COMPUTATIONAL FLUID DYNAMICS (CFD) APPLIED IN THE DRUG DELIVERY DESIGN PROCESS TO THE NASAL PASSAGES: A REVIEW

2012 ◽  
Vol 12 (01) ◽  
pp. 1230002 ◽  
Author(s):  
MARIT KLEVEN ◽  
MORTEN C. MELAAEN ◽  
PER G. DJUPESLAND
Keyword(s):  
Fluid Dynamics ◽  
Drug Delivery ◽  
Design Process ◽  
Computer Aided Design ◽  
Nasal Airway ◽  
Nasal Drug Delivery ◽  
Physical Experiments ◽  
Computer Aided

Computer fluid dynamics (CFD) has for many years now been employed to study and solve fluid problems in the industry and offers an attractive method for accurately describing systems at a reasonable cost. Computer-aided methods are becoming increasingly important in medicine. Due to a combination of increased computer efficiency and advanced numerical techniques, the realism of these simulations has been enhanced in recent years. Over the past decade, computer-aided design has emerged as a method that is both sufficiently rigorous and efficient to be used for studies of the fluid dynamics in complex airway structures like the nasal airway. Physical experiments in vitro and in vivo are often expensive and time-consuming, and CFD has gained increasing attention as a tool in the design process of devices delivering drugs to the respiratory tract. This paper provides a review of the development of CFD in the studies of nasal airway fluid dynamics, particle and filtering properties in health and disease. Special emphasis is given to studies related to CFD studies used in the development of nasal drug delivery devices. The accuracy and value of CFD for the study of drug delivery design to the nose is reviewed in comparison to experimental results with other methods. Some important challenges when dealing with grid generation and flow simulations in these complex geometries with variable multiphase flow patterns in alternate directions are discussed.

scholarly journals Development of a framework for whole-cell models creation

2019 ◽  
Author(s):  
Frederico Chaves Carvalho ◽  
Paulo Eduardo Ambrósio
Keyword(s):  
Computer Aided Design ◽  
Development Process ◽  
Scientific Discovery ◽  
Cell Models ◽  
Whole Cell ◽  
Early Stages ◽  
Computer Aided ◽  
Aided Design

The use of whole-cell models in research has the potential to be a powerful tool for scientific discovery, allowing researchers to test hypotheses faster than using in-vitro or in vivo methods. Such models can be considered the equivalent of Computer Aided Design for Biology. However, given their complexity, it is still difficult to employ them as an instrument in investigations. In order to solve this problem, we are developing a framework with the purpose to guide and help scientists through the process of creating whole-cell models faster, enabling them to use these tools as part of their research. This paper brings details of the early stages of the framework’s development process

scholarly journals Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1180
Author(s):  
Giovanna Rassu ◽  
Milena Sorrenti ◽  
Laura Catenacci ◽  
Barbara Pavan ◽  
Luca Ferraro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Detailed Examination ◽  
Delivery Systems ◽  
Nasal Drug Delivery ◽  
In Vivo Models ◽  
Nasal Application

Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipients, as solubilizers and absorption promoters, and as active ingredients due to their several biological activities (antiviral, antiparasitic, anti-atherosclerotic, and neuroprotective). The use of CDs in nasal formulations allowed obtaining versatile drug delivery systems intended for local and systemic effects, as well as for nose-to-brain transport of drugs. In vitro and in vivo models currently employed are suitable to analyze the effects of CDs in nasal formulations. Therefore, CDs are versatile pharmaceutical materials, and due to the continual synthesis of new CDs derivatives, the research on the new nasal applications is an interesting field evolving in the coming years, to which Italian research will still contribute.

scholarly journals State of the Art on Biomaterials for Soft Tissue Augmentation in the Oral Cavity. Part II: Synthetic Polymers-Based Biomaterials

