Ameliorative Effect of Traditional Chinese Medicine Prescriptions on α-Naphthylisothiocyanate and Carbon-tetrachloride Induced Toxicity in Rats

1997 ◽  
Vol 25 (02) ◽  
pp. 185-196 ◽  
Author(s):  
Chin-Chuan Tsai ◽  
Shung-Te Kao ◽  
Chao-Tien Hsu ◽  
Chun-Ching Lin ◽  
Jim-Shoung Lai ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Carbon Tetrachloride ◽  
Traditional Chinese Medicine ◽  
Liver Injury ◽  
Serum Total Bilirubin ◽  
Glutamate Pyruvate Transaminase ◽  
Ameliorative Effect ◽  
Glutamate Pyruvate ◽  
Experimental Liver ◽  
Elevated Lipid

Syh-Mo-Yin (SMY), Guizhi-Fuling-Wan (GFW), Shieh-Qing-Wan (SQW) and Syh-Nih-San (SNS) are prescriptions of Traditional Chinese Medicine (TCM) for liver disease. The effects of these four prescriptions against experimental liver injury induced by α-Naphthylisothiocyanate (ANIT) and carbon tetrachloride ( CCl 4) were studied. Rats treated with ANIT (100 mg/kg) exhibited elevations of serum total bilirubin (TBI), alkaline phosphatase (ALP), glutamate-oxalatetransaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) as well as cholestasis and parenchymanecrosis. In rats receiving SMY, SQW and SNS treatment after ANIT challenged, the biochemical and morphological parameters of liver injury were significantly reduce. Elevated lipid peroxidation (LPO) level in liver tissue, associated with an increase in serum GOT and GPT level, was observed in CCl 4-treated rats. Treatment with these four prescriptions on CCl 4-induced liver injury rats showed a remarkable hepatoprotective effect. A significant decrease in peroxidative level suggested that these prescriptions have anti free radical properties.

The Effectiveness of Tsu-San-Li (St-36) and Tai-Chung (Li-3) Acupoints for Treatment of Acute Liver Damage in Rats

2001 ◽  
Vol 29 (02) ◽  
pp. 221-226 ◽  
Author(s):  
Hsu-Jan Liu ◽  
Sheng-Feng Hsu ◽  
Chang-Chi Hsieh ◽  
Tin-Yun Ho ◽  
Ching-Liang Hsieh ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Acupuncture Therapy ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Male Rats ◽  
Acute Liver Damage ◽  
Glutamate Pyruvate Transaminase ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

This study investigated the effects of acupuncture on carbon tetrachloride (CCl4) induced acute liver injury in male rats (n = 36). The experimental groups were injected with CCl4 before, during, or after acupuncture therapy. Acupoints similar to the human Tsu-San-Li (St-36) and Tai-Chung (Li-3) were needled bilaterally. Rats treated with CCl4 had higher levels of serum glutamate-oxalate-transaminase (sGOT) and serum glutamate-pyruvate-transaminase (sGPT). Comparing the experimental groups, biochemical and pathological parameters of liver injury were significantly reduced when rats were acupunctured after, not before, CCl4-induced hepatotoxicity. Acupuncture at the Tsu-Sa-Li and Tai-Chung acupoints cannot prevent acute liver injury but may be effective in treating liver injury induced by carbon tetrachloride in rats.

Actinidia rubricaulisAttenuates Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats

2007 ◽  
Vol 35 (01) ◽  
pp. 81-88 ◽  
Author(s):  
Jung-Chun Liao ◽  
Kun-Hung Lin ◽  
Hao-Yuan Cheng ◽  
Jin-Bin Wu ◽  
Ming-Tsuen Hsieh ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Experimental Period ◽  
Hepatoprotective Effect ◽  
Glutamate Pyruvate Transaminase ◽  
Chronic Liver Injury ◽  
Glutamate Pyruvate ◽  
Ethanol Extracts ◽  
Serum Glutamate

The purpose of this study was to evaluate the antioxidant activity and hepatoprotective effect of ethanol extracts of Actinidia rubricaulis (AR) on chronic liver injury induced by carbon tetrachloride ( CCl4) in rats. CCl4(20%, 0.5 ml/rat) was given twice a week for 8 weeks, and animals received AR throughout the entire experimental period. AR reduced the elevated levels of serum glutamate-oxalate-transaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) caused by CCl4at weeks 1,3,6, and 8. The biochemical data were consistent with those of the histological observations. The AR extract recovered the CCl4-induced liver injury and showed antioxidant effect in assays of antioxidant enzyme activity, such as SOD, GSH-Px and GSH-Rd. Based on these results, we suggest that the hepatoprotective effect of the AR is related to its antioxidant activity.

