scholarly journals Combination of venlafaxine and phentermine/topiramate induced psychosis: A case report

2018 ◽  
Vol 8 (2) ◽  
pp. 95-99 ◽  
Author(s):  
Jaclyn Homola ◽  
Robin Hieber
Keyword(s):  
Case Report ◽  
Extended Release ◽  
Case Reports ◽  
Individual Case ◽  
Once Daily ◽  
Pubmed Search ◽  
Self Harm ◽  
Irritable Bowel ◽  
Mental Health Unit ◽  
The Brain

Abstract Background: Various publications have noted increases in dopamine, specifically in the mesolimbic region of the brain, to have a direct correlation to psychotic-like symptoms. Venlafaxine, a first-line medication for depression, inhibits the reuptake of both serotonin and norepinephrine. Additionally, venlafaxine weakly inhibits the reuptake of dopamine. Phentermine/topiramate (Qsymia®), specifically the phentermine component, functions by blocking the dopamine and norepinephrine transporter, similar to amphetamine. Case Report: A 40-year-old Hispanic woman was admitted to the inpatient mental health unit based on reports of delusional thinking and several attempts of self-harm. Past medical history was significant for major depressive disorder, posttraumatic stress disorder, anxiety, irritable bowel syndrome, and migraines. The patient was started on venlafaxine (75 mg extended-release by mouth once daily) for depression approximately 1 month prior to admission. Furthermore, the patient was restarted on a previously prescribed medication, oral phentermine/topiramate for weight loss, in combination with venlafaxine, approximately 1 week prior to the bizarre behavior. The patient denied any psychosis or changes in behavior when medications were taken individually prior to the combination. The patient was treated with lurasidone (40 mg by mouth daily) with resolution of psychosis. Discussion: A PubMed search revealed no current literature or case reports on psychosis induced by the combination of venlafaxine and phentermine/topiramate. Individual case reports of psychosis in patients on venlafaxine alone and the phentermine component of phentermine/topiramate alone have been reported.

Antidepressant withdrawal mania: Two case reports

2017 ◽  
Vol 41 (S1) ◽  
pp. S540-S540
Author(s):  
D. Pereira ◽  
I. Carreira Figueiredo ◽  
M. Marinho ◽  
R. Fernandes ◽  
V. Viveiros
Keyword(s):  
Case Report ◽  
Emergency Service ◽  
Case Reports ◽  
Unipolar Depression ◽  
Clinical State ◽  
Gradual Improvement ◽  
Clinical Criteria ◽  
The Past ◽  
Pubmed Search ◽  
Competing Interest

IntroductionAlthough rarely reported, antidepressant discontinuation may induce hypomania or mania even in the absence of bipolar disorder [1,2].ObjectivesWe report two cases of antidepressant withdrawal induced mania.MethodsClinical process consultation and PubMed search were performed in November 2016 using the search keywords antidepressant, mania and discontinuation.ResultsCase report 1: a dysthymic 60 years old woman with 20 years of psychiatric following had been treated with venlafaxine 150 mg/daily the past year. She abruptly stopped taking this drug, developing heightened mood, irritability and racing thoughts five days later. She was admitted at our hospital, initiating then valproate and antipsychotics. Two weeks later, the hypomania clinical state remitted completely.Case report 2: a 64 years old woman, with a 12-year-old diagnosis of unipolar depression was brought to our emergency service with complaints of disorganized behavior, paranoid delusional ideas, excessive speech, irritable mood and reduced need for sleep, 1 week after abrupt trazodone 150 mg/daily discontinuation. Valproic acid 1000 mg/daily and olanzapine 20 mg/daily were introduced, with gradual improvement of symptoms. Two weeks later she was completely asymptomatic.ConclusionPsychiatrists should be aware of the risk of antidepressant withdrawal induced mania. More studies should be conducted about this subject, aiming for the clarification of risk factors and the establishment of clinical criteria for this phenomenon.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Overview on Neurological Manifestations of Thyroid Disease

2021 ◽  
pp. 171-178
Author(s):  
Mohammed Salah Hussein ◽  
Faisal Mohammed Alyahya ◽  
Husam Fouad K. Barradah ◽  
Adeeb Abdullah Almuhanaa ◽  
B. Alzhrani, Olayan Mohammed ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Case Reports ◽  
Neuromuscular Disorders ◽  
Case Series ◽  
Individual Case ◽  
Clinical Aspects ◽  
Pubmed Search ◽  
Hereditary Chorea ◽  
Critical Organ ◽  
Google Search

