Effects of intraduodenal glucose infusion on gastric myoelectrical activity and antropyloroduodenal motility

1998 ◽  
Vol 274 (6) ◽  
pp. G1038-G1044 ◽  
Author(s):  
M. A. M. T. Verhagen ◽  
M. Samsom ◽  
A. J. P. M. Smout
Keyword(s):  
Motor Activity ◽  
Dominant Frequency ◽  
Glucose Infusion ◽  
Pressure Waves ◽  
Gastric Myoelectrical Activity ◽  
Myoelectrical Activity ◽  
Motility Index ◽  
Antral Motility ◽  
Pyloric Tone ◽  
Pyloric Motility

Intraduodenal nutrient infusions cause an inhibition of antral motility and an increase in pyloric motility. The involvement of gastric myoelectrical activity in this intestinogastric feedback was studied. Electrogastrography and antropyloroduodenal manometry were performed in 10 healthy volunteers. The effects of 20-min infusions of 25% glucose (4 kcal/min) and saline were compared. Intraduodenal glucose infusions caused a decrease in the power of the dominant frequency in the electrogastrogram ( P = 0.028), but the frequency itself remained unchanged. The total number of dysrhythmias increased ( P = 0.035). An inhibition of antral motor activity ( P = 0.001), an increase in the number of isolated pyloric pressure waves ( P = 0.027), and an increase in basal pyloric tone ( P = 0.001) were simultaneously recorded. The change in power during glucose infusion correlated positively with the change in the antral motility index ( rs= 0.50, P = 0.001). It is concluded that inhibition of gastric myoelectrical activity is one of the mechanisms underlying an inhibition of motor activity in the gastric antrum.

Effects of meal volume and composition on gastric myoelectrical activity

1998 ◽  
Vol 274 (2) ◽  
pp. G430-G434 ◽  
Author(s):  
Daniela Levanon ◽  
Ming Zhang ◽  
William C. Orr ◽  
J. D. Z. Chen
Keyword(s):  
Dominant Frequency ◽  
Gastric Myoelectrical Activity ◽  
Myoelectrical Activity ◽  
Standard Meal ◽  
High Fiber ◽  
Gastric Slow Waves ◽  
Food Properties ◽  
Postprandial Motility ◽  
Significant Difference ◽  
Effect Of Food

The absence of a standard meal in electrogastrography may limit its clinical significance. Different meals may fail to produce the expected postprandial motility pattern. The aim of this study was to investigate the effect of meal volume and composition on postprandial myoelectrical activity. Fourteen healthy subjects were given four meals that differed from a “reference meal” in one single parameter (volume, calorie, or fiber content). Gastric myoelectrical activity was measured using surface electrogastrography. Spectral and statistical analyses were performed to investigate the effect of food properties on electrogastrogram (EGG) parameters. It was found that the reference meal produced a postprandial increase in the dominant frequency ( P < 0.007), dominant power ( P < 0.04), and percentage of normal 2–4 cycle/min gastric slow waves ( P > 0.05). Similar changes were observed with the low-volume and high-fiber meals but not with the reduced-calorie meal. Fasting EGG parameters in all four sessions showed no significant difference. It was concluded that low-calorie meals do not result in expected postprandial physiological responses and thus are not appropriate for EGG tests. A volume reduction of down to one-half the volume of a regular meal does not affect postprandial changes of the EGG; thus a condensed test meal may be recommended for symptomatic patients.

scholarly journals Cholinergic effects on human gastric motility

Gut ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 346-354 ◽  
Author(s):  
H P Parkman ◽  
D M Trate ◽  
L C Knight ◽  
K L Brown ◽  
A H Maurer ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Gastric Motility ◽  
Normal Subjects ◽  
Cholinergic Stimulation ◽  
Gastric Myoelectrical Activity ◽  
Solid Meal ◽  
Myoelectrical Activity ◽  
Motility Index ◽  
Antroduodenal Manometry ◽  
Cholinergic Effects

BACKGROUNDCholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated.AIMSTo determine the effects of cholinergic stimulation and inhibition on myoelectric, contractile, and emptying parameters of gastric motility.METHODSTen normal subjects underwent three studies each, using simultaneous electrogastrography (EGG), antroduodenal manometry, and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of baseline fasting manometry and EGG, subjects received saline intravenously, atropine (0.6 mg then 0.25 mg/hour intravenously), or bethanechol (5 mg subcutaneously). This was followed by another 30 minutes’ recording and by three hours of postprandial recording after ingestion of a technetium-99m labelled solid meal.RESULTSDuring fasting, atropine decreased, whereas bethanechol increased, the antral manometric motility index and EGG power. Postprandially, atropine decreased the amplitude of antral contractions by DAS, decreased the postprandial antral manometric motility index, and slowed gastric emptying. Atropine caused a slight increase in postprandial frequency of antral contractions by DAS and gastric myoelectrical activity by EGG. Bethanechol slightly increased the amplitude, but slightly decreased the frequency of antral contractions by DAS and decreased the frequency of gastric myoelectrical activity by EGG, with no significant increase in the motility index or gastric emptying.CONCLUSIONSCholinergic antagonism with atropine reduces antral contractility and slows gastric emptying. Cholinergic stimulation with bethanechol increases antral contractility, but decreases the frequency of antral contractions, without altering the antral motility index or gastric emptying.

Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers

1988 ◽  
Vol 254 (5) ◽  
pp. G671-G679 ◽  
Author(s):  
R. Heddle ◽  
J. Dent ◽  
N. W. Read ◽  
L. A. Houghton ◽  
J. Toouli ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Pressure Waves ◽  
Motor Patterns ◽  
Lipid Infusion ◽  
Motor Responses ◽  
Luminal Content ◽  
Transpyloric Flow ◽  
Duodenal Lumen ◽  
Pyloric Tone ◽  
Pyloric Motility

The delivery of lipid to the duodenum has been shown to slow gastric emptying and to increase the resistance to gastric outflow. To investigate mechanisms responsible for these effects, we have recorded antropyloroduodenal motility in nine healthy volunteers during alternate intraduodenal infusions of normal saline and triglyceride emulsion (Intralipid 10%). During the lipid infusions there were reproducible, major changes in the patterns of motility. Pressure waves, apparently isolated to the pylorus, usually started within 10 min of initiation of the lipid infusion. After 20-25 min of lipid infusion these waves occurred at median rates of 2.4 and 2.8/min (1st and 2nd lipid infusions, respectively); these rates were significantly greater (P less than 0.05) than the median rates (all less than or equal to 0.4/min) observed during the equivalent period of the succeeding saline infusions. During 10 of 22 lipid infusions, isolated pyloric pressure waves were associated with sustained pyloric tone. Infusion of lipid into the duodenum suppressed antral pressure waves in all subjects and initiated brief periods of regular duodenal contractions during 11 of 22 infusions. These studies have demonstrated alterations of antropyloroduodenal motor patterns in response to changes in the duodenal luminal content. The effects on antral and pyloric motility are probably of importance in the regulation of transpyloric flow by nutrients in the duodenal lumen.

scholarly journals Use of Electrogastrography in Preclinical Studies of Cholinergic and Anticholinergic Agents in Experimental Pigs

2015 ◽  
pp. S647-S652 ◽  
Author(s):  
J. KVĚTINA ◽  
I. TACHECÍ ◽  
M. PAVLÍK ◽  
M. KOPÁČOVÁ ◽  
S. REJCHRT ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
The Netherlands ◽  
Dominant Frequency ◽  
Preclinical Studies ◽  
Anticholinergic Agents ◽  
Gastric Myoelectrical Activity ◽  
Myoelectrical Activity ◽  
Non Invasive ◽  
Invasive Method ◽  
Experimental Pigs

Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. The purpose of this study was to evaluate the effect of atropine and neostigmine on the EGG in experimental pigs. Adult female pigs were administrated atropine (1.5 mg i.m., n=6) and neostigmine (0.5 mg i.m., n=6) after the baseline EGG, followed by a 90-min trial recording (MMS, Enschede, the Netherlands). Running spectral analysis was used for the evaluation. The results were expressed as dominant frequency of slow waves and EGG power (areas of amplitudes). Neostigmine increased continuously the dominant frequency and decreased significantly the EGG power. Atropine did not change the dominant frequency significantly. However, atropine increased significantly the EGG power (areas of amplitudes) from basal values to the maximum at the 10-20-min interval. After that period, the areas of amplitudes decreased significantly to the lowest values at the 60-90-min interval. In conclusion, cholinergic and anticholinergic agents affect differently EGG in experimental pigs.