Effect ofGanoderma tsugaeon Chronically Carbon Tetrachloride-Intoxicated Rats

2004 ◽  
Vol 32 (06) ◽  
pp. 841-850 ◽  
Author(s):  
Yueh-Wern Wu ◽  
Kuan-Dee Chen ◽  
Wen-Chuan Lin
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Liver Injury ◽  
Serum Albumin ◽  
Experimental Period ◽  
Chronic Liver ◽  
Glutamate Pyruvate Transaminase ◽  
Chronic Liver Injury ◽  
Glutamate Pyruvate ◽  
G Ratio

The purpose of this study was to evaluate the hepatoprotective and anti-fibrotic actions of crude extracts of Ganoderma tsugae (GTE) on chronic liver injury induced by carbon tetrachloride ( CCl4) in rats. CCl4(20%, 0.5 ml/rat) was given twice a week for 8 weeks, and animals received GTE through the whole experimental period. GTE showed obvious reducing actions on the elevated levels of glutamate-oxalate-transaminase (GOT) and glutamate-pyruvate-transaminase (GPT) caused by CCl4at weeks 3, 6 and 8. Liver fibrosis in rats induced by CCl4led to the drop of serum albumin and hepatic protein concentrations, while GTE increased serum albumin and hepatic protein concentrations. The CCl4-induced liver fibrosis may prolong the prothrombine time and increase albumin/globulin (A/G) ratio. GTE significantly decreased the prothrombine time and A/G ratio. Liver fibrosis induced by CCl4markedly increased the weight of the spleen, hepatic water and hydroxyproline contents in rats, while GTE decreased the rat's spleen weights, hepatic water and hydroxyproline contents. All these results clearly demonstrated that GTE has hepatoprotective and anti-fibrotic activities.

Expression of Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and CD147 in the Traditional Chinese Medicine “Compound T11” for Treatment of Chronic Liver Injury

Pharmacology ◽  
2018 ◽  
Vol 103 (3-4) ◽  
pp. 128-135
Author(s):  
Huaming Xu ◽  
Nian Yang ◽  
Zhenqiang Zhang ◽  
Chunling Niu ◽  
Wensheng Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Carbon Tetrachloride ◽  
Traditional Chinese Medicine ◽  
Liver Injury ◽  
Matrix Metalloproteinase ◽  
Protein Expression ◽  
Chronic Liver ◽  
Matrix Metalloproteinase 2 ◽  
Chronic Liver Injury ◽  
Dose Treatment

Objectives: To measure the expression of matrix metalloproteinase (MMP)-2, tissue inhibitor of matrix metalloproteinase inhibitor (TIMP)-2, and CD147 in mice with chronic liver injury induced by carbon tetrachloride after treatment with the traditional Chinese medicine (TCM) “Compound T11”. Method: Sixty male ICR mice were divided randomly into 6 groups of 10: control (C), model (M), low-dose treatment (LT; 50 mg/mL of Compound T11), medium-dose treatment (MT, 100 mg/mL), high-dose treatment (HT, 150 mg/mL), and positive drug treatment (YT, 67.5 mg/mL). Each group was modeled for 7 weeks. Groups M, LT, MT, HT, and YT were injected (s.c.) with 20% carbon tetrachloride diluted with olive oil, and group C was given olive oil in the same way twice a week. After modeling, the treatment groups were administered Compound T11 at the concentrations shown above by oral gavage daily for 2 weeks, while group C was given 0.5% carboxymethyl cellulose sodium. After the final treatment, mice were killed and their liver tissues were excised. Immunohistochemical staining was performed to measure the protein expression of MMP-2, TIMP-2, and CD147, and western blotting was used to measure the protein expression of MMP-2, TIMP-2, CD147, and α-smooth muscle actin (SMA). MMP-2, TIMP-2, and CD147 mRNA expression was determined by quantitative fluorescence real-time PCR. Results: Compound T11 increased the protein expression of MMP-2 and CD147 and decreased the protein expression of TIMP-2 and α-SMA. Conclusions: Treatment of chronic liver injury by TCM Compound T11 may be associated with changes to the expression of MMP-2 and CD147, and the inhibition of TIMP-2 expression.

