Does endothelin-1 participate in the exercise-induced changes of blood flow distribution of muscles in humans?

1997 ◽  
Vol 82 (4) ◽  
pp. 1107-1111 ◽  
Author(s):  
Seiji Maeda ◽  
Takashi Miyauchi ◽  
Michiko Sakane ◽  
Makoto Saito ◽  
Shinichi Maki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Femoral Vein ◽  
Plasma Concentrations ◽  
Flow Distribution ◽  
Plasma Norepinephrine ◽  
Blood Flow Distribution ◽  
Endothelin 1 ◽  
Ergometer Exercise ◽  
Exercise Induced ◽  
Induced Changes

Maeda, Seiji, Takashi Miyauchi, Michiko Sakane, Makoto Saito, Shinichi Maki, Katsutoshi Goto, and Mitsuo Matsuda. Does endothelin-1 participate in the exercise-induced changes of blood flow distribution of muscles in humans? J. Appl. Physiol. 82(4): 1107–1111, 1997.—Endothelin-1 (ET-1) is an endothelium-derived potent vasoconstrictor peptide that potentiates contractions to norepinephrine in human vessels. We previously reported that the circulating plasma concentration of ET-1 is significantly increased after exercise (S. Maeda, T. Miyauchi, K. Goto, and M. Matsuda. J. Appl. Physiol. 77: 1399–1402, 1994). To study the roles of ET-1 during and after exercise, we investigated whether endurance exercise affects the production of ET-1 in the circulation of working muscles and nonworking muscles. Male athletes performed one-leg cycle ergometer exercise of 30-min duration at intensity of 110% of their individual ventilatory threshold. Plasma concentrations of ET-1 in both sides of femoral veins (veins in the working leg and nonworking leg) and in the femoral artery (artery in the nonworking leg) were measured before and after exercise. The plasma ET-1 concentration in the femoral vein in the nonworking leg was significantly increased after exercise, whereas that in femoral vein in the working leg was not changed. The arteriovenous difference in ET-1 concentration was significantly increased after exercise in the circulation of the nonworking leg but not of the working leg, which suggests that the production of ET-1 was increased in the circulation of the nonworking leg by exercise. The present study also demonstrated that the plasma norepinephrine concentrations were elevated by exercise in the femoral veins of both the working and nonworking legs, suggesting that the sympathetic nerve activity was augmented in both legs during exercise. Therefore, the present study demonstrates the possibility that the increase in production of ET-1 in nonworking muscles may cause vasoconstriction and hence decrease blood flow in nonworking muscles through its direct vasoconstrictive action or through an indirect effect of ET-1 to enhance vasoconstrictions to norepinephrine and that these responses may be helpful in increasing blood flow in working muscles. We propose that endogenous ET-1 contributes to the exercise-induced redistribution of blood flow in muscles.

Exercise-induced changes in blood zinc and related proteins in humans

1985 ◽  
Vol 58 (5) ◽  
pp. 1453-1458 ◽  
Author(s):  
H. Ohno ◽  
K. Yamashita ◽  
R. Doi ◽  
K. Yamamura ◽  
T. Kondo ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Zinc Concentration ◽  
Plasma Concentrations ◽  
Cycle Ergometer ◽  
Male Students ◽  
Ergometer Exercise ◽  
Exercise Induced ◽  
Induced Changes ◽  
Related Proteins ◽  
Blood Zinc

Effects of cycle ergometer exercise (approximately 75% maximum ventilatory O2 consumption for 30 min) on the concentrations of zinc and related proteins in erythrocytes and/or plasma were studied on 11 sedentary male students. Lower concentrations of total zinc and of zinc derived from carbonic anhydrase I type (CA-I) in erythrocytes were observed immediately after exercise, but they disappeared after 30 min of rest. The change in total zinc concentration in erythrocytes correlated well with that in CA-I concentration immediately after exercise, as well as after rest. The concentration of carbonic anhydrase II type (CA-II)-derived zinc did not vary substantially at any time. On the other hand, there were significant increases in the plasma concentrations of total zinc and of alpha 2-macroglobulin (alpha 2-MG)-bound zinc immediately after exercise, whereas no such effect was noted in albumin-bound zinc. A positive correlation was found between total zinc and alpha 2-MG concentrations in plasma immediately after exercise. In addition, the change in the activity of alkaline phosphatase, a zinc metalloenzyme, correlated well with that in the total zinc concentration in plasma. These results suggest that a brief physical exercise induces the movement of zinc into plasma.

