Age- and Gender-Specific Prevalence of Risk Factors in Patients with First-Ever Ischemic Stroke in China

Background. Evidences are accumulating that age and gender have great impact on the distribution of stroke risk factors. Such data are lacking in Chinese population.Methods. 1027 patients with first-ever ischemic stroke (IS) were recruited and divided into young adult (<50 years), middle-aged (50∼80 years), and very old (>80 years) groups according to stroke onset ages. Vascular risk factors were collected and compared among groups.Results. Female patients were globally older than male patients at stroke onset and having higher prevalence of diabetes mellitus (DM), heart diseases, and atrial fibrillation (AF). However, females were less likely to drink heavily or smoke than males. Young patients had a much higher proportion of smoking and drinking than middle-aged and very old patients and the highest family history of hypertension, while very old patients had the highest prevalence of heart diseases and AF but lowest proportion of positive family history of vascular diseases. Hypertension and DM were equally frequent among three groups.Conclusion. Our study showed that vascular risk factors had a specific age and gender distribution pattern in Chinese IS patients. Secondary prevention strategy should emphasize on the control of different risk factors based on patient’s age and gender.

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Pulsatile hemodynamics and cardiovascular risk factors in very old patients

Journal of Hypertension ◽

10.1097/hjh.0b013e32835ed5b9 ◽

2013 ◽

Vol 31 (5) ◽

pp. 848-857 ◽

Cited By ~ 8

Author(s):

Michel E. Safar ◽

Peter M. Nilsson

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Old Patients ◽

Very Old ◽

Very Old Patients

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Relations between Normal Serum Gamma-glutamyltransferase and Risk Factors of Coronary Heart Diseases according to Age and Gender

Korean Journal of Clinical Laboratory Science ◽

10.15324/kjcls.2016.48.1.22 ◽

2016 ◽

Vol 48 (1) ◽

pp. 22-29

Author(s):

Se Young Kwon ◽

Young Ak Na

Keyword(s):

Risk Factors ◽

Heart Diseases ◽

Normal Serum ◽

Age And Gender ◽

Gamma Glutamyltransferase ◽

Coronary Heart Diseases ◽

And Gender

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Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia

Journal of Clinical Medicine ◽

10.3390/jcm8070961 ◽

2019 ◽

Vol 8 (7) ◽

pp. 961 ◽

Cited By ~ 8

Author(s):

Cillóniz ◽

Dominedò ◽

Ielpo ◽

Ferrer ◽

Gabarrús ◽

...

Keyword(s):

Risk Factors ◽

Prognostic Factors ◽

Antibiotic Therapy ◽

Lower Risk ◽

Chronic Renal Disease ◽

Community Acquired Pneumonia ◽

Old Patients ◽

Very Old ◽

Independent Risk Factors ◽

Very Old Patients

Background: Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4219 patients hospitalized with CAP during the study period, 1238 (29%) were very old. The prevalence of sepsis in this age group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.

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Prevalence and risk factors of sepsis in very old patients with CAP

10.1183/13993003.congress-2019.pa2907 ◽

2019 ◽

Author(s):

Catia Cilloniz Campos ◽

Cristina Dominedò ◽

Antonella Ielpo ◽

Miquel Ferrer ◽

Albert Gabarrús ◽

...

Keyword(s):

Risk Factors ◽

Old Patients ◽

Very Old ◽

Very Old Patients

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Letter to Editor: C-reactive Protein, Physical Disability, And Prognosis In Very Old Patients With Ischemic Stroke

The Journals of Gerontology Series A ◽

10.1093/gerona/57.8.m520 ◽

2002 ◽

Vol 57 (8) ◽

pp. M520-M522 ◽

Cited By ~ 7

Author(s):

E. Ceccarelli ◽

C. Donati ◽

S. Forconi ◽

R. Cappelli ◽

L. Masotti

Keyword(s):

Ischemic Stroke ◽

Physical Disability ◽

C Reactive Protein ◽

Old Patients ◽

Very Old ◽

Reactive Protein ◽

Very Old Patients

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A multicenter report on the natural history of myelodysplastic syndromes in very old patients (aged over 85 years)

Leukemia & Lymphoma ◽

10.1080/10428194.2018.1538513 ◽

2019 ◽

Vol 60 (5) ◽

pp. 1324-1327

Author(s):

Laura S. McDonald ◽

Peter McCarthy ◽

Mohammad Khan ◽

Patrick Hogan ◽

Eileen Kelleher ◽

...

