IN-VITRO BIOACTIVITY EVALUATION OF K2O-SUBSTITUTED Na2O-CaO-P2O5-SiO2 GLASS BIOCERAMICS

2018 ◽  
Vol 25 (05) ◽  
pp. 1850104
Author(s):  
REHANA ZIA ◽  
MADEEHA RIAZ ◽  
AYESHA ASGHAR ◽  
TOUSIF HUSSAIN
Keyword(s):  
Body Fluid ◽  
Glass Ceramics ◽  
Proper Function ◽  
Processing Temperature ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
Solid State Method ◽  
X Ray ◽  
Ceramic Samples

In the present work, the effect of K2O/Na2O substitution on the bioactivity of Na2O-CaO-P2O5-SiO2 ceramics prepared by solid-state method was studied. Ceramics-based bioactive implants are economical; they require low processing temperature and are more bioactive when compared with glasses, glass ceramics and composites. K2O is known to control proper function of cells and stimulate bone formation process. The hydroxyapatite layer developed on the surface of samples after soaking in stimulated body fluid solution was studied by X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy and atomic absorption spectroscopy. The results showed an increase in the bioactivity of the samples as Na2O was partially replaced with K2O. The addition of K2O enhanced the apatite-forming ability of the ceramic samples and makes it suitable for filling defects and fracture in bones.

Bioactive Composite Materials for Bone Tissue Applications

2006 ◽  
Vol 514-516 ◽  
pp. 985-989
Author(s):  
B.J.M. Leite Ferreira ◽  
M.G.G.M. Duarte ◽  
M. Helena Gil ◽  
Rui N. Correia ◽  
J. Román ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Bone Tissue ◽  
Tissue Repair ◽  
Body Fluid ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Biodegradable Composite ◽  
Scanning Electron

Two materials with potential application in bone tissue repair have been developed: 1) a non-biodegradable composite based in a new methacrylic-co-acrylic matrix; and 2) a biodegradable composite based in a chitosan (Ch) matrix. Both matrices were reinforced with glass-ceramic particles of composition (mol%) 70 SiO2 – 30 CaO. The in vitro bioactivity of composites was assessed by soaking in simulated body fluid (SBF) for periods of up to 7 days at 37º C. X-ray diffraction (XRD) and scanning electron microscopy coupled with X-ray energy dispersive spectroscopy (SEM-EDS) were used for deposit identification after different soaking periods. Calcium phosphate particulate deposits were detected after 3 days of immersion, followed by growth and maturation towards apatite.

scholarly journals Characterisation of the surface structure and bioactivity of glass and glass ceramics using surface topography

2012 ◽  
Vol 10 (6) ◽  
pp. 1890-1898 ◽  
Author(s):  
Gabriela Lutišanová ◽  
Martin Palou ◽  
Milan Mikula ◽  
Jana Kozánková
Keyword(s):  
Surface Structure ◽  
Surface Topography ◽  
Body Fluid ◽  
Glass Ceramics ◽  
Apatite Layer ◽  
In Vitro Bioactivity ◽  
Ceramic Samples ◽  
Melting Technique ◽  
The Relationship

AbstractThe present paper reports the results of the relationship between the surface topography, microstructure and the in vitro bioactivity of samples with and without fluorapatite content in simulated body fluid. Glasses and glass ceramics belonging to the Li2O-SiO2-CaO-P2O5-CaF2 system were prepared by using conventional melting technique following by heat treatment to obtain glass ceramics. This current study demonstrates the benefits of combining two microscopic methods for better investigation of the surface structure. The formation of apatite layer on the surface and the increase in surface roughness proved that the glasses and glass ceramics with bioactive fluorapatite content could satisfy to the requirements for biomaterial applications. The results also showed that the roughness of apatite layer formed after immersion in body fluid on the surface of glasses with fluorapatite was more pronounced than that of equivalent glass ceramic samples cured under the same conditions.

