scholarly journals Resolution of Paraneoplastic Collagenous Enterocolitis after Resection of Colon Cancer

2006 ◽  
Vol 20 (5) ◽  
pp. 357-360 ◽  
Author(s):  
Hugh J Freeman ◽  
Ken W Berean
Keyword(s):  
Colon Cancer ◽  
Weight Loss ◽  
Large Intestine ◽  
Inflammatory Disease ◽  
Inflammatory Process ◽  
Watery Diarrhea ◽  
Intestinal Involvement ◽  
Mucosal Involvement ◽  
Small And Large Intestine

A 52-year-old woman developed severe watery diarrhea, weight loss, anemia and hypoalbuminemia. A localized colon cancer was detected. Subsequently, extensive collagenous mucosal involvement of the small and large intestine was discovered. After resection of the colon cancer, her symptoms resolved. In addition, resolution of the inflammatory process occurred, including the subepithelial collagen deposits. Despite extensive small and large intestinal involvement, both clinical and histological resolution of collagenous inflammatory disease was evident. Collagenous enterocolitis is an inflammatory process that may represent a distinctive and reversible paraneoplastic phenomenon.

Comparison of Transport Capacity of Small and Large Intestine

1961 ◽  
Vol 41 (5) ◽  
pp. 500-504 ◽  
Author(s):  
N. Cordero ◽  
T. Hastings Wilson
Keyword(s):  
Large Intestine ◽  
Transport Capacity ◽  
Small And Large Intestine

A newborn girl with watery diarrhea, weight loss, and severe metabolic acidosis

1994 ◽  
Vol 6 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Victor Nizet ◽  
Cedric j. Priebe
Keyword(s):  
Weight Loss ◽  
Metabolic Acidosis ◽  
Watery Diarrhea ◽  
Severe Metabolic Acidosis ◽  
Newborn Girl

scholarly journals Small and Large Intestine (II): Inflammatory Bowel Disease, Short Bowel Syndrome, and Malignant Tumors of the Digestive Tract

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2325
Author(s):  
Yolanda Ber ◽  
Santiago García-Lopez ◽  
Carla J. Gargallo-Puyuelo ◽  
Fernando Gomollón
Keyword(s):  
Inflammatory Bowel Disease ◽  
Short Bowel Syndrome ◽  
Large Intestine ◽  
Malignant Tumors ◽  
Short Bowel ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Macro And Micronutrients ◽  
Enteral And Parenteral Nutrition ◽  
Small And Large Intestine

The small intestine is key in the digestion and absorption of macro and micronutrients. The large intestine is essential for the absorption of water, to allow adequate defecation, and to harbor intestinal microbiota, for which their nutritional role is as important as it is unknown. This article will describe the causes and consequences of malnutrition in patients with inflammatory bowel diseases, the importance of screening and replacement of micronutrient deficits, and the main indications for enteral and parenteral nutrition in these patients. We will also discuss the causes of short bowel syndrome, a complex entity due to anatomical or functional loss of part of the small bowel, which can cause insufficient absorption of liquid, electrolytes, and nutrients and lead to complex management. Finally, we will review the causes, consequences, and management of malnutrition in patients with malignant and benign digestive tumors, including neuroendocrine tumors (present not only in the intestine but also in the pancreas).

Kinetics of Calcium Absorption in the Small and Large Intestine of the FrogRana pipiens

1995 ◽  
Vol 68 (6) ◽  
pp. 1093-1117 ◽  
Author(s):  
Douglas R. Robertson
Keyword(s):  
Large Intestine ◽  
Calcium Absorption ◽  
Kinetics Of ◽  
Small And Large Intestine

BOTH HUMAN SP-A1 AND SP-A2 GENES ARE EXPRESSED IN SMALL AND LARGE INTESTINE

2001 ◽  
Vol 20 (5) ◽  
pp. 367-386 ◽  
Author(s):  
Zhenwu Lin, Daphne deMello, David S. Phelp
Keyword(s):  
Large Intestine ◽  
Small And Large Intestine

scholarly journals Expression of IL-10 receptors on epithelial cells from the murine small and large intestine

2000 ◽  
Vol 12 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Timothy L. Denning ◽  
Nicola A. Campbell ◽  
Fei Song ◽  
Roberto P. Garofalo ◽  
Gary R. Klimpel ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Large Intestine ◽  
Small And Large Intestine

scholarly journals Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Jiao Wu ◽  
Sai-Ching Jim Yeung ◽  
Sicheng Liu ◽  
Aiham Qdaisat ◽  
Dewei Jiang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Weight Loss ◽  
Cancer Patients ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Colorectal Cancer Patient ◽  
Nutrition Support ◽  
Immunodeficient Mice ◽  
The Impact

AbstractWeight loss and cachexia are common problems in colorectal cancer patients; thus, parenteral and enteral nutrition support play important roles in cancer care. However, the impact of nonessential amino acid components of nutritional intake on cancer progression has not been fully studied. In this study, we discovered that gastrointestinal cancer patients who received cysteine as part of the parenteral nutrition had shorter overall survival (P < 0.001) than those who did not. Cystine indeed robustly promotes colon cancer cell growth in vitro and in immunodeficient mice, predominately by inhibiting SESN2 transcription via the GCN2-ATF4 axis, resulting in mTORC1 activation. mTORC1 inhibitors Rapamycin and Everolimus block cystine-induced cancer cell proliferation. In addition, cystine confers resistance to oxaliplatin and irinotecan chemotherapy by quenching chemotherapy-induced reactive oxygen species via synthesizing glutathione. We demonstrated that dietary deprivation of cystine suppressed colon cancer xenograft growth without weight loss in mice and boosted the antitumor effect of oxaliplatin. These findings indicate that cyst(e)ine, as part of supplemental nutrition, plays an important role in colorectal cancer and manipulation of cyst(e)ine content in nutritional formulations may optimize colorectal cancer patient survival.

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