scholarly journals Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Hao-Jie Pu ◽  
Yun-Feng Cao ◽  
Rong-Rong He ◽  
Zhi-Long Zhao ◽  
Jin-Hui Song ◽  
...  
Keyword(s):  
Free Radicals ◽  
Liver Damage ◽  
Restraint Stress ◽  
Liver Cells ◽  
Protective Effects ◽  
Male Mice ◽  
Stress Effects ◽  
Restraint Tube ◽  
Hepatoprotective Effects ◽  
The Relationship

The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.

The Hepatoprotective Effects of Taiwan Folk Medicine Ham-Hong-Chho in Rats

1996 ◽  
Vol 24 (03n04) ◽  
pp. 231-240 ◽  
Author(s):  
Hwa-Woei Chih ◽  
Chun-Ching Lin ◽  
Kung-Sheng Tanga
Keyword(s):  
Liver Damage ◽  
Broad Spectrum ◽  
Folk Medicine ◽  
Protective Effects ◽  
Histological Observation ◽  
Bidens Pilosa ◽  
Potential Effectiveness ◽  
Liver Injuries ◽  
Hepatoprotective Effects ◽  
Hepatic Lesions

Bidens pilosa L. var minor (Blume) Sherff, B. pilosa L. and B. chilensis DC (compositae), commonly known as "Ham-hong-chho" in Taiwan, have been traditionally used for medicinal purposes. To clarify and compare the hepatoprotective effects of these three plants, we evaluated their potential effectiveness on CCl4- and acetaminophen-induced acute hepatic lesions in rats. The results indicated that the increase in SGOT and SGPT activities caused by CCl4 (3.0 mI/kg, s.c.) and acetaminophen administration (600 mg/kg, i.p.) could be significantly reduced by treating with the extracts of all the three kinds of "Ham-hong-chho" and the extract of B. chilensis exhibited the greatest hepatoprotective effects. These phenomena were also conflflDed by histological observation. Liver damage induced by CCl4 and acetaminophen was markedly improved in the extract of B. chilensis treated groups, while groups treated with the extracts of B. pilosa var minor and B. pilosa demonstrated only moderate protective effects. The pharmacological and pathological effects of these three crude groups were compared with Bupleurum chinense, which has been reported previously as a treatment criteria in the CCl4 model, and with silymarin as a standard reference medicine in the acetaminophen model. The results suggest that B. pilosa var minor, B. pilosa and B. chilensis can protect liver injuries from various hepatotoxins and have potential as broad spectrum antihepatic agents.

scholarly journals Protective Effects of Edible Plants against Nicotine Induced Reproductive Toxicity –A Review

2020 ◽  
Vol 11 (3) ◽  
pp. 4068-4073
Author(s):  
Kanimozhi S ◽  
Bupesh G ◽  
Sumathy G ◽  
Jeganath S
Keyword(s):  
Free Radicals ◽  
Tobacco Smoke ◽  
Sperm Quality ◽  
Sperm Count ◽  
Reproductive Toxicity ◽  
Human Sperm ◽  
Protective Effects ◽  
Epididymal Sperm ◽  
The Relationship ◽  
Adverse Affects

Numerous examinations have announced that the Nicotine present in tobacco smoke adverse affects sperm parameters, fundamental plasma, and different other richness factors. These harms are because of the natural finding that smoking expands the degree of free radicals, consequently bringing about oxidative pressure. Accordingly, an increment of free radicals, DNA harm and lipid peroxidation in human sperm may happen to bring about impedance of sperm quality. nicotine organization in trial creatures was initiate to influence spermatogenesis, epididymal sperm count, motility and treating capability of sperms. Huge quantities of restorative herbs have been recorded in siddha framework that improve spermatogenesis and increment the nature of sperm. The present review gives an outline on the relationship between male richness incited by nicotine and defensive impacts of different natural plants on it. The paper additionally features the dynamic, common standards, and rough concentrates of plants, which have been valuable in improving nicotine instigated testicular harms and supportive in spermatogenesis and multiplication. Despite the fact that the discoveries of this survey propose numerous herbs are extremely viable against nicotine actuated male barrenness still increasingly clinical preliminaries are prescribed to show their viability on nicotine instigated male infertility

scholarly journals Hepatoprotector Effect of Coconut Water (Cocos nucifera L.) and Folic Acid to the Liver Histopathological Desccription of Pregnant Wistar Female Rats (Rattus norvegicus) Induced by Carbamate

2020 ◽  
Vol 6 (1) ◽  
pp. 53
Author(s):  
Muhammad Rosyid Ridho ◽  
Aris Prasetyo ◽  
Hairrudin Hairrudin
Keyword(s):  
Free Radicals ◽  
Folic Acid ◽  
Liver Damage ◽  
Liver Cells ◽  
The Body ◽  
Coconut Water ◽  
Female Rats ◽  
Test Results ◽  
Liver Histopathology ◽  
Significant Difference

