Renorenal Reflexes: Role of Substance P and Prostaglandins

Physiology ◽  
1993 ◽  
Vol 8 (5) ◽  
pp. 228-232
Author(s):  
UC Kopp
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Substance P ◽  
Sensory Neurons ◽  
Urine Output ◽  
The Central Nervous System ◽  
Pelvic Pressure

The kidney is capable of transmitting information from sensory neurons to the central nervous system. Prostaglandins and substance P contribute to the activation of renal sensory neurons produced by increases in renal pelvic pressure that lead to a reflex increase in contralateral urine output.

scholarly journals Further Observations on Proprioceptors in Crustacea and a Hypothesis About Their Function

1958 ◽  
Vol 37 (2) ◽  
pp. 379-396 ◽  
Author(s):  
J. S. Alexandrowicz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Connective Tissue ◽  
Sensory Neurons ◽  
Similar Pattern ◽  
Nerve Cells ◽  
The Central Nervous System

In the coxal region of Eupagurus bernardus the following receptor organs have been found: (1) a muscular receptor spanning the thoracico-coxal articulation, its innervation, in which several neurons take part, being arranged on a similar pattern as in Carcinus; (2) two innervated elastic strands running along the bundles of mm. levator and depressor basipoditis respectively and inserting into the tendons of these muscles; (3) a coxo-basipodite receptor consisting of connective tissue strand with numerous bipolar nerve cells ending on it. With the exception of the coxo-basipodite receptor, all sensory neurons of these organs have their cell bodies located in the central nervous system.It is suggested that these receptors convey impulses elicited by the movements of the legs and some hypotheses concerning the role of each of them are put forward.

Substance p: localization in the central nervous system and in some primary sensory neurons

Science ◽  
1975 ◽  
Vol 190 (4217) ◽  
pp. 889-890 ◽  
Author(s):  
T. Hokfelt ◽  
J. Kellerth ◽  
G. Nilsson ◽  
B. Pernow
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
The Central Nervous System

scholarly journals Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
Kate Marie Lewis ◽  
Renée Jade Turner ◽  
Robert Vink
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Substance P ◽  
Blood Brain Barrier ◽  
Neurogenic Inflammation ◽  
Brain Barrier ◽  
Acute Injury ◽  
Blood Brain ◽  
The Central Nervous System

Classical inflammation is a well-characterized secondary response to many acute disorders of the central nervous system. However, in recent years, the role of neurogenic inflammation in the pathogenesis of neurological diseases has gained increasing attention, with a particular focus on its effects on modulation of the blood-brain barrier BBB. The neuropeptide substance P has been shown to increase blood-brain barrier permeability following acute injury to the brain and is associated with marked cerebral edema. Its release has also been shown to modulate classical inflammation. Accordingly, blocking substance P NK1 receptors may provide a novel alternative treatment to ameliorate the deleterious effects of neurogenic inflammation in the central nervous system. The purpose of this paper is to provide an overview of the role of substance P and neurogenic inflammation in acute injury to the central nervous system following traumatic brain injury, spinal cord injury, stroke, and meningitis.

The iroquois complex controls the somatotopy of Drosophila notum mechanosensory projections

Development ◽  
1998 ◽  
Vol 125 (18) ◽  
pp. 3563-3569 ◽  
Author(s):  
N. Grillenzoni ◽  
J. van Helden ◽  
C. Dambly-Chaudiere ◽  
A. Ghysen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sensory Neurons ◽  
Internal Representation ◽  
External World ◽  
Model System ◽  
Gene Complex ◽  
Lateral Region ◽  
The Central Nervous System

Sensory neurons can establish topologically ordered projections in the central nervous system, thereby building an internal representation of the external world. We analyze how this ordering is genetically controlled in Drosophila, using as a model system the neurons that innervate the mechanosensory bristles on the back of the fly (the notum). Sensory neurons innervating the medially located bristles send an axonal branch that crosses the central nervous system midline, defining a ‘medial’ identity, while the ones that innervate the lateral bristles send no such branch, defining a ‘lateral’ identity. We analyze the role of the proneural genes achaete and scute, which are involved in the formation of the medial and lateral bristles, and we show that they have no effect on the ‘medial’ and ‘lateral’ identities of the neurons. We also analyze the role of the prepattern genes araucan and caupolican, two members of the iroquois gene complex which are required for the expression of achaete and scute in the lateral region of the notum, and we show that their expression is responsible for the ‘lateral’ identity of the projection.

scholarly journals The Role of Substance P in Neurodegenerative Diseases

2020 ◽  
Author(s):  
Atefeh Ghahremanloo ◽  
Fariba Mohammadi ◽  
Seyed Isaac Hashemy
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Substance P ◽  
Neurodegenerative Disorders ◽  
Review Article ◽  
The Central Nervous System ◽  
Lateral Sclerosis

Abstract- Tachykinins (TKs) are a family of neuropeptides widely distributed in the human body, especially in the nervous system. TKs have exhibited both neuroprotective and neurodegenerative properties in the central nervous system (CNS) and spinal cord. Also, several studies have shown that substance P (SP), as a pioneering neuropeptide of the TK family, is engaged in the pathogenesis of neurodegenerative disorders (NDs), such as Alzheimer disease, Multiple Sclerosis, Parkinson’s disease, Huntington’s disease, and Amyotrophic lateral sclerosis. However, a huge body of information available about the level of SP in NDs demonstrates that SP and its receptors might be prognostic or diagnostic factors for NDs. The present review article summarizes the roles of TKs in common neurodegenerative disorders.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

Role of a nurse in the rehabilitation of children using ReviMotion hardware and software complex

2020 ◽  
pp. 49-56
Author(s):  
T. Shirshova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
School Age Children ◽  
Equipment Management ◽  
School Age ◽  
Rehabilitation Process ◽  
Software Complex ◽  
Trained Personnel ◽  
The Central Nervous System

Disorders of the musculoskeletal system in school-age children occupy 1-2 places in the structure of functional abnormalities. Cognitive impairment without organic damage to the central nervous system is detected in 30-56% of healthy school children. Along with the increase in the incidence rate, the demand for rehabilitation systems, which allow patients to return to normal life as soon as possible and maintain the motivation for the rehabilitation process, is also growing. Adaptation of rehabilitation techniques, ease of equipment management, availability of specially trained personnel and availability of technical support for complexes becomes important.

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