Discoveries and Innovations in Drug Development (Vol. 26, No. 1, Full Issue)

2021 ◽  
Vol 26 (01) ◽  
Keyword(s):  
Drug Development ◽  
Digital Technology ◽  
Medical Officer ◽  
The Other ◽  
Antigen Specificity ◽  
Antimicrobial Coatings ◽  
Transplantation Rejection ◽  
Oncology Drug Development ◽  
Patient Centric

For the month of January 2022, APBN looks at some discoveries and innovation in pharmacology. In Features, Dr Harish Dave, Co-Founder and Chief Medical Officer of AUM Biosciences, discusses today's shifting paradigm in oncology drug development towards highly selective, minimally toxic, and patient-centric treatments, while Jade Pallett, Chief Technology Officer for Zoono UK & Europe, sheds light on how antimicrobial coatings outdo traditional methods of disinfection. Then, we have A/Prof Alexandra Sharland, Dr Nicole Mifsud, and Eric Son to elucidate how understanding antigen-specificity of host T cells can reduce organ transplantation rejection. Finally, in Spotlights, we have two interviews – one where we speak to Mr Willson Deng, CEO of Arcstone, on the role of digital technology in supporting MedTech manufacturing, and the other with Liu Qun, Head of IQVIA, China, where we learn more about the Chinese biopharmaceutical market.

scholarly journals Who’s Afraid of the Audience? Digital and Post-Digital Perspectives on Aesthetics

2014 ◽  
Vol 3 (1) ◽  
pp. 120-130 ◽  
Author(s):  
Lotte Philipsen
Keyword(s):  
Immanuel Kant ◽  
Digital Technology ◽  
Aesthetic Experience ◽  
The Other ◽  
Artistic Practice ◽  
Works Of Art ◽  
Practical Analysis ◽  
The Way

This article analyses how works of art that make use of or refer to digital technology can be approached, analysed, and understood aesthetically from two different perspectives. One perspective, which I shall term a ‘digital’ perspective, mainly focuses on poetics (or production) and technology when approach- ing the works, whereas the other, which I shall term a ‘post-digital’ perspective, focuses on aesthetic experience (or reception) when approaching the works. What I tentatively and for the purpose of practical analysis term the ‘digital’ and the ‘post-digital’ perspectives do not designate two different sets of concrete works of art or artistic practice and neither do they describe different periods.[1] Instead, the two perspectives co-exit as different discursive positions that are concretely ex- pressed in the way we talk about aesthetics in relation to art that makes use of and/or refers to digital technology. In short: When I choose here to talk about a digital and a post-digital perspective, I talk about two fundamentally different ways of ascribing aes- thetic meaning to (the same) concrete works of art. By drawing on the ideas of especially Immanuel Kant and Dominic McIver Lopes, it is the overall purposes of this article to ana- lyse and compare how the two perspectives understand the concept of aesthetics and to discuss some of the implications following from these understandings. As it turns out, one of the most significant implications is the role of the audience. 

scholarly journals A Cidade entre Imagens e Imaginários: Algumas contribuições dos olhares skatistas

ILUMINURAS ◽  
2020 ◽  
Vol 21 (54) ◽  
Author(s):  
Luiz Antonio Feliciano
Keyword(s):  
Digital Technology ◽  
Urban Culture ◽  
Sao Paulo ◽  
The Other ◽  
The Internet ◽  
São Paulo ◽  
Hybrid Device ◽  
The Relationship ◽  
The City

Resumo:Esse trabalho discute a importância da produção visual, sobretudo, a fotografia, na constituição da imagem da cidade. Aborda, também, o papel da tecnologia digital na composição das subjetividades contemporâneas e suas contribuições para se fortalecer uma cultura urbana, mesmo em meio às limitações impostas pela sociedade. Para sua realização observou-se etnograficamente um grupo de skatistas, em uma pista de skate, numa cidade do interior de São Paulo. A importância dada ao celular foi um traço recorrente que permeou grande parte das discussões. Portar um aparelho híbrido e produzir imagens é uma maneira de contribuir para a construção do imaginário sobre a cidade, sobretudo, quando essas imagens veiculam pela internet. Acredita-se que o trabalho traz problematizações sobre os jovens na relação consigo, com o outro, com o grupo e com a cidade.Palavras-chave: Subjetividade. Cidade. Jovem. Skatista. Tecnologia  THE CITY BETWEEN IMAGES AND IMAGINARY: SOME CONTRIBUTIONS FROM SKATEBOARDERS' EYES Abstract: This work discusses the importance of visual production, especially photography, in the constitution of the city’s image. It also addresses the role of digital technology in the composition of contemporary subjectivities and its contributions to strengthening an urban culture, even amid the limitations imposed by society. For its realization it was observed ethnographically a group of skateboarders, in a skate track, in a city of the interior of São Paulo. The importance given to cellular was a recurrent trait that permeated much of the discussions. Carrying a hybrid device and producing images is a way of contributing to the construction of the imaginary about the city, especially when these images are transmitted through the internet. It is believed that the work brings problematizations about young people in the relationship with themselves, with the other, with the group and with the city.Keywords: Subjectivity. City. Young. Skater. Technology

