scholarly journals Rhabdomyolysis following Acute Extended-Release Quetiapine Poisoning: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Antonios Liolios ◽  
Othman Sentissi
Keyword(s):  
Case Report ◽  
Extended Release ◽  
Psychiatric Patients ◽  
Case Reports ◽  
Clinical Findings ◽  
Major Depressive ◽  
The Past ◽  
Acute Rhabdomyolysis ◽  
Somatic Comorbidities ◽  
Release Form

Background. During the past few years, there have been a number of case reports concerning rhabdomyolysis following quetiapine poisoning; however, there has been none concerning the medication in its extended-release form.Methods. We present the case report of a 48-year-old man presenting a major depressive disorder and borderline personality disorder, who after voluntary intoxication with 12000 mg of quetiapine extended-release developed signs of acute rhabdomyolysis.Results. The rhabdomyolysis was confirmed by the laboratory and the clinical findings, with elevated levels of creatinine, creatine phosphokinase, and CRP.Discussion. We would like to pinpoint the importance of this complication and our concern of prescribing it for psychiatric patients with chronic somatic comorbidities.

Antidepressant withdrawal mania: Two case reports

2017 ◽  
Vol 41 (S1) ◽  
pp. S540-S540
Author(s):  
D. Pereira ◽  
I. Carreira Figueiredo ◽  
M. Marinho ◽  
R. Fernandes ◽  
V. Viveiros
Keyword(s):  
Case Report ◽  
Emergency Service ◽  
Case Reports ◽  
Unipolar Depression ◽  
Clinical State ◽  
Gradual Improvement ◽  
Clinical Criteria ◽  
The Past ◽  
Pubmed Search ◽  
Competing Interest

IntroductionAlthough rarely reported, antidepressant discontinuation may induce hypomania or mania even in the absence of bipolar disorder [1,2].ObjectivesWe report two cases of antidepressant withdrawal induced mania.MethodsClinical process consultation and PubMed search were performed in November 2016 using the search keywords antidepressant, mania and discontinuation.ResultsCase report 1: a dysthymic 60 years old woman with 20 years of psychiatric following had been treated with venlafaxine 150 mg/daily the past year. She abruptly stopped taking this drug, developing heightened mood, irritability and racing thoughts five days later. She was admitted at our hospital, initiating then valproate and antipsychotics. Two weeks later, the hypomania clinical state remitted completely.Case report 2: a 64 years old woman, with a 12-year-old diagnosis of unipolar depression was brought to our emergency service with complaints of disorganized behavior, paranoid delusional ideas, excessive speech, irritable mood and reduced need for sleep, 1 week after abrupt trazodone 150 mg/daily discontinuation. Valproic acid 1000 mg/daily and olanzapine 20 mg/daily were introduced, with gradual improvement of symptoms. Two weeks later she was completely asymptomatic.ConclusionPsychiatrists should be aware of the risk of antidepressant withdrawal induced mania. More studies should be conducted about this subject, aiming for the clarification of risk factors and the establishment of clinical criteria for this phenomenon.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Non-Surgical Management of Iatrogenic Extrusion of Calcium Hydroxide Based Intracanal Medicament in Clinical Endodontics – A Case Report

2021 ◽  
Vol 10 (33) ◽  
pp. 2863-2866
Author(s):  
Akshay Khandelwal
Keyword(s):  
Case Report ◽  
Calcium Hydroxide ◽  
Surgical Management ◽  
Case Reports ◽  
Barium Sulphate ◽  
The Past ◽  
Nonsurgical Management ◽  
System 2 ◽  
Periapical Healing ◽  
Periapical Diseases

Calcium hydroxide is used as an intracanal medicament in endodontics as it reduces intracanal microbial load and exudate discharge from infected teeth. Reports have shown that extrusion of calcium hydroxide periapically leads to an increased incidence of swelling, delayed periapical healing, nerve paraesthesia and other complications. Teeth with immature apex or those undergoing apical resorption are prone to higher chances of periapical medicament extrusion, especially under high pressure delivery systems. This case report discusses nonsurgical management of periapically extruded non-setting calcium hydroxide by an innovative technique which is less invasive and comfortable both for the clinician and the patient. Calcium hydroxide is widely used as an intracanal medicament for the treatment of pulpal and periapical diseases.1 The intracanal placement of calcium hydroxide can be done with a lentulospiral or a syringe-based delivery system.2 If extruded periapically, there is an increased incidence of swelling, delayed periapical healing, nerve paraesthesia and other complications.3 Case reports in the past have suggested surgical management of periapically extruded calcium hydroxide. The purpose of this case report is to discuss an orthograde nonsurgical management of periapically extruded calcium hydroxide based intracanal medicament containing barium sulphate during endodontic treatment.

