scholarly journals Validated Spectrophotometric Estimation of Famciclovir in Tablet Dosage Form

2009 ◽  
Vol 6 (3) ◽  
pp. 780-784 ◽  
Author(s):  
J. Adlin Jino Nesalin ◽  
C. Jose Gnana Babu ◽  
G. Vijaya Kumar ◽  
T. Tamizh Mani
Keyword(s):  
Statistical Analysis ◽  
Acidic Medium ◽  
Dosage Form ◽  
Ion Pair ◽  
Alizarin Red S ◽  
Routine Analysis ◽  
Orange Ii ◽  
Alizarin Red ◽  
Spectrophotometric Methods ◽  
Tablet Dosage

Two simple and sensitive spectrophotometric methods have been developed for the estimation of Famciclovir (FCR) in bulk and tablet dosage form. Methods A and B are based on the formation of ion-pair complexes of the drug with dyes such as orange II (OG-II) and alizarin red S (AR-S) in acidic medium followed by their extraction with chloroform to give colored chromogen with absorption maxima at 480 nm and 440 nm respectively. Beer’s law is valid in the concentration range of 2-10 mcg/mL for both the methods. These developed methods were validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the methods are reproducible and selective for the routine analysis of the said drug.

scholarly journals Validated Extractive Spectrophotometric Estimation of Tadalafil in Tablet Dosage Form

2009 ◽  
Vol 6 (3) ◽  
pp. 611-614
Author(s):  
J. Adlin Jino Nesalin ◽  
C. Jose Gnana Babu ◽  
G. Vijaya Kumar ◽  
T. Tamizh Mani
Keyword(s):  
Statistical Analysis ◽  
Dosage Form ◽  
Bromothymol Blue ◽  
Ion Pair ◽  
Routine Analysis ◽  
Bromocresol Green ◽  
Buffer Solution ◽  
Spectrophotometric Methods ◽  
Beer’S Law ◽  
Tablet Dosage

Two simple spectrophotometric methods have been developed for the estimation of tadalafil in both pure and tablet dosage form. Methods A and B are based on the formation of ion-pair complexes of the drug with dyes such as bromothymol blue (BTB) and bromocresol green (BCG) in acidic buffer solution followed by their extraction with chloroform to form yellow colored chromogen with absorption maxima at 420 nm and 415 nm respectively. Beer’s law is valid in the concentration range of 10-50 mcg/mL for both the methods. These developed methods were validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the methods are reproducible and selective for the routine analysis of the said drug.

scholarly journals Spectrophotometric Determination of Zidovudine in Pharmaceutical Dosage Forms

2012 ◽  
Vol 9 (1) ◽  
pp. 89-92
Author(s):  
J. Sudhakar Reddy ◽  
MD. S. Maqsood Ahmed ◽  
I. E. Chakravarthy ◽  
K. Prabhavathi
Keyword(s):  
Statistical Analysis ◽  
Dosage Form ◽  
Dosage Forms ◽  
Ion Pair ◽  
Reagent Blank ◽  
Pharmaceutical Dosage Forms ◽  
Extractable Complex ◽  
Bulk Drug ◽  
Tablet Dosage

A simple, sensitive and economical spectrophotometric method has been developed for the determination of zidovudine in commercial dosage forms. The method was based on the formation of chloroform extractable complex of zidovudine with wool fast blue. The absorbance of the extractable ion pair complex is measured at the wavelength of maximum absorbance 590 nm against the reagent blank treated similarly. Statistical analysis proves that the proposed methods are reproducible and selective for the estimation of zidovudine in bulk drug and in its tablet dosage form.

scholarly journals Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

2012 ◽  
Vol 2012 ◽  
pp. 1-10
Author(s):  
Madihalli S. Raghu ◽  
Kanakapura Basavaiah ◽  
Kudige N. Prashanth ◽  
Kankapura B. Vinay
Keyword(s):  
Human Urine ◽  
Standard Addition ◽  
Cost Effective ◽  
Molar Absorptivity ◽  
Ion Pair ◽  
Alizarin Red S ◽  
Alizarin Red ◽  
Spectrophotometric Methods ◽  
Spiked Human Urine

The present study describes two simple, rapid, selective, and cost-effective spectrophotometric methods for the determination of an antiallergic drug, fexofenadine hydrochloride (FFH), in bulk drug, tablets, and in spiked human urine. The first method (method A) is based on the formation of yellow-colored ion-pair complex between FFH and alizarin red S (AZS) in acid medium which was extracted into dichloromethane, and the absorbance was measured at 440 nm. The second method (method B) is based on the breaking of the yellow FFH–AZS ion-pair complex in alkaline medium followed by the measurement of the violet-colored free dye at 590 nm. Under the optimized conditions, Beer’s law is obeyed over the concentration ranges of 0.4–12.0 and 0.2–3.5 μg  FFH for method A and method B, respectively, and the corresponding molar absorptivity values are 3.80 × 104 and 1.61 × 105 L . The Sandell’s sensitivity, detection, and quantification limits are also reported. The proposed methods were successfully applied to the determination of FFH in pure drug and commercial tablets. The accuracy and reliability of the proposed methods were further established by recovery studies via standard addition technique.

