scholarly journals Decreased maximal heart rate with aging is related to reduced β-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate

2008 ◽  
Vol 105 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Demetra D. Christou ◽  
Douglas R. Seals
Keyword(s):  
Heart Rate ◽  
Maximal Oxygen Consumption ◽  
Older Men ◽  
Exercise Heart Rate ◽  
Maximal Heart Rate ◽  
Adrenergic Stimulation ◽  
Ganglionic Blockade ◽  
Intrinsic Heart Rate ◽  
Age Related ◽  
Aerobic Exercise Capacity

A decrease in maximal exercise heart rate (HRmax) is a key contributor to reductions in aerobic exercise capacity with aging. However, the mechanisms involved are incompletely understood. We sought to gain insight into the respective roles of intrinsic heart rate (HRint) and chronotropic β-adrenergic responsiveness in the reductions in HRmax with aging in healthy adults. HRmax (Balke treadmill protocol to exhaustion), HRint (HR during acute ganglionic blockade with intravenous trimethaphan), and chronotropic β-adrenergic responsiveness (increase in HR with incremental intravenous infusion of isoproterenol during ganglionic blockade) were determined in 15 older (65 ± 5 yr) and 15 young (25 ± 4 yr) healthy men. In the older men, HRmax was lower (162 ± 9 vs. 191 ± 11 beats/min, P < 0.0001) and was associated with a lower HRint (58 ± 7 vs. 83 ± 9 beats/min, P < 0.0001) and chronotropic β-adrenergic responsiveness (0.094 ± 0.036 vs. 0.154 ± 0.045 ΔHR/[isoproterenol]: P < 0.0001). Both HRint ( r = 0.87, P < 0.0001) and chronotropic β-adrenergic responsiveness ( r = 0.61, P < 0.0001) were positively related to HRmax. Accounting for the effects of HRint and chronotropic β-adrenergic responsiveness reduced the age-related difference in HRmax by 83%, rendering it statistically nonsignificant ( P = 0.2). Maximal oxygen consumption was lower in the older men (34.9 ± 8.1 vs. 48.6 ± 6.7 ml·kg−1·min−1, P < 0.0001) and was positively related to HRmax ( r = 0.62, P < 0.0001), HRint ( r = 0.51, P = 0.002), and chronotropic β-adrenergic responsiveness ( r = 0.47, P = 0.005). Our findings indicate that, together, reductions in HRint and chronotropic responsiveness to β-adrenergic stimulation largely explain decreases in HRmax with aging, with the reduction in HRint playing by far the greatest role.

Physiological factors associated with the lower maximal oxygen consumption of master runners

1989 ◽  
Vol 66 (2) ◽  
pp. 949-954 ◽  
Author(s):  
A. M. Rivera ◽  
A. E. Pels ◽  
S. P. Sady ◽  
M. A. Sady ◽  
E. M. Cullinane ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cardiac Output ◽  
Stroke Volume ◽  
Maximal Oxygen Consumption ◽  
Maximal Heart Rate ◽  
Distance Runners ◽  
Physiological Factors ◽  
Factors Associated ◽  
Older Athletes ◽  
Maximal Cardiac Output

We examined the hemodynamic factors associated with the lower maximal O2 consumption (VO2max) in older formerly elite distance runners. Heart rate and VO2 were measured during submaximal and maximal treadmill exercise in 11 master [66 +/- 8 (SD) yr] and 11 young (32 +/- 5 yr) male runners. Cardiac output was determined using acetylene rebreathing at 30, 50, 70, and 85% VO2max. Maximal cardiac output was estimated using submaximal stroke volume and maximal heart rate. VO2max was 36% lower in master runners (45.0 +/- 6.9 vs. 70.4 +/- 8.0 ml.kg-1.min-1, P less than or equal to 0.05), because of both a lower maximal cardiac output (18.2 +/- 3.5 vs. 25.4 +/- 1.7 l.min-1) and arteriovenous O2 difference (16.6 +/- 1.6 vs. 18.7 +/- 1.4 ml O2.100 ml blood-1, P less than or equal to 0.05). Reduced maximal heart rate (154.4 +/- 17.4 vs. 185 +/- 5.8 beats.min-1) and stroke volume (117.1 +/- 16.1 vs. 137.2 +/- 8.7 ml.beat-1) contributed to the lower cardiac output in the older athletes (P less than or equal 0.05). These data indicate that VO2max is lower in master runners because of a diminished capacity to deliver and extract O2 during exercise.