scholarly journals No Bull: A Case of Alpha-Gal Syndrome Associated With Buffalo Meat Sensitivity

2019 ◽  
Vol 10 ◽  
pp. 215265671989336
Author(s):  
Marija Rowane ◽  
Reimus Valencia ◽  
Benjamin Stewart-Bates ◽  
Jason Casselman ◽  
Robert Hostoffer
Keyword(s):  
Case Report ◽  
Immunoglobulin E ◽  
Case Reports ◽  
The United States ◽  
Tick Saliva ◽  
Buffalo Meat ◽  
The Past ◽  
First Case ◽  
Delayed Anaphylaxis ◽  
History Of

Introduction Alpha (⍺)-gal syndrome (AGS) is an immunoglobulin E (IgE) antibody response against the glycoprotein carbohydrate galactose-⍺-1,3-galactose-β-1-(3)4-N-acetylglucosamine-R (Gal⍺-1,3Galβ1-(3)4GlcNAc-R or ⍺-gal) that is present in Ixodida (tick) saliva and noncatarrhine mammals as well as cetuximab, antivenom, and the zoster vaccine. The most frequently observed anaphylactic reactions in AGS are observed after beef, pork, lamb, and deer meat consumption. We present the first case of anaphylaxis to buffalo meat. Case Report A 55-year-old man presented with a history of recurrent urticaria that only developed approximately 7 hours after buffalo consumption. The patient denied history of Ixodidae bites but admitted to frequent hiking outdoors. Anti-⍺-1,3-gal IgE was positive (30.80 kU/L). The patient was advised to strictly avoid red meat. Discussion The prevalence of AGS has been increased in all continents in the past decade, and several Ixodidae species have been associated with this hypersensitivity. The list of IgE-mediated reactions to various types of meat has expanded to kangaroo, whale, seal, and crocodile, although these have not been associated with AGS. van Nunen only cautioned against consumption of exotic meats, such as buffalo, but no published case report describes AGS associated with anaphylaxis to this type of meat. Conclusion AGS is a mammalian meat allergy that has been increasingly prevalent worldwide, especially in Ixodidae endemic regions of Australia and the United States. Multiple AGS case reports published in the past decade demonstrate rapidly increasing understanding of underlying mechanisms provoking ongoing sensitization to help devise management strategies and dietary information. We offer the first case report of delayed anaphylaxis to buffalo meat.

scholarly journals Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports

2019 ◽  
Vol 7 (24) ◽  
pp. 4378-4382 ◽  
Author(s):  
Nguyen Phuong Tu ◽  
Pham Ba Nha ◽  
Nguyen Duy Hung ◽  
Nguyen Hoang Minh ◽  
Hoang Ngoc Anh ◽  
...  
Keyword(s):  
Case Report ◽  
Early Treatment ◽  
Case Reports ◽  
Autoimmune Encephalitis ◽  
Reproductive Function ◽  
Prolonged Treatment ◽  
Ovarian Teratoma ◽  
The Past ◽  
Nmda Receptor Encephalitis ◽  
Quality Life

BACKGROUND: N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis appears common in the world, but the number of clinical cases in Vietnam which were recorded is rare. CASE REPORT: We describe two new cases of disease in recent years with the aim of contributing to diagnosis and treatment experiences. These cases were noted over the past 3 years with the patients who have been treated at lower levels but have no results. They came to us when symptoms became worse and therefore required prolonged treatment with special intensive care facilities. The atypical and easily confused symptoms are the reasons that make the disease be detected late; leading to a much higher cost of treatment and the complication may appear in the patient. In the past, patients with these manifestations were diagnosed with unexplained encephalitis and severe sequelae or death. Autoimmune encephalitis has many types; NMDA encephalitis associated with ovarian teratoma is the most common autoimmune encephalitis in young women. CONCLUSION: In conclusion, based on the case report, we hope to contribute some experiences on the diagnosis and the strategy in early treatment. With most female patients at very young age, early treatment to avoid complications will help patients have a quality life and maintain reproductive function.

