Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives
Keyword(s):
H Nmr
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Present study describes the synthesis of a novel series of 3,5-diiodo-4-(5-nitro-1H-2-imidazolyl)benzoyl amino acids and di/tri/tetrapeptides using diisopropylcarbodiimide/dicyclohexylcarbodiimide (DIPC/DCC) as coupling agents andN-methylmorpholine/triethylamine (NMM/TEA) as bases. Structure elucidation of all the newly synthesized compounds was done by elemental analysis and IR,1H NMR,13C NMR and mass spectral data. Synthesized imidazolopeptides were screened for their anthelmintic activity and found to possess moderate to good bioactivity against earthwormsMegascoplex konkanensis, Pontoscotex corethruses and Eudrilus eugenieawhen compared to reference drugs - albendazole and mebendazole at dose level of 2 mg mL−1.
2015 ◽
Vol 49
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pp. 99-103
1986 ◽
Vol 51
(12)
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pp. 2810-2816
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Synthesis of Novel Triazolo[4,3-a]Quinoxaline Darivatives Containing Pyridinyl and Thiazole Nucleous
2015 ◽
Vol 52
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pp. 63-73