In vivo and ex vivo Bone Mineral Density and Structure Measurements Using XtremeCTR — A High-Resolution pQCT (HRpQCT)

2008 ◽  
pp. 635-648 ◽  
Author(s):  
Maurus Neff ◽  
Helmut R. Radspieler ◽  
Ling Qin ◽  
Maximilian A. Dambacher
Keyword(s):  
Bone Mineral Density ◽  
High Resolution ◽  
Bone Mineral ◽  
Ex Vivo ◽  
Mineral Density

Third metacarpal bone mineral density assessment in the standing horse by dual X-ray absorptiometry

2005 ◽  
Vol 18 (01) ◽  
pp. 26-30 ◽  
Author(s):  
C. Delguste ◽  
G. Perona ◽  
P. Lebecque ◽  
F. Duboeuf ◽  
O. Lepage ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Ex Vivo ◽  
Metacarpal Bone ◽  
Test Accuracy ◽  
Mineral Density ◽  
X Ray ◽  
Highly Correlated ◽  
Density Assessment

SummaryBone mineral density (BMD) is correlated to mechanical properties of bone. In the horse, dual energy X-ray absorptiometry (DXA) has yet only been performed ex-vivo, but a new portable DXA device would be ideal for in-vivo BMD measurement. We explored field suitability, precision and accuracy of this device for in-vivo third metacarpal density assessment. Precision was analysed by calculating measurement variation under repeated measurement tests with (reproducibility) and without (repeatability) limb repositioning. Repeatability and reproducibility were tested ex-vivo, at the same time that intra- and inter-operator reproducibility were assessed in-vivo. In order to test accuracy, bone mineral content (BMC) of several bone samples determined by DXA and ashing were compared. Repeatability was 1.47% and reproducibility 1.69% ex-vivo. In-vivo reproducibility varied between 2.91 and 4.06% for intraoperator test and between 3.13 and 5.53% for interoperator test. BMC measured by DXA and ash weight were highly correlated (R2>0.99). In conclusion, under described conditions this DXA device is usable, accurate and precise. Its sensitiveness reaches 8.23% in an individual longitudinal monitoring. Using the third metacarpal bone as an example, we have shown that this device is suitable for experimental or clinical monitoring.

The effects of ovariectomy on bone mineral density, geometrical, and biomechanical characteristics in the rabbit femur

2010 ◽  
Vol 23 (01) ◽  
pp. 31-36 ◽  
Author(s):  
M. E. Kara ◽  
F. Sevil
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Animal Studies ◽  
Biomechanical Properties ◽  
Mineral Density ◽  
Cross Sectional ◽  
Tomographic Images ◽  
Three Point Bending ◽  
Rabbit Femur

SummaryThe aim of the study was to evaluate the bone mineral density, as well as the biomechanic and morphometric changes in the femur of ovariectomised rabbits.Twenty-four six-month-old New Zealand rabbits were randomly divided into an ovariectomy (n = 12) and a sham (n = 12) group. Six rabbits in each group were euthanatized at eight and 16 weeks after surgery, and the femora were resected. The morphometric data were obtained from tomographic images. Periosteal and endosteal diameters and cortical thickness were measured. Total cross-sectional, cortical and medullary areas were also measured. The bone mineral content, the bone area and the bone mineral density were measured from the proximal, distal and mid-shaft of the femur as well as the total femur by dual energy X-ray absorptiometry. Employing the three-point bending method, the ultimate force, stiffness and work-to-failure were measured. The mechanical data were normalised to obtain intrinsic biomechanical properties such as ultimate stress, elastic modulus, and toughness, all of which are independent of size and shape.The results indicated that the femur was both larger and weaker 16 weeks after surgery in the ovariectomised group. Results also suggest that the rabbit might be a useful animal model for investigation of diseases related to oestrogen loss such as human postmenopausal osteoporosis. However, additional studies with advanced techniques at several time points via in vivo animal studies, and precision and predictability analyses should be designed to standardise the rabbit as a model for osteoporosis.

scholarly journals Assessing bone mineral density in vivo: digitized fluoroscopy and ultrasound

2004 ◽  
Vol 83 (2) ◽  
pp. 207-214 ◽  
Author(s):  
R.H. Fleming ◽  
D. Korver ◽  
H.A. McCormack ◽  
C.C. Whitehead
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density

Bone Evaluation by High-Resolution Peripheral Quantitative Computed Tomography in Patients With Adrenal Incidentaloma

2020 ◽  
Vol 105 (8) ◽  
pp. e2726-e2737
Author(s):  
Aline Barbosa Moraes ◽  
Marcela Pessoa de Paula ◽  
Francisco de Paula Paranhos-Neto ◽  
Emanuela Mello Ribeiro Cavalari ◽  
Felipe Fernandes Cordeiro de Morais ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
High Resolution ◽  
Distal Radius ◽  
Bone Mineral ◽  
Quantitative Computed Tomography ◽  
Adrenal Incidentaloma ◽  
Peripheral Quantitative Computed Tomography ◽  
Mineral Density ◽  
X Ray

Abstract Context Data regarding high-resolution peripheral quantitative computed tomography (HR-pQCT) in patients with adrenal incidentaloma (AI) are unknown. Purpose To evaluate the areal bone mineral density (aBMD), microstructure, and fractures in patients with nonfunctioning AI (NFAI) and autonomous cortisol secretion (ACS). Methods We evaluated 45 patients with NFAI (1 mg dexamethasone suppression test [DST] ≤1.8 µg/dL) and 30 patients with ACS (1 mg DST 1.9-5.0 µg/dL). aBMD was measured using dual-energy X-ray absorptiometry; vertebral fracture by spine X-ray; and bone geometry, volumetric bone mineral density (vBMD), and microstructure by HR-pQCT. Results Patients with ACS showed lower aBMD values at the spine, femoral neck, and radius 33% than those with NFAI. Osteoporosis was frequent in both groups: NFAI (64.9%) and ACS (75%). Parameters at the distal radius by HR-pQCT were decreased in patients with ACS compared to those with NFAI: trabecular vBMD (Tb.vBMD, P = 0.03), inner zone of the trabecular region (Inn.Tb.vBMD, P = 0.01), the bone volume/tissue volume ratio (BV/TV, P = 0.03) and trabecular thickness (P = 0.04). As consequence, a higher ratio of the outer zone of the trabecular region/inner zone vBMD (Meta/Inn.vBMD, P = 0.003) was observed. A correlation between the cortisol levels after 1 mg DST and Meta/Inn.vBMD ratio was found (r = 0.29; P = 0.01). The fracture frequency was 73.7% in patients with ACS vs 55.6% in patients with NFAI (P = 0.24). Conclusion Our findings point to an association between trabecular bone microarchitectural derangement at the distal radius and ACS. Our data suggest that AI have a negative impact on bone when assessed by HR-pQCT, probably associated to subclinical hypercortisolism.

Dual-Energy CT–based Phantomless in Vivo Three-dimensional Bone Mineral Density Assessment of the Lumbar Spine

Radiology ◽  
2014 ◽  
Vol 271 (3) ◽  
pp. 778-784 ◽  
Author(s):  
Julian L. Wichmann ◽  
Christian Booz ◽  
Stefan Wesarg ◽  
Konstantinos Kafchitsas ◽  
Ralf W. Bauer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Three Dimensional ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Mineral Density ◽  
Bone Mineral Density Assessment ◽  
Density Assessment
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