scholarly journals Partial Ureteropelvic Junction Disruption after Blunt Trauma: Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Jalal Eddine El Ammari ◽  
Youness Ahallal ◽  
Mohammed Jamal El Fassi ◽  
M. Hassan Farih
Keyword(s):  
Blunt Trauma ◽  
Multiple Organ ◽  
Ureteropelvic Junction ◽  
Current Status ◽  
Tender Mass ◽  
Trauma Case ◽  
High Index Of Suspicion ◽  
Delays In Diagnosis ◽  
Retrograde Ureteropyelography ◽  
Made In

Partial ureteropelvic junction disruption as a result of blunt trauma is rare and frequently missed by the initial trauma evaluation. Delays in diagnosis have also been associated with significant morbidity. A high index of suspicion should lead to appropriate investigations, and the management will be determined by the severity of the disruption. We present herein a 24-year-old man who was admitted to the Emergency Room with multiple organ injuries caused by a severe blunt trauma. Emergency celiotomy was performed for massive hemoperitoneum and shattered spleen which led to splenectomy. The diagnosis of partial UPJ disruption was missed preoperatively and suspected in CT scan after appearance of flank tender mass. Confirmation was obtained in retrograde ureteropyelography and treated conservatively with indwelling ureteral stent. We present herein an extensive review of the literature to examine the current status of this entity and to determine if improvements could be made in the diagnosis and treatment.

scholarly journals Post Traumatic Isolated Ureteropelvic Junction Avulsion in a Child

2016 ◽  
Vol 10 (3) ◽  
pp. 160-162 ◽  
Author(s):  
Tanveer I. Dar ◽  
Muddasar H. Rather ◽  
Abdul R. Khawaja ◽  
Mujahid A. Mir ◽  
Syed S. Nazir
Keyword(s):  
Blunt Trauma ◽  
High Index ◽  
Initial Presentation ◽  
Ureteropelvic Junction ◽  
Post Traumatic ◽  
High Index Of Suspicion

Isolated ureteropelvic junction injuries due to blunt trauma are very rare and are missed at initial presentation in more than 50% patients. Hence they need high index of suspicion for diagnosis which is the main aim of reporting this case.

The Role of Histones and Heparin in Sepsis: A Review

2021 ◽  
pp. 088506662199232
Author(s):  
Xiaojuan Zhang ◽  
Xin Li
Keyword(s):  
Septic Shock ◽  
Multiple Organ ◽  
Clinical Settings ◽  
The Past ◽  
Life Saving ◽  
Extracellular Histones ◽  
Sepsis And Septic Shock ◽  
Development And Management ◽  
Made In

Septic shock with multiple organ failure is a devastating situation in clinical settings. Through the past decades, much progress has been made in the management of sepsis and its underlying pathogenesis, but a highly effective therapeutic has not been developed. Recently, macromolecules such as histones have been targeted in the treatment of sepsis. Histones primarily function as chromosomal organizers to pack DNA and regulate its transcription through epigenetic mechanisms. However, a growing body of research has shown that histone family members can also exert cellular toxicity once they relocate from the nucleus into the extracellular space. Heparin, a commonly used anti-coagulant, has been shown to possess life-saving capabilities for septic patients, but the potential interplay between heparin and extracellular histones has not been investigated. In this review, we summarize the pathogenic roles of extracellular histones and the therapeutic roles of heparin in the development and management of sepsis and septic shock.

scholarly journals Narrative review of EHDI in South Africa

2015 ◽  
Vol 62 (1) ◽  
Author(s):  
Selvarani Moodley ◽  
Claudine Storbeck
Keyword(s):  
South Africa ◽  
Hearing Loss ◽  
Hearing Screening ◽  
Narrative Review ◽  
Current Status ◽  
Western Cape ◽  
Comprehensive Overview ◽  
National Priority ◽  
Newborn Hearing ◽  
Made In

Background: With 17 babies born with hearing loss every day in South Africa, there is a pressing need for systematic Early Hearing Detection and Intervention (EHDI) services. Progress is being made in offering newborn hearing screening and studies have been conducted to document these processes within South Africa. However, due to the lack of a national and holistic overview of EHDI services to date, an accurate picture of the current status of EHDI within the South African context is required. Objective: To document and profile what has been published within the field of EHDI in South Africa over the last two decades (Jan 1995–Sept 2014) in order to gain a comprehensive overview of the current status and practice of screening and diagnosis in the field of paediatric hearing loss. Method: A narrative review of peer-reviewed articles related to EHDI in South Africa was conducted by searching the EBSCOHOST, SCOPUS and JSTOR databases for the period January 1995 to September 2014. Results: Results indicate that over the last two decades research and publications in the field of EHDI have increased considerably. These publications have revealed extensive knowledge related to paediatric hearing screening and intervention services in South Africa; however, this knowledge seems to be limited primarily to the provinces of Gauteng and the Western Cape. Furthermore, studies pertaining to diagnosis have revealed that, although much has been written on the scientific aspects on tools for diagnosis of hearing loss, there is a lack of comprehensive information on diagnostic protocols and procedures. Conclusion: Despite the clear progress being made in South Africa in the field of early hearing detection and intervention, there is a need for comprehensive studies on protocols and procedures in diagnosing paediatric hearing loss. Finally, the narrative review revealed a clear need to ensure that development and growth in the field of EHDI is a national priority and extends beyond the two provinces currently showing growth.

