Adult Neurogenesis Supports Short-Term Olfactory Memory

Adult neurogenesis has captivated neuroscientists for decades, with hopes that understanding the programs underlying this phenomenon may provide unique insight toward avenues for brain repair. Interestingly, however, despite intense molecular and cellular investigation, the evolutionary roles and biological functions for ongoing neurogenesis have remained elusive. Here I review recent work published in the Journal of Neuroscience that reveals a functional role for continued neurogenesis toward forming short-term olfactory memories.

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Faculty Opinions recommendation of Sleep deprivation specifically impairs short-term olfactory memory in Drosophila.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3684956.3408054 ◽

2010 ◽

Author(s):

Björn Brembs

Keyword(s):

Sleep Deprivation ◽

Short Term ◽

Olfactory Memory

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Review: Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function

Neuropathology and Applied Neurobiology ◽

10.1111/nan.12107 ◽

2014 ◽

Vol 40 (1) ◽

pp. 3-12 ◽

Cited By ~ 46

Author(s):

S. M. G. Braun ◽

S. Jessberger

Keyword(s):

Adult Neurogenesis ◽

Brain Function ◽

Normal Brain ◽

Brain Repair ◽

Neuropsychiatric Disease ◽

Normal Brain Function

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Episodic Ultradian Events—Ultradian Rhythms

Biology ◽

10.3390/biology8010015 ◽

2019 ◽

Vol 8 (1) ◽

pp. 15 ◽

Cited By ~ 7

Author(s):

Grace Goh ◽

Shane Maloney ◽

Peter Mark ◽

Dominique Blache

Keyword(s):

Central Nervous System ◽

Molecular Basis ◽

Single Cells ◽

Biological Functions ◽

Ultradian Rhythms ◽

Short Term ◽

Modern Biology ◽

The Central Nervous System ◽

Unicellular Organisms ◽

Fast Lane

In the fast lane of chronobiology, ultradian events are short-term rhythms that have been observed since the beginning of modern biology and were quantified about a century ago. They are ubiquitous in all biological systems and found in all organisms, from unicellular organisms to mammals, and from single cells to complex biological functions in multicellular animals. Since these events are aperiodic and last for a few minutes to a few hours, they are better classified as episodic ultradian events (EUEs). Their origin is unclear. However, they could have a molecular basis and could be controlled by hormonal inputs—in vertebrates, they originate from the activity of the central nervous system. EUEs are receiving increasing attention but their aperiodic nature requires specific sampling and analytic tools. While longer scale rhythms are adaptations to predictable changes in the environment, in theory, EUEs could contribute to adaptation by preparing organisms and biological functions for unpredictability.

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Consequences of variation in feeding behaviour for the probability of cows starting a meal as estimated from pooled data

Proceedings of the British Society of Animal Science ◽

10.1017/s1752756200011662 ◽

2003 ◽

Vol 2003 ◽

pp. 7-7

Author(s):

M. P. Yeates ◽

B. J. Tolkamp ◽

I. Kyriazakis

Keyword(s):

Food Intake ◽

Recent Work ◽

Feeding Behaviour ◽

Biological Significance ◽

Simulation Models ◽

Farm Animals ◽

Short Term ◽

Pooled Data ◽

Intake Regulation ◽

Insight Into

The analysis of short-term feeding behaviour may give insights into how food intake is regulated in farm animals. Food intake is often recorded in terms of feeding events, e.g. visits to feeders, which can be clustered into meals. This enables calculation of the probability of cows starting a meal in relation to time since the last meal, which is thought to give insight into intake regulation. Starting probabilities are often calculated after data have been pooled, e.g. across day and night or across individuals. Recent work suggested that such pooling might have strongly affected previously published conclusions. We therefore constructed simulation models to investigate how such pooling affects interpretation of feeding behaviour and consequently the biological significance attached to results.

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Targeting Adult Neurogenesis for Poststroke Therapy

Stem Cells International ◽

10.1155/2017/5868632 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 19

Author(s):

Jianfei Lu ◽

Anatol Manaenko ◽

Qin Hu

Keyword(s):

Stem Cells ◽

Adult Neurogenesis ◽

Subventricular Zone ◽

Tissue Repair ◽

Therapeutic Interventions ◽

Subgranular Zone ◽

Brain Repair ◽

Function Recovery ◽

Newborn Neurons ◽

And Function

Adult neurogenesis mainly occurs at the subventricular zone (SVZ) on the walls of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG). However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integration. Stroke activates neural stem cells (NSCs) in both SVZ and SGZ. This process is regulated by a wide variety of signaling pathways. However, the newborn neurons derived from adult neurogenesis are insufficient for tissue repair and function recovery. Thus, enhancing the endogenous neurogenesis driven by ischemia and promoting the survival of newborn neurons can be promising therapeutic interventions for stroke. Here, we present an overview of the process of adult neurogenesis and the potential of stroke-induced neurogenesis on brain repair.

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