Hypothyroidism and hyperthyroidism are both prevalent medical conditions that are frequently accompanied with neurologic and neuromuscular dysfunction. Triiodothyronine (T3) and thyroxine (T4) hormones are produced by the thyroid gland and play a crucial role in tissue formation and metabolism. Both of these hormones have a variety of impacts on the brain and neuromuscular system. Specially in children, because brain development can be effected by any disturbances in Thyroidal hormones level. And thus, conditions like Allan-Herndon-Dudley Syndrome & Benign Hereditary Chorea is considered genetic thyroidal diseases both will be discussed in this review. hypothyroidism can have serious consequences for neuropsychiatric function. The pathophysiological processes underlying the neurological symptoms of hypothyroidism and hyperthyroidism are likely to be multifactorial, in this review we will be looking at multiple neurological as well as psychiatric manifestations related to thyroidal hormones disorders. Methods: We used the phrases "hypothyroidism," "hyperthyroidism," "neurological problems," "neuropathy," "myopathy," "congenital hypothyroidism," and "encephalopathy" in a PubMed search, google scholar and google search engines. Case series, individual case reports, systematic reviews, retrospective analyses, and randomized controlled trials were among the papers examined. Classification of thyroidal dysfunction has been made depending on the thyroidal hormones level. The neurological consequences of congenital hypothyroidism were examined, as well as the clinical aspects of hypothyroidism and hyperthyroidism-related neuromuscular disorders, as well as other autoimmune illnesses. Hashimoto encephalopathy's evidence and pathophysiological issues were also examined. Conclusion: Thyroid is critical organ due to role of its thyroidal hormones, both hypothyroidism and hyperthyroidism induce some serious neurological and phycological disorders, some of which is genetic, hypothyroidism can impact the development of child and thus regular thyroidal hormones testing is recommended in children who demonstrates any signs of neurological psychiatric  or cognitive disease.

Abstract 1122‐000051: Isolated Diplacusis Due to Ipsilateral Temporal Lobe Infarction: A Case Report

2021 ◽  
Vol 1 (S1) ◽  
Author(s):  
Ali Kerro ◽  
Reza Bavarsad Shahripour
Keyword(s):  
Case Report ◽  
Temporal Lobe ◽  
Case Reports ◽  
Sensorineural Deafness ◽  
Screen Test ◽  
Acute Onset ◽  
First Case ◽  
Ischemic Infarct ◽  
Pubmed Search ◽  
The Right

Introduction : Double hearing or Diplacusis is a synchronous double perception of a sound and can have Binauralis or Monauralis pattern, with inner ear disorders being the main culprit [1] . Other forms of Auditory illusions have been reported as a co‐manifestation of stroke syndromes, but none as an isolated presentation [1][2] . This is a case of a 77‐year‐old male with acute onset isolated Diplacusis in a patient due to a right temporal lobe ischemic infarct. To our knowledge, this is the first case report of an isolated diplacusis due to cortical infarct. Methods : A case presentation with Pubmed search of review articles and case reports. Results : The patient had a past medical history of sensorineural deafness in his left ear. He described any sound heard as the same quality but occurring with an echo heard a fraction of a second later in his right ear. There was no decreased hearing quality or tinnitus reported in his right ear. His drug screen test was negative. His examination was only remarkable for a sensorineural hearing loss pattern on his left ear. His (NIHSS) was zero, and no other cranial nerve abnormalities were detected. His MRI was significant for a punctate restricted diffusion on the right temporal lobe, resembling an ischemic infarct (Figure). Conclusions : Isolated diplacusis can present as acute ischemic stroke in the temporal lobe. Further studies are needed to understand its pathophysiology.

scholarly journals Homoeopathic Treatment of Pituitary Adenoma: A Case Report

2020 ◽  
Vol 7 (2) ◽  
pp. 109-128
Author(s):  
Nur-E-Alam Rasel ◽  
Md. Sofiqul Alam ◽  
Md. Mostafizur Rahman Siddique ◽  
Narottam Debnath ◽  
Md. Jahangir Alam ◽  
...  
Keyword(s):  
Case Report ◽  
Pituitary Adenoma ◽  
Pituitary Adenomas ◽  
Combined Therapy ◽  
Optic Chiasm ◽  
Individual Case ◽  
The Body ◽  
Near Future ◽  
The Brain