Influence of cardiac innervation on intrinsic heart rate in dogs

1990 ◽  
Vol 258 (4) ◽  
pp. H1132-H1137 ◽  
Author(s):  
J. M. Evans ◽  
D. C. Randall ◽  
J. N. Funk ◽  
C. F. Knapp
Keyword(s):  
Heart Rate ◽  
Intrinsic Rate ◽  
Conscious State ◽  
Autonomic Innervation ◽  
Autonomic Activity ◽  
Cardiac Innervation ◽  
Cardiac Denervation ◽  
Ganglionic Blockade ◽  
Intrinsic Heart Rate

Intrinsic heart rate is defined as the rate at which the heart beats when all cardiac neural and hormonal inputs are removed. We determined the effect of prevailing autonomic innervation of the heart on the intrinsic heart rate in chronically maintained, sedated, normally innervated dogs (n = 14), and in 14 other dogs that had previously (greater than 12 day) undergone complete surgical cardiac denervation. Intrinsic rate was determined in both groups using the following two procedures: 1) pharmacological effector blockade; and 2) pharmacological ganglionic blockade. The intrinsic rate determined by effector blockade was 142.9 +/- 7.2 (SE) beats/min in the dogs with intact cardiac innervation. When the same treatment was given after total surgical cardiac denervation, intrinsic rate was 97.9 +/- 4.8 beats/min. Intrinsic heart rate was significantly (P less than 0.05) lower in surgically denervated dogs. Ganglionic blockade in surgically denervated animals yielded an intrinsic rate of 90.0 +/- 8.5 beats/min, which was again significantly lower than the corresponding value of 128.4 +/- 5.5 beats/min in normal dogs. There was no difference in the intrinsic heart rate as determined by effector vs. ganglionic blockade in either group of dogs. An additional six dogs were subjected to selective surgical sinoatrial nodal parasympathectomy; their intrinsic rate (effector blockade) in the conscious state was 115.8 +/- 4.3 beats/min; this was significantly lower than the corresponding value for normal dogs and significantly greater than in dogs subject to total surgical cardiac denervation. The lower rate observed in the totally denervated and selectively denervated dogs after effector and/or ganglionic blockades implies that intrinsic heart rate depends on the level or nature of prevailing autonomic activity.

Meta-analysis of the age-associated decline in maximal aerobic capacity in men: relation to training status

2000 ◽  
Vol 278 (3) ◽  
pp. H829-H834 ◽  
Author(s):  
Teresa M. Wilson ◽  
Hirofumi Tanaka
Keyword(s):  
Meta Analysis ◽  
Maximal Oxygen Consumption ◽  
Group Differences ◽  
Maximal Heart Rate ◽  
Maximal Aerobic Capacity ◽  
Cross Sectional ◽  
Physically Active ◽  
Age Related ◽  
Rate Of Decline ◽  
Exercise Status

Based on cross-sectional data, we recently reported that, in contrast to the prevailing view, the rate of decline in maximal oxygen consumption (V˙o 2 max) with age is greater in physically active compared with sedentary healthy women. We tested this hypothesis in men using a meta-analytic study ofV˙o 2 max values in the published literature. A total of 242 studies (538 subject groups and 13,828 subjects) met the inclusion criteria and were arbitrarily separated into sedentary (214 groups, 6,231 subjects), active (159 groups, 5,621 subjects), and endurance-trained (165 groups, 1,976 subjects) populations. Body fat percent increased with age in sedentary and active men ( P < 0.001), whereas no change was observed in endurance-trained men.V˙o 2 max was inversely and strongly related to age within each population ( r = −0.80 to −0.88, all P < 0.001) and was highest in endurance-trained and lowest in sedentary populations at any age. Absolute rates of decline inV˙o 2 max with age were not different ( P > 0.05) in sedentary (−4.0 ml ⋅ kg−1 ⋅ min−1 ⋅ decade−1), active (−4.0), and endurance-trained (−4.6) populations. Similarly, there were no group differences ( P > 0.05) in the relative (%) rates of decline inV˙o 2 max with advancing age (−8.7, −7.3, and −6.8%/decade, respectively). Maximal heart rate was inversely related to age within each population ( r = −0.88 to −0.93, all P < 0.001), but the rate of age-related reduction was not different among the populations. There was a significant decline in running mileage and speed with advancing age in the endurance-trained men. The present cross-sectional meta-analytic findings do not support the hypothesis that the rate of decline inV˙o 2 max with age is related to habitual aerobic exercise status in men.