Topography and measurement of pyloric pressure waves and tone in humans

1988 ◽  
Vol 255 (4) ◽  
pp. G490-G497 ◽  
Author(s):  
R. Heddle ◽  
J. Dent ◽  
J. Toouli ◽  
N. W. Read
Keyword(s):  
Lipid Emulsion ◽  
Control Period ◽  
High Specificity ◽  
Pressure Waves ◽  
Technical Challenge ◽  
Side Hole ◽  
Intraduodenal Infusion ◽  
Moderate Sensitivity ◽  
Pyloric Tone ◽  
Pyloric Motility

The topography of human pyloric pressure is ill defined, and previous studies of pyloric motility in humans have given conflicting results. A detailed profile of pyloric pressure has been recorded in seven healthy volunteers using a manometric assembly with 13 side holes spaced at 3-mm intervals on reverse aspect of a 3.5-cm long sleeve sensor. After a fasting control period of 40 min, recordings were made for 40 min during intraduodenal infusion of a lipid emulsion. Two major patterns of pressure waves were seen during the fasting control period, namely pressure waves confined to a narrow pyloric zone (isolated pyloric pressure waves) and pressure waves that were less localized and involved the antrum and/or duodenum. During lipid infusion the motility pattern was dominated by isolated pyloric pressure waves and localized pyloric tone. Ninety-two percent of the isolated pyloric pressure waves recorded by the sleeve were recorded by only one or two side holes, consistent with a phasically active zone less than 9 mm in length. Pyloric tone was confined to an even narrower zone and was most often recorded by only one side hole. When both tone and isolated pyloric pressure waves occurred together, they were recorded by the same side holes. By comparison with the side holes, the sleeve recorded 89% of isolated pyloric pressure waves and 98% of nonlocalized waves and recorded pyloric tone with a moderate sensitivity but high specificity. The technical challenge of recording localized pyloric contraction is considerable, and much of the conflict between previous studies of the human pylorus is explicable on methodological grounds.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Gastric myoelectrical activity in neonates of different gestational ages by means of electrogastrography

2003 ◽  
Vol 58 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Alexander Roberto Precioso ◽  
Gilberto R. Pereira ◽  
Flávio Adolfo Costa Vaz
Keyword(s):  
Dominant Frequency ◽  
Motion Artifacts ◽  
Full Term ◽  
Recording Device ◽  
Gastric Myoelectrical Activity ◽  
Myoelectrical Activity ◽  
Term Neonates ◽  
Mean Values ◽  
Premature Neonates ◽  
Group I

PURPOSE: to describe the patterns of the gastric myoelectrical activity, pre-and postprandially, in clinically stable neonates of different gestational ages, during their first two weeks of life by means of Electrogastrography. PATIENTS AND METHODS: Electrogastrography was recorded in forty-five clinically stable neonates of different gestational ages (group I: 15 neonates of > 37 weeks, group II: 15 premature neonates of 32-37 weeks; Group III: 15 premature neonates of 28-31 weeks) receiving intermittent enteral feedings during their first two weeks of life. Electrogastrography recordings were performed for 1 hour pre-and postprandially. The Electrogastrography signal was recorded using the portable MicroDigitrapper Electrogastrography recording device and after motion artifacts were deleted, the remaining Electrogastrography data were submitted to quantitative analysis based on the "Running Spectrum Analysis". RESULTS: The percentages of normogastria, pre-and postprandially were greater than the percentages of gastric dysrythmias in all three studied groups. Furthermore, all neonates had the mean values of the Electrogastrography dominant frequency predominantly within the normogastria range, in both periods analyzed. There were no significant differences in the relative change of the Electrogastrography dominant power among the groups. CONCLUSION: This study demonstrates that the Electrogastrography patterns are similar between premature and full term neonates during the pre-and postprandial periods. The results of this study also indicate that the gastric myoelectrical activity in premature and full term neonates is immature, as compared to that described for older neonates, children and adults.

