Optimal measurement locations for diagnosis of aortic abnormalities in a lumped-parameter model of the systemic circulation using sensitivity analysis

2017 ◽  
Vol 10 (08) ◽  
pp. 1750116 ◽  
Author(s):  
R. Gul ◽  
S. Bernhard
Keyword(s):  
Sensitivity Analysis ◽  
Systemic Circulation ◽  
The Body ◽  
Lumped Parameter Model ◽  
Aorta Ascendens ◽  
Optimal Measurement ◽  
Linear Elastic ◽  
Lumped Parameter ◽  
Basic Theme ◽  
Cardiovascular Simulator

The basic theme of this work is to identify the optimal measurement locations for pressure and flow in the systemic circulation to detect aortic stenoses and aneurysms in early stages of a disease. For this purpose, a linear elastic lumped parameter model of the fluid dynamical simulator, major arterial cardiovascular simulator (MACSim), is considered and global sensitivity analysis is applied to identify the better measurement locations for pressure and flow in the systemic circulation. The obtained results of sensitivity analysis provide insight that enable the experimentalists to optimize their experimental setups for detecting aortic stenoses and aneurysms using parameter estimation process. From the results, it is observed that the stenosis in the thoracic aorta can be identified from both pressure and flow at the location itself, nearby nodes, aorta ascendens, arcus aorta, arteria subclavia and arteria axillaris. On the other hand, the preferable measurement locations for abdominal aneurysms are locations themselves, nearby nodes and left/right leg of the body.

scholarly journals STUDY OF UNCERTAINTIES ON A 0D MODEL OF THE SYSTEMIC CIRCULATION

2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Gilmar Ferreira Da Silva Filho ◽  
Rafael Alves Bonfim De Queiroz ◽  
Luis Paulo Da Silva Barra ◽  
Bernardo Martins Rocha
Keyword(s):  
Sensitivity Analysis ◽  
Computational Models ◽  
Clinical Decision Making ◽  
Systemic Circulation ◽  
Lumped Parameter Model ◽  
Patient Specific ◽  
Accurate Estimation ◽  
Clinical Patient ◽  
Lumped Parameter ◽  
Input Parameters

Cardiovascular system is intensely researched to understand the intricate nature of the heart and blood circulation. Nowadays we have well evolved computational models which are useful in many ways for the understanding and analysis of physiological and pathophysiological conditions of the heart. However, the practical use of these models and their results for clinical decision making in specific patients is not straightforward. In this context, models predictions must be accurate and reliable, which can be assessed by quantification of uncertainties in the predictions and sensitivity analysis of the input parameters. Lumped parameter models for the cardiovascular physiology can provide useful data for clinical patient-specific applications. However, the accurate estimation of all parameters of these models is a difficult task, and therefore the determination of the most sensitive parameters is an important step towards the calibration of these models. We perform uncertainty quantification and sensitivity analysis based on generalised polynomial chaos expansion in a lumped parameter model for the systemic circulation. The objective of this work is to verify the effect of uncertainties from input parameters on the predictions of the models and to identify parameters that contribute significantly to relevant quantities of interest. Numerical experiments are performed and results indicate a set of the most relevant parameters in the context of these models.

scholarly journals Sensitivity Analysis of the Transmission Chain of a Horizontal Machining Tool Axis to Design and Control Parameters

2014 ◽  
Vol 6 ◽  
pp. 169064 ◽  
Author(s):  
Stefano Mauro ◽  
Stefano Pastorelli ◽  
Tharek Mohtar
Keyword(s):  
Sensitivity Analysis ◽  
Lumped Parameter Model ◽  
Control Parameters ◽  
Damping Coefficients ◽  
Transmission Chain ◽  
Lumped Parameter ◽  
Tool Axis ◽  
Optimal Value ◽  
Structural Parts ◽  
And Control

This paper reports how a numerical controlled machine axis was studied through a lumped parameter model. Firstly, a linear model was derived in order to apply a modal analysis, which estimated the first mechanical frequency of the system as well as its damping coefficients. Subsequently, a nonlinear system was developed by adding friction through experimentation. Results were validated through the comparison with a commercial servoaxis equipped with a Siemens controller. The model was then used to evaluate the effect of the stiffness of the structural parts of the axis on its first natural frequency. It was further used to analyse precision, energy consumption, and axis promptness. Finally a cost function was generated in order to find an optimal value for the main proportional gain of the position loop.