Optometric Management of a Post-Concussion Patient: A Case Report

2016 ◽  
pp. 238-243
Keyword(s):  
Case Report ◽  
Young Adult ◽  
Visual System ◽  
Clinical Findings ◽  
The Past ◽  
Convergence Insufficiency ◽  
The Military ◽  
Vision Therapy ◽  
Myopic Astigmatism ◽  
Spectacle Correction

Over the past decade, there has been increased emphasis on the diagnosis and treatment of concussion, especially in the military and in sports. In this case report, the optometric management of a post-concussion, young-adult is described. He was diagnosed with low myopic astigmatism, convergence insufficiency, fusional instability, oculomotor dysfunction, and photosensitivity. Treatment included tinted spectacle correction for fulltime wear and conventional oculomotor-based vision therapy. At the cessation of the vision therapy, as well as three years later, he was effectively asymptomatic with normal clinical findings. These results demonstrate the efficacy of a comprehensive optometric approach in concussion, with evidence suggestive of considerable residual visual system plasticity.

Immune Mechanisms of Depression

2017 ◽  
Author(s):  
Caroline Ménard ◽  
Madeline L. Pfau ◽  
Georgia E. Hodes ◽  
Scott J. Russo
Keyword(s):  
Immune System ◽  
Lupus Erythematosus ◽  
Clinical Findings ◽  
Behavioral Symptoms ◽  
Biological Factors ◽  
Major Depressive ◽  
The Past ◽  
Inflammatory Conditions ◽  
Stress Models ◽  
Pro Inflammatory Cytokines

Mood disorders such as major depressive disorder (MDD) are diagnosed largely based upon behavioral symptoms rather than biological factors. Some have argued that a lack of rigorous biomarker-based diagnosis is the reason why 30%–50% of MDD patients are unresponsive to traditional antidepressant medications. Over the past few decades, MDD has been shown to be highly prevalent in patients suffering from chronic inflammatory conditions, such as lupus erythematosus, multiple sclerosis, etc. Moreover, subgroups of MDD patients have shown consistently higher levels of circulating pro-inflammatory cytokines. Together, these clinical findings suggest that alterations within the immune system might contribute to the behavioral symptoms of MDD. In this chapter, we review the growing literature in both humans with MDD and in rodent stress models of depression that support a role for the immune system in depression.

scholarly journals Case Reporting in Homeopathy—An Overview of Guidelines and Scientific Tools

Homeopathy ◽  
2021 ◽  
Author(s):  
Michael Teut ◽  
Robbert A. van Haselen ◽  
Lex Rutten ◽  
Chetna Deep Lamba ◽  
Gerhard Bleul ◽  
...  
Keyword(s):  
Case Report ◽  
Case Reports ◽  
Special Focus ◽  
Central Importance ◽  
Quality Of Reporting ◽  
The Past ◽  
Case Documentation ◽  
Scientific Value ◽  
Based Medicine

AbstractCase reports have been of central importance to the development of homeopathy over the past 200 years. With a special focus on homeopathy, we give an overview on guidelines and tools that may help to improve the quality of case reports. Reporting guidelines such as CARE (Case Report), HOM-CASE (Homeopathic Clinical Case Reports), and the WissHom Documentation Standard help to improve the quality of reporting and strengthen the scientific value of a case report. Additional scientific tools such as prospective outcome assessment, prognostic factor research, cognition-based medicine, and the Modified Naranjo Criteria for Homeopathy (MONARCH) score may be helpful in improving case documentation and evaluation.

scholarly journals Combination of venlafaxine and phentermine/topiramate induced psychosis: A case report

2018 ◽  
Vol 8 (2) ◽  
pp. 95-99 ◽  
Author(s):  
Jaclyn Homola ◽  
Robin Hieber
Keyword(s):  
Case Report ◽  
Extended Release ◽  
Case Reports ◽  
Individual Case ◽  
Once Daily ◽  
Pubmed Search ◽  
Self Harm ◽  
Irritable Bowel ◽  
Mental Health Unit ◽  
The Brain