In-Vitro Bioactivity Characterization of Sodium-Potassium Mica and Fluorapatite Containing Glass Ceramics

2007 ◽  
Vol 330-332 ◽  
pp. 185-188
Author(s):  
Gultekin Goller ◽  
Can Cekli ◽  
Ipek Akin ◽  
Erdem Demirkesen
Keyword(s):  
Glass Ceramics ◽  
Xrd Analysis ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
Sodium Potassium ◽  
X Ray ◽  
Ftir Technique ◽  
Molecular Bonding

The aim of this study is to find out the crystallization behaviour and in-vitro bioactivity character of machinable glass ceramics having different ratios of Na/K mica and apatite phases, to ascertain the best machinable composition. In order to investigate the bioactivity behavior of the samples the simulated body fluid (SBF) was prepared. Samples were removed from the solution after 1 hour, 1 day, 1, 2, 3 and 4 weeks. FEG-SEM was used to characterize the morphology of precipitation HCA layer on the surface depending on time. Molecular bonding characterization of HCA layers were carried out by using Fourier Transform Infrared Spectroscopy (FTIR) technique. The thin film X-ray diffraction (TF-XRD) analysis was used to characterize the variation of chemical composition on precipitated layer by time. Optimum results were obtained by the composition, containing 70wt% Na/K mica and 30wt% fluorapatite which had an average mica size of 3-4 microns.

A study on using expanded perlite with hydroxyapatite: Reinforced bio-composites

2021 ◽  
pp. 095441192199656
Author(s):  
Erdoğan Karip ◽  
Mehtap Muratoğlu
Keyword(s):  
Body Fluid ◽  
Xrd Analysis ◽  
Cold Isostatic Pressing ◽  
Expanded Perlite ◽  
X Ray Diffraction ◽  
Pressing Method ◽  
X Ray ◽  
Infra Red ◽  
Ft Ir

People are exposed to different kinds of diseases or various accidents in life. Hydroxyapatite (HA) has been widely employed for bone treatment applications. In this study, HA was extracted from sheep bones. Bio-composites were doped with 1, 5, and 10 wt.% of expanded perlite and 5 wt.% of ZrO2–MgO-P2O5. The bio-composites were prepared by the cold isostatic pressing method (250 MPa) and sintered at 900°C for 1 h. In order to evaluate the characteristics of the bio-composites, microhardness, density, X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) analyses were carried out on them. Additionally, the specimens whose characteristics were determined were kept in synthetic body fluid (SBF), and their in vitro behavior was examined. As a result, it was observed that microhardness increased as both the weight and the grain size of the expanded perlite were increased. Calcium silicate, tri-calcium phosphate, and hydroxyapatite were observed in the XRD analysis of all samples, and the formation of apatite structures was increased by addition of ZrO2–MgO–P2O5.

THE STUDY ON GRANTING BIOACTIVITY OF Ti ALLOY BY SURFACE TREATMENT

2010 ◽  
Vol 17 (02) ◽  
pp. 153-157 ◽  
Author(s):  
N. R. HA ◽  
Z. X. YANG ◽  
G. C. KIM ◽  
K. H. HWANG ◽  
D. S. SEO ◽  
...  
Keyword(s):  
Surface Treatment ◽  
Body Fluid ◽  
Surface Effect ◽  
In Vitro Test ◽  
Ti Alloy ◽  
X Ray Diffraction ◽  
X Ray ◽  
Chemical Surface ◽  
Vitro Test

Titanium alloys are superior of biocompatibility, mechanical properties and chemical stability. The biocompatibility of Ti alloy is related to the surface effect between human tissue and implant. Therefore, the purpose of this study is to investigate the bioactivity of Ti alloy by alkali and acid chemical surface treatment; and the biocompatibility of Ti alloy was evaluated by in vitro test. Higher bone-bonding ability and bioactivity of the substrate were obtained by the formation of apatite layers on the Ti alloy in simulated body fluid. The microstructures of apatite layer were investigated by scanning electron microscope (SEM) and the formed phases were analyzed with X-ray diffraction (XRD).