Exercise causes tissue-specific enhancement of endothelin-1 mRNA expression in internal organs

1998 ◽  
Vol 85 (2) ◽  
pp. 425-431 ◽  
Author(s):  
Seiji Maeda ◽  
Takashi Miyauchi ◽  
Tsutomu Kobayashi ◽  
Katsutoshi Goto ◽  
Mitsuo Matsuda
Keyword(s):  
Blood Flow ◽  
Plasma Concentrations ◽  
Coronary Vessels ◽  
Treadmill Running ◽  
Sedentary Control ◽  
Internal Organs ◽  
Tissue Specific ◽  
Endothelin 1 ◽  
Internal Mammary ◽  
Exercise Induced

Endothelin-1 (ET-1) is a potent vasoconstrictor peptide, which also potentiates contractions to norepinephrine in human internal mammary and coronary vessels. Exercise causes a redistribution of blood flow, i.e., the increase in working muscles that is partly attributable to a decrease in visceral blood flow. We hypothesized that exercise causes a tissue-specific increase in ET-1 expression in internal organs. We studied whether exercise affects expression of preproET-1 mRNA in the kidneys and lungs. The rats performed treadmill running (0% grade) for 45 min at a speed of 25 m/min. The plasma concentrations of ET-1, epinephrine, and norepinephrine were greater in the exercise rats than in the sedentary control rats. The expression of preproET-1 mRNA in the kidneys was markedly higher in the exercise rats than in the sedentary control rats, whereas that in the lungs did not differ between the two groups. Therefore, the present study provides a possibility that the exercise-induced increase in production of ET-1 in the kidneys causes vasoconstriction and hence decreases blood flow in the kidneys through its direct vasoconstrictive action and/or its indirect effect of enhancing vasoconstrictions to norepinephrine.

Distribution of venous remodeling in exercise-induced pulmonary hemorrhage of horses follows reported blood flow distribution in the equine lung

2013 ◽  
Vol 114 (7) ◽  
pp. 869-878 ◽  
Author(s):  
Kurt J. Williams ◽  
N. Edward Robinson ◽  
Heather DeFeijter-Rupp ◽  
Melissa Millerick-May ◽  
Alice Stack ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Blood Flow ◽  
Interstitial Fibrosis ◽  
Pulmonary Veins ◽  
Pulmonary Hemorrhage ◽  
Flow Distribution ◽  
Strenuous Exercise ◽  
Blood Flow Distribution ◽  
Sample Score ◽  
Exercise Induced

Exercise-induced pulmonary hemorrhage (EIPH), which has been reported in humans and a variety of domestic animals following strenuous exercise, is most often documented in racehorses. Remodeling of pulmonary veins (VR) in equine EIPH was recently described, suggesting that it contributes to the pathogenesis of the disease. The cause of VR is unknown. We tested the hypothesis that the development of VR follows pulmonary blood flow distribution, preferentially occurring in the caudodorsal lung region. Furthermore, we hypothesized that VR underpins development of the other lesions of EIPH pathology. The lungs of 10 EIPH-affected horses and 8 controls were randomly sampled for histopathology (2,520 samples) and blindly scored for presence and severity of VR, hemosiderin (H), and interstitial fibrosis (IF). Mean sample score (MSS), mean lesion score, and percent samples with lesions were determined in four dorsal and three ventral lung regions, and the frequency, spatial distribution, and severity of lesions were determined. MSS for VR and H were significantly greater dorsally than ventrally ( P < 0.001) and also decreased significantly in the caudocranial direction ( P < 0.001). IF decreased only in the caudocranial direction. The percent samples with lesions followed the same distribution as MSS. VR often was accompanied by H; IF never occurred without VR and H. Similarity of the distribution of EIPH lesions and the reported fractal distribution of pulmonary blood flow suggests that VR develops in regions of high blood flow. Further experiments are necessary to determine whether VR is central to the pathogenesis of EIPH.

Influence of blood rheology on intrarenal blood flow distribution

1976 ◽  
Vol 230 (5) ◽  
pp. 1448-1454 ◽  
Author(s):  
KM McDonald
Keyword(s):  
Blood Flow ◽  
Arterial Pressure ◽  
Flow Distribution ◽  
Blood Rheology ◽  
Blood Flow Distribution ◽  
Cortical Level ◽  
Arteriolar Resistance ◽  
Anesthetized Dogs ◽  
Intrarenal Blood Flow ◽  
Induced Changes