Abstract Carbamate is an insecticide with a working mechanism that inhibits the enzyme acetylcholineestrase (AChE). Obstacles to AChE will cause the formation of excessive free radicals in the body causing oxidative stress and causing lipid peroxidation in body cells, including hepatocyte cells in the liver. Pregnant women have a change in detoxification activity in the liver due to exposure to xenobiotic substances during pregnancy causing a decrease in cytochrome P450 1A2 (CYP1A2) which will cause an increase in free radicals and can damage liver cells. Coconut water contains antioxidants that can neutralize free radicals in the body. While folic acid can encourage improvement in morphology of liver cells. The purpose of this study was to determine the hepatoprotector effect of coconut water and folic acid on the histopathology of the liver of pregnant female wistar rats induced by carbamate. The design of this study is true experimental with a post test only control group design. The sampling method used is simple random sampling. The number of samples in this study were 28 rats divided into 4 groups K (aquades), P1 (carbamate), P2 (carbamate and coconut water), and P3 (carbamate and folic acid). At the end of the study rat liver was taken to then become histological preparations. The One Way ANOVA test results showed a significant difference between groups compared (p <0.05). Post hoc LSD test results showed that group P1 had damaged liver histopathology, there were significant differences with group K and P3 (p <0.05), but there were no significant differences when compared with group P2 (p = 0.826). Meanwhile, the P3 group had significant differences when compared with all groups (p <0.05). The conclusion of this study is that giving coconut water cannot prevent liver damage due to carbamate induction, while folic acid has been shown to prevent liver damage due to carbamate induction, from liver histopathology. Keywords: carbamate, coconut water, folic acid, liver histopathology

scholarly journals Resveratrol Protects against Restraint Stress Effects on Stomach and Spleen in Adult Male Mice

Animals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 736 ◽  
Author(s):  
Wael Ennab ◽  
Sheeraz Mustafa ◽  
Quanwei Wei ◽  
Zengpeng Lv ◽  
Ngekure M.X. Kavita ◽  
...  
Keyword(s):  
Adult Male ◽  
Restraint Stress ◽  
Control Group ◽  
Male Mice ◽  
Negative Effects ◽  
Quantitative Distribution ◽  
Stress Effects ◽  
Gastric Cells ◽  
Splenic Size ◽  
Apoptosis Inducing Factor

The objectives were to investigate whether restraint stress (which is known as a mixture of psychologic and physical stress) exerts negative effects on the stomach and spleen, and whether the phenolic compound resveratrol (RES) exerts any protective roles. Fifty adult male mice were divided into five groups, with 10 mice per group as follows: control (C), restraint stress (RS), RS with vehicle (RS + V), RS with 2 mg/kg of resveratrol (RS + 2 mg RES), and RS with 20 mg/kg of resveratrol (RS + 20 mg RES). Mice were restrained in conical centrifuge tubes for 4 h daily to establish the RS model. RS + 2 mg RES, RS + 20 mg RES, and RS + V groups were given an oral dose of resveratrol or vehicle for 15 consecutive days, while the control group was not exposed to restraint stress. Herein, we showed that restraint stress decreased body weight and food and water consumption in stressed groups RS and RS + V compared to controls, while the groups treated with resveratrol showed improvements. Moreover, restraint stress caused acute damage to the morphology of gastric cells and reduced the quantitative distribution of parietal cells along with their decreased size and diameter, pointing to gastritis or ulcer. Furthermore, the antibody against the apoptosis-inducing factor (AIF) was highly attached in the RS groups. Splenic size, weight, and length were also greatly augmented in the stressed groups compared to the controls, while these phenomena were not observed in the RS + 2 mg RES group. Our findings proved significant ameliorating effects of resveratrol against restraint stress in adult male mice.

Protective Effects of Bilberry (Vaccinium myrtillusL.) Extract on Restraint Stress-Induced Liver Damage in Mice

2008 ◽  
Vol 56 (17) ◽  
pp. 7803-7807 ◽  
Author(s):  
Li Bao ◽  
Xin-Sheng Yao ◽  
Chin-Chin Yau ◽  
Daniel Tsi ◽  
Chew-Sern Chia ◽  
...  
Keyword(s):  
Liver Damage ◽  
Restraint Stress ◽  
Protective Effects

scholarly journals 1,25(OH)2D3 Inhibited Ferroptosis in Zebrafish Liver Cells (ZFL) by Regulating Keap1-Nrf2-GPx4 and NF-κB-hepcidin Axis