Aerobic work capacity in middle-aged Norwegian men

1965 ◽  
Vol 20 (3) ◽  
pp. 432-436 ◽  
Author(s):  
K. Lange Andersen ◽  
Lars Hermansen
Keyword(s):  
Heart Rate ◽  
Oxygen Uptake ◽  
Age Groups ◽  
Older Men ◽  
Work Capacity ◽  
Maximal Heart Rate ◽  
Middle Aged ◽  
Younger Age ◽  
Exercise Induced ◽  
Aerobic Work Capacity

Maximal oxygen uptake and related respiratory and circulatory functions were measured in sedentary and well-trained middle-aged men. Maximal oxygen uptakes averaged 2.63 liter/min in sedentary men and 3.36 liter/min in well-trained men, the latter value being essentially the same as found in young untrained students. The heart rate/ oxygen uptake relationship was found to be the same for sedentary-living men, regardless of age, but maximal heart rate was lower in older men. The maximal heart rate is probably the same in well-trained as in sedentary middle-aged men, this in contrast to what has been observed in younger age groups, where training reduces maximal heart rate. The exercise-induced hyperventilation takes place at an oxygen uptake corresponding to 70–80% of the capacity, this being the same in trained and untrained, and essentially the same as found in young adult subjects. maximal O2 uptake Submitted on March 23, 1964

scholarly journals Confirming Maximal Oxygen Uptake: Is Heart Rate the Answer?

2018 ◽  
Vol 39 (03) ◽  
pp. 198-203 ◽  
Author(s):  
Don Keiller ◽  
Dan Gordon
Keyword(s):  
Heart Rate ◽  
Young Adults ◽  
Oxygen Uptake ◽  
Maximal Oxygen Uptake ◽  
Accurate Method ◽  
Maximal Heart Rate ◽  
Age Related

AbstractThis study investigates heart rate (HR), in 11 young adults (22.4±3.21yr), at V̇O2max, to ascertain whether measured maximal heart rate (HRmax), as determined by a plateau in HR (HRplat), can reliably confirm V̇O2max. V̇O2max and HRplat were determined, using the parameters of a V̇O2≤50 ml•min−1 and a ∆HR≤2b•min−1, respectively, over the final 60 s of sampling. V̇O2 was also independently determined using a verification phase protocol. A HRplat was achieved by 91% of participants (∆HR=1.3±1b•min−1) and critically the time at which HRmax was reached coincided with that at which V̇O2max was achieved. Moreover RER and ΔRER criteria were reached significantly earlier (p<0.05) than V̇O2max, whilst age-related heart rate maximums (HRage), were not achieved by many participants. The results suggest that a HRplat ≤2 b•min−1 is a more accurate method, within the group tested, to determine whether a ‘true’ V̇O2max has been achieved, than other secondary criteria and potentially avoids the requirement for an additional verification phase.

EFFECT OF INTENSE TRAINING ON MAXIMAL HEART RATE IN OLDER MEN

1986 ◽  
Vol 18 (supplement) ◽  
pp. S54
Author(s):  
K. G. McDougal ◽  
D. Allen
Keyword(s):  
Heart Rate ◽  
Older Men ◽  
Maximal Heart Rate ◽  
Intense Training

Decline in VO2max with aging in master athletes and sedentary men

1990 ◽  
Vol 68 (5) ◽  
pp. 2195-2199 ◽  
Author(s):  
M. A. Rogers ◽  
J. M. Hagberg ◽  
W. H. Martin ◽  
A. A. Ehsani ◽  
J. O. Holloszy
Keyword(s):  
Heart Rate ◽  
Exercise Training ◽  
Maximal Heart Rate ◽  
Master Athletes ◽  
Endurance Exercise Training ◽  
Age Related ◽  
O2 Pulse ◽  
Rate Of Decline ◽  
Sedentary Subjects

