Endogenous opioids are differentially involved in appetitive and consummatory aspects of sexual behavior of male rats

1994 ◽  
Vol 266 (2) ◽  
pp. R606-R613 ◽  
Author(s):  
W. R. Van Furth ◽  
I. G. Wolterink-Donselaar ◽  
J. M. van Ree
Keyword(s):  
Sexual Behavior ◽  
Neural Control ◽  
Test Chamber ◽  
Endogenous Opioids ◽  
Male Rats ◽  
Opioid Antagonist ◽  
Sexual Performance ◽  
Repeated Testing ◽  
Ejaculation Latency ◽  
Male Wistar Rats

The sexual activity of 40 male Wistar rats was tested weekly in a bilevel test chamber to evaluate the involvement of endogenous opioids in the appetitive and consummatory aspects of sexual behavior. It has been suggested that the increase of the anticipatory level-changing behavior over repeated testing, displayed before the introduction of a receptive female, is sexually motivated. Two doses of the opioid antagonist naloxone, 1 and 10 mg/kg, prevented the increase of the anticipatory level-changing over four repeated tests of sexually experienced rats without prior experience in the bilevel test chamber and decreased the number of level changes of rats displaying a high number of level changes. Analysis of the pattern of inhibition suggested that the lower dose of naloxone may reduce sexual reward and that, in addition, the higher dose may block the expression of motivation. In contrast, naloxone treatment facilitated the efficiency of the sexual performance, with less mounts and intromissions preceding ejaculation and a shorter ejaculation latency, implying an inhibitory role of endogenous opioids in the neural control of some aspects of sexual performance (e.g., ejaculatory threshold). These results suggest that endogenous opioids may increase sexual appetite and diminish sexual performance.

scholarly journals Prosexual Effect ofChrysactinia mexicanaA. Gray (Asteraceae), False Damiana, in a Model of Male Sexual Behavior

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
R. Estrada-Reyes ◽  
O. A. Ferreyra-Cruz ◽  
G. Jiménez-Rubio ◽  
O. T. Hernández-Hernández ◽  
L. Martínez-Mota
Keyword(s):  
Sexual Behavior ◽  
Aqueous Extract ◽  
Scientific Evidence ◽  
Male Rats ◽  
Control Group ◽  
Traditional Use ◽  
Male Sexual Behavior ◽  
Ejaculation Latency ◽  
Turnera Diffusa ◽  
Central Level

Chrysactinia mexicanaA. Gray (Asteraceae) andTurnera diffusaWilld (Turneraceae) are employed in traditional medicine as aphrodisiacs; however, there is no scientific evidence supporting the prosexual properties ofC. mexicana. The aim of this study was to determine whether an aqueous extract ofC. mexicana(Cm) stimulates rat male sexual behavior in the sexual exhaustion paradigm. Sexually exhausted (SExh) male rats were treated with Cm (80, 160, and 320 mg/kg), an aqueous extract ofT. diffusa(Td), or yohimbine. The sexual exhaustion state in the control group was characterized by a low percentage of males exhibiting mounts, intromissions, and ejaculations and no males demonstrating mating behavior after ejaculation. Cm (320 mg/kg), Td, or yohimbine significantly increased the proportion of SExh rats that ejaculated and resumed copulation after ejaculation. In males that exhibited reversal of sexual exhaustion, Cm (320 mg/kg) improved sexual performance by reducing the number of intromissions and shrinking ejaculation latency. The effects of treatments on sexual behavior were not related with alterations in general locomotion. In conclusion, the prosexual effects of Cm, as well as those of Td, are established at a central level, which supports the traditional use ofC. mexicanafor stimulating sexual activity.

