Actinidia rubricaulisAttenuates Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats

2007 ◽  
Vol 35 (01) ◽  
pp. 81-88 ◽  
Author(s):  
Jung-Chun Liao ◽  
Kun-Hung Lin ◽  
Hao-Yuan Cheng ◽  
Jin-Bin Wu ◽  
Ming-Tsuen Hsieh ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Experimental Period ◽  
Hepatoprotective Effect ◽  
Glutamate Pyruvate Transaminase ◽  
Chronic Liver Injury ◽  
Glutamate Pyruvate ◽  
Ethanol Extracts ◽  
Serum Glutamate

The purpose of this study was to evaluate the antioxidant activity and hepatoprotective effect of ethanol extracts of Actinidia rubricaulis (AR) on chronic liver injury induced by carbon tetrachloride ( CCl4) in rats. CCl4(20%, 0.5 ml/rat) was given twice a week for 8 weeks, and animals received AR throughout the entire experimental period. AR reduced the elevated levels of serum glutamate-oxalate-transaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) caused by CCl4at weeks 1,3,6, and 8. The biochemical data were consistent with those of the histological observations. The AR extract recovered the CCl4-induced liver injury and showed antioxidant effect in assays of antioxidant enzyme activity, such as SOD, GSH-Px and GSH-Rd. Based on these results, we suggest that the hepatoprotective effect of the AR is related to its antioxidant activity.

Effect ofGanoderma tsugaeon Chronically Carbon Tetrachloride-Intoxicated Rats

2004 ◽  
Vol 32 (06) ◽  
pp. 841-850 ◽  
Author(s):  
Yueh-Wern Wu ◽  
Kuan-Dee Chen ◽  
Wen-Chuan Lin
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Liver Injury ◽  
Serum Albumin ◽  
Experimental Period ◽  
Chronic Liver ◽  
Glutamate Pyruvate Transaminase ◽  
Chronic Liver Injury ◽  
Glutamate Pyruvate ◽  
G Ratio

The purpose of this study was to evaluate the hepatoprotective and anti-fibrotic actions of crude extracts of Ganoderma tsugae (GTE) on chronic liver injury induced by carbon tetrachloride ( CCl4) in rats. CCl4(20%, 0.5 ml/rat) was given twice a week for 8 weeks, and animals received GTE through the whole experimental period. GTE showed obvious reducing actions on the elevated levels of glutamate-oxalate-transaminase (GOT) and glutamate-pyruvate-transaminase (GPT) caused by CCl4at weeks 3, 6 and 8. Liver fibrosis in rats induced by CCl4led to the drop of serum albumin and hepatic protein concentrations, while GTE increased serum albumin and hepatic protein concentrations. The CCl4-induced liver fibrosis may prolong the prothrombine time and increase albumin/globulin (A/G) ratio. GTE significantly decreased the prothrombine time and A/G ratio. Liver fibrosis induced by CCl4markedly increased the weight of the spleen, hepatic water and hydroxyproline contents in rats, while GTE decreased the rat's spleen weights, hepatic water and hydroxyproline contents. All these results clearly demonstrated that GTE has hepatoprotective and anti-fibrotic activities.

The Effectiveness of Tsu-San-Li (St-36) and Tai-Chung (Li-3) Acupoints for Treatment of Acute Liver Damage in Rats

2001 ◽  
Vol 29 (02) ◽  
pp. 221-226 ◽  
Author(s):  
Hsu-Jan Liu ◽  
Sheng-Feng Hsu ◽  
Chang-Chi Hsieh ◽  
Tin-Yun Ho ◽  
Ching-Liang Hsieh ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Acupuncture Therapy ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Male Rats ◽  
Acute Liver Damage ◽  
Glutamate Pyruvate Transaminase ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

This study investigated the effects of acupuncture on carbon tetrachloride (CCl4) induced acute liver injury in male rats (n = 36). The experimental groups were injected with CCl4 before, during, or after acupuncture therapy. Acupoints similar to the human Tsu-San-Li (St-36) and Tai-Chung (Li-3) were needled bilaterally. Rats treated with CCl4 had higher levels of serum glutamate-oxalate-transaminase (sGOT) and serum glutamate-pyruvate-transaminase (sGPT). Comparing the experimental groups, biochemical and pathological parameters of liver injury were significantly reduced when rats were acupunctured after, not before, CCl4-induced hepatotoxicity. Acupuncture at the Tsu-Sa-Li and Tai-Chung acupoints cannot prevent acute liver injury but may be effective in treating liver injury induced by carbon tetrachloride in rats.

scholarly journals Hepatoprotective Effect of Cuscuta campestris Yunck. Whole Plant on Carbon Tetrachloride Induced Chronic Liver Injury in Mice