Fifteen well-trained master endurance athletes [62.0 +/- 2.3 (SE) yr] and 14 sedentary control subjects (61.4 +/- 1.4 yr) were reevaluated after an average follow-up period of approximately 8 yr to obtain information regarding the effects of physical activity on the age-related decline in maximal O2 uptake capacity (VO2max). The master athletes had been training for 10.2 +/- 2.9 yr before initial testing and continued to train during the follow-up period. The sedentary subjects' VO2max declined by an average of 3.3 ml.kg-1.min-1 (33.9 +/- 1.7 vs. 30.6 +/- 1.6, P less than 0.001) over the course of the study, a decline of 12% per decade. In these subjects maximal heart rate declined 8 beats/min (171 vs. 163) and maximal O2 pulse decreased from 0.20 to 0.18 ml.kg-1.beat (P less than 0.05). The master athletes' VO2 max decreased by an average of 2.2 ml.kg-1.min-1 (54.0 +/- 1.7 vs. 51.8 +/- 1.8, P less than 0.05), a 5.5% decline per decade. The master athletes' maximal heart rate was unchanged (171 +/- 3 beats/min) and their maximal O2 pulse decreased from 0.32 to 0.30 ml.kg-1.beat (P less than 0.05). These findings provide evidence that the age-related decrease in VO2max of master athletes who continue to engage in regular vigorous endurance exercise training is approximately one-half the rate of decline seen in age-matched sedentary subjects. Furthermore our results suggest that endurance exercise training may reduce the rate of decline in maximal heart rate that typically occurs as an individual ages.

scholarly journals The Effect of Routine Gymnastics toward Post-Exercise Heart Rate Recovery in Elderly

2020 ◽  
Author(s):  
Arie Ramdhiani Mahassa ◽  
Mohammad Rizki Akbar ◽  
Sri Yusnita Irda Sari
Keyword(s):  
Heart Rate ◽  
Heart Rate Recovery ◽  
Exercise Duration ◽  
Exercise Heart Rate ◽  
Autonomic Nerves ◽  
Cross Sectional ◽  
Post Exercise ◽  
Age Related ◽  
Significant Difference ◽  
Minute Post

Background: Age-related change in autonomic nerves covers parasympathetic function decrease that hampers heart rate (HR) control.  The effective attempt to improve autonomic nervous function for elderly is routine exercise, however exercise duration among elderly is not always standardized. This study is aimed to compare the effect of different exercise duration to post-exercise Heart Rate Recovery (HRR) between two elderly groups with the same frequency, intensity, type criteria of routine exercise. Method: Method was cross-sectional study which compared exercise duration of standardized group (3x90 minutes/week) and unstandardized group (3x30 minutes/week). Group 1 was elders with standardized duration from Healthy Heart Club and Group 2 was elders who take unstandardized duration from Elderly Home in Bandung city. Each group consisted of 43 elders and data were collected in July-August 2019. After one hour of medium intensity exercise, all respondents were examined for resting HR (HRrest), maximum HR (HRmax), one minute post-exercise HR, and four minutes post-exercise HR. HRR was obtained by subtracting HRmax by one minute post-exercise HR and normal if  > 12 bpm. Analysis data was done by SPSS with Mann-Whitney U Test, Fisher Chi Square and Logistic regression. Result: Most of respondents were 60-69 years old and female. Respondents in unstandardized group were more low education, hypertension and smoking. The HRrest of both groups was categorized as normal but increased greater (30x/min)  in standardized group. The result showed a significant difference in comparation of median HRR (p=0.001) and number of normal and abnormal HRR (p=0.001) between both groups. Gender, smoking and standardized duration of exercise associated with abnormality of HRR, elders who take unstandardized duration have 12.7 times risk to get abnormal HRR. Conclusion: Routine exercise for elderly is recommended in standardized duration with minimal 150 minutes per week in order to increase post-exercise HRR.

scholarly journals Analysis of Fitness Status Variations of Under-16 Soccer Players Over a Season and Their Relationships With Maturational Status and Training Load

