Spatial correlation of regional pulmonary perfusion

1992 ◽  
Vol 72 (6) ◽  
pp. 2378-2386 ◽  
Author(s):  
R. W. Glenny
Keyword(s):  
Spatial Correlation ◽  
Three Dimensional ◽  
Flow Distribution ◽  
Pulmonary Perfusion ◽  
Heterogeneous Distribution ◽  
Mechanically Ventilated ◽  
Regional Flow ◽  
Flow Perfusion ◽  
Highly Correlated ◽  
Three Dimensional Coordinate

Despite the heterogeneous distribution of pulmonary blood flow, perfusion appears to be spatially ordered, with neighboring regions of lung having similar magnitudes of flow. This premise was tested by determining the spatial correlation of regional flow [rho(d)] as a function of distance (d) between regions. Regional pulmonary perfusion was measured in both supine and prone positions in seven anesthetized mechanically ventilated dogs with radiolabeled microspheres. After excision and drying, the lungs were cubed into pieces 1.2 cm on a side, with a three-dimensional coordinate assigned to each piece. The microsphere-determined flow to each piece was measured by radioactive counts, and rho(d) was calculated for all paired pieces within the same lobe. rho(d) was greatest for adjacent pieces (d = 1.2 cm) and decreased with increasing d, becoming negative at large distances in all dogs and positions. The spatial correlation of flow between adjacent pieces, rho(1.2 cm), was greater in the supine than in the prone position (0.66 vs. 0.72, P less than 0.05). The observations for each dog and position were fit to the equation rho(d) = d(a)+b.d+c, and the coefficients were used to compare rho(d) in the supine and prone positions. rho(d) differed in the two positions (P less than 0.05), with rho(d) falling off more rapidly with distance in the supine position. When trends in flow due to gravity were mathematically removed, differences between supine and prone positions were no longer observed. The spatial correlation of regional pulmonary perfusion was anisotropic in both supine and prone positions. The observation that regional pulmonary perfusion is highly correlated over large spatial distances has important implications for models of flow distribution.

Vasomotor tone does not affect perfusion heterogeneity and gas exchange in normal primate lungs during normoxia

2000 ◽  
Vol 89 (6) ◽  
pp. 2263-2267 ◽  
Author(s):  
Robb W. Glenny ◽  
H. Thomas Robertson ◽  
Michael P. Hlastala
Keyword(s):  
Blood Flow ◽  
Gas Exchange ◽  
Regional Blood Flow ◽  
Flow Distribution ◽  
Regional Perfusion ◽  
Vasomotor Tone ◽  
Heterogeneous Distribution ◽  
Mechanically Ventilated ◽  
Before And After ◽  
Spatial Coordinates

To determine whether vasoregulation is an important cause of pulmonary perfusion heterogeneity, we measured regional blood flow and gas exchange before and after giving prostacyclin (PGI2) to baboons. Four animals were anesthetized with ketamine and mechanically ventilated. Fluorescent microspheres were used to mark regional perfusion before and after PGI2 infusion. The lungs were subsequently excised, dried inflated, and diced into ∼2-cm3 pieces ( n = 1,208–1,629 per animal) with the spatial coordinates recorded for each piece. Blood flow to each piece was determined for each condition from the fluorescent signals. Blood flow heterogeneity did not change with PGI2 infusion. Two other measures of spatial blood flow distribution, the fractal dimension and the spatial correlation, did not change with PGI2 infusion. Alveolar-arterial O2 differences did not change with PGI2 infusion. We conclude that, in normal primate lungs during normoxia, vasomotor tone is not a significant cause of perfusion heterogeneity. Despite the heterogeneous distribution of blood flow, active regulation of regional perfusion is not required for efficient gas exchange.

Mechanisms of improvement in pulmonary gas exchange during isovolemic hemodilution

1999 ◽  
Vol 87 (1) ◽  
pp. 132-141 ◽  
Author(s):  
Steven Deem ◽  
Richard G. Hedges ◽  
Steven McKinney ◽  
Nayak L. Polissar ◽  
Michael K. Alberts ◽  
...  
Keyword(s):  
Blood Flow ◽  
Fractal Dimension ◽  
Gas Exchange ◽  
Spatial Correlation ◽  
Pulmonary Blood Flow ◽  
Minute Ventilation ◽  
Flow Distribution ◽  
Pulmonary Gas Exchange ◽  
Normal Lung ◽  
Blood Flow Distribution

