scholarly journals Ceramide in Cystic Fibrosis: A Potential New Target for Therapeutic Intervention

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Gabriella Wojewodka ◽  
Juan B. De Sanctis ◽  
Danuta Radzioch
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Inflammatory Response ◽  
Therapeutic Intervention ◽  
Bacterial Infections ◽  
Potential Role ◽  
Cell Signalling ◽  
Membrane Microdomains ◽  
Molecular Processes

Patients with cystic fibrosis (CF) are afflicted with many symptoms but the greatest challenge is the fight against chronic bacterial infections, leading to decreased lung function and ultimately death. Our group has recently found reduced levels of ceramides in CF patients and mice. Ceramides are sphingolipids involved in the structure of cell membranes but also participate in the inflammatory response, in cell signalling through membrane microdomains (lipid rafts), and in apoptosis. These characteristics of ceramides make them strong candidates for therapeutic intervention in CF. As more studies have come to evaluate the role of ceramide in CF, conflicting results have been described. This paper discusses various views regarding the potential role of ceramide in CF, summarizes methods of ceramide detection and their role in the regulation of cellular and molecular processes.

scholarly journals Cystic fibrosis-related diabetes and lung disease: an update

2021 ◽  
Vol 30 (159) ◽  
pp. 200293
Author(s):  
Bernadette J. Prentice ◽  
Adam Jaffe ◽  
Shihab Hameed ◽  
Charles F. Verge ◽  
Shafagh Waters ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
High Glucose ◽  
Potential Role ◽  
Early Mortality ◽  
Genetic Modifiers ◽  
Immunomodulatory Effects ◽  
Glucose Levels ◽  
The Many

The development of cystic fibrosis-related diabetes (CFRD) often leads to poorer outcomes in patients with cystic fibrosis including increases in pulmonary exacerbations, poorer lung function and early mortality. This review highlights the many factors contributing to the clinical decline seen in patients diagnosed with CFRD, highlighting the important role of nutrition, the direct effect of hyperglycaemia on the lungs, the immunomodulatory effects of high glucose levels and the potential role of genetic modifiers in CFRD.

Potential role of the cellular allergen stimulation test (CAST) in diagnosis of allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis

2007 ◽  
Vol 42 (4) ◽  
pp. 314-318 ◽  
Author(s):  
Stephanie Ringer ◽  
Uta-Christina Hipler ◽  
Peter Elsner ◽  
Felix Zintl ◽  
Jochen Mainz
Keyword(s):  
Cystic Fibrosis ◽  
Potential Role ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Stimulation Test

Abstract 105: Platelet-Neutrophil Aggregates play a crucial role in regulating vasculitis in Kawasaki Disease

Circulation ◽  
2015 ◽  
Vol 131 (suppl_2) ◽  
Author(s):  
Kentaro Ueno
Keyword(s):  
Kawasaki Disease ◽  
Crucial Role ◽  
Bacterial Infections ◽  
Time Course ◽  
Acute Inflammation ◽  
Potential Role ◽  
Platelet Factor ◽  
Normal Volunteers ◽  
Inflammatory Activation

Objective: Circulating platelet-neutrophil aggregates play a crucial role in amplifying acute inflammation and could promote adverse effects involving vascular injury. The aim of this study was to clarify the role of platelet-neutrophil aggregates in patients with Kawasaki disease (KD). Methods: We analyzed 40 patients with KD (30 intravenous immunoglobulin [IVIG] responders and 10 IVIG non-responders), 7 febrile patients with bacterial infections, and 9 normal volunteers. Thirty-three patients with KD were treated with IVIG alone, and remaining seven were treated with IVIG plus prednisolone. We evaluated the rate of platelet-neutrophil aggregates and measured the platelet factor 4 (PF4) and β-thromboglobulin (β-TG) levels in patients with KD. Results: The rate of platelet-neutrophil aggregates was significantly higher in patients with KD than in both patients with bacterial infection and normal volunteers. There was a trend toward increased rate of platelet-neutrophil aggregates within 2 or 3 days after IVIG than before IVIG. The rate of platelet-neutrophil aggregates was significantly higher in patients who showed coronary artery abnormalities (CAA) than in those who showed without CAA and was correlated with PF4 and β-TG levels in patients with KD. Comparing time course analysis, the rate of platelet-neutrophil aggregates was significantly decreased in patients treated with IVIG plus prednisolone than in those treated with IVIG alone. Conclusions: Our findings demonstrate that platelet-neutrophil aggregates play a crucial role in regulating vasculitis, and are involved in the development of CAA. Additional prednisolone treatment in the acute phase of KD might have a potential role in inhibiting amplified reciprocal inflammatory activation by suppressing platelet-neutrophil aggregates.