Keyword(s):

Natural History ◽

Myelodysplastic Syndromes ◽

Old Patients ◽

Very Old ◽

History Of ◽

Very Old Patients

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Ischemic Stroke in the Very Old: The Lausanne Stroke Registry

Stroke ◽

10.1161/str.32.suppl_1.365-b ◽

2001 ◽

Vol 32 (suppl_1) ◽

pp. 365-365

Author(s):

Gabriel R de Freitas ◽

Virginija Gaigalaite ◽

Guy van Melle ◽

Gerald Devuyst ◽

Julien Bogousslavsky

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Developed Countries ◽

Large Artery ◽

Short Term ◽

Old Patients ◽

Very Old ◽

Stroke Registry ◽

Poor Outcome ◽

Artery Disease

P145 Background: Although the population of developed countries is changing and the very old represent the fastest-growing group, there are few studies on ischemic stroke in this age group. The aim of this study was to investigate characteristics of ischemic stroke in very old patients (VOP). Methods: We studied risk factors, etiology, clinical findings, lesion topography and short-term (one month) outcome in patients aged 80 years or older presenting with a first ever ischemic stroke compared to younger patients (YP), aged between 45 and 79 years. Logistic regression analysis was used to identify whether very old age was an independent predictor of poor outcome (mRS 4–6). Results: 452 patients (13%) were older than 80 years, and 2,889 (87%) between 45 and 79 years. There was a higher proportion of females in the VOP than in the YP (53% vs. 34%; P<0.001). The VOP group had lower frequencies for smoking (7% vs. 32%; P<0.001), hypercholesterolemia (16% vs. 27%; P<0.001) and an elevated hematocrit (12% vs. 19%; P<0.001). In contrast, a history of atrial fibrillation (23% vs. 9%; P<0.001) and coronary artery disease (30% vs. 22%; P<0.001) was more common in the VOP. Cardioembolic stroke was more frequent in the VOP (28% vs. 21%; P<0.001), whereas large artery disease was less frequent (18% vs. 24%; P<0.001). The frequency of small artery disease was comparable in the two groups. VOP more often presented an abrupt onset of symptoms (81% vs. 73%; P<0.001) and isolated Wernicke-type aphasia (4% vs. 1%; P<0.001), but a lower frequency of headache (7% vs. 14%; P<0.001). Except for a higher proportion of lesions in the left posterior superficial branch of the middle cerebral artery in VOP (9% vs. 6%; P=0.03), there was no difference in the cerebral territories involved. A poor outcome was more frequent in VOP than in YP (17% vs. 12%; P=0.003), but this was not seen after correction for confounding factors. Conclusions: Patients older than 80 years have different risk factors and stroke features compared with patients between 45 and 79 years. Although VOP have a poorer prognosis, age per se is not a predictor of short-term disability and death. Knowledge of these findings may improve stroke prevention and acute treatment in VOP.

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Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired pneumonia

10.20944/preprints201906.0183.v1 ◽

2019 ◽

Cited By ~ 1

Author(s):

Catia Cilloniz ◽

Cristina Dominedò ◽

Antonella Ielpo ◽

Miquel Ferrer ◽

Albert Gabarrus ◽

...

Keyword(s):

Risk Factors ◽

Prognostic Factors ◽

Antibiotic Therapy ◽

Lower Risk ◽

Chronic Renal Disease ◽

Community Acquired Pneumonia ◽

Old Patients ◽

Very Old ◽

Independent Risk Factors ◽

Very Old Patients

Background: Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4,219 patients hospitalized with CAP during the study period, 1,238 (29%) were very old. The prevalence of sepsis in this aged group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.

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