Malignant Melanoma of the Urethra: A Rare Histologic Subdivision of Vulvar Cancer with a Poor Prognosis

Malignant melanoma of the urethra is a rare tumour that is difficult to diagnose and treat, resulting in a poor prognosis. In this paper, we present the case of a 65-year-old woman who was referred to a gynaecologist because of a urethral mass that mimicked a caruncle. The tumour was removed by local excision, and a pathological analysis revealed a malignant melanoma. Distal urethrectomy was performed after three months with no evidence of residual tumour. There was no evidence of disease at a six-year followup. In this paper, we compare the epidemiology, treatment, staging, and prognosis of vulvar cancer in general to malignant melanoma of the vulva in particular.

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Primary Malignant Melanoma Limited to the External Auditory Canal: A Rare Presentation

Annals of Otology and Neurotology ◽

10.1055/s-0041-1735991 ◽

2021 ◽

Author(s):

Dillip Kumar Samal ◽

C. Preetam ◽

Anjan Kumar Sahoo

Keyword(s):

Malignant Melanoma ◽

Local Excision ◽

External Auditory Canal ◽

Wide Local Excision ◽

Poor Prognosis ◽

Late Presentation ◽

Rare Presentation ◽

Slow Growing ◽

Disease Free

AbstractMalignant melanoma limited to the external auditory canal is very rare. These patients present relatively late as compared with melanoma involving other subsites of external ear. However, the tumor is slow-growing but shows aggressive behavior with a poor prognosis when presented late. We have a 44-year-old female who presented with a blackish lesion, which was bleeding on and off from her left ear. She was managed with wide local excision, preserving maximum part of external auditory canal cartilage. The histopathology of the lesion was suggestive of malignant melanoma. After a thorough evaluation, she was kept under close follow-up. Malignant melanoma of external auditory canal shows poor prognosis usually, mainly because of late presentation. Thus, early diagnosis is crucial, as in our case, where wide local excision was sufficing, and the patient is disease-free after 4 years of follow-up.

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A case of laparoscopic partial hepatic S7 resection for postoperative liver metastasis of rectal malignant melanoma

Surgical Case Reports ◽

10.1186/s40792-021-01316-2 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Makoto Takahashi ◽

Yasuhiro Morita ◽

Tatsuya Hayashi ◽

Susumu Yanagibasi ◽

Shunsuke Sato ◽

...

Keyword(s):

Liver Metastasis ◽

Malignant Melanoma ◽

Poor Prognosis ◽

Rare Case ◽

Laparoscopic Resection ◽

Case Presentation ◽

Liver Segment ◽

Hepatic Recurrence ◽

Pathological Analysis ◽

S 100

Abstract Background Anorectal malignant melanoma (ARMM) has an extremely poor prognosis, and there is no report of resection of liver metastases so far. We report herein a rare case of postoperative laparoscopic partial hepatic S7 resection for rectal malignant melanoma. Case presentation A 51-year-old female patient with a diagnosis of an ARMM underwent a laparoscopic rectal amputation. Eleven months later, computed tomography (CT) revealed a 14-mm nodule in liver segment 7 (S7), which was diagnosed as a hepatic recurrence of the ARMM. Because no other recurrences were found, a laparoscopic partial resection of S7 was performed. Pathological analysis found intracellular melanin deposition, and immunostaining was S-100 (+), HMB-45 (+), and SOX-10 (+). Based on these findings, a liver metastasis of malignant melanoma was diagnosed. The patient is alive 7 months after the second surgery and has so far experienced no recurrences. Conclusion We reported an extremely rare case of a laparoscopic resection of a liver metastasis following surgery for ARMM.

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A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma

Case Reports in Pediatrics ◽

10.1155/2018/1306824 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Ikuma Nozaki ◽

Yumi Tone ◽

Junko Yamanaka ◽

Hideko Uryu ◽

Yuko Shimizu-Motohashi ◽

...

Keyword(s):

Malignant Melanoma ◽

Malignant Transformation ◽

Poor Prognosis ◽

Mediastinal Mass ◽

Bone Biopsy ◽

Systematic Evaluation ◽

Anterior Mediastinal Mass ◽

Malignant Teratoma ◽

Experienced Pain

We report about a 14-year-old boy who presented with an anterior mediastinal mass that was diagnosed as malignant teratoma. Surgical resection was performed along with pre- and postoperative chemotherapy. Although elevated alpha-fetoprotein became negative, he experienced pain in his right hip joint 3 months after resection. Systematic evaluation revealed multiple locations of metastasis, and the pathological diagnosis based on bone biopsy was malignant melanoma originating from malignant teratoma, which rapidly progressed. He died 15 months after diagnosis of the original malignant teratoma. Diagnosing and treating malignant transformation of teratoma, including malignant melanoma, is difficult because it is very rare. To our knowledge, this is the second reported case of malignant melanoma arising from a mediastinum malignant teratoma, with both cases having a poor prognosis. In addition to the follow-up of tumor markers, systematic evaluation, including imaging, should be considered even after remission to monitor malignant transformation of teratoma. We expect to establish a successful therapy and improve mortality rate after more such cases are accumulated.

