scholarly journals Isolated Pancreatic Tuberculosis Mimicking Malignancy in an Immunocompetent Host

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Pooja Raghavan ◽  
Dhyan Rajan
Keyword(s):  
Chronic Pancreatitis ◽  
Diagnostic Testing ◽  
Immunocompetent Patient ◽  
Pancreatic Abscess ◽  
Immunocompetent Host ◽  
Pancreatic Tuberculosis ◽  
Pancreatic Masses ◽  
High Prevalence ◽  
Immunocompromised Hosts

Despite the high prevalence of tuberculosis (TB) worldwide, pancreatic TB is rare. When present, pancreatic TB is frequently associated with miliary TB, often in immunocompromised hosts. Pancreatic TB may present as a pancreatic abscess, acute or chronic pancreatitis, and cystic or solid pancreatic masses. We present a case of an immunocompetent patient who presented with two discrete pancreatic masses and was subsequently diagnosed with isolated pancreatic TB. This case suggests that clinicians should have a heightened suspicion of pancreatic TB when faced with discrete pancreatic lesions, especially in patients from areas where the infection is endemic. Such recognition may lead to appropriate diagnostic testing, and possible resolution of pancreatic lesions with antituberculin therapy.

scholarly journals Disseminated Nocardia beijingensis Infection in an Immunocompetent Patient

2020 ◽  
Author(s):  
Moni Roy ◽  
Annia Martial ◽  
Sharjeel Ahmad
Keyword(s):  
Literature Review ◽  
Immunocompetent Patient ◽  
Chest Ct ◽  
Primary Site ◽  
Immunocompetent Host ◽  
Onset Seizure ◽  
Pulmonary System ◽  
Life Threatening ◽  
Immunocompromised Hosts ◽  
New Onset

Nocardia is a genus of aerobic, non-motile and non-spore-forming filamentous branching bacteria with fragmentation into bacillary or coccoid forms. Infections caused by Nocardia often occur in immunocompromised hosts and are potentially life-threatening. Nocardia beijingensis has rarely been reported to cause infection in immunocompetent hosts. We present a case of disseminated infection due to Nocardia beijingensis in a patient with no known medical comorbidities, who presented with new-onset seizure. Another interesting finding in our case is that our patient did not have any pulmonary symptoms despite chest CT showing the pulmonary system as the likely primary site of infection. As per our literature review, this is the seventh reported case of infection due to Nocardia beijingensis in an immunocompetent host.

scholarly journals A cavitary pneumonia caused by leptotrichia species in an immunocompetent patient

2012 ◽  
Vol 4 (1) ◽  
pp. 24 ◽  
Author(s):  
Tze Shien Lo
Keyword(s):  
Immunocompetent Patient ◽  
Immunocompetent Host ◽  
Oral Flora ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus ◽  
Normal Human ◽  
Immunocompromised Hosts

<em>Leptotrichia species </em>(LS) is an anaerobic Gram negative bacillus in the <em>Bacteroidaceae</em> family and part of the normal human oral flora. It is rarely pathogenic, but occasionally causes diseases in immunocompromised hosts. I am reporting a case of cavitary pneumonia caused by LS in an immunocompetent host.

Aspergillus Infection in an Immunocompetent Host With Supravalvular Aortic Stenosis

2017 ◽  
Vol 11 (4) ◽  
pp. NP99-NP102 ◽  
Author(s):  
Sedigheh Saedi ◽  
Zahra Khajali ◽  
Azin Alizadehasl
Keyword(s):  
Aortic Stenosis ◽  
Left Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Immunocompetent Patient ◽  
Left Ventricular ◽  
Supravalvular Aortic Stenosis ◽  
Immunocompetent Host ◽  
Mycotic Pseudoaneurysm ◽  
Left Ventricular Outflow ◽  
Immunocompromised Hosts

Supravalvular aortic stenosis is the rarest form of left ventricular outflow tract obstruction. Aspergillus endocarditis is also rare and generally reported in immunocompromised hosts. Here we present a case of an immunocompetent patient with supravalvular aortic stenosis complicated by aortic mycotic pseudoaneurysm due to invasive aspergillosis.