2021 ◽  
Vol 22 (21) ◽  
pp. 11334
Author(s):  
Ke Cheng ◽  
Yanqing Huang ◽  
Chunfang Wang
Keyword(s):  
Vitamin D ◽  
Liver Cells ◽  
Oxygen Species ◽  
Protective Effects ◽  
Iron Ion ◽  
Total Glutathione ◽  
Programed Cell Death ◽  
The Relationship ◽  
Gpx Activity ◽  
Zebrafish Liver

Ferroptosis is a kind of iron-dependent programed cell death. Vitamin D has been shown to be an antioxidant and a regulator of iron metabolism, but the relationship between vitamin D and ferroptosis is poorly studied in fish. This study used zebrafish liver cells (ZFL) to establish a ferroptosis model to explore the effect of 1,25(OH)2D3 on cell ferroptosis and its mechanism of action. The results showed that different incubation patterns of 1,25(OH)2D3 improved the survival rate of ZFL, mitigated mitochondrial damage, enhanced total glutathione peroxidase (GPx) activity, and reduced intracellular reactive oxygen species (ROS), lipid peroxidation (LPO), and malondialdehyde (MDA), as well as iron ion levels, with the best effect at 200 pM 1,25(OH)2D3 preincubation for 72 h. Preincubation of ZFL at 200 pM 1,25(OH)2D3 for 72 h downgraded keap1 and ptgs2 gene expression, increased nrf2, ho-1, fth1, gpx4a,b expression, and lowered the expression of the nf-κb p65,il-6,il-1β gene, thus reducing the expression of hamp1. The above results indicate that different incubation patterns of 1,25(OH)2D3 have protective effects on ferroptosis of ZFL induced by ferroptosis activator RSL3 and 1,25(OH)2D3 can inhibit ferroptosis of ZFL by regulating Keap1–Nrf2–GPx4 and NF-κB–hepcidin axis.

scholarly journals Antioxidant properties of flavonoid derivatives and their hepatoprotective effects on CCl4induced acute liver injury in mice

RSC Advances ◽  
2018 ◽  
Vol 8 (28) ◽  
pp. 15366-15371
Author(s):  
Cen Xiang ◽  
Yuou Teng ◽  
Chaoran Yao ◽  
Xuehui Li ◽  
Menglin Cao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Free Radicals ◽  
Liver Injury ◽  
Liver Damage ◽  
Acute Liver Injury ◽  
Antioxidant Properties ◽  
The Body ◽  
Hepatoprotective Effects ◽  
Excessive Accumulation

Excessive accumulation of free radicals in the body can cause liver damage, aging, cancer, stroke, and myocardial infarction.

Effect of curcumin analogue synthetic product from cullilawan oil for the liver damage treatment in male mice (Mus musculus L.)

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Imanuel Berly Delvis Kapelle ◽  
Wasmen Manalu ◽  
Fensia Analda Souhoka
Keyword(s):  
Liver Damage ◽  
Mus Musculus ◽  
Liver Cells ◽  
Synthesis Process ◽  
Male Mice ◽  
Curcumin Analogue ◽  
Synthetic Product ◽  
Blood Biochemical ◽  
Histopathological Images

AbstractThe active component in cullilawan oil can be synthesized into curcumin analogue product, which has pharmacological activity. The synthesis process by using conventional and microwave methods can produce different isomer products. Different synthesis products and models of animal are used to provide different hepatoprotective effects. The aim of this study was to use the curcumin analogue synthetic products (AKS-k and AKS-m) from cullilawan oil in male mice (Mus musculus L.) liver damage treatment induced by carbon tetrachloride (CCl4). The in vivo method was employed using biochemical of blood and histopathological images of liver cells as indicators. The results showed that the curcumin analogue synthetic product using microwave methods had better pharmacological effects than the conventional method product in terms of the results of blood biochemical analysis and microscopic images of liver cells.

HPV VACCINE AND CERVICAL CANCER

2011 ◽  
pp. 108-115
Author(s):  
Vu Quoc Huy Nguyen
Keyword(s):  
Cervical Cancer ◽  
Relative Risk ◽  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Preventive Strategy ◽  
Protective Effects ◽  
Papilloma Virus ◽  
Vaccine Trials ◽  
Close Relationship ◽  
The Relationship

Persistent infection with high-risk Human Papilloma Virus (HPV) has been identified as the causal factor of cervical cancer, with relative risk up to 300-400 folds. This very close relationship leads to the preventive strategy of vaccination against HPV infections and HPV-related lesions. The article describes molecular and immunologic characteristics of HPV, currently available HPV vaccines and its protective effects; the relationship between HPV vaccination and cervical cancer screening, and an introduction to therapeutic HPV vaccine trials.

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