Electrospun Borneol-PVP Nanocomposites

The present work investigates the validity of electrospun borneol-polyvinylpyrrolidone (PVP) nanocomposites in enhancing drug dissolution rates and improving drug physical stability. Based on hydrogen bonding interactions andviaan electrospinning process, borneol and PVP can form stable nanofiber-based composites. FESEM observations demonstrate that composite nanofibers with uniform structure could be generated with a high content of borneol up to 33.3% (w/w). Borneol is well distributed in the PVP matrix molecularly to form the amorphous composites, as verified by DSC and XRD results. The composites can both enhance the dissolution profiles of borneol and increase its physical stability against sublimation for long-time storage by immobilization of borneol molecules with PVP. The incorporation of borneol in the PVP matrix weakens the tensile properties of nanofibers, and the mechanism is discussed. Electrospun nanocomposites can be alternative candidates for developing novel nano-drug delivery systems with high performance.

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Deaggregation and Crystallization Inhibition by Small Amount of Polymer Addition for a Co-Amorphous Curcumin-Magnolol System

Pharmaceutics ◽

10.3390/pharmaceutics13101725 ◽

2021 ◽

Vol 13 (10) ◽

pp. 1725

Author(s):

Jiawei Han ◽

Luyuan Li ◽

Meiling Su ◽

Weili Heng ◽

Yuanfeng Wei ◽

...

Keyword(s):

Physical Stability ◽

Drug Dissolution ◽

Amorphous Systems ◽

Polymer Addition ◽

Promising Strategy ◽

Crystallization Inhibition ◽

Water Wettability ◽

Long Time ◽

Enhanced Surface ◽

Pvp K30

Different from previously reported co-amorphous systems, a co-amorphous curcumin-magnolol (CUR-MAG CM) system, as compared with its crystalline counterparts, exhibited decreased dissolution due to its aggregation during dissolution. The main purpose of the present study is to deaggregate CUR-MAG CM to optimize drug dissolution and explore the deaggregation mechanism involved. Herein, a small amount of polymer (HPMC, HPC, and PVP K30) was co-formulated at 5% (w/w) with CUR-MAG CM as ternary co-amorphous systems. The polymer addition changed the surface properties of CUR-MAG CM including improved water wettability enhanced surface free energy, and hence exerted a deaggregating effect. As a result, the ternary co-amorphous systems showed faster and higher dissolution as compared with crystalline CUR/MAG and CUR-MAG CM. In addition, the nucleation and crystal growth of dissolved CUR and MAG molecules were significantly inhibited by the added polymer, maintaining a supersaturated concentration for a long time. Furthermore, polymer addition increased the Tg of CUR-MAG CM, potentially involving molecular interactions and inhibiting molecular mobility, resulting in enhanced physical stability under 25 °C/60% RH and 40 °C/75% RH conditions. Therefore, this study provides a promising strategy to optimize the dissolution and physical stability of co-amorphous systems by deaggregation and crystallization inhibition via adding small amounts of polymers.

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Metronidazole- and Amoxicillin-Loaded PLGA and PCL Nanofibers as Potential Drug Delivery Systems for the Treatment of Periodontitis: In Vitro and In Vivo Evaluations

Biomedicines ◽

10.3390/biomedicines9080975 ◽

2021 ◽

Vol 9 (8) ◽

pp. 975

Author(s):

Shahla Mirzaeei ◽

Mahla Mansurian ◽

Kofi Asare-Addo ◽

Ali Nokhodchi

Keyword(s):

Drug Delivery ◽

Drug Release ◽

High Performance ◽

Drug Delivery Systems ◽

Periodontal Diseases ◽

Delivery Systems ◽

Electrospinning Process ◽

In Vitro Drug Release

The purpose of this study was to prepare poly (D-L) lactide-co-glycolide (PLGA) and poly ε-caprolactone (PCL) nanofibers containing metronidazole and amoxicillin using an electrospinning process as intrapocket sustained-release drug delivery systems for the treatment of periodontal diseases. Scanning electron microscopy showed that the drug containing PLGA and PCL nanofibers produced from the electrospinning process was uniform and bead-free in morphology. The obtained nanofibers had a strong structure and resisted external tension according to the tensiometry results. The cytotoxicity results indicated acceptable cell viability (>80%). Quantification by high-performance liquid chromatography showed almost complete in vitro drug release between 7 and 9 days, whereas 14 days were required for complete drug release in vivo. No significant signs of irritation or inflammatory reaction were detected after three weeks of subcutaneous implantation of nanofibers in the animal models, thus indicating suitable compatibility. The results therefore suggest that the designed nanofibers can be used as potential commercial formulations in the treatment of periodontitis as controlled-release intrapocket drug delivery systems that can increase patient compliance. This is due to their ability to reduce the frequency of administration from three times daily in a systemic manner to once weekly as local delivery.

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Applications of Ion Exchange Resin in Oral Drug Delivery Systems

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i03.9556 ◽

2017 ◽

Vol 7 (03) ◽

Author(s):

Kathpalia Harsha ◽

Das Sukanya

Keyword(s):

Drug Delivery ◽

Ion Exchange ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Physical Stability ◽

Delivery Systems ◽

Oral Drug ◽

Ion Exchange Resins ◽

Exchange Resins ◽

Oral Drug Delivery Systems

Ion Exchange Resins (IER) are insoluble polymers having styrene divinylbenzene copolymer backbone that contain acidic or basic functional groups and have the ability to exchange counter ions with the surrounding aqueous solutions. From the past many years they have been widely used for purification and softening of water and in chromatographic columns, however recently their use in pharmaceutical industry has gained considerable importance. Due to the physical stability and inert nature of the resins, they can be used as a versatile vehicle to design several modified release dosage forms The ionizable drug is complexed with the resin owing to the property of ion exchange. This resin complex dissociatesin vivo to release the drug. Based on the dissociation strength of the drug from the drug resin complex, various release patterns can be achieved. Many formulation glitches can be circumvented using ion exchange resins such as bitter taste and deliquescence. These resins also aid in enhancing disintegrationand stability of formulation. This review focuses on different types of ion exchange resins, their preparation methods, chemistry, properties, incompatibilities and their application in various oral drug delivery systems as well as highlighting their use as therapeutic agents.