scholarly journals Simultaneous Infection with Two Drug-SusceptibleMycobacterium tuberculosis Strains in an Immunocompetent Host

1999 ◽  
Vol 37 (12) ◽  
pp. 4156-4157 ◽  
Author(s):  
Marion Pavlic ◽  
Franz Allerberger ◽  
Manfred P. Dierich ◽  
Wolfgang M. Prodinger
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Restriction Fragment Length Polymorphism ◽  
Length Polymorphism ◽  
Fragment Length ◽  
Fragment Length Polymorphism ◽  
Epidemiological Data ◽  
Immunocompetent Patient ◽  
Immunocompetent Host ◽  
Simultaneous Infection ◽  
Restriction Fragment Length

An important assumption for DNA fingerprinting ofMycobacterium tuberculosis is that patients are infected with only one strain at a time. Nonetheless, we demonstrate a case of simultaneous infection with two drug-susceptible strains of M. tuberculosis in an immunocompetent patient by IS6110restriction fragment length polymorphism and spoligotyping. Epidemiological data prove the patient's involvement in two independent clusters. Thus, double infections should be suspected with fingerprints showing divergent band intensities.

scholarly journals Fatal Case of Cerebral Aspergillum in an Immunocompetent Patient

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Guive Sharifi ◽  
Mohammadreza Hajiesmaeili ◽  
Ilad Alavi Darazam ◽  
Maryam Haghighimorad ◽  
Muhanna Kazempour ◽  
...  
Keyword(s):  
Trigeminal Nerve ◽  
Fatal Case ◽  
Brain Lesion ◽  
Immunocompetent Patient ◽  
Motor Deficit ◽  
Prepontine Cistern ◽  
Post Operation ◽  
Magnetic Resonance Imaging Mri ◽  
Immunocompromised Hosts ◽  
Intracranial Aspergillosis

Introduction: Cerebral aspergillum is rare and usually misdiagnosed because its presentation mimics tuberculous meningitis, brain abscess, or tumor. The diagnosis and treatment of central nervous system (CNS) infections due to Aspergillus are very difficult because accurate diagnosis is often made intra-operatively. Case Presentation: Here, we report a case of cerebral aspergilloma in an immunocompetent host. A 35-year-old man admitted with progressive left hemifacial paresthesia followed by severe pain in trigeminal nerve territory. On physical examination, except for fifth nerve palsy and difficult mastication, there was not any sensory and motor deficit. Magnetic resonance imaging (MRI) of the brain showed T1 iso and T2 low signal lesion in the left parasellar region with enhancement. The lesion is extended to the left side of the prepontine cistern in the course of trigeminal nerve, craniotomy, and total surgical resection of the mass was performed. Isolated brain lesion and the pathology from stereotactic biopsy confirmed cerebral aspergillosis. The result of testing for human immunodeficiency virus (HIV) was negative. Although the patient had two subsequent recurrences, at first, good outcome was achieved by treatment with a combination of surgical intervention, and antifungal amphotericin B deoxycholate was administered, then changed to voriconazole. Unfortunately, after two years, he experienced new progressive symptoms, and the patient died despite several reoperations due to malfunctioning of external ventricle devices as well as the treatment of recurrent post-operation meningitis and voriconazole therapy. Conclusions: Most cases of intracranial aspergillosis show that this infection is pathogenic in immunocompromised hosts; however, in some cases, invasive Aspergillus was reported as an opportunistic infection in immunocompetent patients. In these patients, though primary cranial aspergillosis is very rare, it is possible that isolated brain involvement in a previously healthy case may be explained by unknown defects in immune pathways or massive exposure to spores.

scholarly journals A reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay for the rapid detection of SARS-CoV-2 within nasopharyngeal and oropharyngeal swabs at Hampshire Hospitals NHS Foundation Trust

2020 ◽  
Author(s):  
Veronica L. Fowler ◽  
Bryony Armson ◽  
Jose L. Gonzales ◽  
Emma L. Wise ◽  
Emma L. A. Howson ◽  
...  
Keyword(s):  
Diagnostic Testing ◽  
Rna Extraction ◽  
Lamp Assay ◽  
Standard Of Care ◽  
Positive Sample ◽  
Diagnostic Sensitivity ◽  
Nucleic Acid Amplification ◽  
Analytical Sensitivity ◽  
Synthetic Dna ◽  
High Prevalence

