Constant-flow ventilation in pigs

1986 ◽  
Vol 61 (6) ◽  
pp. 2238-2242 ◽  
Author(s):  
P. Webster ◽  
A. S. Menon ◽  
A. S. Slutsky
Keyword(s):  
Steady State ◽  
Gas Exchange ◽  
Gas Flow ◽  
Blood Gases ◽  
Maximum Flow ◽  
Constant Flow ◽  
Catheter Position ◽  
Flow Rates ◽  
Co2 Partial Pressure ◽  
Flow Through

Constant-flow ventilation (CFV) is a ventilatory technique in which physiological blood gases can be maintained in dogs by a constant flow of fresh gas introduced via two catheters placed in the main-stem bronchi (J. Appl. Physiol. 53: 483–489, 1982). High-velocity gas exiting from the catheters can create uneven pressure differences in adjacent lung segments, and these pressure differences could lead to gas flow through collateral channels. To examine this hypothesis, we studied CFV in pigs, animals known to have a high resistance to collateral ventilation. In three pigs we examined steady-state gas exchange, and in six others we studied unsteady gas exchange at three flow rates (20, 35, and 50 l/min) and three catheter positions (0.5, 1.5, and 2.5 cm distal to the tracheal carina). During steady-state runs we were unable to attain normocapnia; the arterial CO2 partial pressure (PaCO2) was approximately 300 Torr at all flow rates and all catheter positions, compared with 20–50 Torr at similar flows and positions in dogs studied previously. The initial unsteady gas-exchange experiments indicated no consistent effect of catheter position or flow rate on the rate of rise of PaCO2. In three other pigs, the rates of rise of PaCO2 were compared with the rates observed with apneic oxygenation (AO). At the maximum flow and deepest position, the rate of rise of PaCO2 was lower during CFV than during AO. These data suggest that flow through collateral channels might be important in producing adequate gas transport during CFV; however, other factors such as airway morphometry and the effects of cardiogenic oscillations may explain the differences between the results in pigs and dogs.

Catheter position and blood gases during constant-flow ventilation

1987 ◽  
Vol 62 (2) ◽  
pp. 513-519 ◽  
Author(s):  
A. S. Slutsky ◽  
A. S. Menon
Keyword(s):  
Steady State ◽  
Flow Rate ◽  
Blood Gases ◽  
Constant Flow ◽  
Arterial Blood Gases ◽  
Catheter Position ◽  
Flow Rates ◽  
Arterial Blood ◽  
Tracheal Carina ◽  
Co2 Elimination

We studied the effect of catheter position and flow rate on gas exchange during constant-flow ventilation (CFV) in eight anesthetized, paralyzed dogs. The distal tips of the insufflation catheters were positioned 0.5, 2.0, 3.5, and 5.0 cm from the tracheal carina. Flow rates were varied between 10 and 55 l/min and steady-state arterial blood gases were measured. At a given flow rate, arterial CO2 pressure (PaCO2) decreased as CFV was administered further into the lung up to a distance of 3.5 cm from the carina; there were no significant differences in PaCO2 at 3.5 and 5.0 cm. For a given catheter position, PaCO2 decreased with increasing flow rate up to a flow rate of 40 l/min. Further increases in flow rate had no significant effect on PaCO2. Arterial O2 pressure (PaO2) was relatively constant at all flow rates and catheter positions. We conclude that, up to a point, CO2 elimination can be improved by positioning the catheters further into the lung; advancing the catheters further than 3.5 cm from the carina may cause over-ventilation of specific lung regions resulting in a relative plateau in CO2 elimination and relatively constant PaO2's. Positioning the catheters further into the lung permits the use of lower flow rates, thus potentially minimizing the risk of barotrauma.

scholarly journals Simulation and Modeling of Flow in a Gas Compressor

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Anna Avramenko ◽  
Alexey Frolov ◽  
Jari Hämäläinen
Keyword(s):  
Steady State ◽  
Mass Flow ◽  
Gas Flow ◽  
Simulation Method ◽  
High Mass ◽  
Ansys Fluent ◽  
Flow Rates ◽  
Mass Flow Rates ◽  
Low Mass ◽  
Flow Through

The presented research demonstrates the results of a series of numerical simulations of gas flow through a single-stage centrifugal compressor with a vaneless diffuser. Numerical results were validated with experiments consisting of eight regimes with different mass flow rates. The steady-state and unsteady simulations were done in ANSYS FLUENT 13.0 and NUMECA FINE/TURBO 8.9.1 for one-period geometry due to periodicity of the problem. First-order discretization is insufficient due to strong dissipation effects. Results obtained with second-order discretization agree with the experiments for the steady-state case in the region of high mass flow rates. In the area of low mass flow rates, nonstationary effects significantly influence the flow leading stationary model to poor prediction. Therefore, the unsteady simulations were performed in the region of low mass flow rates. Results of calculation were compared with experimental data. The numerical simulation method in this paper can be used to predict compressor performance.