Severe anemia is associated with remarkable stability of pulmonary gas exchange (S. Deem, M. K. Alberts, M. J. Bishop, A. Bidani, and E. R. Swenson. J. Appl. Physiol. 83: 240–246, 1997), although the factors that contribute to this stability have not been studied in detail. In the present study, 10 Flemish Giant rabbits were anesthetized, paralyzed, and mechanically ventilated at a fixed minute ventilation. Serial hemodilution was performed in five rabbits by simultaneous withdrawal of blood and infusion of an equal volume of 6% hetastarch; five rabbits were followed over a comparable time. Ventilation-perfusion (V˙a/Q˙) relationships were studied by using the multiple inert-gas-elimination technique, and pulmonary blood flow distribution was assessed by using fluorescent microspheres. Expired nitric oxide (NO) was measured by chemiluminescence. Hemodilution resulted in a linear fall in hematocrit over time, from 30 ± 1.6 to 11 ± 1%. Anemia was associated with an increase in arterial [Formula: see text] in comparison with controls ( P < 0.01 between groups). The improvement in O2 exchange was associated with reducedV˙a/Q˙heterogeneity, a reduction in the fractal dimension of pulmonary blood flow ( P = 0.04), and a relative increase in the spatial correlation of pulmonary blood flow ( P = 0.04). Expired NO increased with anemia, whereas it remained stable in control animals ( P < 0.0001 between groups). Anemia results in improved gas exchange in the normal lung as a result of an improvement in overallV˙a/Q˙matching. In turn, this may be a result of favorable changes in pulmonary blood flow distribution, as assessed by the fractal dimension and spatial correlation of blood flow and as a result of increased NO availability.

scholarly journals Spatio-Temporal Coupling Characteristics and the Driving Mechanism of Population-Land-Industry Urbanization in the Yangtze River Economic Belt

Land ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 400
Author(s):  
Liejia Huang ◽  
Peng Yang ◽  
Boqing Zhang ◽  
Weiyan Hu
Keyword(s):  
Economic Development ◽  
Spatial Correlation ◽  
Yangtze River ◽  
Three Dimensional ◽  
Driving Mechanism ◽  
The Yangtze River ◽  
Central Cities ◽  
Urban Agglomerations ◽  
Development Level ◽  
Coordination Degree

The purpose of this paper is to probe into the coupled coordination of urbanization in population, land, and industry to improve urbanization quality. A coupled coordination degree model, spatial analysis method and spatial metering model are employed. The study area is 110 prefecture-level cities in the Yangtze River Economic Belt. The study shows that: (1) the coupling degree of the population-land-industry urbanization grew very slowly between 2006 and 2016. On the whole, the three-dimensional urbanization is in a running-in period, and land-based urbanization dominates, while population-based urbanization and industry-based urbanization are relatively lagging behind. (2) The three major urban agglomerations, the Chengdu-Chongqing, the middle reaches of the Yangtze River and the Yangtze River Delta, are parallel to the whole area in terms of the coupling degree of the three dimensional urbanization with a well-ordered structure, especially in the central cities of the three major urban agglomerations. (3) There is significant spatial correlation in the coupling degree and coordination degree of the three-dimensional urbanization. The high value of coupling degree and coordination degree are clustered continuously in developed cities, provincial capitals, and central cities of the downstream reaches of the Yangtze River. (4) The coordinated degree has significant positive spatial autocorrelation, showing obvious spatial agglomeration characteristics: H-H agglomeration areas are concentrated in the downstream developed areas such as Jiangsu, Zhejiang, and Shanghai. L-L agglomeration areas are mainly concentrated in upstream undeveloped areas, but the number of their cities shows a decreasing trend. (5) The coordination degree of the three-dimensional urbanization is the result of the comprehensive effect of economic development level, the government’s decision-making behavior, and urban location. Among them, the economic development level, urbanization investment, traffic condition, and urban geographical location play a decisive role. This paper contributes to the existing literatures by exploring urbanization quality, spatial correlation and influencing factors from the perspectives of the three-dimensional urbanization in the Yangtze River Economic Belt. The conclusion might be helpful to promote the coupling and coordinated development of urbanization in population-land-industry, and ultimately to improve urbanization quality in the Yangtze River Economic Belt.

scholarly journals Regional Distribution and Kinetics of Three Sites on the GABAA Receptor: Lack of Effect of Portacaval Shunting

1992 ◽  
Vol 12 (2) ◽  
pp. 334-346 ◽  
Author(s):  
Anke M. Mans ◽  
Kelli M. Kukulka ◽  
Keith J. McAvoy ◽  
Norman C. Rokosz
Keyword(s):  
Kinetic Parameters ◽  
Regional Distribution ◽  
Three Dimensional ◽  
Portacaval Shunt ◽  
Brain Regions ◽  
Significant Heterogeneity ◽  
Heterogeneous Distribution ◽  
Dimensional Reconstruction ◽  
Benzodiazepine Site ◽  
Gaba Neurotransmission

