scholarly journals PKCαand ERβAre Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Debra A. Tonetti ◽  
Weihua Gao ◽  
Diana Escarzaga ◽  
Kelly Walters ◽  
April Szafran ◽  
...  
Keyword(s):  
African American ◽  
African American Women ◽  
Triple Negative ◽  
Endocrine Resistance ◽  
Immunohistochemical Analysis ◽  
Tumor Grade ◽  
The United States ◽  
Breast Cancers ◽  
Caucasian Patients ◽  
Caucasian Women

Although the incidence of breast cancer in the United States is higher in Caucasian women compared with African American women, African-American patients have more aggressive disease as characterized by a higher percentage of triple-negative breast cancers (TNBCs), high-grade tumors, and a higher mortality rate. PKCαis a biomarker associated with endocrine resistance and poor prognosis and ERβis emerging as a protective biomarker. Immunohistochemical analysis of ERβand PKCαexpression was performed on 198 formalin-fixed paraffin-embedded primary infiltrating ductal carcinomas from 105 African-American and 93 Caucasian patients. PKCαis positively correlated with TNBC in patients of both races and with high tumor grade in African-American patients. Patients with TNBC express less nuclear ERβcompared with all other subtypes. We find no difference in frequency or intensity of PKCαor ERβexpression between African-American and Caucasian patients. PKCαand ERβare discussed as potential therapeutic targets for the treatment of patients with TNBC.

scholarly journals AR negative triple negative or “quadruple negative” breast cancers in African American women have an enriched basal and immune signature

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0196909 ◽  
Author(s):  
Melissa Davis ◽  
Shweta Tripathi ◽  
Raymond Hughley ◽  
Qinghua He ◽  
Sejong Bae ◽  
...  
Keyword(s):  
African American ◽  
African American Women ◽  
Triple Negative ◽  
Breast Cancers ◽  
American Women ◽  
Immune Signature

scholarly journals Structural Violence of Schooling: A Genealogy of a Critical Family History of Three Generations of African American Women in a Rural Community in Florida

Genealogy ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 20
Author(s):  
Evelyn Newman Phillips ◽  
Wangari Gichiru
Keyword(s):  
African American ◽  
Family History ◽  
African American Women ◽  
White Supremacy ◽  
Structural Violence ◽  
The United States ◽  
Structural Barriers ◽  
American Women ◽  
Three Generations ◽  
American Children

Through the lens of structural violence, Black feminism and critical family history, this paper explores how societal structures informed by white supremacy shaped the lives of three generations of rural African American women in a family in Florida during the middle to the late twentieth century. Specifically, this study investigates how disparate funding, segregation, desegregation, poverty and post-desegregation policies shaped and limited the achievement trajectories among these women. Further, an oral historical examination of their lives reveals the strategies they employed despite their under-resourced and sometimes alienating schooling. The paper highlights the experiences of the Newman family, descendants of captive Africans in the United States that produced three college-educated daughters and a granddaughter despite structural barriers that threatened their progress. Using oral history interviews, archival resources and first-person accounts, this family’s story reveals a genealogy of educational achievement, barriers and agency despite racial and gendered limitations in a Southern town. The findings imply that their schooling mirrors many of the barriers that other Blacks face. However, this study shows that community investment in African American children, plus teachers that affirm students, and programs such as Upward Bound, help to advance Black students in marginalized communities. Further, these women’s lives suggest that school curriculums need to be anti-racist and public policies that affirm each person regardless of the color of their skin. A simple solution that requires the structural violence of whiteness be eliminated from the schooling spheres.

scholarly journals Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women

2021 ◽  
Vol 14 (7) ◽  
pp. 101086
Author(s):  
Mansoor Saleh ◽  
Darshan Shimoga Chandrashekar ◽  
Sayed Shahin ◽  
Sumit Agarwal ◽  
Hyung-Gyoon Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Comparative Analysis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Caucasian Women

“I Don’t Know and I Don’t Want to Know”: A Qualitative Examination of Older African American Women’s Knowledge and Experiences With HIV