Sexual behavior decreases pain sensitivity and stimulates endogenous opioids in male rats

1981 ◽  
Vol 70 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Henry Szechtman ◽  
Moshe Hershkowitz ◽  
Rabi Simantov
Keyword(s):  
Sexual Behavior ◽  
Pain Sensitivity ◽  
Endogenous Opioids ◽  
Male Rats

Gonadal steroid modulation of naloxone-induced LH secretion in the rat

1984 ◽  
Vol 101 (1) ◽  
pp. 33-39 ◽  
Author(s):  
F. Petraglia ◽  
V. Locatelli ◽  
A. Pen̄alva ◽  
D. Cocchi ◽  
A. R. Genazzani ◽  
...  
Keyword(s):  
Chronic Administration ◽  
Significant Rise ◽  
Endogenous Opioids ◽  
Gonadal Steroids ◽  
Female Rats ◽  
Male Rats ◽  
Opioid Antagonist ◽  
Acute Administration ◽  
Lh Releasing Hormone ◽  
Lh Secretion

ABSTRACT The effect of acute administration of the opioid receptor antagonist naloxone hydrochloride (5 mg/kg, s.c.) on plasma LH levels was evaluated in female and male rats 24, 36 and 48 h and 1,3 and 5 weeks after gonadectomy and in 5-week gonadectomized rats after acute or chronic (2 weeks) administration of oestradiol benzoate (OB, 10 μg/rat per day, s.c.), testosterone propionate (TP, 150 μg/rat, s.c.) or dihydrotestosterone propionate (DHT, 150 μg/rat, s.c.) respectively. Concurrent evaluation of plasma LH after administration of LH releasing hormone (LHRH, 1 μg/kg, i.p.) was performed in the same experimental groups. In rats of both sexes, a significant rise in plasma LH after naloxone was observed in sham-operated and recently gonadectomized rats (24–48 h); in female rats 36 and 48 h after gonadectomy the rise was higher than in controls. One, 3 and 5 weeks after gonadectomy, naloxone failed to stimulate LH release in both female and male rats. In gonadectomized rats undergoing steroid replacement therapy, OB administered 72 h before testing, TP (16 and 72 h) and DHT (16 h) were the most effective in reinstituting the LH response to naloxone. Chronic administration of gonadal steroids did not restore normal LH responsiveness to naloxone. In most experimental groups, LH responses after naloxone were clearly unrelated to pituitary LH responsiveness to LHRH, which indicates that the opioid antagonist was acting via the central nervous system. In conclusion, these results demonstrate that: (1) gonadal steroids are critically important for the inhibitory effect of endogenous opioids on LH secretion to be manifested; (2) inhibition by the opiatergic system on LH secretion is more dependent on a modulatory action of gonadal steroids than on their simple presence or absence. J. Endocr. (1984) 101, 33–39

scholarly journals Orexin mediates initiation of sexual behavior in sexually naive male rats, but is not critical for sexual performance

2010 ◽  
Vol 58 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Andrea R. Di Sebastiano ◽  
Sabrina Yong-Yow ◽  
Lauren Wagner ◽  
Michael N. Lehman ◽  
Lique M. Coolen
Keyword(s):  
Sexual Behavior ◽  
Male Rats ◽  
Sexual Performance

Effect of methanolic extract of Alchornea cordifolia leaves on the sexual behavior of senescent and sexually inexperienced rats

2018 ◽  
Vol 7 (6) ◽  
pp. 471-476
Author(s):  
Marie Ide Ngaha Njila ◽  
◽  
Goh Yong Meng ◽  
Mahdi Ebrahimi ◽  
Elmutaz Atta Awad ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Reproductive Performance ◽  
Methanolic Extract ◽  
Group Iv ◽  
Sexual Performance ◽  
Group Iii ◽  
Ejaculation Latency ◽  
Group I ◽  
Intromission Latency ◽  
Group Ii