This study examined the effects of hematocrit and colloid-induced changes in blood rheology on renal blood flow (RBF) distribution. Blood viscosity, measured by coneplate viscometry, was raised 65% in anesthetized dogs either by increasing hematocrit or giving isoncotic dextran 500. Blood volume was kept constant and arterial pressure was unchanged. An increase in hematocrit caused either no change in RBF or a slight increase at each cortical level (zones 1-4). However, dextran hyperviscosity caused decreases in all four zones, the most pronounced in zone 1 (8.03-5.19 ml min(-1) g(-1)) and the least in zone 4 (1.63-1.46 ml min(-1) g(-1)). These data suggest either that increased hematocrit has less effect on "apparent viscosity" of blood within the kidney than does plasma colloid or that increased hematocrit causes renal vasodilatation while colloid hyperviscosity does not cause it. Since GFR remained constant in both types of hyperviscosity, it is possible that GFR is the autoregulated variable and the observed changes in RBF distribution and vascular resistance resulted from the changes in afferent and efferent arteriolar resistance required to preserve GFR.

Hemodynamic Effects And Changes Of Blood Flow Distribution By Dextran 70, Dihydroergotamin (DHE) And Their Combination

1981 ◽  
Author(s):  
B Lindblad ◽  
D Bergqviat
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Femoral Vein ◽  
Venous Pressure ◽  
Flow Distribution ◽  
Tissue Blood Flow ◽  
Blood Flow Distribution ◽  
Arterial Blood ◽  
Dextran 70 ◽  
The Central Nervous System

Dextran 70 and DHE are both effective in reducing the risk for postoperative thromboembolic complications. As they at least in part have different mechanisms of action it is important to analyse if their combination potentiates the prophylactic effect. Therefore it is necessary to study the effect on hemodynamics and tissue blood flow, a problem which is delt with in this report.MATERIAL AND METHODS: In 18 dogs the following parameters were followed: cardiac output, heart rate, arterial blood pressure, central venous pressure, pulmonary artery pressure, left atrium pressure and volume blood flow in the femoral vein. Blood flow distribution was determined by the radioactive microsphere technique.RESULTS: Dextran 70 gave an increase of cardiac output and femoral vein flow. Other hemodynamic parameters were mainly unaffected. Total peripheral resistance decreased. DHE increased arterial blood pressure, central venous pressure and pulmonary arterial pressure. Cardiac output and femoral vein flow were unchanged.Tissue blood flow increased in general slightly after infusion of dextran 70. No significant change in blood flow distribution was seen. DHE reduced pancreatic and thyroid blood flow and increased tissue blood flow to the central nervous system. The blood flow to other organs including the heart was unaffected. The combination of dextran 70 and DHE influenced hemodynamic parameters and flow distribution in an additative way.CONCLUSIONS: From this experimental study it is concluded that it is possible to combine dextran and DHE without inducing a circulatory overload. DHE increased tissue blood flow to the central nervous system.

scholarly journals Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity

2010 ◽  
Vol 108 (2) ◽  
pp. 378-386 ◽  
Author(s):  
Ilkka Heinonen ◽  
Jukka Kemppainen ◽  
Kimmo Kaskinoro ◽  
Juha E. Peltonen ◽  
Ronald Borra ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Intensity ◽  
Muscle Blood Flow ◽  
Flow Distribution ◽  
Voluntary Exercise ◽  
Adenosine Infusion ◽  
Blood Flow Distribution ◽  
Flow Heterogeneity ◽  
Exercise Hyperemia ◽  
Exercise Induced

Adenosine is a widely used pharmacological agent to induce a “high-flow” control condition to study the mechanisms of exercise hyperemia, but it is not known how well an adenosine infusion depicts exercise-induced hyperemia, especially in terms of blood flow distribution at the capillary level in human muscle. Additionally, it remains to be determined what proportion of the adenosine-induced flow elevation is specifically directed to muscle only. In the present study, we measured thigh muscle capillary nutritive blood flow in nine healthy young men using PET at rest and during the femoral artery infusion of adenosine (1 mgmin−1l thigh volume−1), which has previously been shown to induce a maximal whole thigh blood flow of ∼8 l/min. This response was compared with the blood flow induced by moderate- to high-intensity one-leg dynamic knee extension exercise. Adenosine increased muscle blood flow on average to 40 ± 7 ml·min−1·100 g muscle−1 with an aggregate value of 2.3 ± 0.6 l/min for the whole thigh musculature. Adenosine also induced a substantial change in blood flow distribution within individuals. Muscle blood flow during the adenosine infusion was comparable with blood flow in moderate- to high-intensity exercise (36 ± 9 ml·min−1·100 g muscle−1), but flow heterogeneity was significantly higher during the adenosine infusion than during voluntary exercise. In conclusion, a substantial part of the flow increase in the whole limb blood flow induced by a high-dose adenosine infusion is conducted through the physiological non-nutritive shunt in muscle and/or also through tissues of the limb other than muscle. Additionally, an intra-arterial adenosine infusion does not mimic exercise hyperemia, especially in terms of muscle capillary flow heterogeneity, while the often-observed exercise-induced changes in capillary blood flow heterogeneity likely reflect true changes in nutritive flow linked to muscle fiber and vascular unit recruitment.