Clinical characteristics and outcomes of traditional Chinese medicine-induced liver injury: a systematic review

2018 ◽  
Vol 12 (4) ◽  
pp. 425-434 ◽  
Author(s):  
Ran Wang ◽  
Xingshun Qi ◽  
Eric M. Yoshida ◽  
Nahum Méndez-Sánchez ◽  
Rolf Teschke ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Liver Injury ◽  
Clinical Characteristics

scholarly journals Literature Review of Traditional Chinese Medicine Herbs–Induced Liver Injury From an Oncological Perspective With RUCAM

2019 ◽  
Vol 18 ◽  
pp. 153473541986947 ◽  
Author(s):  
Hei Ching Chow ◽  
Tsz Him So ◽  
Horace Cheuk Wai Choi ◽  
Ka On Lam
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Liver Injury ◽  
Literature Review ◽  
Symptom Relief ◽  
Assessment Method ◽  
Current Evidence ◽  
Pueraria Lobata ◽  
Level Of Evidence ◽  
Wide Range

Traditional Chinese medicine (TCM) herbs are commonly regarded to be safe with minimal toxicities in Chinese communities. Cancer patients who are receiving Western oncology therapy often concurrently take TCM herbs for anticancer and symptom relief purposes. We performed a literature review for current evidence on TCM herb–induced liver injury from an oncological perspective. A literature search on PubMed was performed to identify publications regarding TCM herbs and concoctions with hepatoprotective or hepatotoxic properties. Lists of commonly used herbs and their causality levels were compiled. In view of the wide range of evidence available, cases assessed by the well-established RUCAM (Roussel Uclaf Causality Assessment Method) algorithm were categorized as the highest level of evidence. More than one case of TCM herb–induced liver injury was confirmed by RUCAM in the following herbs and concoctions: Lu Cha ( Camellia sinensis), Bai Xian Pi ( Dictamnus dasycarpus), Tu San Qi ( Gynura segetum), Jin Bu Huan ( Lycopodium serratum), He Shou Wu ( Polygoni multiflora), Ge Gen ( Pueraria lobata), Dan Lu Tong Du tablet, Shou Wu Pian, Xiao Chai Hu Tang, Xiao Yin pill, and Yang Xue Sheng Fa capsule. Finally, TCM with anticancer or symptom relief uses were discussed in detail with regard to their hepatotoxic or hepatoprotective properties.

Ameliorative Effect ofSilene apricaon Liver Injuries Induced by Carbon Tetrachloride and Acetaminophen

2002 ◽  
Vol 30 (02n03) ◽  
pp. 235-243 ◽  
Author(s):  
Yu-Jen Ko ◽  
Wen-Tsuan Hsieh ◽  
Yueh-Wern Wu ◽  
Wen-Chuan Lin
Keyword(s):  
Lipid Peroxidation ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Oral Administration ◽  
Acute Liver Injury ◽  
Ethanol Extract ◽  
Liver Injuries ◽  
Ameliorative Effect

The effect of oral administration of a 50% ethanol extract of Silene aprica (SA) on acute liver injury was examined in rats intoxicated with carbon tetrachloride (CCl4) and acetaminophen. The results indicated that SA protected the liver from CCl4- and acetaminophen-induced injury as judged by morphological and biochemical observations. An increase in both lipid peroxidation (LPO) and triglyceride concentrations occurred in the liver with CCl4injection , SA administration significantly reduced these changes.

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