Abstract Background: Various publications have noted increases in dopamine, specifically in the mesolimbic region of the brain, to have a direct correlation to psychotic-like symptoms. Venlafaxine, a first-line medication for depression, inhibits the reuptake of both serotonin and norepinephrine. Additionally, venlafaxine weakly inhibits the reuptake of dopamine. Phentermine/topiramate (Qsymia®), specifically the phentermine component, functions by blocking the dopamine and norepinephrine transporter, similar to amphetamine. Case Report: A 40-year-old Hispanic woman was admitted to the inpatient mental health unit based on reports of delusional thinking and several attempts of self-harm. Past medical history was significant for major depressive disorder, posttraumatic stress disorder, anxiety, irritable bowel syndrome, and migraines. The patient was started on venlafaxine (75 mg extended-release by mouth once daily) for depression approximately 1 month prior to admission. Furthermore, the patient was restarted on a previously prescribed medication, oral phentermine/topiramate for weight loss, in combination with venlafaxine, approximately 1 week prior to the bizarre behavior. The patient denied any psychosis or changes in behavior when medications were taken individually prior to the combination. The patient was treated with lurasidone (40 mg by mouth daily) with resolution of psychosis. Discussion: A PubMed search revealed no current literature or case reports on psychosis induced by the combination of venlafaxine and phentermine/topiramate. Individual case reports of psychosis in patients on venlafaxine alone and the phentermine component of phentermine/topiramate alone have been reported.

scholarly journals Assessment of the Quality of Case Reports in the Journal of Acupuncture Research Using the CARE and STRICTA Guidelines

2020 ◽  
Vol 37 (4) ◽  
pp. 224-232
Author(s):  
Eun-Young Nam ◽  
Ji Hye Hwang
Keyword(s):  
Clinical Trials ◽  
Case Report ◽  
Case Reports ◽  
Needle Insertion ◽  
Clinical Findings ◽  
Quality Of Reporting ◽  
Disease Condition ◽  
Care Guidelines ◽  
Acupuncture Research

The purpose of this study was to assess the quality of the case reports in the Journal of Acupuncture Research (JAR). All case reports were retrieved from November 2017 to June 2020. There were 19 case reports included in this assessment based on the case report (CARE) guidelines and case report and standards for reporting interventions in clinical trials of acupuncture (STRICTA) guidelines. The overall quality of reporting was relatively high (83.08% on Case Report guidelines and 77.78% on Standards for Reporting Interventions in Clinical Trials of Acupuncture guidelines), but several crucial items remained substantially underreported, such as identifying as a case report (keywords), patient information and perspective, clinical findings, diagnostic assessment, and intervention information. In 18 out of 19 included case reports of acupuncturerelated interventions, several items remained considerably underreported such as acupuncture regimen variation, depth of needle insertion, response sought, and experience of acupuncturists. In the classification by disease, condition, or syndrome, 13 out of 19 included case reports were for musculoskeletal disorders (68.4%), which is the main clinical medical field of Korean medicine services. The results of this study may help develop more appropriate reporting guidelines for case reports published in JAR.

Fournier's gangrene as Amyand's hernia complication

2019 ◽  
Vol 98 (7) ◽  
pp. 291-296
Keyword(s):  
Case Report ◽  
Case Reports ◽  
Rare Condition ◽  
Sporadic Case ◽  
Fournier’S Gangrene ◽  
Amyand’S Hernia ◽  
Fournier's Gangrene ◽  
Randomized Controlled Studies ◽  
Based Medicine ◽  
Hernia Complication

Introduction: Fournier’s gangrene is a rare but fast deteriorating and serious condition with high mortality. In most cases, it is characterized as necrotizing fasciitis of the perineum and external genitals. Amyand’s hernia is a rare condition where the appendix is contained in the sac of an inguinal hernia. Inflammatory alterations in the appendix account only for 0.1 % of the cases when Amyand’s hernia is verified. Fournier’s gangrene as a complication of a late diagnosis of appendicitis located in the inguinal canal is described in the literature as rare case reports. Case report: The case report of a 70-year-old patient with Fournier’s gangrene resulting from gangrenous appendicitis of Amyand’s hernia. Conclusion: Fournier’s gangrene as a complication of Amyand’s hernia is a rare condition. Only sporadic case reports thereof can be found in the literature. Because of the rarity of this pathology and the lack of randomized controlled studies, it is difficult to determine the optimal treatment according to the principles of evidence-based medicine. An appropriate approach for this condition appears to be the combination of guidelines developed in Amyand’s therapy according to Losanoff and Basson, along with the recommended “gold standard” therapy for Fournier’s gangrene. This means early and highly radical surgical debridement, adequate antibiotic therapy and intensive care.

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