Numerical Analysis of the VAD Outflow Cannula Positioning on the Blood Flow in the Patient–Specific Brain Supplying Arteries

2020 ◽  
Vol 22 (2) ◽  
pp. 619-636 ◽  
Author(s):  
Zbigniew Tyfa ◽  
Damian Obidowski ◽  
Krzysztof Jóźwik
Keyword(s):  
Blood Flow ◽  
Computer Aided Design ◽  
Volume Flow Rate ◽  
Flow Distribution ◽  
Primary Objective ◽  
Patient Specific ◽  
Blood Flow Distribution ◽  
Reconstruction Process ◽  
Outflow Cannula ◽  
The Brain

AbstractThe primary objective of this research can be divided into two separate aspects. The first one was to verify whether own software can be treated as a viable source of data for the Computer Aided Design (CAD) modelling and Computational Fluid Dynamics CFD analysis. The second aspect was to analyze the influence of the Ventricle Assist Device (VAD) outflow cannula positioning on the blood flow distribution in the brain-supplying arteries. Patient-specific model was reconstructed basing on the DICOM image sets obtained with the angiographic Computed Tomography. The reconstruction process was performed in the custom-created software, whereas the outflow cannulas were added in the SolidWorks software. Volumetric meshes were generated in the Ansys Mesher module. The transient boundary conditions enabled simulating several full cardiac cycles. Performed investigations focused mainly on volume flow rate, shear stress and velocity distribution. It was proven that custom-created software enhances the processes of the anatomical objects reconstruction. Developed geometrical files are compatible with CAD and CFD software – they can be easily manipulated and modified. Concerning the numerical simulations, several cases with varied positioning of the VAD outflow cannula were analyzed. Obtained results revealed that the location of the VAD outflow cannula has a slight impact on the blood flow distribution among the brain supplying arteries.

Mechanisms of improvement in pulmonary gas exchange during isovolemic hemodilution

1999 ◽  
Vol 87 (1) ◽  
pp. 132-141 ◽  
Author(s):  
Steven Deem ◽  
Richard G. Hedges ◽  
Steven McKinney ◽  
Nayak L. Polissar ◽  
Michael K. Alberts ◽  
...  
Keyword(s):  
Blood Flow ◽  
Fractal Dimension ◽  
Gas Exchange ◽  
Spatial Correlation ◽  
Pulmonary Blood Flow ◽  
Minute Ventilation ◽  
Flow Distribution ◽  
Pulmonary Gas Exchange ◽  
Normal Lung ◽  
Blood Flow Distribution

Severe anemia is associated with remarkable stability of pulmonary gas exchange (S. Deem, M. K. Alberts, M. J. Bishop, A. Bidani, and E. R. Swenson. J. Appl. Physiol. 83: 240–246, 1997), although the factors that contribute to this stability have not been studied in detail. In the present study, 10 Flemish Giant rabbits were anesthetized, paralyzed, and mechanically ventilated at a fixed minute ventilation. Serial hemodilution was performed in five rabbits by simultaneous withdrawal of blood and infusion of an equal volume of 6% hetastarch; five rabbits were followed over a comparable time. Ventilation-perfusion (V˙a/Q˙) relationships were studied by using the multiple inert-gas-elimination technique, and pulmonary blood flow distribution was assessed by using fluorescent microspheres. Expired nitric oxide (NO) was measured by chemiluminescence. Hemodilution resulted in a linear fall in hematocrit over time, from 30 ± 1.6 to 11 ± 1%. Anemia was associated with an increase in arterial [Formula: see text] in comparison with controls ( P < 0.01 between groups). The improvement in O2 exchange was associated with reducedV˙a/Q˙heterogeneity, a reduction in the fractal dimension of pulmonary blood flow ( P = 0.04), and a relative increase in the spatial correlation of pulmonary blood flow ( P = 0.04). Expired NO increased with anemia, whereas it remained stable in control animals ( P < 0.0001 between groups). Anemia results in improved gas exchange in the normal lung as a result of an improvement in overallV˙a/Q˙matching. In turn, this may be a result of favorable changes in pulmonary blood flow distribution, as assessed by the fractal dimension and spatial correlation of blood flow and as a result of increased NO availability.

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