Pulsatile hemodynamics and cardiovascular risk factors in very old patients

2013 ◽  
Vol 31 (5) ◽  
pp. 848-857 ◽  
Author(s):  
Michel E. Safar ◽  
Peter M. Nilsson
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Old Patients ◽  
Very Old ◽  
Very Old Patients

scholarly journals Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia

2019 ◽  
Vol 8 (7) ◽  
pp. 961 ◽  
Author(s):  
Cillóniz ◽  
Dominedò ◽  
Ielpo ◽  
Ferrer ◽  
Gabarrús ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prognostic Factors ◽  
Antibiotic Therapy ◽  
Lower Risk ◽  
Chronic Renal Disease ◽  
Community Acquired Pneumonia ◽  
Old Patients ◽  
Very Old ◽  
Independent Risk Factors ◽  
Very Old Patients

Background: Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4219 patients hospitalized with CAP during the study period, 1238 (29%) were very old. The prevalence of sepsis in this age group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.

scholarly journals Age- and Gender-Specific Prevalence of Risk Factors in Patients with First-Ever Ischemic Stroke in China

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Xiao-ying Yao ◽  
Yan Lin ◽  
Jie-li Geng ◽  
Ya-meng Sun ◽  
Ying Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Heart Diseases ◽  
Vascular Risk ◽  
Age And Gender ◽  
Old Patients ◽  
Very Old ◽  
History Of ◽  
And Gender ◽  
Very Old Patients

Background. Evidences are accumulating that age and gender have great impact on the distribution of stroke risk factors. Such data are lacking in Chinese population.Methods. 1027 patients with first-ever ischemic stroke (IS) were recruited and divided into young adult (<50 years), middle-aged (50∼80 years), and very old (>80 years) groups according to stroke onset ages. Vascular risk factors were collected and compared among groups.Results. Female patients were globally older than male patients at stroke onset and having higher prevalence of diabetes mellitus (DM), heart diseases, and atrial fibrillation (AF). However, females were less likely to drink heavily or smoke than males. Young patients had a much higher proportion of smoking and drinking than middle-aged and very old patients and the highest family history of hypertension, while very old patients had the highest prevalence of heart diseases and AF but lowest proportion of positive family history of vascular diseases. Hypertension and DM were equally frequent among three groups.Conclusion. Our study showed that vascular risk factors had a specific age and gender distribution pattern in Chinese IS patients. Secondary prevention strategy should emphasize on the control of different risk factors based on patient’s age and gender.

Prevalence and risk factors of sepsis in very old patients with CAP

2019 ◽  
Author(s):  
Catia Cilloniz Campos ◽  
Cristina Dominedò ◽  
Antonella Ielpo ◽  
Miquel Ferrer ◽  
Albert Gabarrús ◽  
...  
Keyword(s):  
Risk Factors ◽  
Old Patients ◽  
Very Old ◽  
Very Old Patients

scholarly journals Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired pneumonia

2019 ◽  
Author(s):  
Catia Cilloniz ◽  
Cristina Dominedò ◽  
Antonella Ielpo ◽  
Miquel Ferrer ◽  
Albert Gabarrus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prognostic Factors ◽  
Antibiotic Therapy ◽  
Lower Risk ◽  
Chronic Renal Disease ◽  
Community Acquired Pneumonia ◽  
Old Patients ◽  
Very Old ◽  
Independent Risk Factors ◽  
Very Old Patients

Background: Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (&ge;80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4,219 patients hospitalized with CAP during the study period, 1,238 (29%) were very old. The prevalence of sepsis in this aged group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.

Escherichia colibacteraemia in adults: age-related differences in clinical and bacteriological characteristics, and outcome

2014 ◽  
Vol 142 (12) ◽  
pp. 2672-2683 ◽  
Author(s):  
C. ROUBAUD BAUDRON ◽  
X. PANHARD ◽  
O. CLERMONT ◽  
F. MENTRÉ ◽  
B. FANTIN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Escherichia Coli ◽  
Death Rate ◽  
The Elderly ◽  
Age Group ◽  
Old Patients ◽  
Very Old ◽  
Comorbidity Score ◽  
Age Related ◽  
Very Old Patients

SUMMARYTo explore the specificities ofEscherichia colibacteraemia in the elderly, the demographic, clinical and bacteriological characteristics and in-hospital mortality rate of ‘young’ (18–64 years,n = 395), ‘old’ (65–79 years,n = 372) and ‘very old’ (⩾80 years,n = 284) adult patients of the multicentre COLIBAFI cohort study were compared. Clinical and bacteriological risk factors for death were jointly identified by logistic regression and multivariate analysis within each group. ‘Young’ and ‘old’ patients had more comorbidities than ‘very old’ patients (comorbidity score: 1·5 ± 1·3 and 1·6 ± 1·2vs. 1·2 ± 1·2, respectively;P < 0·001), and were more frequently nosocomially infected (22·3% and 23·8%vs. 8·8%, respectively;P < 0·001). ‘Old’ patients had the poorest prognosis (death rate: 16·4%vs.10·4% for ‘young’ and 12·0% for ‘very old’ patients, respectively;P = 0·039). Risk factors for death were age group-specific, suggesting a host–pathogen relationship evolving with age.