2016 ◽  
Vol 17 (12) ◽  
pp. 2056 ◽  
Author(s):  
Wen-Huang Peng ◽  
Yi-Wen Chen ◽  
Meng-Shiou Lee ◽  
Wen-Te Chang ◽  
Jen-Chieh Tsai ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Chronic Liver Injury ◽  
Whole Plant ◽  
Cuscuta Campestris

Protective and Therapeutic Effects of Huanglian-Jie-Du-Tang on Hepatotoxin-induced Liver Injuries

1996 ◽  
Vol 24 (03n04) ◽  
pp. 219-229 ◽  
Author(s):  
Song-Chow Lin ◽  
Chun-Ching Lin ◽  
Fung-Jou Lu ◽  
Yun-Ho Lin ◽  
Ching-Hsein Chen
Keyword(s):  
Carbon Tetrachloride ◽  
Experimental Models ◽  
Hepatoprotective Effect ◽  
Therapeutic Effects ◽  
Liver Injuries ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Hepatoprotective Effects ◽  
Experimental Liver ◽  
Serum Glutamate

The hepatoprotective effect of Huanglian-Jie-Du-Tang (HLJDT), a Chinese medicinal prescription, was investigated in three kinds of experimental models. The animals were treated with HLJDT (300 mg/kg, p.o.) thrice at 2, 4 and 10 hours after administration with carbon tetrachloride (32 μl/kg, i.p.), acetaminophen (600 mg/kg, i.p.) and β-D-galactosamine (188 mg/kg, i.p.). Significant hepatoprotective effects on carbon tetrachloride and actaminophen induced liver injuries were noted, but no significant effect on β-D-galactosamine induced liver injury was observed. These hepatoprotective effects were evidenced by comparing the serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) levels in HLJDT treated and untreated groups. Serum enzyme activities in the carbon tetrachloride and acetaminophen experiments were significantly lower in the treated groups while the herbal prescription has no effect on the β-D-galactosamine experiment. These results demonstrated that Huanglian-Jie-Du-Tang has a hepatoprotective effect against experimental liver injuries induced by specific hepatotoxins, and therefore may be useful in treating some, but not all, liver injuries.

The Hepatoprotective Effect of Selenium-Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride-Induced Chronic Liver Injury in Rats

2018 ◽  
Vol 83 (2) ◽  
pp. 525-534 ◽  
Author(s):  
Mohammed Hamid ◽  
Yassin Abdulrahim ◽  
Dandan Liu ◽  
Gang Qian ◽  
Alamzeb Khan ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Gum Arabic ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Chronic Liver Injury

scholarly journals Effect of garlic extract (Allium sativum) on hepatic microanatomy structure and serum glutamate-pyruvate transaminase levels in rats after oral treatment of CCl4

2006 ◽  
Vol 4 (2) ◽  
pp. 72-78 ◽  
Author(s):  
WIWIK YULIA TRISTININGRUM ◽  
MARTI HARINI ◽  
TETRI WIDIYANI
Keyword(s):  
Carbon Tetrachloride ◽  
Allium Sativum ◽  
Oral Treatment ◽  
Garlic Extract ◽  
Central Vein ◽  
Glutamate Pyruvate Transaminase ◽  
Wistar Strain ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

Garlic (Allium sativum L.) is known to have various pharmacological activities, such as antidiabetic, antihypertensive, anti-cholesterol, anti-atherosclerosis, thrombocyte antiaggregation, initiate fibrinolysis, antiviral and antimicrobial, anticancer and antioxidant. The objectives of this research were to determine the effect of garlic extract (Allium sativum L.) on the microanatomy structure of liver and the serum glutamate-pyruvate transaminase (SGPT) levels in rats (Rattus norvegicus L.) after the oral treatment of carbon tetrachloride (CCl4). The study was conducted by using 25 Wistar strain rat aged 2-3 months with body weight 200-250 grams divided into five groups, each group consisted of 5 rats as replicates which kept under the same conditions and treated for 28 days. The results showed that the treatment of garlic extract had an effect on the improvement of microanatomy structure of damaged liver cells in rats after oral treatment of carbon tetrachloride (CCl4). The damage was in the form of fatty liver, pyknotic, karyorrhexis, karyolysis and central vein dilatation. The treatment of garlic extract also reduced the serum pyruvate-transaminase glutamate (SGPT) levels in rats after the oral treatment of carbon tetrachloride (CCl4).

scholarly journals Hepatoprotective Effects of Thespesia lampas Dalz & Gibs in CCl4 Induced Liver Injury in Rats

1970 ◽  
Vol 7 (1) ◽  
pp. 11-13 ◽  
Author(s):  
B Sangameswaran ◽  
Chumbhale Deshraj ◽  
BR Balakrishnan ◽  
B Jayakar
Keyword(s):  
Carbon Tetrachloride ◽  
Tween 80 ◽  
Treated Group ◽  
Hepatoprotective Activity ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Pyruvate Transaminase ◽  
Chronic Liver Damage ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

