scholarly journals Lipid-Lowering and Antioxidative Activities of Aqueous Extracts ofOcimum sanctumL. Leaves in Rats Fed with a High-Cholesterol Diet

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Thamolwan Suanarunsawat ◽  
Watcharaporn Devakul Na Ayutthaya ◽  
Thanapat Songsak ◽  
Suwan Thirawarapan ◽  
Somlak Poungshompoo
Keyword(s):  
Lipid Profile ◽  
Bile Acids ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Ocimum Sanctum ◽  
High Cholesterol ◽  
Leaf Extracts ◽  
Cardiac Tissues ◽  
High Level

The present study was conducted to investigate the lipid-lowering and antioxidative activities ofOcimum sanctumL. (OS) leaf extracts in liver and heart of rats fed with high-cholesterol (HC) diet for seven weeks. The results shows that OS suppressed the high levels of serum lipid profile and hepatic lipid content without significant effects on fecal lipid excretion. Fecal bile acids excretion was increased in HC rats treated with OS. The high serum levels of TBARS as well as AST, ALT, AP, LDH, CK-MB significantly decreased in HC rats treated with OS. OS suppressed the high level of TABARS and raised the low activities of GPx and CAT without any impact on SOD in the liver. As for the cardiac tissues, OS lowered the high level of TABARS, and raised the activities of GPx, CAT, and SOD. Histopathological results show that OS preserved the liver and myocardial tissues. It can be concluded that OS leaf extracts decreased hepatic and serum lipid profile, and provided the liver and cardiac tissues with protection from hypercholesterolemia. The lipid-lowering effect is probably due to the rise of bile acids synthesis using cholesterol as precursor, and antioxidative activity to protect liver from hypercholesterolemia.

scholarly journals Effect of Ethanol Extract of Glycine Max (Soy Bean) on Serum Lipid Profile of Fat-Fed Hyperlipidemic Rats

2018 ◽  
Vol 10 (1) ◽  
pp. 21-26
Author(s):  
K Sharmin ◽  
R Ahmed ◽  
A Momtaz ◽  
SA Chowdhury ◽  
NA Maya ◽  
...  
Keyword(s):  
Glycine Max ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Experimentally Induced

Hypercholesterolemia is one of the important causes of cardiovascular disease related mortality and morbidity and recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to see the effect of glycine max (soy bean) on serum lipid profile of experimentally induced hyperlipidemic rats. Hypercholesterolemia was induced by high cholesterol diet containing 1% cholesterol in olive oil. This study was done on 24 long Norwegian rats (Rattus norvegicus) weighing about 200-210 gram. For convenience, the study was divided into Experiment I and Experiment II. In experiment I, 12 rats were divided into two groups- Group A (n = 6, control group) fed on laboratory diet and Group B (n=6) fed on laboratory diet and soy bean extract for 35 days. In experiment II, the remaining 12 rats were divided into 2 groups, Group C (n=6) were fed on laboratory diet and high cholesterol diet (HCD) for 35 days and Group D (n=6) were fed laboratory diet and high cholesterol diet on initial 10 days and soy bean extract was added along with high cholesterol diet for next 25 days. Serum TC, TG, LDL-C and HDL-C were measured after 35 days. HCD increased TG, TC and LDL-C significantly in group C. Glycine max (soy bean) treated group showed that it decreased plasma TC, TG and LDL-C in experimentally induced hyperlipidemic rats but Glycine max (soy bean) did not show any significant lipid lowering effect in normolipidemic rats. The results of this experimental study indicate that Glycine max can act as a cholesterol lowering agent and thereby can improve cardiovascular functions.Bangladesh J Med Biochem 2017; 10(1): 21-26

Comparative Effect of Garden Egg Fruit, Oat and Apple on Serum Lipid Profile in Rats Fed a High Cholesterol Diet

2005 ◽  
Vol 4 (4) ◽  
pp. 245-249 ◽  
Author(s):  
James Karho Edijala . ◽  
Samuel Ogheneovo Asa . ◽  
George Edaghogho Eri . ◽  
Uzezi Atomatofa .
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Comparative Effect

scholarly journals Study of serum lipid profile in type 2 diabetes mellitus patients and its association with diabetic nephropathy