scholarly journals TRANSCUTANEOUS MULTICHANNEL ELECTROGASTROGRAPHY: NORMAL PARAMETERS IN A BRAZILIAN POPULATION

2020 ◽  
Vol 57 (4) ◽  
pp. 428-433
Author(s):  
Nayara Salgado CARVALHO ◽  
Diego Cardoso BAIMA ◽  
Ricardo Correa BARBUTI ◽  
Paulo Jose Pereira Campos CARVALHO ◽  
Joffre REZENDE FILHO ◽  
...  
Keyword(s):  
Dominant Frequency ◽  
Brazilian Population ◽  
Healthy Individuals ◽  
Gastric Myoelectrical Activity ◽  
Noninvasive Technique ◽  
Solid Meal ◽  
Myoelectrical Activity ◽  
Recurrent Vomiting ◽  
A Prospective Study ◽  
Instability Coefficient

ABSTRACT BACKGROUND: Electrogastrography (EGG) is a noninvasive technique for the assessment of gastric myoelectrical activity using electrodes placed on the abdominal surface. Changes in gastric myoelectrical activity may be associated with diseases such as gastroparesis, functional dyspepsia, nausea, and recurrent vomiting. In Brazil, no studies to date have assessed gastric myoelectrical activity using multichannel EGG in healthy individuals. OBJECTIVE: To establish normal values of transcutaneous multichannel EGG in healthy Brazilian individuals. METHODS: This was a prospective study including 20 healthy individuals who underwent EGG. Recording was performed during two periods: a preprandial recording was performed for 30 minutes, and a postprandial recording was performed for 30 minutes after a soft-solid meal of 400 kcal (20 grams of proteins, 60 grams of carbohydrates, and 9 grams of fat). RESULTS: We assessed dominant frequency (DF) parameters, %DF distribution, the instability coefficient, and the power ratio (PR). A total of 20 individuals (11 women and 9 men) with a mean age of 39.5±7.4 years were included. Mean DF (95%CI) ranged from 2.4 to 3.1 cpm in the resting phase and 2.6 to 3.2 cpm in the postprandial period. The %DF in normogastria range was >70% in all healthy individuals. We identified that only one individual did not present a positive response to the test meal, and the other 19 individuals showed a PR greater than 1. The instability coefficient did not change significantly with meal intake. CONCLUSION: Multichannel EGG may be applied in future studies to evaluate gastric motility disorders in the Brazilian population.

Serosal and cutaneous recordings of gastric myoelectrical activity in patients with gastroparesis

1994 ◽  
Vol 266 (1) ◽  
pp. G90-G98 ◽  
Author(s):  
J. D. Chen ◽  
B. D. Schirmer ◽  
R. W. McCallum
Keyword(s):  
Electrical Stimulation ◽  
Slow Wave ◽  
Test Meal ◽  
Frequency Change ◽  
Fasting State ◽  
Gastric Myoelectrical Activity ◽  
Myoelectrical Activity ◽  
Gastric Slow Wave ◽  
Student’S T ◽  
Student’S T Test

The aims of this study were to 1) investigate gastric myoelectrical activity in patients with gastroparesis, 2) validate the cutaneous electrogastrogram (EGG) in tracking the frequency change of the gastric slow wave, and 3) investigate the effect of electrical stimulation on gastric myoelectrical activity. Gastric myoelectrical activity was recorded in 12 patients with documented gastroparesis using serosal electrodes for > 200 min in each subject. All recordings were made at least 4 days after surgery. Each session consisted of a 30-min recording in the fasting state and a 30-min recording after a test meal. The test meal (liquid or mixed) was selected according to patient's tolerance. Electrical stimulation was performed in three subjects via the serosal electrodes at a frequency of 3 cycles/min. Gastric myoelectrical activity was recorded using serosal electrodes in each session. The serosal recording showed slow waves of 2.5 to 4.0 cycles/min in all 12 subjects. Absence of spikes was noted in 11 of the 12 subjects. The simultaneous serosal and cutaneous recording of gastric myoelectrical activity showed that the frequency of the EGG was exactly the same as that of the serosal recording. Liquid meals resulted in a significant decrease in slow-wave frequency (Student's t test, P = 0.006), and the EGG accurately reflected this change. Electrical stimulation had no effect on the frequency of the gastric slow wave and did not induce spikes.(ABSTRACT TRUNCATED AT 250 WORDS)

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