Acute Patellar Osteomyelitis in a Child after a Blunt Trauma: Case Report

2016 ◽  
Vol 29 (4) ◽  
pp. 270
Author(s):  
Hoe Jeong Chung ◽  
Doo Sup Kim ◽  
Jun Seop Yeom ◽  
Young Hwan Jang
Keyword(s):  
Case Report ◽  
Blunt Trauma ◽  
Trauma Case

The current status of aquatic biological resources and their habitat cross-border section in the Dnieper river within the Smolensk region Russian Federation and the Republic of Belarus

2021 ◽  
pp. 8-21
Author(s):  
Alexey Ivanovich Nikitenko ◽  
Dmitry Vladimirovich Goryachev ◽  
Vladimir Gennadlevich Kostousov ◽  
Georgy Prokofievich Prischepov ◽  
Viktor Kazimirovich Rizevsky ◽  
...  
Keyword(s):  
Size Structure ◽  
Reproductive Potential ◽  
Current Status ◽  
Commercial Fishing ◽  
Biological Resources ◽  
The Status ◽  
The Republic ◽  
Share Value ◽  
Made In ◽  
Russian Section

The study presents materials on the status of aquatic biological resources and their habitat in the Dnieper River within the territory of the Russian and the Belarus. In the recent period, there has been hardly any complex fishery research in the upper reach of the river within the boundaries of the Smolensk Region due to the lack of commercial fishing; the same can be applied to the reach of the river within the Vitebsk Region in Belarus. The collection of materials and scientific and research accounting network surveys for monitoring the state of aquatic bioresources were carried out on the Dnieper River as part of the research in 2019 according to a preplanned grid of stations. When fishing for scientific research purposes, 20 net-stops of smooth frame nets were made in the Russian section, and 9 net-stops were made in the Belarusian section. In the Russian section of the Dnieper River, the species composition was 16 species of fish, and in the Belarusian section — 22 species. The main catch in the Russian section is roach 29% and chub 20%, in the Belarusian section bream — from 3 to 46%, roach — from 19 to 63% and gustera — from 1.8 to 33%, in a slightly smaller number of river perch (on average up to 10%). The share value of roach and guster tends to decrease from the upper to the lower areas, bream-on the contrary to increase, the value of perch is approximately equal in all areas. In the size structure of the caught fish species, there is a dynamic with a good reproductive potential.

scholarly journals Drug Discovery against Acanthamoeba Infections: Present Knowledge and Unmet Needs

Pathogens ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 405 ◽  
Author(s):  
Hany M. Elsheikha ◽  
Ruqaiyyah Siddiqui ◽  
Naveed Ahmed Khan
Keyword(s):  
Recent Progress ◽  
Unmet Needs ◽  
Drug Repurposing ◽  
Present Knowledge ◽  
Current Status ◽  
Therapeutic Landscape ◽  
Pharmacological Targets ◽  
Health Complications ◽  
Interfering Rna ◽  
Made In

Although major strides have been made in developing and testing various anti-acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health complications, and side effects associated with the use of currently available drugs necessitate the development of more effective and safe therapeutic regimens. For any new anti-acanthamoebic drugs to be more effective, they must have either superior potency and safety or at least comparable potency and an improved safety profile compared to the existing drugs. The development of the so-called ‘next-generation’ anti-acanthamoebic agents to address this challenge is an active area of research. Here, we review the current status of anti-acanthamoebic drugs and discuss recent progress in identifying novel pharmacological targets and new approaches, such as drug repurposing, development of small interfering RNA (siRNA)-based therapies and testing natural products and their derivatives. Some of the discussed approaches have the potential to change the therapeutic landscape of Acanthamoeba infections.

scholarly journals A Painful Pulsatile Abdominal Mass in a Young Man with Elevated Blood Pressures: An Unusual Presentation of Phaeochromocytoma

