allow cancer progression. Recently, it has been shown that tumor exosomes carry large fragments of dsDNA, which may reflect the mutational status of parental cells. Although it has been described that a stressful microenvironment can influence exosomal cargo, the effects on DNA packing and its transfer into recipient cells have yet to be investigated. Here, we report that exosomes derived from SW480 (human colorectal adenocarcinoma cell line) cells can carry dsDNA fragments containing the entire coding sequence of both TP53 and KRAS genes, harboring the SW480-related TP53 c.818G > A and KRAS c.35G > T typical mutations. We also report the following: that cell stimulation with lipopolysaccharides (LPS) promotes the selective packaging of the TP53 gene, but not the KRAS gene; that exosomes secreted by SW480 cells efficiently transfer the mutated sequences into normal CCD841-CoN colon epithelial and THLE-2 hepatic cells; that this mechanism is more efficient when the cells had been previously incubated with pro-inflammatory cytokines; that the TP53 gene appears actively transcribed in both recipient cells; and that mutated mRNA levels are not influenced by cytokine treatment. Our data strongly suggest that pro-inflammatory stimulation promotes the horizontal transfer of an oncogene by exosomes, although this remains a rare event. Further studies are needed to assess the impact of the oncogenic transfer by exosomes in malignant transformation and its role in tumor progression.


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