scholarly journals IL-10 and TNFαGenotypes in SLE

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Patricia López ◽  
Carmen Gutiérrez ◽  
Ana Suárez
Keyword(s):  
Genetic Variants ◽  
Cytokine Production ◽  
Clinical Phenotype ◽  
Lymphocyte Activation ◽  
Interleukin 10 ◽  
Promoter Regions ◽  
Relevant Role ◽  
Steady State Levels ◽  
Necrosis Factor

The production of two regulators of the inflammatory response, interleukin 10 (IL-10) and tumor necrosis factorα(TNFα), has been found to be deeply deregulated in SLE patients, suggesting that these cytokines may be involved in the pathogenesis of the disease. Genetic polymorphisms at the promoter regions of IL-10 and TNFαgenes have been associated with different constitutive and induced cytokine production. Given that individual steady-state levels of these molecules may deviate an initial immune response towards different forms of lymphocyte activation, functional genetic variants in their promoters could influence the development of SLE. The present review summarizes the information previously reported about the involvement of IL-10 and TNFαgenetic variants on SLE appearance, clinical phenotype, and outcome. We show that, in spite of the heterogeneity of the populations studied, the existing knowledge points towards a relevant role of IL-10 and TNFαgenotypes in SLE.

Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-α

1995 ◽  
Vol 25 (10) ◽  
pp. 2888-2893 ◽  
Author(s):  
Johannes Barsig ◽  
Sabine Küsters ◽  
Kathrin Vogt ◽  
Hans-Dieter Volk ◽  
Gisa Tiegs ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Redundancy and recombination in the Echinococcus AgB multigene family: is there any similarity with protozoan contingency genes?

Parasitology ◽  
2006 ◽  
Vol 133 (4) ◽  
pp. 411-419 ◽  
Author(s):  
K. L. HAAG ◽  
B. GOTTSTEIN ◽  
N. MÜLLER ◽  
A. SCHNORR ◽  
F. J. AYALA
Keyword(s):  
Genetic Variants ◽  
Multigene Family ◽  
Somatic Hypermutation ◽  
Host Immunity ◽  
Promoter Regions ◽  
Antigen B ◽  
Gene Copies ◽  
Upstream Promoter ◽  
Gene Redundancy

Numerous genetic variants of the Echinococcus antigen B (AgB) are encountered within a single metacestode. This could be a reflection of gene redundancy or the result of a somatic hypermutation process. We evaluate the complexity of the AgB multigene family by characterizing the upstream promoter regions of the 4 already known genes (EgAgB1-EgAgB4) and evaluating their redundancy in the genome of 3 Echinococcus species (E. granulosus, E. ortleppi and E. multilocularis) using PCR-based approaches. We have ascertained that the number of AgB gene copies is quite variable, both within and between species. The most repetitive gene seems to be AgB3, of which there are more than 110 copies in E. ortleppi. For E. granulosus, we have cloned and characterized 10 distinct upstream promoter regions of AgB3 from a single metacestode. Our sequences suggest that AgB1 and AgB3 are involved in gene conversion. These results are discussed in light of the role of gene redundancy and recombination in parasite evasion mechanisms of host immunity, which at present are known for protozoan organisms, but virtually unknown for multicellular parasites.

scholarly journals The role of cytokines in the prognosis of children with dengue shock syndrome in vietnam

2019 ◽  
Vol 10 (3) ◽  
pp. 2519-2524
Author(s):  
Tram Van Ta ◽  
Hai Thanh Tran ◽  
Quyen Nguyen Than Ha ◽  
Xuong Tuyet Nguyen ◽  
Vu Kien Tran ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Interleukin 10 ◽  
Cytokine Levels ◽  
Almost All ◽  
Factor Α ◽  
Necrosis Factor

Dengue shock syndrome (DSS) is a severe complication of dengue hemorrhagic fever (DHF) and can lead to death, but DSS incidence and effects are difficult to predict via clinical examination. With consideration of this issue, this research determined the role of cytokines in the severity and prognosis of DHF in children. This prospective cohort research involved 234 patients who were aged 18 months to 18 years old, admitted to Tien Giang General Hospital, and diagnosed as having DHF. The cytokine levels of the patients were recorded from admission to discharge. Almost all the patients (>67%) exhibited increased interleukin 10 (IL-10), IL-6, and IL-2, whereas only 0.43% (the lowest) presented with elevated IL-12. Concentrations of IL-2, IL-4, IL-13, and tumor necrosis factor-α were highest in the patients infected with DENV-1, followed by those infected with DENV-3 and DENV-2. IL-12 concentration decreased with increasing days of fever occurrence. No correlation was found between cytokine concentrations in the first day of hospitalization and shock in the DHF patients. The concentration of cytokines during the first day of hospitalization (i.e., patients with a fever lasting less than 72 hours) cannot be used as a guide in determining DSS prognosis.

scholarly journals Dysregulation of Cytokines in Acute Q Fever: Role of Interleukin‐10 and Tumor Necrosis Factor in Chronic Evolution of Q Fever

2003 ◽  
Vol 187 (6) ◽  
pp. 956-962 ◽  
Author(s):  
Amélie Honstettre ◽  
Guenièvre Imbert ◽  
Eric Ghigo ◽  
Frédérique Gouriet ◽  
Christian Capo ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Q Fever ◽  
Interleukin 10 ◽  
Acute Q Fever ◽  
Necrosis Factor
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