2002 ◽  
Vol 30 (4) ◽  
pp. 490-494 ◽  
Author(s):  
B. M. K. Lee ◽  
L. K. Ti
Keyword(s):  
Abdominal Mass ◽  
Ventilatory Support ◽  
Young Patients ◽  
Multiple Organ ◽  
Unusual Presentation ◽  
Adrenergic Blockade ◽  
Elevated Blood ◽  
Delay In Diagnosis ◽  
Blood Pressures ◽  
High Index Of Suspicion

We report an unusual presentation of phaeochromocytoma in a young man with a painful, pulsatile abdominal mass and elevated blood pressures. This led to a delay in diagnosis and resulted in the administration of triggers of catecholamine release, possibly causing a catecholamine surge. This caused the development of catecholamine-induced cardiomyopathy and multiple organ failure, requiring inotropic and ventilatory support, intra-aortic balloon pump and dialysis. Fortunately, his condition reversed with supportive treatment and alpha-adrenergic blockade. This illustrates the importance of having a high index of suspicion of phaeochromocytoma, especially in young patients with elevated blood pressures.

scholarly journals Lassa Fever: Viral Replication, Disease Pathogenesis, and Host Immune Modulations

Pathogens ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 437
Author(s):  
Hinh Ly
Keyword(s):  
Lassa Fever ◽  
West African ◽  
Host Factors ◽  
Current Status ◽  
Special Issue ◽  
African Countries ◽  
Disease Pathogenesis ◽  
Virus Life Cycle ◽  
Key Issues ◽  
Made In

Despite major discoveries made in the last few decades about Lassa fever, there are still many unresolved key issues that hamper the development of effective vaccines and therapies against this deadly disease that is endemic in several West African countries. Some of these issues include the lack of a detailed understanding of the viral and participating host factors in completing the virus life cycle, in mediating disease pathogenesis or protection from disease, and in activating or suppressing host innate and cellular immunity against virus infection, as well as of the animal models required for testing vaccines and therapeutics. This Special Issue is devoted to understanding some of these important issues and to exploring the current status of the research and development in combating Lassa fever.

scholarly journals Predicting the geoeffective properties of coronal mass ejections: current status, open issues and path forward

2019 ◽  
Vol 377 (2148) ◽  
pp. 20180096 ◽  
Author(s):  
A. Vourlidas ◽  
S. Patsourakos ◽  
N. P. Savani
Keyword(s):  
Space Weather ◽  
Coronal Mass Ejections ◽  
Technology Development ◽  
Action Plan ◽  
Current Status ◽  
Weather Impact ◽  
Solar Eruptions ◽  
Holding Back ◽  
Open Issues ◽  
Made In

Much progress has been made in the study of coronal mass ejections (CMEs), the main drivers of terrestrial space weather thanks to the deployment of several missions in the last decade. The flow of energy required to power solar eruptions is beginning to be understood. The initiation of CMEs is routinely observed with cadences of tens of seconds with arc-second resolution. Their inner heliospheric evolution can now be imaged and followed routinely. Yet relatively little progress has been made in predicting the geoeffectiveness of a particular CME. Why is that? What are the issues holding back progress in medium-term forecasting of space weather? To answer these questions, we review, here, the measurements, status and open issues on the main CME geoeffective parameters; namely, their entrained magnetic field strength and configuration, their Earth arrival time and speed, and their mass (momentum). We offer strategies for improving the accuracy of the measurements and their forecasting in the near and mid-term future. To spark further discussion, we incorporate our suggestions into a top-level draft action plan that includes suggestions for sensor deployment, technology development and modelling/theory improvements. This article is part of the theme issue ‘Solar eruptions and their space weather impact’.

scholarly journals MEASUREMENT OF THE η → π+π-π0 DECAY WITH WASA-at-COSY DETECTOR

2011 ◽  
Vol 26 (03n04) ◽  
pp. 622-624
Author(s):  
◽  
PATRIK ADLARSON ◽  
MARCIN ZIELIŃSKI
Keyword(s):  
Dalitz Plot ◽  
Quark Mass ◽  
Mass Difference ◽  
Current Status ◽  
Hadronic Decays ◽  
Density Population ◽  
Physics Programme ◽  
Made In

One of the objectives of the physics programme of the WASA-at-COSY facility is to study the isospin violating η hadronic decays into π+π-π0 systems driven by the term of QCD Lagrangian which depends on the d and u quark mass difference. These studies can be made in terms of the Dalitz plot parameters describing the density population which is proportional to the square of the amplitude |A(x, y)|2. This contribution describes the current status of the analysis of the η → π+π-π0 decay in the pd →3 Heη and as well in the pp → ppη reaction with WASA-at-COSY.

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