Parameter Sensitivity Analysis of a Lumped-Parameter Model of Lymphangions in Series

2012 ◽  
Author(s):  
Samira Jamalian ◽  
James E. Moore ◽  
Christopher D. Bertram ◽  
Will Richardson
Keyword(s):  
Sensitivity Analysis ◽  
Interstitial Fluid ◽  
Lymphatic System ◽  
Lumped Parameter Model ◽  
Node Dissection ◽  
Parameter Sensitivity Analysis ◽  
Protein Balance ◽  
Vital Functions ◽  
Lumped Parameter ◽  
In Series

The lymphatic system is responsible for vital functions in the human body. In particular, it plays an important role in the immune system mechanism whereby undesirable elements are destroyed in the lymph nodes. But cancer cells also spread via the lymphatic system. The system maintains fluid and protein balance by gathering approximately 4 L/day of interstitial fluid and returning it to the venous system. Lymphedema, an ailment of the system for which there is no known cure, primarily affects cancer patients who have undergone lymph node dissection [1]. To understand how to treat such pathologies of the lymphatic system, it is first necessary to examine its fluid flow and pumping mechanisms quantitatively.

scholarly journals Parameter sensitivity analysis of a lumped-parameter model of a chain of lymphangions in series

2013 ◽  
Vol 305 (12) ◽  
pp. H1709-H1717 ◽  
Author(s):  
Samira Jamalian ◽  
Christopher D. Bertram ◽  
William J. Richardson ◽  
James E. Moore
Keyword(s):  
Sensitivity Analysis ◽  
Flow Rate ◽  
Pressure Difference ◽  
Lymphatic System ◽  
Lumped Parameter Model ◽  
Average Flow Rate ◽  
Average Flow ◽  
Lumped Parameter ◽  
Time Average ◽  
A Chain

Any disruption of the lymphatic system due to trauma or injury can lead to edema. There is no effective cure for lymphedema, partly because predictive knowledge of lymphatic system reactions to interventions is lacking. A well-developed model of the system could greatly improve our understanding of its function. Lymphangions, defined as the vessel segment between two valves, are the individual pumping units. Based on our previous lumped-parameter model of a chain of lymphangions, this study aimed to identify the parameters that affect the system output the most using a sensitivity analysis. The system was highly sensitive to minimum valve resistance, such that variations in this parameter caused an order-of-magnitude change in time-average flow rate for certain values of imposed pressure difference. Average flow rate doubled when contraction frequency was increased within its physiological range. Optimum lymphangion length was found to be some 13–14.5 diameters. A peak of time-average flow rate occurred when transmural pressure was such that the pressure-diameter loop for active contractions was centered near maximum passive vessel compliance. Increasing the number of lymphangions in the chain improved the pumping in the presence of larger adverse pressure differences. For a given pressure difference, the optimal number of lymphangions increased with the total vessel length. These results indicate that further experiments to estimate valve resistance more accurately are necessary. The existence of an optimal value of transmural pressure may provide additional guidelines for increasing pumping in areas affected by edema.

scholarly journals Bond Graph Model of Cerebral Circulation: Toward Clinically Feasible Systemic Blood Flow Simulations

2020 ◽  
Author(s):  
Shan Su ◽  
Pablo J. Blanco ◽  
Lucas O. Müller ◽  
Peter J. Hunter ◽  
Soroush Safaei
Keyword(s):  
Cerebral Circulation ◽  
Graph Model ◽  
Bond Graph ◽  
The Body ◽  
Lumped Parameter Model ◽  
Desktop Computer ◽  
Detailed Model ◽  
Simulation Speed ◽  
Lumped Parameter ◽  
Proposed Model

The primary paper Safaei et al. (2018) proposed an anatomically detailed model of the human cerebral circulation that runs faster than real-time on a desktop computer and is designed for use in clinical settings when the speed of response is important. Based on a one-dimensional formulation of the flow of an incompressible fluid in distensible vessels, a lumped parameter model was developed for 218 arterial segments. The proposed model improved simulation speed by approximately 200-fold while preserved accuracy. Bond graph formulation was used to ensure mass and energy conservation. The model predicted the pressure and flow signatures in the body.