Most pituitary adenomas are slow-growing and benign, which means they are not cancer and do not spread to other parts of the body. They generally have a slow but severe impact on vision due to compression of the optic nerves, optic chiasm, and cavernous sinus.  However, as they grow big they can put pressure on nearby structures, such as the nerves that connect the eyes to the brain and cause symptoms. Pituitary adenomas are the third most common intracranial tumor and arise from the pituitary gland. An individual case is presented in this paper with radiological evidence (MRI) of a large lobulated intrasellar mass (3.0 cm transversely, 3.5 cm craniocaudally and 2 cm anteroposteriorly) with supra-sellar extension is causing elevation of the floor of the 3rd ventricle of the brain. Pituitary macroadenoma and hemorrhagic foei, pituitary apoplexy, and pituitary adenomas were founded by different CT scan and MRI reports in different laboratories. The patient was treated with constitutional homoeopathic medicines – Natrum muriticum-m/1, 16 doses up to Natrum muriticum-m/20, 16 doses each from 26/04/2014 to 07/08/2017. Before treatment imaging was done several times from 6/04/2011 to 12/01/2012showed complete resolution of the pituitary adenoma and during treatment3 follow-up imaging was done on 25/07/2015 and 06/08/2017. This case report reviews the clinical presentation, homoeopathic management, and treatment of the major classification of pituitary adenomas and call attention to the need for repertorization in individualized homoeopathic prescription. It is hoped that if this type of clinical research continues in the future, homeopathy will have a breakthrough result and it’s symptomatic medical treatment will play a beneficial role in the near future from the deadly evils of various types of chemotherapy, radiotherapy, or combined therapy.

scholarly journals Cerebral Vasculitis in Ulcerative Colitis Is Predominantly Venular: Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Paul T. Parks ◽  
Alexander S. Easton
Keyword(s):  
Ulcerative Colitis ◽  
Case Report ◽  
Grey Matter ◽  
Case Reports ◽  
Venous Occlusion ◽  
Cerebral Vasculitis ◽  
Review Of The Literature ◽  
Demyelinating Disorder ◽  
Extraintestinal Complications ◽  
The Brain

Extraintestinal complications of ulcerative colitis include isolated case reports of cerebral vasculitis. In this case report, we describe autopsy findings in a 50-year-old female who died as a result of massive multifocal cerebral hemorrhage. Microscopic examination of the left colon showed findings typical for ulcerative colitis. Examination of the brain showed an extensive vasculitis. More affected vessels were noted in grey matter than in white matter. Many showed fibrinoid necrosis, invasion by neutrophils and thrombosis. There was extensive perivascular hemorrhage with associated infarction. Vessel analysis shows most of the vessels to have been venous rather than arterial. There were no perivascular sleeves of demyelination to suggest a primary demyelinating disorder, such as acute hemorrhagic leucoencephalitis. Our analysis shows that veins are the likely target of cerebral vasculitis in ulcerative colitis. This has clinical implications because venous occlusion generally causes massive intracerebral hemorrhage with a high mortality.

scholarly journals Rhabdomyolysis following Acute Extended-Release Quetiapine Poisoning: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Antonios Liolios ◽  
Othman Sentissi
Keyword(s):  
Case Report ◽  
Extended Release ◽  
Psychiatric Patients ◽  
Case Reports ◽  
Clinical Findings ◽  
Major Depressive ◽  
The Past ◽  
Acute Rhabdomyolysis ◽  
Somatic Comorbidities ◽  
Release Form

Background. During the past few years, there have been a number of case reports concerning rhabdomyolysis following quetiapine poisoning; however, there has been none concerning the medication in its extended-release form.Methods. We present the case report of a 48-year-old man presenting a major depressive disorder and borderline personality disorder, who after voluntary intoxication with 12000 mg of quetiapine extended-release developed signs of acute rhabdomyolysis.Results. The rhabdomyolysis was confirmed by the laboratory and the clinical findings, with elevated levels of creatinine, creatine phosphokinase, and CRP.Discussion. We would like to pinpoint the importance of this complication and our concern of prescribing it for psychiatric patients with chronic somatic comorbidities.

scholarly journals Phenytoin toxicity as a forgoer of schizophrenia like psychosis: a case report

2019 ◽  
Vol 7 (7) ◽  
pp. 2853
Author(s):  
Prasanta Dihingia ◽  
Anshu Kumar Jha
Keyword(s):  
Case Report ◽  
Epileptic Patient ◽  
Case Reports ◽  
Once Daily ◽  
Time Period ◽  
Anti Epileptic Drug ◽  
Drug History ◽  
Triggering Factor ◽  
To Come ◽  
Phenytoin Toxicity

This is a case report describing the toxicity of phenytoin overdose. It is very uncommon to find an anti-epileptic drug causing psychosis and till date only a few studies have found such a co-relation. A psychiatric patient was admitted in our department of medicine with the complain of ingestion of 30 tablets of phenytoin. On examination he was found to have auditory and visual hallucinations. He was restless and had an ill sustained concentration. First and foremost, thing was to stop the prescribed phenytoin tablets and sedate the patient with haloperidol and promethazine. Then, he was switched over to Levetiracetam 500 mg i.v. thrice daily, Clobazam 10 mg once daily and Resperidone 3 mg twice daily. On investigation we found serum phenytoin level >40 mg/dl. This was sufficient to support our diagnosis as after stopping the drug his symptoms improved. There have been case reports of epileptic patient presenting with psychosis but usually after 10-15 years, unlike our case. In our case this time period was reduced to 12 hours as there was a triggering factor present. So, if a known epilepsy patient develops psychosis, the drug history should be given a big importance and if required serum phenytoin level should be assessed to come to the diagnosis of “phenytoin induced schizophrenia like psychosis.