The regional distribution of binding sites on the GABAA receptor and their kinetic parameters were measured by quantitative autoradiography in brains from normal rats and rats with a portacaval shunt, a model of portal systemic encephalopathy in which GABA neurotransmission may be altered. The ligands used were [3H]flunitrazepam (a benzodiazepine-site agonist), [3H]-Ro 15-1788 (a benzodiazepine-site antagonist), [3H]muscimol (a GABA-site agonist), and [35S] t-butylbicyclo-phosphorothionate (35S-TBPS, a convulsant that binds to a site near the chloride channel). Some brains were analyzed by computerized image analysis and three-dimensional reconstruction. The regional distribution of binding of the benzodiazepines was very similar, but the patterns obtained with [3H]muscimol and [35S]TBPS were different in many areas, suggesting a heterogeneous distribution of several subtypes of the GABAA receptor. The kinetic parameters were determined in brain regions for [3H]flunitrazepam, [3H]Ro15-1788, and [3H]muscimol. For each ligand, the Kd showed a significant heterogeneity among brain regions (at least threefold), contrary to conclusions drawn from earlier studies. In portacaval shunted rats, binding of all four ligands was essentially unchanged from that in control rats, indicating that, if there was an abnormality in GABA neurotransmission during portal systemic shunting, it was not reflected by altered binding to the main sites on the GABAA receptor.

A Finite Element Model of the Human Knee Joint for the Study of Tibio-Femoral Contact

2002 ◽  
Vol 124 (3) ◽  
pp. 273-280 ◽  
Author(s):  
Tammy L. Haut Donahue ◽  
M. L. Hull ◽  
Mark M. Rashid ◽  
Christopher R. Jacobs
Keyword(s):  
Finite Element ◽  
Articular Cartilage ◽  
Three Dimensional ◽  
Element Model ◽  
Maximum Pressure ◽  
Contact Behavior ◽  
Element Size ◽  
Solid Models ◽  
Flexion Extension ◽  
Three Dimensional Coordinate

As a step towards developing a finite element model of the knee that can be used to study how the variables associated with a meniscal replacement affect tibio-femoral contact, the goals of this study were 1) to develop a geometrically accurate three-dimensional solid model of the knee joint with special attention given to the menisci and articular cartilage, 2) to determine to what extent bony deformations affect contact behavior, and 3) to determine whether constraining rotations other than flexion/extension affects the contact behavior of the joint during compressive loading. The model included both the cortical and trabecular bone of the femur and tibia, articular cartilage of the femoral condyles and tibial plateau, both the medial and lateral menisci with their horn attachments, the transverse ligament, the anterior cruciate ligament, and the medial collateral ligament. The solid models for the menisci and articular cartilage were created from surface scans provided by a noncontacting, laser-based, three-dimensional coordinate digitizing system with an root mean squared error (RMSE) of less than 8 microns. Solid models of both the tibia and femur were created from CT images, except for the most proximal surface of the tibia and most distal surface of the femur which were created with the three-dimensional coordinate digitizing system. The constitutive relation of the menisci treated the tissue as transversely isotropic and linearly elastic. Under the application of an 800 N compressive load at 0 degrees of flexion, six contact variables in each compartment (i.e., medial and lateral) were computed including maximum pressure, mean pressure, contact area, total contact force, and coordinates of the center of pressure. Convergence of the finite element solution was studied using three mesh sizes ranging from an average element size of 5 mm by 5 mm to 1 mm by 1 mm. The solution was considered converged for an average element size of 2 mm by 2 mm. Using this mesh size, finite element solutions for rigid versus deformable bones indicated that none of the contact variables changed by more than 2% when the femur and tibia were treated as rigid. However, differences in contact variables as large as 19% occurred when rotations other than flexion/extension were constrained. The largest difference was in the maximum pressure. Among the principal conclusions of the study are that accurate finite element solutions of tibio-femoral contact behavior can be obtained by treating the bones as rigid. However, unrealistic constraints on rotations other than flexion/extension can result in relatively large errors in contact variables.

scholarly journals Numerical Network Modeling of Heat and Moisture Transfer through Capillary-Porous Building Materials

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1819
Author(s):  
Borys Basok ◽  
Borys Davydenko ◽  
Anatoliy M. Pavlenko
Keyword(s):  
Building Materials ◽  
Moisture Transfer ◽  
Three Dimensional ◽  
Total Pore Volume ◽  
Equivalent Diameter ◽  
Average Pore ◽  
The Difference ◽  
Three Dimensional Coordinate ◽  
Solid Liquid ◽  
Heat And Moisture

The article presents the modeling of the dynamics of the vapor-gas mixture and heat and mass transfer (sorption-desorption) in the capillary structure of the porous medium. This approach is underpinned by the fact that the porous structure is represented by a system of linear microchannels oriented along the axes of a three-dimensional coordinate system. The equivalent diameter of these channels corresponds to the average pore diameter, and the ratio of the total pore volume to the volume of the entire porous material corresponds to its porosity. The entire channel area is modeled by a set of cubic elements with a certain humidity, moisture content, pressure and temperature. A simulation is carried out taking into account the difference in temperatures of each of the phases: solid, liquid and gas.

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