The Hepatoprotective Effects of Taiwan Folk Medicine Ham-Hong-Chho in Rats

Bidens pilosa L. var minor (Blume) Sherff, B. pilosa L. and B. chilensis DC (compositae), commonly known as "Ham-hong-chho" in Taiwan, have been traditionally used for medicinal purposes. To clarify and compare the hepatoprotective effects of these three plants, we evaluated their potential effectiveness on CCl4- and acetaminophen-induced acute hepatic lesions in rats. The results indicated that the increase in SGOT and SGPT activities caused by CCl4 (3.0 mI/kg, s.c.) and acetaminophen administration (600 mg/kg, i.p.) could be significantly reduced by treating with the extracts of all the three kinds of "Ham-hong-chho" and the extract of B. chilensis exhibited the greatest hepatoprotective effects. These phenomena were also conflflDed by histological observation. Liver damage induced by CCl4 and acetaminophen was markedly improved in the extract of B. chilensis treated groups, while groups treated with the extracts of B. pilosa var minor and B. pilosa demonstrated only moderate protective effects. The pharmacological and pathological effects of these three crude groups were compared with Bupleurum chinense, which has been reported previously as a treatment criteria in the CCl4 model, and with silymarin as a standard reference medicine in the acetaminophen model. The results suggest that B. pilosa var minor, B. pilosa and B. chilensis can protect liver injuries from various hepatotoxins and have potential as broad spectrum antihepatic agents.

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Protective Effects of Nutria Bile against Thioacetamide-Induced Liver Injury in Mice

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/6059317 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Joo-Yeon Kong ◽

Seong-Chan Yeon ◽

Hu Jang Lee ◽

Changkeun Kang ◽

Jin-Kyu Park ◽

...

Keyword(s):

Liver Injury ◽

Hepatic Function ◽

Alien Invasive Species ◽

Protective Effects ◽

Marker Protein ◽

Hepatic Inflammation ◽

Myocastor Coypus ◽

Liver Injuries ◽

Hepatoprotective Effects ◽

Bear Bile

Several eradication programs have been developed and executed to curb alien invasive species that tend to damage the ecological environments they colonize; however, only few studies have evaluated the utilization of carcasses of these species after eradication. Nutria (Myocastor coypus) is an invasive rodent species targeted by eradication programs in many countries. We noted that nutria produce large amounts of ursodeoxycholic acid (UDCA) in their bile. UDCA is a unique component responsible for the anti-inflammatory and hepatoprotective effects exerted by bear bile. Therefore, we sought to examine the medicinal utility of nutria carcasses by investigating the hepatoprotective effect of their bile in mice. C57BL/6 mice were injected with thioacetamide (TAA), which induced liver damage by increasing Kupffer cell infiltration. Administration of nutria bile reduced hepatic inflammation, improved hepatic function, and increased the levels of senescence marker protein 30 (an indicator of hepatocyte viability). Our results show that nutria bile exerts protective effects against TAA-induced liver injury in mice, suggesting that nutria carcasses may be used for the treatment of liver injuries.

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Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/161062 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Hao-Jie Pu ◽

Yun-Feng Cao ◽

Rong-Rong He ◽

Zhi-Long Zhao ◽

Jin-Hui Song ◽

...

Keyword(s):

Free Radicals ◽

Liver Damage ◽

Restraint Stress ◽

Liver Cells ◽

Protective Effects ◽

Male Mice ◽

Stress Effects ◽

Restraint Tube ◽

Hepatoprotective Effects ◽

The Relationship

The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.

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Hepatoprotective Effects of Taiwan Folk Medicine: Ixeris chinensis (Thunb.) Nak. on Experimental Liver Injuries

The American Journal of Chinese Medicine ◽

10.1142/s0192415x94000309 ◽

1994 ◽

Vol 22 (03n04) ◽

pp. 243-254 ◽

Cited By ~ 4

Author(s):

Song-chow Lin ◽

Chun-ching Lin ◽

Yun-ho Lin ◽

Chih-jung Yao

Keyword(s):

Single Dose ◽

Folk Medicine ◽

Hepatoprotective Activity ◽

Histopathological Changes ◽

Experimental Animals ◽

Liver Injuries ◽

Acute Elevation ◽

Serum Transaminases ◽

Hepatoprotective Effects ◽

Experimental Liver

The hepatoprotective effects of Ixeris chinensis (Thunb.) Nak. were studied on acute hepatitis induced in mice by a single dose of carbon tetrachloride (31.25 μl/kg, ip) or acetaminophen (600 mg/kg, ip), and in rats by a single dose of β-D-galactosamine (188 mg/kg, ip). Hepatoprotective activity was monitored by estimating the serum transaminases (SGOT and SGPT) levels and histopathological changes in the livers of experimental animals. The Ixeris chinensis (Thunb.) Nak. extracts significantly inhibited the acute elevation of serum transaminases. Histopathologically, the crude I. chinensis extract significantly ameliorated hepatotoxin-induced histopathological changes in the livers of experimental animals. All pharmacological and histopathological effects of Ixeris chinensis (Thunb.) Nak. were compared with Bupleurum chinense DC., which has been previously reported as a treatment herb for hepatitis.