The Role of PET/CT and SPECT/CT in Oncology Drug Development

2013 ◽  
Vol 2 (1) ◽  
pp. 42-52 ◽  
Author(s):  
Karen A Kurdziel ◽  
Liza Lindenberg ◽  
Esther Mena ◽  
Baris Turkbey ◽  
Peter Choyke
Keyword(s):  
Drug Development ◽  
Oncology Drug ◽  
Pet Ct ◽  
Oncology Drug Development

Plasma Levels of Protein S, Protein C, and Factor X: Effects of Sex, Hormonal State and Age

1995 ◽  
Vol 74 (05) ◽  
pp. 1271-1275 ◽  
Author(s):  
C M A Henkens ◽  
V J J Bom ◽  
W van der Schaaf ◽  
P M Pelsma ◽  
C Th Smit Sibinga ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Postmenopausal Women ◽  
Protein C ◽  
Blood Donors ◽  
Premenopausal Women ◽  
Protein S ◽  
The Other ◽  
Factor X ◽  
Normal Ranges

SummaryWe measured total and free protein S (PS), protein C (PC) and factor X (FX) in 393 healthy blood donors to assess differences in relation to sex, hormonal state and age. All measured proteins were lower in women as compared to men, as were levels in premenopausal women as compared to postmenopausal women. Multiple regression analysis showed that both age and subgroup (men, pre- and postmenopausal women) were of significance for the levels of total and free PS and PC, the subgroup effect being caused by the differences between the premenopausal women and the other groups. This indicates a role of sex-hormones, most likely estrogens, in the regulation of levels of pro- and anticoagulant factors under physiologic conditions. These differences should be taken into account in daily clinical practice and may necessitate different normal ranges for men, pre- and postmenopausal women.

On the role of the dispute between "non-possessors" and "Josephites" in the culture of Moscow's prediction

1998 ◽  
pp. 61-62
Author(s):  
N. S. Jurtueva
Keyword(s):  
The Other ◽  
Moral Transformation ◽  
15Th Century ◽  
The Future ◽  
Secular Power

In the XIV century. centripetal tendencies began to appear in the Moscow principality. Inside the Russian church, several areas were distinguished. Part of the clergy supported the specificobar form. The other understood the need for transformations in society. As a result, this led to a split in the Russian church in the 15th century for "non-possessors" and "Josephites". The former linked the fate of the future with the ideology of hesychasm and its moral transformation, while the latter sought support in alliance with a strong secular power.

From Container to Claustrum: Projective Identification in Couples

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Tamara Feldman
Keyword(s):  
Psychological Health ◽  
Projective Identification ◽  
The Self ◽  
The Other ◽  
Intimate Partners ◽  
And Control ◽  
The Relationship ◽  
As If

This paper is a contribution to the growing literature on the role of projective identification in understanding couples' dynamics. Projective identification as a defence is well suited to couples, as intimate partners provide an ideal location to deposit unwanted parts of the self. This paper illustrates how projective identification functions differently depending on the psychological health of the couple. It elucidates how healthier couples use projective identification more as a form of communication, whereas disturbed couples are inclined to employ it to invade and control the other, as captured by Meltzer's concept of "intrusive identification". These different uses of projective identification affect couples' capacities to provide what Bion called "containment". In disturbed couples, partners serve as what Meltzer termed "claustrums" whereby projections are not contained, but imprisoned or entombed in the other. Applying the concept of claustrum helps illuminate common feelings these couples express, such as feeling suffocated, stifled, trapped, held hostage, or feeling as if the relationship is killing them. Finally, this paper presents treatment challenges in working with more disturbed couples.

Thomas More's “rule” of pleasure before, after, and inUtopia

Moreana ◽  
2017 ◽  
Vol 54 (Number 207) (1) ◽  
pp. 36-56
Author(s):  
Gerard Wegemer
Keyword(s):  
Human Nature ◽  
The Other ◽  
Biblical Allusions ◽  
De Officiis

After establishing a context of More's lifelong engagement with the “calculus” of pleasure, this essay shows how the section devoted to the Utopians' pleasure philosophy is structured around five formulations of a “rule” to calculate “true and honest [honesta]” pleasure in ways that playfully imitate and echo the “rule” Cicero formulates several times in De officiis to discern one's duty when there seems to be a conflict between honestas et utilitas. When followed, the Utopian pleasure calculus shows the necessary role of societas, officii, iustitia, caritas, and the other aspects of human nature, most importantly friendship, that Cicero stresses in his rule and that he argued Epicurus ignored. Much of the irony and humor of this section depends on seeing the predominance of Ciceronian vocabulary in Raphael's unusual defense [patrocinium] of pleasure, rather than a Ciceronian defense of duty rooted in honestas. Throughout, however, this essay also shows how More goes beyond Cicero by including Augustinian and biblical allusions to suggest ways that our final end is not as Epicurus or the Stoics or Cicero claim; the language and allusions of this section point to a level of good cheer and care for neighbors and for God in ways quite different from any classical thinker.

Sign in / Sign up

Export Citation Format

Share Document