In Vitro Study of Microplasma Sprayed Hydroxyapatite Coatings in Simulated Body Fluid

2009 ◽  
Vol 79-82 ◽  
pp. 815-818 ◽  
Author(s):  
Qiu Ying Zhao ◽  
Ding Yong He ◽  
Xiao Yan Li ◽  
Jian Min Jiang
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Carbonate Apatite ◽  
In Vitro Test ◽  
X Ray Diffraction ◽  
X Ray ◽  
Amorphous Phases ◽  
Hydroxyapatite Coatings ◽  
Vitro Test

Hydroxyapatite (HA) coatings were deposited onto Ti6Al4V substrate by microplasma spraying (MPS) in the current research. The morphology, phase compositions, and percentage of crystallinity of the coatings were characterized by means of scanning electron microscopy (SEM) and X-ray diffraction. An in vitro evaluation by soaking the coatings in simulated body fluid (SBF) for up to 14 days was conducted aiming at the evaluation of their bioactivity. Results from the present investigation suggest that microplasma sprayed HA coatings exhibited certain roughness, pores, and microcracks. Thermal decomposition existed in the coatings where HA, α-TCP，β-TCP, amorphous phases, and CaO-exclusive impurities were observed. The in vitro test indicated that HA coatings deposited by MPS possessed better bioactivity and stability. A layer of carbonate-apatite covered most of the coating surface, which did not exhibit significant spalling after incubation in SBF.

scholarly journals The Atomic-Scale Interaction of Bioactive Glasses with Simulated Body Fluid

2005 ◽  
Vol 480-481 ◽  
pp. 21-26 ◽  
Author(s):  
L.J. Skipper ◽  
F.E. Sowrey ◽  
D.M. Pickup ◽  
R.J. Newport ◽  
K.O. Drake ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Sol Gel ◽  
Atomic Scale ◽  
X Ray Diffraction ◽  
Bioactive Glasses ◽  
Edge Structure ◽  
X Ray ◽  
X Ray Absorption

The formation of a carbonate-containing hydroxyapatite, HCAp, layer on bioactive calcium silicate sol-gel glass of the formula (CaO)0.3(SiO2)0.7 has been studied in-vitro in Simulated Body Fluid (SBF). Extended X-ray Absorption Fine Structure (EXAFS), X-ray Absorption Near Edge Structure (XANES), X-ray diffraction (XRD), and solid state nuclear magnetic resonance (NMR) measurements have been performed with results showing the formation of a significantly amorphous HCAp layer after less than 5 hours in solution.

scholarly journals Investigation on Structural and Optical Properties of Willemite Doped Mn2+Based Glass-Ceramics Prepared by Conventional Solid-State Method

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Nur Farhana Samsudin ◽  
Khamirul Amin Matori ◽  
Josephine Ying Chi Liew ◽  
Yap Wing Fen ◽  
Mohd Hafiz Mohd Zaid ◽  
...  
Keyword(s):  
Glass Ceramic ◽  
Glass Ceramics ◽  
Structural Evolution ◽  
Emission Spectra ◽  
Soda Lime ◽  
X Ray Diffraction ◽  
Glass Waste ◽  
Solid State Method ◽  
Ceramic Samples ◽  
Zno Crystal

Mn-doped willemite (Zn2SiO4:Mn2+) glass-ceramics derived from ZnO-SLS glass system were prepared by a conventional melt-quenching technique followed by a controlled crystallization step employing the heat treatment process. Soda lime silica (SLS) glass waste, ZnO, and MnO were used as sources of silicon, zinc, and manganese, respectively. The obtained glass-ceramic samples were characterized using the X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared (FTIR), UV-Visible (UV-Vis), and photoluminescence (PL) spectroscopy. The results of XRD revealed that ZnO crystal and willemite (β-Zn2SiO4) were presented as major embedded crystalline phases. This observation was consistent with the result of FESEM which showed the presence of irregularity in shape and size of willemite crystallites. FTIR spectroscopy exhibits the structural evolution of willemite based glass-ceramics. The optical band gap shows a decreasing trend as the Mn-doping content increased. Photoluminescent technique was applied to characterize the role of Mn2+ions when entering the willemite glass-ceramic structure. By measuring the excitation and emission spectra, the main emission peak of the glass-ceramic samples located at a wavelength of 585 nm after subjecting to 260 nm excitations. The following results indicate that the obtained glass-ceramics can be applied as phosphor materials.

