scholarly journals Retinol Binding Protein-4 Is Associated with TNF-αand Not Insulin Resistance in Subjects with Type 2 Diabetes Mellitus and Coronary Heart Disease

2009 ◽  
Vol 26 (3) ◽  
pp. 135-140 ◽  
Author(s):  
Nasser M. Al-Daghri ◽  
Omar S. Al-Attas ◽  
Majed Alokail ◽  
Hossam M. Draz ◽  
Ahmed Bamakhramah ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Hypoglycemic Agents ◽  
Control Group ◽  
Diabetic Patients ◽  
Oral Hypoglycemic Agents ◽  
Low Carbohydrate Diet

We studied the association between RBP4 and various markers related to insulin resistance and diabetic complications as well as inflammatory markers in Saudi population suffering from type 2 diabetes and coronary heart disease. Patients with type 2 diabetes were divided into 3 groups according to the type of treatment and involvement of coronary artery disease. Serum RBP4, TNF-α, insulin, CRP, resistin, leptin and adiponectin were analysed in all samples. RBP4 levels increased significantly in the group of diabetic subjects treated with oral hypoglycemic agents and diabetic patients with coronary heart disease (30.2 ± 11.8; 33.4 ± 13.6 respectively), while there was no significant change in the other group for diabetic subjects on low-carbohydrate diet (25.1 ± 10.9) compared to control group (22.6 ± 9.5). RPB4 levels were positively correlated with TNF-α in the group of diabetic subjects on oral hypoglycemic agents and diabetic patients with coronary heart disease (r= 0.52,P< 0.05;r= 0.58,P< 0.05 respectively). No correlations were found between RBP4 levels and insulin resistance in all studied groups. Our findings suggest that serum RBP4 levels is associated with pro-inflammatory cytokine (TNF-α) and is not associated with insulin resistance among patients with type 2 diabetes and coronary heart disease.

scholarly journals Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients

2017 ◽  
Vol 14 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Wen-Jia Chen ◽  
Yue Liu ◽  
Yu-Bin Sui ◽  
Bo Zhang ◽  
Xiao-Hui Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Levels ◽  
Control Group ◽  
Diabetic Patients ◽  
Model Assessment ◽  
Newly Diagnosed

Background: Musclin is a newly identified skeletal muscle–derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correlations between musclin plasma levels and various metabolic parameters in patients with type 2 diabetes mellitus. Materials and methods: In this hospital-based study, plasma samples were collected from the enrolled individuals, including 38 newly diagnosed, treatment-naive type 2 diabetes mellitus patients and 41 age- and gender-matched control subjects. Plasma musclin levels were examined by radioimmunoassay. Results: Compared with the control group, musclin plasma levels were significantly higher in untreated type 2 diabetes mellitus patients. Musclin levels in the plasma of newly diagnosed type 2 diabetes mellitus patients were positively correlated with fasting plasma glucose, haemoglobin A1c, serum insulin, triglycerides and homeostasis model assessment of insulin resistance. Furthermore, multivariate logistic regression analysis showed that the level of musclin was associated with the presence of type 2 diabetes mellitus. Receiver operating characteristic curve analysis yielded an area under the curve for musclin of 0.718 in type 2 diabetes mellitus. Conclusion: The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Our results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus.

Prevalences of Type 2 Diabetes, the Insulin Resistance Syndrome, and Coronary Heart Disease in an Elderly, Biethnic Population

Diabetes Care ◽  
1998 ◽  
Vol 21 (6) ◽  
pp. 959-966 ◽  
Author(s):  
R. D. Lindeman ◽  
L. J. Romero ◽  
R. Hundley ◽  
A. S. Allen ◽  
H. C. Liang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Insulin Resistance Syndrome

Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease

2016 ◽  
Vol 48 (04) ◽  
pp. 263-268 ◽  
Author(s):  
A. Farrokhian ◽  
F. Bahmani ◽  
M. Taghizadeh ◽  
S. Mirhashemi ◽  
MH Aarabi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Selenium Supplementation ◽  
Hs Crp

scholarly journals The Effect and Mechanism of Trimethylamine-N-oxide, a Metabolite of Intestinal Flora,  on Coronary Heart Disease in Type 2 Diabetic Patients

2020 ◽  
Author(s):  
jie li ◽  
Xiaoqin Ha ◽  
Xiaoling Cai ◽  
Chenyuan Yan ◽  
Caixia Jia ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Western Blot ◽  
Mrna Level ◽  
Elevated Serum ◽  
Intestinal Flora ◽  
Diabetic Patients ◽  
Rrna Gene

Abstract BackgroundTrimethylamine N-Oxide (TMAO) has been shown to be an independent risk factor for cardiovascular disease. Our aim is to study the effects of TMAO on type 2 diabetes mellitus-coronary heart disease and to explore its mechanism.MethodsA total of 50 healthy controls , 50 T2DM patients and 50 T2DM combined with CHD patients were enrolled. Serum samples were collected to detect glucose, myocardial enzyme spectrum and TMAO level. The 16S rRNA gene sequencing analyzed the diversity of intestinal flora. Taking the ZDF rat as the experimental object, the model of T2DM combined with CHD was established in rats. Blood samples were taken to detect glucose, myocardial enzyme spectrum and TMAO level. The inflammatory protein and mRNA expression of TLR4, NLRP3, Caspase-1 and IL-1β were detected by Western blot and RT-qPCR. In vitro culture of H9c2(2-1) for experiments. The CCK-8 method was used to detect the survival rate of cells after glucose and TMAO treatment. After the cells were treated with selected glucose and TMAO, the cells were treated with selected glucose, TMAO and BAY11-7082, Western blot detected the presence of pyroptosis and the pathway of TLR4/NF-κB/NLRP3. RT-qPCR was used to determine the mRNA level of inflammatory factor.DiscussionChanges in the composition of intestinal flora in patients with type 2 diabetes can lead to elevated serum TMAO levels. Animal and cell experiments have confirmed that elevated TMAO level may lead to inflammatory myocardial injury in rats and is related to the mechanism of TLR4/NF-κB/NLRP3.