Alchornea cordifolia, a shrub found in tropical Africa, is used to treat several physiological disorders, including male infertility and impotency. The main objective of this study was to determine the effect of the methanolic extract of Alchornea cordifolia leaves on the sexual behavior of senescent and sexually inexperienced rats. In order to evaluate aphrodisiac properties and reproductive performance, rats were divided into groups: group I receiving distilled water, group II receiving testosterone, group III receiving sildenafil citrate, group IV and V receiving the methanolic extract of Alchornea cordifolia leaves at 200 mg / kg and 400 mg / kg, respectively. The treatment was done by gavage for groups I, III, IV and V and subcutaneous injection of testosterone every three days for group II for 14 days. On days 1, 7 and 14, the rats were mated to the receptive females. At the end of this last treatment, the rats were mated with gonad-intact females. 14 days after of treatment, the extract leads to an increase in libido and sexual performance parameters (mounts, intromissions and ejaculations frequency) and an increase in sexual desire (decrease of mount and intromission latency). The extract also prolonged the duration of coitus by increasing the ejaculation latency and the average interval of copulation. An increase in the percentage of female’s rats impregnated as well as the numbers of implantations were recorded in females’ rats mated with the males treated with our extract. These results reveal the potential of the methanolic extract of Alchornea cordifolia leaves to improve male reproductive performance justifying its use in traditional medicine

Chronic immobilization stress induces anxiety-related behaviors and affects brain essential minerals in male rats

2020 ◽  
pp. 1-8
Author(s):  
Zafer Sahin ◽  
Alpaslan Ozkurkculer ◽  
Omer Faruk Kalkan ◽  
Ahmet Ozkaya ◽  
Aynur Koc ◽  
...  
Keyword(s):  
Immobilization Stress ◽  
Central Area ◽  
Essential Elements ◽  
Male Rats ◽  
Control Group ◽  
Male Wistar Rats ◽  
Swimming Test ◽  
The Brain ◽  
Center Area ◽  
Chronic Immobilization Stress

Abstract. Alterations of essential elements in the brain are associated with the pathophysiology of many neuropsychiatric disorders. It is known that chronic/overwhelming stress may cause some anxiety and/or depression. We aimed to investigate the effects of two different chronic immobilization stress protocols on anxiety-related behaviors and brain minerals. Adult male Wistar rats were divided into 3 groups as follows ( n = 10/group): control, immobilization stress-1 (45 minutes daily for 7-day) and immobilization stress-2 (45 minutes twice a day for 7-day). Stress-related behaviors were evaluated by open field test and forced swimming test. In the immobilization stress-1 and immobilization stress-2 groups, percentage of time spent in the central area (6.38 ± 0.41% and 6.28 ± 1.03% respectively, p < 0.05) and rearing frequency (2.75 ± 0.41 and 3.85 ± 0.46, p < 0.01 and p < 0.05, respectively) were lower, latency to center area (49.11 ± 5.87 s and 44.92 ± 8.04 s, p < 0.01 and p < 0.01, respectively), were higher than the control group (8.65 ± 0.49%, 5.37 ± 0.44 and 15.3 ± 3.32 s, respectively). In the immobilization stress-1 group, zinc (12.65 ± 0.1 ppm, p < 0.001), magnesium (170.4 ± 1.7 ppm, p < 0.005) and phosphate (2.76 ± 0.1 ppm, p < 0.05) levels were lower than the control group (13.87 ± 0.16 ppm, 179.31 ± 1.87 ppm and 3.11 ± 0.06 ppm, respectively). In the immobilization stress-2 group, magnesium (171.56 ± 1.87 ppm, p < 0.05), phosphate (2.44 ± 0.07 ppm, p < 0.001) levels were lower, and manganese (373.68 ± 5.76 ppb, p < 0.001) and copper (2.79 ± 0.15 ppm, p < 0.05) levels were higher than the control group (179.31 ± 1.87 ppm, 3.11 ± 0.06 ppm, 327.25 ± 8.35 ppb and 2.45 ± 0.05 ppm, respectively). Our results indicated that 7-day chronic immobilization stress increased anxiety-related behaviors in both stress groups. Zinc, magnesium, phosphate, copper and manganese levels were affected in the brain.

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