scholarly journals Polymorphisms of the Fibrinogen-Beta Gene are Related to 2-Hour Glucose Level after Oral Glucose Tolerance Test in Hong Kong Chinese

2008 ◽  
Vol 24 (3) ◽  
pp. 167-173 ◽  
Author(s):  
Louisa Y. F. Wong ◽  
Kwok Leung Ong ◽  
Bernard M. Y. Cheung ◽  
Raymond Y. H. Leung ◽  
Yu Bun Man ◽  
...  
Keyword(s):  
Hong Kong ◽  
Glucose Tolerance ◽  
Fibrinogen Level ◽  
Plasma Fibrinogen ◽  
Hong Kong Chinese ◽  
Stepwise Multiple Regression ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Human Fibrinogen

Fibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-βgene (FGB) variants, −455G>A, −249C>T, and −148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. BothFGBvariants, −455G>A and −148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers ofFGBAC-haplotype, comprising the two nucleotide variants at positions −455 and −249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L,p= 0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L,p= 0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p= 0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance.

scholarly journals Sitagliptin improves glycaemic excursion after a meal or after an oral glucose load in J apanese subjects with impaired glucose tolerance

2015 ◽  
Vol 17 (11) ◽  
pp. 1033-1041 ◽  
Author(s):  
K. Kaku ◽  
T. Kadowaki ◽  
Y. Terauchi ◽  
T. Okamoto ◽  
A. Sato ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

scholarly journals Interesting insulin response to oral glucose load in young Japanese subjects with impaired glucose tolerance

Diabetes Care ◽  
2000 ◽  
Vol 23 (5) ◽  
pp. 710-712 ◽  
Author(s):  
Y. Tanaka ◽  
Y. Atsumi ◽  
K. Matsuoka ◽  
T. Onuma ◽  
R. Kawamori
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Japanese Subjects

Response of incretins (GIP and GLP-1) to an oral glucose load in female and male subjects with normal glucose tolerance

2014 ◽  
Vol 106 (2) ◽  
pp. e25-e29 ◽  
Author(s):  
Toshihiro Matsuo ◽  
Yoshiki Kusunoki ◽  
Tomoyuki Katsuno ◽  
Takashi Ikawa ◽  
Takafumi Akagami ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Normal Glucose ◽  
Male Subjects

Effect of an enkephalin-analogue (FK 33-824) on glucose tolerance in man

1983 ◽  
Vol 104 (1) ◽  
pp. 85-90 ◽  
Author(s):  
X. Jeanrenaud ◽  
E. Maeder ◽  
E. Del Pozo ◽  
J. P. Felber
Keyword(s):  
Glucose Tolerance ◽  
Insulin Response ◽  
Normal Subjects ◽  
Glucose Absorption ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Oral Test ◽  
Insulin Response To Glucose ◽  
Glucose Curve

Abstract. The purpose of the present work was to study the effect of a methionine-enkephalin analogue (FK 33-824) on glucose tolerance in man. Groups of 5 to 8 normal subjects were given a 0.5 mg im injection of the drug or placebo just before a 100 g oral glucose load or a 0.5 g/kg iv glucose load. In the enkephalin analogue treated subjects, diminished insulin response to glucose was observed following the oral glucose load, with insulin values significantly lower than in the controls from time 10 to 90 min, but no corresponding change in the glucose curve. This effect was not observed when glucose was given iv in another group of 5 subjects in whom the significant blunting of the insulin response was accompanied by a significant decrease in glucose tolerance. These observations demonstrate that in man, enkephalin produces a decrease in insulin secretion in response to both oral and iv glucose loads. The absence of any marked impairment in glucose tolerance in the oral test in spite of the decreased insulin response suggests that enkephalin might have an additional effect in delaying glucose absorption.

scholarly journals An Oral Glucose Load Decreases Postprandial Extracellular Vesicles in Obese Adults with and without Prediabetes