scholarly journals Prevalence and Risk Factors of Coronary Heart Disease in Chinese Patients with type 2 Diabetes Mellitus, 2013-2018

2020 ◽  
Author(s):  
Chenchen Wang ◽  
Zuoling Xie ◽  
Xi Huang ◽  
Zheng Wang ◽  
Haiyan Shangguan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Regression Analysis ◽  
Heart Disease ◽  
Diabetic Patients ◽  
Population Census ◽  
Chd Risk ◽  
Chd Risk Factors

Abstract Background: Coronary heart disease (CHD) is the most common cause of death in patients with type 2 diabetes (T2DM). We aim to estimate the prevalence of CHD and cardiovascular risk factors in Chinese diabetic inpatients.Methods: A total of 66536 diabetic inpatients from 2013 to 2018 were investigated, demographic and clinical data were gathered from 30693 patients with T2DM. The age-standardized prevalence of CHD was calculated on the basis of data from Chinese population census in 2010. Multiple imputation was used to impute missing values and logistic regression analysis was used to analyze the risk factors.Results: The crude prevalence of CHD was estimated to be 23.5% and a standardized prevalence was 13.9% (16.0% in men and 11.9% in women). More than half of diabetic patients with CHD have 4 or above of the 5 traditional risk factors, which is much higher than 38.96% of diabetic patients (p<0.01). Multivariate regression analysis showed that diabetes duration, hypertension, smoking, underweight, overweight, obesity, hypoglycemia were significantly associated with a higher risk of CHD (all p<0.05). The odds ratio of CHD in patients having 3, 4, or 5 CHD risk factors were 2.35 (95%CI 1.81- 3.04), 2.96 (95%CI 2.28- 3.85), and 5.29 (95%CI 4.04- 6.93), compared with diabetes patients without any other risk factors.Conclusions: The prevalence of CHD was rather high in Chinese T2DM inpatients, aggregation of CHD risk factors was more seriously, hierarchical CHD prevention strategies based on risk factors are needed for them.

scholarly journals EFFECT OF EXERCISE ON INSULIN RESISTANCE IN OBESE TYPE 2 DIABETES PATIENTS

2022 ◽  
Vol 28 (1) ◽  
pp. 59-61
Author(s):  
Bin Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Resistance Index ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetes Patients

ABSTRACT Introduction: Type 2 diabetes mellitus (T2DM), also known as non-insulin-dependent diabetes mellitus (NIDDM), accounts for more than 90% of the total number of diabetes mellitus cases and often occurs in middle-aged and elderly people. Objective: To investigate the effect of exercise intervention on insulin resistance in obese type 2 diabetes patients. Methods: Eighty-six obese diabetic patients were screened as experimental subjects in physical examinations and randomly divided into observation and control groups. Visceral fat volume, fasting blood glucose, and fasting insulin of all subjects were measured before and after completion of the 6-month experimental implementation. The insulin resistance was calculated for both groups and the values for each indicator were compared statistically between groups. Results: Control of body weight, body mass index, blood glucose, blood lipids and insulin resistance index were better in the observation group than in the control group, and the difference was statistically significant (P < 0.05). Conclusions: Basal intervention with quantitative exercise can significantly improve insulin resistance in obese type 2 diabetes patients and the effect is better than treatment with diet and conventional exercise. Level of evidence II; Therapeutic studies - investigation of treatment results.

scholarly journals Flow Mediated Dilatation Is Reduced with the Progressive Stages of Glomerular Filtration Rate and Albuminuria in Type 2 Diabetic Patients without Coronary Heart Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Hiroyuki Ito ◽  
Mina Nakashima ◽  
Kentaro Meguro ◽  
Haruki Furukawa ◽  
Hitomi Yamashita ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Flow Mediated Dilatation

We aimed to clarify the usefulness of measuring the flow mediated dilatation (FMD) in patients with type 2 diabetes mellitus without and with coronary heart disease (CHD). The FMD was measured in 480 patients with type 2 diabetes and in 240 nondiabetic subjects. The FMD was significantly lower in the subjects with CHD (n= 145,5.4±3.2%) than in those without CHD (n= 95,6.9±3.5%) among the nondiabetic subjects. The FMD was also lower in the subjects both with CHD (n= 161,5.6±2.8%) and without CHD (n= 319,6.1±3.3%) among the patients with diabetes compared to those without both diabetes and CHD. The FMD showed a significant positive correlation with the estimated glomerular filtration rate (eGFR) in the diabetic patients without CHD, while there was no significant association in those with CHD. The FMD was significantly lower with the progressive stages of the GFR or albuminuria in the patients without CHD among those with diabetes, although the FMD was not different in those with CHD. In conclusion, the FMD is considered to be useful for the detection of atherosclerosis in patients with type 2 diabetes, even if overt macroangiopathy is not diagnosed.

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