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Protective and Therapeutic Effects of Ban-zhi-lian on Hepatotoxin-induced Liver Injuries

The American Journal of Chinese Medicine ◽

10.1142/s0192415x9400005x ◽

1994 ◽

Vol 22 (01) ◽

pp. 29-42 ◽

Cited By ~ 6

Author(s):

Song-chow Lin ◽

Chun-ching Lin ◽

Yun-ho Lin ◽

Ching-hsein Chen

Keyword(s):

Liver Damage ◽

Experimental Models ◽

Therapeutic Effects ◽

Protective Effects ◽

Liver Injuries ◽

Serum Glutamate Pyruvate Transaminase ◽

Glutamate Pyruvate ◽

Experimental Liver ◽

Serum Glutamate ◽

Experimental Liver Damage

The hepatoprotective effect of Ban-zhi-lian was investigated in three kinds of experimental models. The animals were treated with Ban-zhi-lian (300 mg/kg, p.o.) at 2, 4, and 10 hours after carbon tetrachloride (32l/kg, i.p.), acetaminophen (600 mg/kg, i.p.), and β-D-galactosamine (188 mg/kg, i.p.) administration. Significant protective effects from these hepatotoxins were expressed. This protection was evidenced by comparing the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and histopathologic examination in animals treated and untreated with Ban-zhi-lian. Serum enzyme activities were significantly lower in Ban-zhi-lian-treated groups. In the histopathologic observation, liver damage induced by three hepatotoxins was markedly improved in Ban-zhi-lian treated animals. These results demonstrated that Ban-zhi-lian has a protective effect against experimental liver damage induced by various hepatotoxins.

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Hepatoprotective Effects of Taiwan Folk Medicine: Wedelia chinensis on Three Hepatotoxin-induced Hepatotoxicity

The American Journal of Chinese Medicine ◽

10.1142/s0192415x9400019x ◽

1994 ◽

Vol 22 (02) ◽

pp. 155-168 ◽

Cited By ~ 11

Author(s):

Song-chow Lin ◽

Chung-ching Lin ◽

Yun-ho Lin ◽

Shyh-jong Shyuu

Keyword(s):

Carbon Tetrachloride ◽

Microscopic Examination ◽

Marked Improvement ◽

Folk Medicine ◽

Hepatoprotective Effect ◽

Liver Injuries ◽

Hepatoprotective Effects ◽

Serum Glutamate ◽

Histopathological Effects ◽

Glutamate Oxaloacetic Transaminase

The hepatoprotective effects of a Taiwanese crude herb, Hwang-hua-mih-tsay (Wedelia chinensis (Osbeck) Merr.), were investigated. Acute hepatitis was induced by three hepatotoxins: carbon tetrachloride and acetaminophen in mice, and D(+)-galactosamine in rats. After treatment with W. chinensis (300 mg/kg, p.o.) at 2,6 and 10 hours, a reduction in the elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels was observed at 24 hrs after hepatotoxins were administered. These serological observations were confirmed by histopathological examinations. A microscopic examination of the liver showed a marked improvement in groups receiving W. chinensis. In order to further confirm the hepatoprotective effect of W. chinensis, all pharmacological and histopathological effects were compared with Bupleurum chinense DC. (family Umbelliferae), a well documented antihepatotoxicity herb. It was concluded that W. chinensis has a definite hepatoprotective effect against liver injuries.

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Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/9861571 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Rui-rong Chen ◽

Juan Liu ◽

Zhe Chen ◽

Wen-jun Cai ◽

Xiu-fen Li ◽

...

Keyword(s):

Carbon Tetrachloride ◽

Folk Medicine ◽

Antioxidant Properties ◽

Underlying Mechanism ◽

Dependent Manner ◽

Protective Effects ◽

Bioactive Components ◽

Hepatoprotective Effects ◽

Dose Dependent ◽

Antioxidant Enzyme Catalase

In Southwestern China, the root of Morinda angustifolia Roxb. has been employed as a folk medicine for treating various types of hepatitis and jaundice. The purpose of this study was to evaluate the hepatoprotective effects of anthraquinones extract from M. angustifolia root (AEMA) in carbon tetrachloride- (CCl4-) induced liver injury in mice and identify the main bioactive components. Results indicated that AEMA pretreatment could significantly, in a dose-dependent manner, attenuate the increased levels of ALT and AST in mice serum induced by CCl4. At doses of 100 and 200 mg/kg, AEMA exhibited significant suppression of the elevated hepatic levels of malondialdehyde (MDA), as well as marked upregulatory effects on the activities of antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice exposed to CCl4. However, AEMA treatment had no effect on the antioxidant enzyme catalase (CAT) or the nonenzymatic antioxidant glutathione (GSH). Furthermore, two anthraquinone constituents were isolated from AEMA and identified as soranjidiol and rubiadin-3-methyl ether. Soranjidiol exhibited similar protective effects to those of AEMA on liver damage induced by CCl4. Overall, our research clearly demonstrated the hepatoprotective effects of the AEMA, and anthraquinones, particularly soranjidiol, should be considered as the main hepatoprotective principles of M. angustifolia. In addition, the underlying mechanism may be, at least in part, related to its antioxidant properties.

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