scholarly journals Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Uta Düesberg ◽  
Julia Wosniok ◽  
Lutz Naehrlich ◽  
Patience Eschenhagen ◽  
Carsten Schwarz
Keyword(s):  
Risk Factors ◽  
Cystic Fibrosis ◽  
Lung Function ◽  
Aspergillus Fumigatus ◽  
Age Groups ◽  
Antibiotic Use ◽  
Lower Lung ◽  
Lung Infections ◽  
The Impact

Abstract Airway inflammation and chronic lung infections in cystic fibrosis (CF) patients are mostly caused by bacteria, e.g. Pseudomonas aeruginosa (PA). The role of fungi in the CF lung is still not well elucidated, but evidence for a harmful and complex role is getting stronger. The most common filamentous fungus in CF is Aspergillus fumigatus (AF). Age and continuous antibiotic treatment have been discussed as risk factors for AF colonisation but did not differentiate between transient and persistent AF colonisation. Also, the impact of co-colonisation of PA and AF on lung function is still under investigation. Data from patients with CF registered in the German Cystic Fibrosis Registry database in 2016 and 2017 were retrospectively analysed, involving descriptive and multivariate analysis to assess risk factors for transient or persistent AF colonisation. Age represented an independent risk factor for persistent AF colonisation. Prevalence was low in children less than ten years, highest in the middle age and getting lower in higher age (≥ 50 years). Continuous antibiotic lung treatment was significantly associated with AF prevalence in all age groups. CF patients with chronic PA infection had a lower lung function (FEV1%predicted), which was not influenced by an additional AF colonisation. AF colonisation without chronic PA infection, however, was significantly associated with a lower function, too. Older age up to 49 years and continuous antibiotic use were found to be the main risk factors for AF permanent colonisation. AF might be associated with decrease of lung function if not disguised by chronic PA infection.

Control of the inflammatory response during pregnancy: potential role of VIP as a regulatory peptide

2018 ◽  
Vol 1437 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Rosanna Ramhorst ◽  
Guillermina Calo ◽  
Daniel Paparini ◽  
Daiana Vota ◽  
Vanesa Hauk ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Potential Role ◽  
Regulatory Peptide

Inflammation response after the cessation of chronic arsenic exposure and post-treatment of natural astaxanthin in liver: potential role of cytokine-mediated cell–cell interactions

2020 ◽  
Vol 11 (10) ◽  
pp. 9252-9262 ◽  
Author(s):  
Zhigang Zhang ◽  
Changming Guo ◽  
Huijie Jiang ◽  
Bing Han ◽  
Xiaoqiao Wang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Rat Liver ◽  
Potential Role ◽  
Arsenic Exposure ◽  
Post Treatment ◽  
Cell Interactions ◽  
Schematic Diagram ◽  
Inflammation Response ◽  
Chronic Arsenic Exposure

Schematic diagram of the mechanism of post treatment with natural astaxanthin attenuating arsenic-induced inflammatory response in rat liver.

Potential Role of Trimethoprim-Sulfamethoxazole in the Treatment of Serious Hospital-Acquired Bacterial Infections

1987 ◽  
Vol 9 (Supplement_2) ◽  
pp. S160-S165 ◽  
Author(s):  
Richard Quintiliani ◽  
Robert E. Levitz ◽  
Charles H. Nightingale
Keyword(s):  
Bacterial Infections ◽  
Potential Role ◽  
Hospital Acquired

scholarly journals The CFTR and ENaC debate: how important is ENaC in CF lung disease?

2012 ◽  
Vol 302 (11) ◽  
pp. L1141-L1146 ◽  
Author(s):  
James F. Collawn ◽  
Ahmed Lazrak ◽  
Zsuzsa Bebok ◽  
Sadis Matalon
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Bacterial Infections ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Ongoing Debate ◽  
The Subject ◽  
Cystic Fibrosis Transmembrane ◽  
Epithelial Sodium Channel Enac

Cystic fibrosis (CF) is caused by the loss of the cystic fibrosis transmembrane conductance regulator (CFTR) function and results in a respiratory phenotype that is characterized by dehydrated mucus and bacterial infections that affect CF patients throughout their lives. Much of the morbidity and mortality in CF results from a failure to clear bacteria from the lungs. What causes the defect in the bacterial clearance in the CF lung has been the subject of an ongoing debate. Here we discuss the arguments for and against the role of the epithelial sodium channel, ENaC, in the development of CF lung disease.

Sign in / Sign up

Export Citation Format

Share Document