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1845
Author(s):  
Manuel Toledano ◽  
Manuel Toledano-Osorio ◽  
Álvaro Carrasco-Carmona ◽  
Cristina Vallecillo ◽  
Raquel Toledano ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Oral Cavity ◽  
Biodegradable Polymers ◽  
Computer Aided Design ◽  
Synthetic Polymers ◽  
Soft Tissue Augmentation ◽  
Tissue Augmentation ◽  
Computer Aided

Most of the polymers used as biomaterials for scaffolds are naturally occurring, synthetic biodegradable, and synthetic non-biodegradable polymers. Since synthetic polymers can be adapted for obtaining singular desired characteristics by applying various fabrication techniques, their use has increased in the biomedical field, in dentistry in particular. The manufacturing methods of these new structures include many processes, such as electrospinning, 3D printing, or the use of computer-aided design/computer-aided manufacturing (CAD/CAM). Synthetic polymers show several drawbacks that can limit their use in clinical applications, such as the lack of cellular recognition, biodegradability, and biocompatibility. Moreover, concerning biodegradable polymers, the time for matrix resorption is not predictable, and non-resorbable matrices are preferred for soft tissue augmentation in the oral cavity. This review aimed to determine a new biomaterial to offset the present shortcomings in the oral environment. Researchers have recently proposed a novel non-resorbable composite membrane manufactured via electrospinning that has allowed obtaining remarkable in vivo outcomes concerning angiogenesis and immunomodulation throughout the polarization of macrophages. A prototype of the protocol for in vitro and in vivo experimentation with hydrogels is explained in order to encourage innovation into the development of promising biomaterials for soft tissue augmentation in the near future.

Exploring the Engineering Design Process Through Computer-Aided Design and 3-D Printing

Science Scope ◽  
2017 ◽  
Vol 041 (01) ◽  
Author(s):  
Nicholas Garafolo ◽  
Nidaa Makki ◽  
Katrina Halasa ◽  
Wondimu Ahmed ◽  
Kristin Koskey ◽  
...  
Keyword(s):  
Engineering Design ◽  
Design Process ◽  
Computer Aided Design ◽  
Engineering Design Process ◽  
Computer Aided ◽  
Aided Design

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

In vitro Lipolysis as a Tool for the Establishment of IVIVC for Lipid-Based Drug Delivery Systems

2019 ◽  
Vol 16 (8) ◽  
pp. 688-697
Author(s):  
Ravinder Verma ◽  
Deepak Kaushik
Keyword(s):  
Drug Delivery ◽  
Ph Value ◽  
Electron Paramagnetic Resonance Spectroscopy ◽  
Rapid Screening ◽  
Resonance Spectroscopy ◽  
Fed State ◽  
In Vitro Lipolysis ◽  
Ph Stat

: In vitro lipolysis has emerged as a powerful tool in the development of in vitro in vivo correlation for Lipid-based Drug Delivery System (LbDDS). In vitro lipolysis possesses the ability to mimic the assimilation of LbDDS in the human biological system. The digestion medium for in vitro lipolysis commonly contains an aqueous buffer media, bile salts, phospholipids and sodium chloride. The concentrations of these compounds are defined by the physiological conditions prevailing in the fasted or fed state. The pH of the medium is monitored by a pH-sensitive electrode connected to a computercontrolled pH-stat device capable of maintaining a predefined pH value via titration with sodium hydroxide. Copenhagen, Monash and Jerusalem are used as different models for in vitro lipolysis studies. The most common approach used in evaluating the kinetics of lipolysis of emulsion-based encapsulation systems is the pH-stat titration technique. This is widely used in both the nutritional and the pharmacological research fields as a rapid screening tool. Analytical tools for the assessment of in vitro lipolysis include HPLC, GC, HPTLC, SEM, Cryo TEM, Electron paramagnetic resonance spectroscopy, Raman spectroscopy and Nanoparticle Tracking Analysis (NTA) for the characterization of the lipids and colloidal phases after digestion of lipids. Various researches have been carried out for the establishment of IVIVC by using in vitro lipolysis models. The current publication also presents an updated review of various researches in the field of in vitro lipolysis.

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