Constant-flow ventilation of apneic dogs

1982 ◽  
Vol 53 (2) ◽  
pp. 483-489 ◽  
Author(s):  
B. E. Lehnert ◽  
G. Oberdorster ◽  
A. S. Slutsky
Keyword(s):  
Gas Flow ◽  
Blood Gases ◽  
Constant Flow ◽  
Blood Gas ◽  
Total Flow ◽  
Flow Rates ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Humidified Air ◽  
Upper Third

The adequacy of constant airway gas flow sustenance of arterial blood gas tensions was investigated in anesthetized-paralyzed mongrel dogs. Gas delivery was achieved via a main-stem bronchi cannulation system constructed of two polyethylene tubes bifurcating at the carina, which rested on the posterior surface of the trachea outside of an endotracheal tube positioned in the upper third of the trachea. Equal flows (total flow = Vin) of humidified air were delivered through each limb of the cannulation system at constant flow rates with Vin ranging from 8 to 28 l/min. Intratracheal pressures at these flows characteristically ranged from 0.1 to 1 cmH2O. Arterial O2 tension varied directly (PaO2 = 0.72 Vin + 74.6), and arterial CO2 tension varied inversely (PaCO2 = -0.73 Vin + 51.2) with Vin during ambient gas, constant-flow ventilation (CFV). During prolonged CFV (greater than 2 h), no evidence of CO2 accumulation or deterioration of PaO2, was observed. This study demonstrates that in apneic dogs normal blood gases can be achieved and maintained over prolonged periods with constant airway flow at low intratracheal pressures.

Experimental, Numerical, and Statistical Investigation of Two Phase Flow in a Cylindrical Perforation Tunnel

2021 ◽  
Author(s):  
Ekhwaiter Abobaker ◽  
Abadelhalim Elsanoose ◽  
Mohammad Azizur Rahman ◽  
Faisal Khan ◽  
Amer Aborig ◽  
...  
Keyword(s):  
Numerical Simulation ◽  
Steady State ◽  
Statistical Analysis ◽  
Flow Rate ◽  
Gas Flow ◽  
Two Phase Flow ◽  
Phase Flow ◽  
Gas Flow Rate ◽  
Two Phase ◽  
Flow Through

Abstract Perforation is the final stage in well completion that helps to connect reservoir formations to wellbores during hydrocarbon production. The drilling perforation technique maximizes the reservoir productivity index by minimizing damage. This can be best accomplished by attaining a better understanding of fluid flows that occur in the near-wellbore region during oil and gas operations. The present work aims to enhance oil recovery by modelling a two-phase flow through the near-wellbore region, thereby expanding industry knowledge about well performance. An experimental procedure was conducted to investigate the behavior of two-phase flow through a cylindrical perforation tunnel. Statistical analysis was coupled with numerical simulation to expand the investigation of fluid flow in the near-wellbore region that cannot be obtained experimentally. The statistical analysis investigated the effect of several parameters, including the liquid and gas flow rate, liquid viscosity, permeability, and porosity, on the injection build-up pressure and the time needed to reach a steady-state flow condition. Design-Expert® Design of Experiments (DoE) software was used to determine the numerical simulation runs using the ANOVA analysis with a Box-Behnken Design (BBD) model and ANSYS-FLUENT was used to analyses the numerical simulation of the porous media tunnel by applying the volume of fluid method (VOF). The experimental data were validated to the numerical results, and the comparison of results was in good agreement. The numerical and statistical analysis demonstrated each investigated parameter’s effect. The permeability, flow rate, and viscosity of the liquid significantly affect the injection pressure build-up profile, and porosity and gas flow rate substantially affect the time required to attain steady-state conditions. In addition, two correlations obtained from the statistical analysis can be used to predict the injection build-up pressure and the required time to reach steady state for different scenarios. This work will contribute to the clarification and understanding of the behavior of multiphase flow in the near-wellbore region.