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Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00303 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1014

Author(s):

Xiao-Hong HAO ◽

Cui-Miao ZHANG ◽

Xiao-Long LIU ◽

Xing-Jie LIANG ◽

Guang JIA ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Recent Advances ◽

Nano Drug Delivery

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Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review

Current Medicinal Chemistry ◽

10.2174/0929867325666180514113136 ◽

2019 ◽

Vol 26 (31) ◽

pp. 5862-5874 ◽

Cited By ~ 3

Author(s):

Wang Liao ◽

Shengnuo Fan ◽

Yuqiu Zheng ◽

Shaowei Liao ◽

Ying Xiong ◽

...

Keyword(s):

Stem Cells ◽

Glioblastoma Multiforme ◽

Self Assembly ◽

Poor Prognosis ◽

Drug Delivery Systems ◽

Drug Carriers ◽

Therapeutic Resistance ◽

Average Survival ◽

Nano Drug Delivery ◽

New Development

Glioblastoma Multiforme (GBM) is the most frequent glioma with a poor prognosis. The mainstay treatment for GBM is chemotherapy, but the average survival of GBM remains unsatisfactory due to therapeutic resistance. Poor permeability restricted by the Blood Brain Barrier (BBB) and the presence of Glioblastoma Stem Cells (GSCs) remain as two problems for chemotherapy. Recently, nanocarriers have attracted much attention in the research of GBM, owing to their advantages in self-assembly, biosafety, release controllability, and BBB penetrability, making them promising candidates for GBM treatment. This article aims to review the biologic signatures of BBB and GSCs, as well as the new development of nano-drug delivery systems to facilitate our understanding of targeted treatment for GBM.

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Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications

Current Drug Targets ◽

10.2174/1389450121666200611140425 ◽

2020 ◽

Vol 21 ◽

Author(s):

Dickson Pius Wande ◽

Qin Cui ◽

Shijie Chen ◽

Cheng Xu ◽

Hui Xiong ◽

...

Keyword(s):

Drug Delivery ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Drug Dissolution ◽

Glycol Succinate ◽

Permeation Enhancer ◽

P Glycoprotein ◽

Us Fda ◽

Anticancer Compound

: As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

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Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Current Topics in Medicinal Chemistry ◽

10.2174/1568026618666180608125344 ◽

2018 ◽

Vol 18 (10) ◽

pp. 857-880 ◽

Cited By ~ 3

Author(s):

Salma E. Ahmed ◽

Nahid Awad ◽

Vinod Paul ◽

Hesham G. Moussa ◽

Ghaleb A. Husseini

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Special Focus ◽

Nano Drug Delivery ◽

Medical Researchers ◽

History Of ◽

Overall Performance ◽

Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

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Current HPLC Methods for Assay of Nano Drug Delivery Systems

Current Topics in Medicinal Chemistry ◽

10.2174/1568026616666161222112305 ◽

2017 ◽

Vol 17 (13) ◽

pp. 1588-1594 ◽

Cited By ~ 3

Author(s):

Serife Evrim Kepekci Tekkeli ◽

Mustafa Volkan Kiziltas

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Nano Drug Delivery

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Boosting Performance of Self-Polarized Fully Printed Piezoelectric Nanogenerators via Modulated Strength of Hydrogen Bonding Interactions

Nanomaterials ◽

10.3390/nano11081908 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1908

Author(s):

Hai Li ◽

Sooman Lim

Keyword(s):

Hydrogen Bonding ◽

Composite Film ◽

High Performance ◽

Composite Films ◽

Β Phase ◽

Hydrogen Bonding Interactions ◽

Barium Titanate Nanoparticles ◽

Surface Modified ◽

Piezoelectric Devices ◽

Piezoelectric Nanogenerators

Self-polarized piezoelectric devices have attracted significant interest owing to their fabrication processes with low energy consumption. Herein, novel poling-free piezoelectric nanogenerators (PENGs) based on self-polarized polyvinylidene difluoride (PVDF) induced by the incorporation of different surface-modified barium titanate nanoparticles (BTO NPs) were prepared via a fully printing process. To reveal the effect of intermolecular interactions between PVDF and NP surface groups, BTO NPs were modified with hydrophilic polydopamine (PDA) and hydrophobic 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PFDTES) to yield PDA-BTO and PFD-BTO, respectively. This study demonstrates that the stronger hydrogen bonding interactions existed in PFD-BTO/PVDF composite film comparative to the PDA-BTO/PVDF composite film induced the higher β-phase formation (90%), which was evidenced by the XRD, FTIR and DSC results, as well as led to a better dispersion of NPs and improved mechanical properties of composite films. Consequently, PFD-BTO/PVDF-based PENGs without electric poling exhibited a significantly improved output voltage of 5.9 V and power density of 102 μW cm−3, which was 1.8 and 2.9 times higher than that of PDA-BTO/PVDF-based PENGs, respectively. This study provides a promising approach for advancing the search for high-performance, self-polarized PENGs in next-generation electric and electronic industries.

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