Dogfish pressor response to potassium blocked by magnesium and phentolamine
1982 ◽
Vol 242
(3)
◽
pp. R185-R188
Keyword(s):
In vivo infusion of MgCl2 blocks the dogfish pressor response to K+. This action of Mg2+ was contrasted to phentolamine in in vivo and in vitro experiments. Mg2+ blocks the spontaneous release of catecholamines from dogfish chromaffin tissue but does not alter the norepinephrine-induced contraction of the isolated dogfish artery. In vivo infusion of Mg2+ causes a significant decrease in resting catecholamine levels and diminishes the catecholamine release caused by K+ challenge. Both Mg2+ and phentolamine block the pressor action of K+, Mg2+ by preventing the K+-induced release of catecholamines and phentolamine by preventing the circulating catecholamines from interacting with alpha-adrenergic receptor sites.
2014 ◽
Vol 112
(11)
◽
pp. 951-959
◽
2013 ◽
Vol 14
(2)
◽
pp. 215-224
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Keyword(s):
1990 ◽
Vol 68
(2)
◽
pp. 735-747
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Keyword(s):
1993 ◽
Vol 120
(2)
◽
pp. 523-535
◽
Keyword(s):
1981 ◽
Vol 78
(2)
◽
pp. 1245-1249
◽
1979 ◽
Keyword(s):