Studies on Development, Bioactivity and Corrosion Behaviour of Nanostructured Titania/Hydroxyapatite Composite Layer on Cp Ti

2011 ◽  
Vol 471-472 ◽  
pp. 325-330 ◽  
Author(s):  
K. Venkateswarlu ◽  
N. Rameshbabu ◽  
Arumugam Chandra Bose ◽  
V. Muthupandi ◽  
S. Subramanian
Keyword(s):  
Corrosion Resistance ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Composite Layer ◽  
In Vitro Bioactivity ◽  
X Ray ◽  
Composite Layers ◽  
Cp Ti ◽  
Nanostructured Titania

Nanostructured titania/hydroxyapatite (HA) composite layer was developed on commercially pure titanium (Cp Ti) implant material by plasma electrolytic processing (PEP) technique in order to improve its bioactivity and corrosion resistance under physiological conditions. The phases present in the developed composite layer were studied by X-ray diffraction (XRD) technique. The surface morphology and thickness of the composite layers were observed by scanning electron microscopy (SEM). The corrosion characteristics of the developed layer were studied by potentiodynamic polarization scan under simulated body fluid (7.4 pH Hanks solution) and simulated osteoclast (4.5 pH) conditions. The in-vitro bioactivity of the composite layers was studied by using Kokubu’s simulated body fluid (SBF) solution. The X-ray diffractograms reveal the presence of anatase TiO2 and HA phases in the developed layer. The SEM results confirm the pore-free morphology of the implant material surface and the thickness of the developed composite layer was observed to be 110 ± 5 µm for 12 min of PEP. The potentiodynamic polarization study shows an improved corrosion resistance and the in-vitro bioactivity test results indicate enhanced apatite forming ability of PEP treated Cp Ti surfaces compared to that of the untreated Cp Ti, under simulated body fluid conditions.

scholarly journals A sol-gel synthesis, characterization and in vitro bioactivity of binary, ternary and quaternary bioglasses with high mechanical strength

2020 ◽  
Vol 10 (4) ◽  
pp. 310-318
Author(s):  
Sara Bouhazma ◽  
Imane Adouar ◽  
Sanae Chajri ◽  
Smaiel Herradi ◽  
Mohamed Khaldi ◽  
...  
Keyword(s):  
Sol Gel ◽  
Environmental Scanning Electron Microscopy ◽  
Environmental Scanning ◽  
In Vitro Tests ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
High Mechanical Strength ◽  
X Ray ◽  
Sol Gel Synthesis

Bioactive powders of the binary SiO2-CaO, ternary SiO2-CaO-P2O5 and quaternary systems SiO2-CaO-P2O5-Na2O/Mg2O were synthesized using a sol-gel route. The gels were converted into bioglasses powders by heat treatments at the temperature of 700°C. The resulting materials were characterized by X-ray diffraction (XRD), Fourier Transform Infrared spectroscopy (FTIR), Environmental Scanning Electron Microscopy (ESEM) and in vitro bioactivity in acellular Simulated Body Fluid (SBF). The in vitro tests showed that the samples had good apatite-forming ability. Glasses doped with sodium and magnesium show good results in terms of bioactivity and mechanical properties. The results showed that the quaternary glass SiO2-CaO-P2O5-Na2O containing Na is the most bioactive, only 6 hours after its immersion in SBF; a layer of hydroxycarbonated apatite (HAC) was deposited on the glass and compressive strength of up to 233.08 MPa with a porosity of 11.02%, due to the presence of the Na2Ca2Si3O9 phase. Magnesium also affects bioactivity because it has improved from binary to ternary to quaternary doped with magnesium, bioactive from 12h of contact with the SBF.

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