A Method to Personalize the Lumped Parameter Model of Coronary Artery

2019 ◽  
Vol 16 (03) ◽  
pp. 1842004 ◽  
Author(s):  
Bao Li ◽  
Wenxin Wang ◽  
Boyan Mao ◽  
Youjun Liu
Keyword(s):  
Heart Rate ◽  
Cardiac Output ◽  
Coronary Artery ◽  
Coronary Flow ◽  
Systemic Circulation ◽  
Aortic Pressure ◽  
Physiological Parameters ◽  
Lumped Parameter Model ◽  
Non Invasive ◽  
Lumped Parameter

A method which can personalize the lumped parameter model of coronary artery and cardiovascular system based on the non-invasive physiological parameters has been developed. The parameters of system were determined by different physiological parameters. The heart module was determined by aortic pressure and heart rate; the systemic circulation module was determined by cardiac output, height and cardio-ankle vascular index (CAVI), while the CAVI was determined by age and aortic pressure; the coronary module was determined by the target waveforms of coronary flow rate predicted from cardiac output. The considerable results proved that this method could be applied to each patient.

Initial Steps Toward Development of a Lumped-Parameter Model of the Lymphatic Network

2013 ◽  
Author(s):  
Samira Jamalian ◽  
Christopher D. Bertram ◽  
James E. Moore
Keyword(s):  
Blood Circulation ◽  
Lymphatic Vessel ◽  
Lymphatic System ◽  
Lymphatic Vessels ◽  
The Body ◽  
Lumped Parameter Model ◽  
Circulation System ◽  
Blood Circulation System ◽  
Lumped Parameter ◽  
Lymphatic Network

One of the primary functions of the lymphatic system is maintaining fluid and protein balance in the body. The system holds this balance by collecting about four liters of fluid every day from the interstitial space and returning it back to the subclavian vein. In contrast to the blood circulation system that relies on the heart for pumping, there is no central pump in the lymphatic system. Thus, the transport of viscous fluid against gravity and pressure difference occurs by recruiting extrinsic and intrinsic pumping mechanisms. Extrinsic pumping is the transport of lymph due to the movements outside the lymphatic vessel such as the pulse in blood vessels, whereas the intrinsic pumping is transport of lymph by contraction of lymphatic muscle cells embedded in the walls of lymphatic vessels. Similar to the veins, the bi-leaflet valves throughout the lymphatic network prevent backflow. Lymphatic valves are biased open and allow for small amounts of back flow before they completely shut.

Modeling of the Seated Human Body in a Vibrational Medium

2014 ◽  
Vol 658 ◽  
pp. 401-406 ◽  
Author(s):  
Daniela Mariana Barbu
Keyword(s):  
Human Body ◽  
Degrees Of Freedom ◽  
Dynamic Environment ◽  
The Body ◽  
Lumped Parameter Model ◽  
Vibration Effect ◽  
Mechanical Oscillations ◽  
Lumped Parameter ◽  
Irregular Period ◽  
Multi Body

Vibrations are mechanical oscillations produced by regular or irregular period movements of a member or body about its rest position. Vibration can affect visual perception, muscles, concentration, circulation and the respiratory system and at certain levels can even result in physical harm to the body. The effect of vibration on the human body is related to the natural frequency of parts of the human body affected. This paper studies the dynamic characteristics of a seated human body system in a vibration environment. The main result is a multi degrees of freedom lumped parameter model. The model provided an analytical tool for human body dynamics research. It also enabled a primary tool for seat and cushioning design. Combining the geometry and the mechanical characteristics of a structure under large deformation into a lumped parameter model enables successful analysis of the human/seat interface system and provides practical results for body protection in dynamic environment. The relative displacements of human parts are evaluated, which can be a basis for the assessment of vibration risk. It is suggested that the multi-body dynamic model is used to evaluate the vibration effect to the seated subjects.

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