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 580 ◽  
Author(s):  
Natalie Z. M. Eichner ◽  
Nicole M. Gilbertson ◽  
Luca Musante ◽  
Sabrina La Salvia ◽  
Arthur Weltman ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Glucose Tolerance ◽  
Extracellular Vesicles ◽  
Augmentation Index ◽  
Annexin V ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Cvd Risk ◽  
Obese Adults

Although extracellular vesicles (EVs) are a novel biomediator of type 2 diabetes (T2D) and cardiovascular disease (CVD), the effects of hyperglycemia on EVs in humans is unknown. We tested the hypothesis that a 75-g oral glucose tolerance test (OGTT) would promote changes in EVs in relation to CVD risk. Twenty-five obese adults (Age: 52.4 ± 3.2 year, BMI: 32.5 ± 1.2 kg/m2) were screened for normal glucose tolerance (NGT, n = 8) and prediabetes (PD, n = 17) using American Diabetes Association criteria (75 g OGTT and/or HbA1c). Body composition (bioelectrical impedance) and fitness (VO2peak) were measured. Arterial stiffness (augmentation index; AIx) was measured at 0, 60- and 120-min while insulin, glucose, and free fatty acids were evaluated every 30 min during the OGTT to assess CVD risk. Annexin V positive (AV+) and Annexin V negative (AV-) total EVs, platelet EVs (CD31+/CD41+; CD41+), leukocyte EVs (CD45+; CD45+/CD41−), platelet endothelial cell adhesion molecule (PECAM) (CD31+) and endothelial EVs (CD 31+/CD41−; CD105+) were collected at 0 and 120 min. There were no differences in age, BMI, or body fat between NGT and PD (all P > 0.63). Total EVs, AV+ CD31+ (PECAM), and AV+ CD31+/CD41- (endothelial) EVs decreased after the OGTT (P ≤ 0.04). Circulating insulin at 2-h correlated with elevated post-prandial AV- CD45+ (r = 0.48, P = 0.04) while arterial stiffness related to reduced total EVs (r = −0.49, P = 0.03) and AV+CD41+ (platelet) (r = −0.52, P = 0.02). An oral glucose load lowers post-prandial total, platelet, and endothelial EVs in obese adults with NGT and prediabetes in relation to CVD risk.

Short-Term Effect of a 75 g Oral Glucose Load on Glycohaemoglobin Levels

1987 ◽  
Vol 24 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Richard D Forrest ◽  
Caroline A Jackson ◽  
Barry J Gould ◽  
Marianne Casburn-Budd ◽  
Julie E Taylor ◽  
...  
Keyword(s):  
Schiff Base ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Assay Method ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Agar Gel ◽  
Electrophoretic Method

Two hundred and twenty-three subjects out of a total of 347 with various degrees of glucose tolerance were recalled after a screening survey for diabetes. They were a randomly selected sample of people over the age of 40 and they underwent a formal 75 g glucose tolerance test in order to assess the effect of a glucose load on glycohaemoglobin levels measured by four different assay methods. Oral glucose loading was found to affect glycohaemoglobin levels only when these were measured by an agar-gel electrophoretic method that did not remove the labile aldimine-linked Schiff base fraction. The increase in glycohaemoglobin during the glucose tolerance test as estimated by this method was proportional to the 2 h blood glucose level. Glycohaemoglobin levels measured by agar-gel electrophoresis with elimination of the Schiff base, by affinity chromatography and by iso-electric focussing, were not affected by a 75 g oral glucose load. We conclude that blood samples for glycohaemoglobin assay may be collected at any time of the day, without regard to the subject's previous food intake, provided an assay method is used that removed the aldimine-linked labile fraction.

Analysis of Glucose Tolerance in Twin Gestations Using an Oral Glucose Load

2002 ◽  
Vol 34 (6) ◽  
pp. 338-340 ◽  
Author(s):  
M. Ihara ◽  
M. Mitao ◽  
H. Yamasaki ◽  
T. Kodama ◽  
T. Murakami ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load
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