2017 ◽  
Vol 4 (6) ◽  
pp. 1513 ◽  
Author(s):  
Ullasini Kolhar ◽  
Priyanka P.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Lipid Lowering

Background: Dyslipidaemia is highly prevalent in type 2 Diabetes mellitus patients. The role of dyslipidaemia in macrovascular complications of Diabetes have been extensively studied but its role in microvascular complications namely nephropathy is still unclear. The present study was undertaken to study the prevalence and pattern of dyslipidaemia and its association with Diabetic nephropathy (DN) in patients with type 2 DM.Methods: 100 patients with type 2 DM attending OPD or admitted, over a period of 1 year were studied. Detailed history was taken and clinical examination was done. Serum lipid profile was studied in all patients and its association with DN was assessed.Results: The prevalence of dyslipidaemia in DM patients in our study was 90% and there was no statistically significant difference in the prevalence among males and females. Poorly controlled diabetics had high prevalence of dyslipidaemia as compared to well controlled diabetics. The prevalence of Diabetic nephropathy in our study was 41%. There was significant association of DN with high Total Cholesterol, high Low-density lipoprotein (LDL-C) and high Triglycerides. There was no significant association of DN with High density lipoprotein (HDL-C).Conclusions: Present study highlights the magnitude of dyslipidaemia in type2 DM patients and that there is a significant association of DN with lipid parameters. Hence patients should be managed with life style modifications with or without lipid lowering agents to achieve target lipid values along with adequate glycemic control to prevent or delay the appearance and progression of DN.

Apple Cider Vinegar Modulates Serum Lipid Profile, Erythrocyte, Kidney, and Liver Membrane Oxidative Stress in Ovariectomized Mice Fed High Cholesterol

2014 ◽  
Vol 247 (8) ◽  
pp. 667-673 ◽  
Author(s):  
Mustafa Nazıroğlu ◽  
Mustafa Güler ◽  
Cemil Özgül ◽  
Gündüzalp Saydam ◽  
Mustafa Küçükayaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
High Cholesterol ◽  
Apple Cider ◽  
Ovariectomized Mice ◽  
Liver Membrane

scholarly journals Pulverized Mangifera indica (Mango) Seed-kernel Modulated Serum Lipid Profile in Monosodium Glutamate-challenged Rats

2017 ◽  
Vol 5 (2) ◽  
pp. 72 ◽  
Author(s):  
Anthony Cemaluk C. Egbuonu ◽  
Gladys A. Ekwuribe
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Mangifera Indica ◽  
Monosodium Glutamate ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Oral Exposure ◽  
Seed Kernel ◽  
Sample Extract

Mangifera indica seed kernel was assessed for antinutirent content and effects on serum lipid profile of monosodium glutamate-challenged rats. Group A rats received 8000 mg/kg body weight, b.w of monosodium glutamate (MSG). Group B rats received the sample extract (300 mg/kg b.w). Group C rats were sham-administered distilled water. Groups D and E rats received 8000 mg/kg b.w of MSG in addition to 200 and 400 mg/kg b.w, respectively of sample extract. Tannin (29.21±5.39 mg/100 g) was highest (p<0.05) while phytate (0.38±0.02 mg/100g) was least. After fourteen days daily oral exposure, MSG-exposed rats had higher (p<0.05) total cholesterol (CHOL), triacylglycerol (TAG) and low density lipoprotein (LDL) but lower (p<0.05) high density lipoprotein (HDL) concentration compared to rats in the other groups. MSG-intoxicated rats co-treated respectively with 200 and 400 mg/kg b.w of the extract had dose dependent reduction (p<0.05) compared to the corresponding effects in non-extract-co-treated MSG-intoxicated rats. Compared to others, rats in the Extract group had higher (p<0.05) CHOL: TAG but lower (p<0.05) TAG:CHOL ratios while rats in the MSG-group had higher (p<0.05) HDL:LDL but lower (p<0.05) LDL:HDL ratios. Results demonstrated the preponderance of tannin in, and significant serum lipid lowering potential in normal and MSG-challenged rats of, the sample. Studies using antinutrient-process-reduced sample in hyperlipidemia-related health-challenged models and collaborating the suggested implication of lipid-profile-component-ratios are warranted and recommended.