25c-nbome: Case report and literature review

2017 ◽  
Vol 41 (S1) ◽  
pp. s874-s875
Author(s):  
M. Preve ◽  
S. Casigliani ◽  
L. Tognola ◽  
R. Traber ◽  
R.A. Colombo
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Case Reports ◽  
Kidney Injury ◽  
Drug Market ◽  
Individual Case ◽  
Future Research ◽  
The Internet ◽  
Future Research Directions ◽  
Competing Interest

IntroductionNovel psychoactive drugs (NPS) have rapidly increase in the last years in the drug market as a recreational use. A new group of toxic phenethylamine derivates named NBOMe of 2 C class present have emerged recently, are frequently bought using the internet and have similar effects to other hallucinogenic drugs; however, they may pose larger risks, due to the limited knowledge about them, their relatively low price and availability via the internet. The purpose of this report is to review the clinical evidence for the potential of abuse of NBOMe compounds. We propose a case report and literature review.MethodWe conducted a systematic review of the literature with the principal database (PubMed, Enbase, PsychInfo) and we present a case report.ResultsThe effects of 25C-NBOMe is characterized by hallucination, violent agitation, rhabdomyolysis and kydney injury.Discussion and conclusionEffects from 25C-NBOMe in our case report were similar to previous individual case reports in literature. The clinical features were also similar to effects from other analogues in the class (25I-NBOMe, 25B-NBOMe). In our case, violent agitation (signs of serotonergic stimulation), rhabdomyolysis and kidney injury were observed. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Vertebral Artery Dissection Caused by Neck Tics

2018 ◽  
Vol 16 (06) ◽  
pp. 408-410 ◽  
Author(s):  
Omer Aydin ◽  
Haydar Tasdemir ◽  
Meltem Ceyhan Bilgici ◽  
Turgay Cokyaman
Keyword(s):  
Case Reports ◽  
Vertebral Artery Dissection ◽  
Hunter Syndrome ◽  
Individual Case ◽  
Artery Dissection ◽  
Pediatric Case ◽  
Tic Disorder ◽  
Vertebrobasilar Ischemia ◽  
The Face ◽  
The Brain

AbstractVertebral arterial dissection (VAD) is a rarely observed cause of vertebrobasilar ischemia. It is often reported as individual case reports in children, and the underlying cause is usually congenital anomalies or trauma to the neck. In this case report, we present a pediatric case of VAD whose magnetic resonance (MR) and computed tomography angiographies were normal and could only be diagnosed after a careful reassessment of the initial brain MRIs considering the dynamic nature of the dissection process. Etiological investigations pointed to the patient's neck tics as the origin of the condition, which is a rare and interesting cause different from the previously reported cases in the literature. Due to the ischemic lesions in the brain stem and the cerebellum, low molecular weight heparin treatment was started and the neurological symptoms rapidly receded. Since a severe tic disorder involving the face and neck has been observed as a rare cause of VAD aside from the previously reported causes such as the Bow–Hunter syndrome reported in archers, congenital cervical anomalies, traumatic mechanical accidents, and cervical chiropractical maneuvers, the sharing of this case will contribute to the literature.

scholarly journals Primary Malignant Parotid Lymphoma: Two Case Reports with Different Disease Progression and Treatment

2011 ◽  
Vol 26 (1) ◽  
pp. 31-33
Author(s):  
Noor Dina Hashim ◽  
Mohd Razif Mohamad Yunus ◽  
Asma Abdullah ◽  
Marina Mat Baki ◽  
Salina Husain ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Lymphoma ◽  
Conservative Management ◽  
Case Reports ◽  
Treatment Options ◽  
Individual Case ◽  
The Other ◽  
Superficial Parotidectomy ◽  
Design Case ◽  
Management Approaches

  Objective: To describe our experience in managing two cases of primary malignant parotid lymphoma.   Methods: Design: Case Report Setting: Tertiary University Referral Center Patients: Two   Results: Both patients underwent superficial parotidectomy. Despite recurrence in one, the disease was controlled with conservative management. However, the disease was more aggressive in the other, requiring additional chemo-radiotherapy.   Conclusion: Malignant parotid lymphoma may present with varying stages, grades and clinical courses, requiring different management approaches. The treatment options are based on grading and staging at diagnosis and should be implemented depending on individual case.   Keywords: Parotid neoplasms, malignant lymphoma

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