2021 ◽  
Vol 11 ◽  
Author(s):  
Hadi Nobari ◽  
Ana Filipa Silva ◽  
Filipe Manuel Clemente ◽  
Marefat Siahkouhian ◽  
Miguel Ángel García-Gordillo ◽  
...  
Keyword(s):  
Heart Rate ◽  
Statistical Significance ◽  
Maximal Oxygen Consumption ◽  
Average Power ◽  
Training Load ◽  
Maximal Heart Rate ◽  
Period 2 ◽  
Two Factors ◽  
Maximal Speed ◽  
And Training

The purposes of this study were (i) to analyze the variations in maximal oxygen consumption (VO2max), maximal heart rate (HRmax), heart rate at rest, acceleration, maximal speed, agility, anaerobic sprint test (RAST) of peak power (RPP), RAST of minimum power, RAST of average power (RAP), and RAST of fatigue index (RFI) during the competitive season, using maturation status and accumulated training load as covariates, and (ii) to describe the differences between responders and non-responders in relation to baseline levels. Twenty-three elite players from the same team competing in the national under-16 competitions were evaluated for 20 weeks in period 1 (before league), middle (mid league), and period 2 (after league). The VO2max (p = 0.009), maximal speed (p = 0.001), RPP (p &lt; 0.001), RAP (p &lt; 0.001), and RFI (p &lt; 0.001) significantly changed across the assessment periods. Interestingly, using accumulated training load and maturation status as covariates revealed no statistical significance (p &gt; 0.05). When analyzing responders and non-responders, only HRmax (between periods 1 and 2) showed no differences between the groups. As a conclusion, it can be seen that accumulated training load and maturation status play an important role in the differences observed across the season. Thus, coaches should consider the importance of these two factors to carefully interpret fitness changes in their players and possibly adjust training decisions according to the maturation level of the players.

Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis

1997 ◽  
Vol 83 (1) ◽  
pp. 160-165 ◽  
Author(s):  
Margaret D. Fitzgerald ◽  
Hirofumi Tanaka ◽  
Zung V. Tran ◽  
Douglas R. Seals
Keyword(s):  
Heart Rate ◽  
Aerobic Exercise ◽  
Aerobic Capacity ◽  
Meta Analysis ◽  
Maximal Heart Rate ◽  
Maximal Aerobic Capacity ◽  
Age Related ◽  
Rate Of Decline ◽  
Sedentary Women ◽  
Exercise Status

Fitzgerald, Margaret D., Hirofumi Tanaka, Zung V. Tran, and Douglas R. Seals. Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis. J. Appl. Physiol. 83(1): 160–165, 1997.—Our purpose was to determine the relationship between habitual aerobic exercise status and the rate of decline in maximal aerobic capacity across the adult age range in women. A meta-analytic approach was used in which mean maximal oxygen consumption (V˙o 2 max) values from female subject groups (ages 18–89 yr) were obtained from the published literature. A total of 239 subject groups from 109 studies involving 4,884 subjects met the inclusion criteria and were arbitrarily separated into sedentary (groups = 107; subjects = 2,256), active (groups = 69; subjects = 1,717), and endurance-trained (groups = 63; subjects = 911) populations.V˙o 2 max averaged 29.7 ± 7.8, 38.7 ± 9.2, and 52.0 ± 10.5 ml ⋅ kg−1 ⋅ min−1, respectively, and was inversely related to age within each population ( r = −0.82 to −0.87, all P < 0.0001). The rate of decline inV˙o 2 max with increasing subject group age was lowest in sedentary women (−3.5 ml ⋅ kg−1 ⋅ min−1⋅ decade−1), greater in active women (−4.4 ml ⋅ kg−1 ⋅ min−1⋅ decade−1), and greatest in endurance-trained women (−6.2 ml ⋅ kg−1 ⋅ min−1 ⋅ decade−1) (all P < 0.001 vs. each other). When expressed as percent decrease from mean levels at age ∼25 yr, the rates of decline inV˙o 2 max were similar in the three populations (−10.0 to −10.9%/decade). There was no obvious relationship between aerobic exercise status and the rate of decline in maximal heart rate with age. The results of this cross-sectional study support the hypothesis that, in contrast to the prevailing view, the rate of decline in maximal aerobic capacity with age is greater, not smaller, in endurance-trained vs. sedentary women. The greater rate of decline inV˙o 2 max in endurance-trained populations may be related to their higher values as young adults (baseline effect) and/or to greater age-related reductions in exercise volume; however, it does not appear to be related to a greater rate of decline in maximal heart rate with age.

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