The extracts of the roots of Thespesia lampas (Malvaceae) were evaluated for hepatoprotective activity in rats by inducing chronic liver damage by subcutaneous injection of 50% v/v carbon tetrachloride in Tween 80 at a dose of 3ml/kg for a period of 4 weeks. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), serum bilirubin and total proteins were estimated to assess the liver function. Hepatic steatosis, centrilobular necrosis, and often swelling of the hepatic cytoplasm were observed in carbontetra chloride treated group, while these were completely absent in the extracts of T. lampas (300 mg/kg b.wt) treated groups (p < 0.01). The present investigation established pharmacological evidence to support the folkloric claim of hepatoprotective activity of T. lampas.Key words: Thespesia lampas, Carbon tetrachloride, Hepatoprotective, Rats, Root extracts  DOI = 10.3329/dujps.v7i1.1201Dhaka Univ. J. Pharm. Sci. 7(1): 11-13, 2008 (June)

Ameliorative Effect of Traditional Chinese Medicine Prescriptions on α-Naphthylisothiocyanate and Carbon-tetrachloride Induced Toxicity in Rats

1997 ◽  
Vol 25 (02) ◽  
pp. 185-196 ◽  
Author(s):  
Chin-Chuan Tsai ◽  
Shung-Te Kao ◽  
Chao-Tien Hsu ◽  
Chun-Ching Lin ◽  
Jim-Shoung Lai ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Carbon Tetrachloride ◽  
Traditional Chinese Medicine ◽  
Liver Injury ◽  
Serum Total Bilirubin ◽  
Glutamate Pyruvate Transaminase ◽  
Ameliorative Effect ◽  
Glutamate Pyruvate ◽  
Experimental Liver ◽  
Elevated Lipid

Syh-Mo-Yin (SMY), Guizhi-Fuling-Wan (GFW), Shieh-Qing-Wan (SQW) and Syh-Nih-San (SNS) are prescriptions of Traditional Chinese Medicine (TCM) for liver disease. The effects of these four prescriptions against experimental liver injury induced by α-Naphthylisothiocyanate (ANIT) and carbon tetrachloride ( CCl 4) were studied. Rats treated with ANIT (100 mg/kg) exhibited elevations of serum total bilirubin (TBI), alkaline phosphatase (ALP), glutamate-oxalatetransaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) as well as cholestasis and parenchymanecrosis. In rats receiving SMY, SQW and SNS treatment after ANIT challenged, the biochemical and morphological parameters of liver injury were significantly reduce. Elevated lipid peroxidation (LPO) level in liver tissue, associated with an increase in serum GOT and GPT level, was observed in CCl 4-treated rats. Treatment with these four prescriptions on CCl 4-induced liver injury rats showed a remarkable hepatoprotective effect. A significant decrease in peroxidative level suggested that these prescriptions have anti free radical properties.

scholarly journals Scutellarin Ameliorated Carbon Tetrachloride-Induced Chronic Liver Injury in Mice

2020 ◽  
Author(s):  
Zhimin Miao ◽  
Yingying Zhao ◽  
Chunyan Li ◽  
Lingmin Chen ◽  
Jianeng Zhou ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Function Analysis ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Mrna Levels ◽  
Chronic Liver Injury ◽  
Tnf Α ◽  
Anti Oxidant ◽  
Underlying Mechanisms

Abstract Background: Erigeron breviscapus (Vant.) Hand. -Mazz. is an edible and traditional medical herb and its extract scutellarin (SCU) is a widely used flavonoid showing anti-oxidant and anti-inflammatory activities. The purpose of this study was to evaluate the hepatoprotective effect of SCU on carbon tetrachloride (CCl4)-induced chronic liver injury in mice and reveal the underlying mechanisms. Methods: Chronic liver injury in mice was induced by intraperitoneal injection of 1 ml/kg CCl4 every three days. SCU (15 mg/kg, 30 mg/kg and 60 mg/kg) was administered through gavage every day. Bifendate (120 mg/kg) serves as a positive drug to validate the effectiveness of SCU.Results: The hepatoprotective effect of SCU was confirmed by liver function analysis, histological analysis and TUNEL assay. Administration of SCU recovered the activities of superoxide dismutase (SOD) and reduced the production of malondialdehyde (MDA). Additionally, treatment with SCU significantly decreased the mRNA levels of pro-inflammatory cytokines including IL-6, IL-1β and TNF-α. Moreover, SCU treatment suppressed the activation of NF-κB by decreasing the degradation of IκBα and inhibited the expression of CYP2E1. The 16S rRNA sequencing demonstrated that intake of SCU significantly remodeled gut microbiota, especially enriching the following: Lactobacillus, Coprobacillus, Akkermansia, Bifidobacterium, Parabacteroides. Conclusion: Our findings showed that SCU effectively ameliorated CCl4-induced chronic liver injury. This hepatoprotective effects might be attributed to inhibition of CCl4-induced NF-κB and CYP2E1 activation and enrichment of beneficial microbial community.

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