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Primary angiosarcoma of the lung and pleura

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2004.687 ◽

2004 ◽

Vol 61 (4) ◽

Cited By ~ 13

Author(s):

G.C. Maglaras ◽

S. Katsenos ◽

J. Kakadelis ◽

C. Katsanos ◽

Z. Metafratzi ◽

...

Keyword(s):

Poor Prognosis ◽

Fiberoptic Bronchoscopy ◽

X Rays ◽

Male Smoker ◽

Epithelioid Angiosarcoma ◽

Rare Tumour ◽

Chest Computed Tomography ◽

Primary Angiosarcoma ◽

Open Lung ◽

Right Thoracotomy

A 46 year old male smoker was admitted for severe continuing hemoptysis. Chest-X-rays and chest computed tomography revealed nodular infiltrates and bilateral hemothorax. Fiberoptic bronchoscopy resulted to non-diagnostic cytological and microbiological findings. Open lung and pleural biopsies after right thoracotomy revealed epithelioid angiosarcoma and further staging assessment showed secondary brain and liver foci. The patient received several courses of chemotherapy but he died one month later. The clinical, radiological, pathological, histochemical and therapeutic aspects of the disease are discussed. Angiosarcoma, a rare tumour with poor prognosis should be taken into consideration in the differential diagnosis of hemoptysis.

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245. Local excision after complete clinical response or minimal residual tumour following neoadjuvant therapy for rectal cancer

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2014.08.238 ◽

2014 ◽

Vol 40 (11) ◽

pp. S100

Author(s):

D. Rega ◽

D. Scala ◽

U. Pace ◽

C. Sassaroli ◽

F. Ruffolo ◽

...

Keyword(s):

Rectal Cancer ◽

Clinical Response ◽

Neoadjuvant Therapy ◽

Local Excision ◽

Residual Tumour ◽

Complete Clinical Response ◽

Minimal Residual

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Primary pineal malignant melanoma

Clinics and Practice ◽

10.4081/cp.2011.e31 ◽

2011 ◽

Vol 1 (2) ◽

pp. 31 ◽

Cited By ~ 4

Author(s):

Oderay Mabel Cedeño Díaz ◽

Roberto Garcia Leal ◽

Cesar La Cruz Pelea

Keyword(s):

Differential Diagnosis ◽

Radiation Therapy ◽

Malignant Melanoma ◽

World Literature ◽

Rare Entity ◽

Rare Tumour ◽

Melanocytic Lesions ◽

The World ◽

Supracerebellar Infratentorial Approach ◽

Visual Abnormalities

Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis.

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A Case of Anorectal Malignant Melanoma that Survived 27 Months by Local Excision and Chemotherapy

Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) ◽

10.4030/jjcs1979.29.6_1036 ◽

2004 ◽

Vol 29 (6) ◽

pp. 1036-1039 ◽

Cited By ~ 1

Author(s):

Kenichi SAKURAI ◽

Sadao AMANO ◽

Mitsuhiko KASHIO ◽

Katsuhisa ENOMOTO ◽

Yoshihito SAITO ◽

...

Keyword(s):

Malignant Melanoma ◽

Local Excision ◽

Anorectal Malignant Melanoma

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MALIGNANT MELANOMA AND PREGNANCY

Romanian Medical Journal ◽

10.37897/rmj.2021.2.2 ◽

2021 ◽

Vol 68 (2) ◽

pp. 143-146

Author(s):

Delia Cudalbă ◽

◽

Nicolae Gică ◽

Radu Botezatu ◽

Corina Gică ◽

...

Keyword(s):

Malignant Melanoma ◽

Poor Prognosis ◽

Skin Lesions ◽

Fetal Medicine ◽

Treatment Need ◽

Pigmented Skin Lesions ◽

Pregnant State ◽

State Diagnosis ◽

Patients With Poor Prognosis ◽

In Pregnancy

Malignant melanoma is one of the most frequent cancers diagnosed during pregnancy. Any pigmented skin lesions that change the color should be examined by an experienced dermatologist and if suspected, should be biopsied. Recent studies showed that malignant melanoma in pregnancy has not a worse outcome compared with non-pregnant state. Diagnosis of melanoma does not require an early delivery excepted pregnant patients with poor prognosis that need more aggressive treatment. Diagnosis and treatment need to be established in specialized centers with a multidisciplinary team. Pregnancy monitoring should be performed by team consisting of an obstetrician, a neonatologist and a specialist in fetal medicine.

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