scholarly journals Study of lipid profile in cases of non-diabetic stroke

2018 ◽  
Vol 5 (1) ◽  
pp. 82
Author(s):  
Ayaskanta Kar ◽  
Chinmayananda Dash ◽  
Malati Murmu ◽  
Karun Mahesh K. P.
Keyword(s):  
Ischaemic Stroke ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Elevated Serum ◽  
Haemorrhagic Stroke ◽  
Serum Total Cholesterol ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Diabetic Patients

Background: To study serum lipid profile in non-diabetic patients with stroke and to determine whether there is any significant correlation between them and to compare the serum lipid profile between ischaemic and haemorrhagic group. Design: Case control study.Methods: The current study was done in the Department of Medicine VIMSAR, Burla, Odisha. Total 100 patients of completed stroke (Ischaemic63 and haemorrhagic37) and 30 controls were included in the study. All cases were adult (more than 14 years of age). Patients with suspected embolic stroke, diabetes (Type 1 and 2) and patients on lipid lowering drugs were excluded from the study. Routine investigations and fasting serum lipid profile was done.Results: 45 patients had elevated serum total cholesterol levels out of which 75.56% had Ischaemic stroke and 24.49% had haemorrhagic stroke. 24 cases had elevated serum Triglyceride levels of which 66.67% had Ischaemic stroke and 29.17% had haemorrhagic stroke. 76.47% of cases having elevated serum LDL cholesterol suffered from Ischaemic stroke where as 20.59% had haemorrhagic stroke.Conclusions: A statistically positive correlation was found between serum total cholesterol, Triglyceride, LDL levels and the risk of stroke.

scholarly journals Influence of technological processing on lipid-lowering activity of substances containing in porcine hearts and aortas

10.5219/1119 ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 331-336
Author(s):  
Elena Kotenkova ◽  
Irina Chernukha
Keyword(s):  
Molecular Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Raw Material ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Control Group ◽  
Standard Diet ◽  
Bioactive Substances ◽  
Wide Range

Edible by-products are a good source of nutrients and bioactive substances and could be used as functional ingredients or for biopeptides production natively contained in raw materials. A wide range of peptides are also formed during the enzymatic hydrolysis or food processing. The comparative results of the effectiveness of isolated certain protein and peptide fractions by ultrafiltration with the same natively presented in raw tissues, as well as the influence of heat treatment on biological activity of origin active substances are presented. The model of rat alimentary hyperlipidemia was developed by adding cholesterol and fat to the standard diet and vitamin D2 injection per os. Serum lipid profile was determined on automatic analyzer BioChem FC-360. Dynamic of changes in serum lipid profile was assessed as corresponding control group medium results in ratio to certain rat data. Two-dimensional electrophoresis (2DE) was performed according to the method of O’Farrell with isoelectric focusing in ampholine pH gradient (IEF-PAGE) with following identification by MALDI-TOF MS and MS/MS mass spectrometry. Consumption of native pig aorta and pig heart during 14th days led to normalization of lipid profile in serum of hyperlipidemic rats, while low molecular weight (LMUF, MW <5 kDa) and medium molecular weight (MMUF, MW = 5 – 30 kDa) ultrafiltrates of pig aorta extract did not strongly influenced on level of triglicerides and, on contrary, elevated high density cholesterol. Consumption of developed product by hyperlipidemic rats during 28th days did not lead to significant changes in serum lipid profile, while on 42nd day all ratios reached ones in group, which were treated with native raw material or isolated active fractions. The stability of developed product was confirmed by proteomic studies. Obtained results open prospects to modernization the technology, presumably use as a matrix dietary meat (e.g. poultry) with incorporated active identified components.

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