AbstractThe COVID-19 pandemic has illustrated the importance of rapid, accurate diagnostic testing for the effective triaging and cohorting of patients and timely tracking and tracing of cases. However, a surge in diagnostic testing quickly resulted in worldwide competition for the same sample preparation and real-time RT-PCR diagnostic reagents (rRT-PCR). Consequently, Hampshire Hospitals NHS Foundation Trust, UK sought to diversify their diagnostic portfolio by exploring alternative amplification chemistries including those that permit direct testing without RNA extraction. This study describes the validation of a SARS-CoV-2 RT-LAMP assay, which is an isothermal, autocycling, strand-displacement nucleic acid amplification technique which can be performed on extracted RNA, “RNA RT-LAMP” or directly from swab “Direct RT-LAMP”. Analytical specificity (ASp) of this new RT-LAMP assay was 100% and analytical sensitivity (ASe) was between 1×101 and 1×102 copies when using a synthetic DNA target. The overall diagnostic sensitivity (DSe) and specificity (DSp) of RNA RT-LAMP was 97% and 99% respectively, relative to the standard of care (SoC) rRT-PCR. When a CT cut-off of 33 was employed, above which increasingly, evidence suggests there is a very low risk of patients shedding infectious virus, the diagnostic sensitivity was 100%. The DSe and DSp of Direct-RT-LAMP was 67% and 97%, respectively. When setting CT cut-offs of ≤33 and ≤25, the DSe increased to 75% and 100%, respectively. Time from swab-to-result for a strong positive sample (CT < 25) was < 15 minutes. We propose that RNA RT-LAMP could replace rRT-PCR where there is a need for increase in throughput, whereas Direct RT-LAMP could be used as a screening tool for triaging patients into appropriate hospitals wards, at GP surgeries and in care homes, or for population screening to identify highly contagious individuals (“super shedders”). Direct RT-LAMP could also be used during times of high prevalence to save critical extraction and rRT-PCR reagents by “screening” out those strong positives from diagnostic pipelines.

scholarly journals Prevalence and peculiarities of clinical signs of periodontium diseases in patients with chronic pancreatitis

2014 ◽  
Vol 18 (2 (70)) ◽  
Author(s):  
N. V. Chornii
Keyword(s):  
Chronic Pancreatitis ◽  
Periodontal Disease ◽  
Clinical Signs ◽  
Periodontal Status ◽  
High Prevalence

This paper presents the results of a study of periodontal status in patients with chronic pancreatitis. The study established the high prevalence of periodontal disease in individuals with chronic pancreatitis.The disease manifested itself in a form of generalized chronic catarrhal gingivitis and chronic generalized periodontitis of mild and moderate degrees.

scholarly journals Fungal nasopharyngitis masquerading as nasopharyngeal mass in an immunocompetent patient: a case report

2019 ◽  
Vol 5 (5) ◽  
pp. 1407
Author(s):  
P. Karthikeyan ◽  
Nikhil Sivanand ◽  
Neelima Vijayan ◽  
Vishnu Kumar ◽  
Nanditha Srinivasa ◽  
...  
Keyword(s):  
Case Report ◽  
Antifungal Therapy ◽  
Budding Yeast ◽  
Immunocompetent Patient ◽  
Necrotic Tissue ◽  
Immunocompetent Host ◽  
Yeast Form ◽  
Fungal Ball ◽  
Nasopharyngeal Mass ◽  
Endoscopic Debridement

<p><span>Isolated nasopharyngeal candidiasis in an immunocompetent host, has not been reported in literature. This is a case of a 48 year old lady with no comorbidities who presented with a mass in the nasopharynx mimicking nasopharyngeal malignancy. Endoscopic debridement and biopsy revealed necrotic tissue with fungal ball composed of filamentous hyphae suggestive of aspergillus and budding yeast form of Candida. A diagnosis of fungal nasopharyngitis was made and started on antifungal therapy for 6 weeks following which patient is relieved of symptoms.</span></p>

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