Characterization of a Radiantly Driven Multistage Knudsen Compressor

2003 ◽  
Author(s):  
M. Young ◽  
Y. L. Han ◽  
E. P. Muntz ◽  
G. Shiflett
Keyword(s):  
Steady State ◽  
Atmospheric Pressure ◽  
Maximum Flow ◽  
Performance Model ◽  
Experimental Results ◽  
Maximum Pressure ◽  
Flow Rates ◽  
Micro Scale ◽  
Knudsen Compressors

Knudsen Compressors are meso/micro scale gas compressors/pumps based on thermal transpiration or thermal creep. The design of radiantly driven Knudsen Compressors is discussed, along with a model that was developed to understand their performance. Experimental pumping performances for Knudsen Compressors with one, two, five, and fifteen stage, radiantly driven cascades are also discussed. Temperature measurements across the transpiration membranes, for various pressures of Nitrogen, were obtained and compared to those predicted by the performance model. The results agree with the model to within 15% consistently under predicting the measured hot side temperature of the transpiration membrane. The pump-down curves, steady-state maximum pressure differences, and maximum flow rates produced by a single stage Knudsen Compressor were obtained. A variety of configurations were studied at pressures from 500 mTorr to atmospheric pressure. The experimental results agreed with the performance model’s predictions to within 20%.

Breath-by-breath variation of FRC: effect on VO2 and VCO2 measured at the mouth

1979 ◽  
Vol 46 (6) ◽  
pp. 1122-1126 ◽  
Author(s):  
H. U. Wessel ◽  
R. L. Stout ◽  
C. K. Bastanier ◽  
M. H. Paul
Keyword(s):  
Steady State ◽  
Gas Exchange ◽  
Gas Flow ◽  
Co2 Gas ◽  
Mean Values ◽  
Gas Uptake ◽  
Source Data ◽  
Alveolar Level ◽  
Age Range

We examined breath-by-breath (B-B) variations of FRC (delta FRC) and their effect on measured O2 and CO2 gas exchange in 52 2- to 4-min segments of continuous air breathing obtained in 29 patients (age range 6--50 yr). Respiratory frequency ranged from 13 to 43 breaths/min, VE from 6.7 to 22.5 l/min (BTPS), and expired VT from 234 to 1,370 ml (BTPS). Computer analysis was based on the following source data measured at the mouth: inspired (VI) and expired (VE) gas flow, FN2, FO2 and FCO2. The analysis provides B-B evaluation of VI, VE, delta FRC in terms of VN2, and VO2 and VCO2 at the mouth and at the alveolar level, i.e., after correction for delta FRC. Significant B-B variations of FRC were found in all studies. delta FRC ranged from +360 to -360 ml (BTPS). For single respiratory cycles VI - VE is primarily a function of N2 exchange at the mouth (VMN2). VO2 and VCO2, uncorrected for delta FRC, are significantly more dispersed about mean values than the corrected gas uptakes (P less than 0.0005). The data support the view that the assumption of VIN2 = VEN2 is invalid for single respiratory cycles. Determination of breath-by-breath VO2 and VCO2 should therefore, not be based on steady-state gas uptake equations. It requires measurement of both inspired and expired breath volumes and evaluation of N2 gas exchange.

Mechanisms of gas exchange with different gases during constant-flow ventilation

1990 ◽  
Vol 68 (1) ◽  
pp. 88-93 ◽  
Author(s):  
F. J. Chen ◽  
A. S. Menon ◽  
S. V. Lichtenstein ◽  
N. Zamel ◽  
A. S. Slutsky
Keyword(s):  
Gas Exchange ◽  
Physical Properties ◽  
Flow Rate ◽  
Constant Flow ◽  
Catheter Position ◽  
Arterial Pco2 ◽  
The Mean ◽  
The Difference ◽  
The Individual ◽  
Different Gases

To investigate the mechanisms responsible for the difference in gas exchange during constant-flow ventilation (CFV) when using gases with different physical properties, we used mixtures of 70% N2-30% O2 (N2-O2) and 70% He-30% O2 (He-O2) as the insufflating gases in 12 dogs. All dogs but one had higher arterial PCO2 (PaCO2) with He-O2 compared with N2-O2. At a flow of 0.37 +/- 0.12 l/s, the mean PaCO2's with N2-O2 and He-O2 were 41.3 +/- 13.9 and 53.7 +/- 20.3 Torr, respectively (P less than 0.01); at a flow rate of 0.84 +/- 0.17 l/s, the mean PaCO2's were 29.1 +/- 11.3 and 35.3 +/- 13.6 Torr, respectively (P less than 0.01). The chest was then opened to alter the apposition between heart and the lungs, thereby reducing the extent of cardiogenic oscillations by 58.4 +/- 18.4%. This intervention did not significantly alter the difference in PaCO2 between N2-O2 and He-O2 from that observed in the intact animals, although the individual PaCO2 values for each gas mixture did increase. When the PaCO2 was plotted against stagnation pressure (rho V2), the difference in PaCO2 between N2-O2 and He-O2 was nearly abolished in both the closed- and open-chest animals. These findings suggest that the different PaCO2's obtained by insufflating gases with different physical properties at a fixed flow rate, catheter position, and lung volume result mainly from a difference in the properties of the jet.