Method Development and Validation of Spectrophotometric Methods for The Estimation of Rizatriptan Benzoate in Pure and Pharmaceutical Dosage Form

2021 ◽  
pp. 6003-6006
Author(s):  
Pushpa Latha E. ◽  
Sailaja B.
Keyword(s):  
Dosage Form ◽  
Method Development ◽  
Limit Of Detection ◽  
Limit Of Quantification ◽  
Pharmaceutical Dosage Form ◽  
Rizatriptan Benzoate ◽  
Spectrophotometric Methods ◽  
Ich Guidelines ◽  
Development And Validation ◽  
Tablet Dosage

Analytical UV derivative spectrophotometric method was developed and validated to quantify Rizatriptan Benzoate in pure drug and tablet dosage form. Based on the spectrophotometric characteristics of Rizatriptan Benzoate, a signal of zero (225nm), first (216nm), second (237nm), third (233nm), fourth (231nm) order derivative spectra were found to be adequate for quantification. The methods obeyed Beer's law in the concentration range of (0.1-360µg/ml) with square correlation coefficient (r2) of 0.999. The mean percentage recovery was found to be 100.01 ± 0.075. As per ICH guidelines the results of the analysis were validated in terms of linearity, precision, accuracy, limit of detection and limit of quantification, and were found to be satisfactory.

DEVELOPMENT OF STABILATING INDICATING ANALYTICAL METHOD FOR FAMOTIDINE AND DICLOFENAC POTASSIUM IN COMBINED DOSAGE FORM

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (06) ◽  
pp. 40-42
Author(s):  
D. R. Chaple ◽  
◽  
S. A Mehta ◽  
M. P Yeole ◽  
P. S. Tarte
Keyword(s):  
Analytical Method ◽  
Dosage Form ◽  
Simultaneous Equation ◽  
Routine Analysis ◽  
Simultaneous Estimation ◽  
Tablet Dosage

This work deals with the simultaneous estimation of famotidine and diclofenac potassium in a tablet dosage form. The method employed is simultaneous equation. The absorption maxima at 266 nm and 286 nm were used for the estimation of famotidine and diclofenac, respectively. Both the drugs and their mixture obey Beer-Lamberts law at selected wavelength in given concentration range. The result of analysis has been validated statistically and recovery studies confirmed the accuracy of the proposed method. The proposed method is simple, rapid, precise and accurate. It is used for the routine analysis of both drugs.

scholarly journals Simultaneous Spectrophotometric Methods for Estimation of Cefpodoxime Proxetil and Potassium Clavulanate in Tablet Dosage form

2010 ◽  
Vol 9 (4) ◽  
pp. 167 ◽  
Author(s):  
A. B. Thomas ◽  
S. B. Dighe ◽  
L. P. Kothapalli ◽  
R. K. Nanda ◽  
S. N. Jagdale ◽  
...  
Keyword(s):  
Dosage Form ◽  
Cefpodoxime Proxetil ◽  
Spectrophotometric Methods ◽  
Potassium Clavulanate ◽  
Tablet Dosage

scholarly journals Spectrophometric Determination of Nelfinavir Mesylate

2006 ◽  
Vol 3 (2) ◽  
pp. 78-82 ◽  
Author(s):  
K. Vanitha Prakash ◽  
Jangala Venkateswara Rao
Keyword(s):  
Ferric Chloride ◽  
Dosage Form ◽  
Potassium Ferricyanide ◽  
Reagent Blank ◽  
Spectrophotometric Methods ◽  
Bluish Green ◽  
Nelfinavir Mesylate ◽  
Bulk Drug ◽  
Tablet Dosage

Two new simple, sensitive, rapid and economical Spectrophotometric Methods (A and B) have been developed for the determination of Nelfinavir Mesylate in pharmaceutical bulk and tablet dosage form. The method A is based on the reaction of Nelfinavir with ferric chloride, potassium ferricyanide and hydrochloric acid to form a bluish green colored chromogen. The Method B is based on the formation of blood red colored chromogen with Ferric chloride and 1,10-phenanthroline. The absorbances of the chromogen were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.

scholarly journals Simple Atomic Absorption Spectroscopic and Spectrophotometric Methods for Determination of Pioglitazone Hydrochloride and Carvedilol in Pharmaceutical Dosage Forms

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Afaf A. Abdelmonem ◽  
Gamal H. Ragab ◽  
Hisham Hashem ◽  
Eman A. Bahgat
Keyword(s):  
Atomic Absorption ◽  
Acidic Medium ◽  
Methylene Chloride ◽  
Ion Pair ◽  
Fast Green ◽  
Experimental Conditions ◽  
Pharmaceutical Dosage Forms ◽  
Spectrophotometric Methods ◽  
Orange G

This study represents simple atomic absorption spectroscopic and spectrophotometric methods for determination of pioglitazone hydrochloride (PGZ-HCl) and carvedilol (CRV) based on formation of ion-pair associates between drugs and inorganic complex, bismuth(III) tetraiodide (Method A) and between drugs and organic acidic dyes, fast green and orange G (Method B). Method A is based on formation of ion-pair associate between drugs and bismuth(III) tetraiodide in acidic medium to form orange-red ion-pair associates, which can be quantitatively determined by two different procedures. The formed ion-pair associate is extracted by methylene chloride, dissolved in acetone, dried, and then decomposed by hydrochloric acid, and bismuth content is determined by direct atomic absorption spectrometric technique (Procedure 1) or extracted by methylene chloride, dissolved in acetone, and quantified spectrophotometrically at 490 nm (Procedure 2). Method B is based on formation of ion-pair associate between drugs and either fast green dye or orange G dye in acidic medium to form ion-pair associates. The formed ion-pair associate is extracted by methylene chloride and quantified spectrophotometrically at 630 nm (for fast green dye method) or 498 nm (for orange G dye method). Optimal experimental conditions have been studied. Both methods are applied for determination of the drugs in tablets without interference.

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