scholarly journals Management of pertrochanteric fractures in patients over 90 years: In-hospital mortality rate, complications and associated risk factors

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mohamed Ghanem ◽  
Jonas Garthmann ◽  
Anja Redecker ◽  
Annette Brigitte Ahrberg-Spiegl ◽  
Johannes Karl Maria Fakler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mortality Rate ◽  
Timing Of Surgery ◽  
Control Group ◽  
Study Group ◽  
Old Patients ◽  
Very Old ◽  
Pertrochanteric Fractures ◽  
Significant Difference ◽  
Very Old Patients

Abstract Purpose This study aims primarily to investigate the outcome following surgical management of pertrochanteric fractures of patients over 90 years compared to the outcome of a control group below 90 years under special consideration of the timing of surgery. The second aim was to analyze potential risk factors for early deaths in very old patients. This study allows us to draw conclusions to minimize complications linked to this particular age segment. Methods The study group consisted of very old patients aged 90 years and older. Geriatric patients aged between 60 and 89 years of age were part of the control group. Type A1 pertrochanteric fractures were typically treated by dynamic hip crews, type A2 and A3 fractures by femoral nails. Full weight bearing physiotherapy was initiated on the day after surgery to improve mobility and muscle strength. Results A total of 71 patients belonged to the study group (mean age: 92.5 years ±2.3 years), whereas 223 patients formed the control group (mean age: 79.9 ± 7.4 years). The mortality rate and the number of detected and documented complications were significantly higher in the study group (p = 0.001; p = 0.009, respectively). Despite the significantly higher complication rate in the > 90-year-old patients, there was no significant difference in the mean length of in-hospital-stay between the both groups (> 90 yrs.: 12.1d; < 90 yrs.: 13.1 d) and the timing of surgery. Conclusion The number of co-morbidities, number of daily-administered medications and the time between admission and surgery have no impact on the outcome. We noticed a longer period between admission and surgery in very old patients who survived. Patients with pertrochanteric fractures should be screened for multimorbidity and cognitive disorders in a standardized manner.

MO187NON-STEROIDAL ANTI-INFLAMMATORY DRUG PRESCRIPTION IN THE YOUNG-OLD AND VERY- OLD: TYPE, ROUTE AND BURDEN OF CARDIOVASCULAR RISK FACTORS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Cynthia Lim ◽  
Jason Choo ◽  
Jia Liang Kwek ◽  
Hanis Abdul Kadir ◽  
Ngiap Chuan Tan
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Older Adults ◽  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Cardiovascular Risk Factors ◽  
Very Old ◽  
Nsaid Prescription ◽  
Young Old

Abstract Background and Aims Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with cardiovascular and kidney adverse effects, especially in older adults. However, NSAIDs are still frequently prescribed to some at-risk groups. We aimed to evaluate the burden of traditional cardiovascular risk factors and pattern of NSAID prescription in the very-old and young-old. Method Cross-sectional study of older adults who received prescriptions over 3 years from a large healthcare cluster in Singapore. Individuals aged 65-79 years were the “young-old” and those ≥80 years were the “very-old”. Prescriptions and traditional cardiovascular risk factors were retrieved from electronic records. Results Among 197,932 older adults (including 41,079 very-old), 49.9% received at least 1 NSAID prescription. Topical NSAIDs were more frequently prescribed among the 19,979 very-old with NSAID prescriptions (91.5% versus 82.9% of the young-old), while oral non-selective (22.1% versus 38.5%) and selective NSAID (15.1% versus 24.9%) were less frequently prescribed compared to the young-old (all p&lt;0.001). The very-old with NSAID prescriptions were more likely to have diabetes (38.2% vs. 32.8%), hypertension (19.3% vs. 14.0%), chronic kidney disease (51.4% vs. 23.6%) and cardiovascular disease (7.0% vs. 3.8%) than the young-old with NSAID prescriptions (all p&lt;0.001). Table 1 shows that among the very-old, the odds of receiving oral non-selective NSAIDs was significantly lower in those with cardiovascular disease, while the odds of receiving oral COX II inhibitors was significantly higher in female and hypertension. Among the young-old, the odds of receiving oral non-selective NSAID was lower in those with cardiovascular disease, diabetes and chronic kidney disease, while the odds of receiving oral COX II inhibitors was higher in female, hypertension, cardiovascular disease and lower in diabetes and chronic kidney disease. Conclusion This study highlights that NSAIDs were frequently prescribed among older adults with comorbidities that may predispose to NSAID-associated adverse events. Physician education and policies are required to avoid potentially inappropriate prescriptions.

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