Experimental Study of Entrance Effects on Laminar Gas Flow Through Silicon Orifices

2005 ◽  
Author(s):  
Aaron J. Knobloch ◽  
Joell R. Hibshman ◽  
George Wu ◽  
Rich Saia
Keyword(s):  
Flow Rate ◽  
Gas Flow ◽  
Flow Area ◽  
Fully Developed Flow ◽  
Flow Rates ◽  
Flow Models ◽  
Entry Length ◽  
Orifice Flow ◽  
Measured Flow ◽  
Flow Through

This study summarizes a fundamental investigation of flow through an array of silicon micromachined rectangular slots. The purpose of the study is to evaluate the effect of entrance pressure, flow area, orifice thickness, slot length, and slot width of the orifice on flow rate. These orifices were fabricated using a simple frontside through wafer DRIE process on a 385 μm thick wafer and wafer bonding to create thicker orifices. The dies were then packaged as part of a TO8 can and flow tested. To complement the results of this experimental work, two simple flow models were developed to predict the effect of geometrical and entrance conditions on the flow rate. These models were based on macroscale assumptions that were not necessarily true in the case of thin orifices. One relationship was based on Pouiselle flow which assumes fully developed flow conditions. Calculation of the entry length required for fully developed flow indicate that in the low Reynolds Number regime (32-550) evaluated, the entry flow development requires 2-8 times the thickness of the thickest orifices used for this study. Therefore, calculations of orifice flow based on a Pouiselle model are an overestimate of the actual measured flow rates. Another model examined typical orifice relationships using head loss at the entrance and exit of the slots did not accurately capture the particular flow rates since it overestimated the expansion or constriction losses. A series of experiments where the pressure was varied between 75 and 1000 Pa were performed. A comparison of the Pouiselle flow solution with experimental results was made which showed that the Pouiselle flow model overpredicts the flow rates and more specifically, the effect of width on the flow rates. The results of these tests were used to develop a transfer function which describes the dependence of flow rate on orifice width, thickness, length, and inlet pressure.

Work With Chemical Additives Advances Understanding of Relative Permeability Shifts

2021 ◽  
Vol 73 (09) ◽  
pp. 37-38
Author(s):  
Chris Carpenter
Keyword(s):  
Steady State ◽  
Relative Permeability ◽  
Flow Rate ◽  
Pressure Difference ◽  
Effective Permeability ◽  
Constant Flow ◽  
Chemical Additives ◽  
Flow Rates ◽  
Steady State Method ◽  
Tight Rocks

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 201520, “Advances in Understanding Relative Permeability Shifts by Imbibition of Surfactant Solutions Into Tight Plugs,” by Mohammad Yousefi, Lin Yuan, and Hassan Dehghanpour, SPE, University of Alberta, prepared for the 2020 SPE Annual Technical Conference and Exhibition, originally scheduled to be held in Denver, Colorado, 5–7 October. The paper has not been peer reviewed. Various chemical additives have been proposed recently to enhance imbibition oil recovery from tight formations during shut-in periods after hydraulic fracturing operations. In the complete paper, the authors develop and apply a laboratory protocol mimicking leakoff, shut-in, and flowback processes to evaluate the effects of fracturing-fluid additives on oil regained permeability. A conventional coreflooding apparatus is modified to measure oil effective permeability (koeff) before and after the surfactant-imbibition experiments. Methodology Proposed Technique for Measuring Oil Effective Permeability. Despite the simplicity of the steady-state method, measuring permeability of tight rocks with this technique is challenging because of its time-consuming nature and the fact that accurate measurement is necessary of extremely low flow rates corresponding to low injectivity of tight rocks. The authors use a pair of plugs from a well drilled in the Montney formation that is a stratigraphic unit of the Lower Triassic age in the western Canadian sedimentary basin located in British Columbia and Alberta. It is mainly a low-permeability siltstone reservoir. In the modified coreflooding apparatus, the authors reduce the effect of compressibility in order to reduce the duration of the transient period by approximately one order of magnitude. Because monitoring changes in pressure is much easier and more accurate than monitoring flow-rate changes, a constant flow-rate mode is used and pressure is recorded with time. Oil is injected at different constant flow rates (qo), and the inlet pressure is monitored. The stable pressure difference across the plug is recorded for each flow rate. After steady-state conditions are reached based on the pressure profile, the qo is increased. This process is repeated until four stable pressure differences corresponding to four different qo are obtained. After the highest qo is reached, it is decreased in similar steps to check the repeatability of each data point. The permeability is calculated with the Darcy equation and slope of the qo vs. stable pressure difference across the plug.

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