2018 ◽  
Vol 44 (7) ◽  
pp. 644-666 ◽  
Author(s):  
Faye Z. Belgrave ◽  
Sarah J. Javier ◽  
Deborah Butler ◽  
Chelsie Dunn ◽  
Joann Richardson ◽  
...  
Keyword(s):  
African American ◽  
African American Women ◽  
Black Church ◽  
The United States ◽  
Sociocultural Factors ◽  
Hiv Knowledge ◽  
Female Population ◽  
American Women ◽  
Heterosexual Women ◽  
Older African American Women

While older African American women (e.g., aged 50 years and older) comprise only 11% of the female population in the United States, they account for 50% of HIV diagnoses among women in this age group. Unique sociocultural factors, including a lack of HIV knowledge and stigma, contribute to HIV risk among older African American women. The goal of this qualitative study was to obtain a nuanced perspective from older African American women about HIV knowledge and experiences with HIV using the framework of intersectionality theory. Focus groups were conducted with 35 African American women who were 50 years and older, nonpartnered, and heterosexual. Women were asked what they knew about HIV and if they thought older women were at risk for HIV. A thematic analysis using NVivo 11 yielded two central themes and three subthemes: HIV knowledge, including experiential knowledge, superficial knowledge, and no knowledge, and stigma around HIV in the Black church. Implications for developing HIV prevention programs and testing messages are discussed.

scholarly journals African American Women and Domestic Violence: Addressing their Voice of Silence

2019 ◽  
Author(s):  
Bernice Kennedy ◽  
Chalice Rhodes (Former Jenkins)
Keyword(s):  
United States ◽  
Domestic Violence ◽  
African American ◽  
Black Women ◽  
African American Women ◽  
White Women ◽  
The United States ◽  
Slave Owner ◽  
American Women ◽  
Strong Black Women

Abstract Historically, during slavery, the international slave trade promoted normalization of violence against African American women. During slavery, African American women endured inhuman conditions because of the majority race views of them as being over-sexualized, physically strong, and immoral. This perception of the African American women as being highly sexual and more sexual than white women results in slave owner justifying their sexual violation and degrading of the African American women. The stereotypical representations of African American women as strong, controlling, dangerous, fearless, and invulnerable may interfere with the African American women receiving the needed services for domestic violence in the community. The Strong Black Women Archetype has been dated back to slavery describing their coping mechanism in dealing with oppression by developing a strong, less traditionally female role. The authors developed a model: The Multidimensional Perspectives of Factors Contributing to Domestic Violence of African American Women in the United States. This model depicts historically, the factors contributing to domestic violence of African American women in the United States. Also, this model addressed the African American women subscribing to the Strong Black Women Archetype to cope with domestic violence. Despite the increase in domestic violence in African American women, they focused more on the issue of racism instead of sexism in America. African American women have experienced the two obstacles of racism and sexism in America. However, African American women and men believe racism is more critical than sexism. Therefore, domestic violence in the African American population may remain silent because of cultural loyalty. However, the voice of silence of African American females is gradually changing with the upcoming generations.

scholarly journals Acculturative status, age, and hypertension among African American women

2021 ◽  
Vol 8 (5) ◽  
pp. 2083
Author(s):  
Fern J. Webb ◽  
Christina Jones ◽  
Ross Jones ◽  
Kristen Morga ◽  
Lori Bilello ◽  
...  
Keyword(s):  
African American ◽  
African American Women ◽  
Cultural Beliefs ◽  
The United States ◽  
Population Based ◽  
Health Interventions ◽  
Traditional Values ◽  
American Women ◽  
Using Data ◽  
Research Assistants

Background: Understanding culture’s impact on hypertension (HTN) is important since its prevalence in African American women (AAW) in the United States is among the highest. It is therefore important to know if younger AAW have similar acculturation status as older AAW when developing culturally relevant interventions.  The objective of this study was to examine the association between acculturation status and age, determining whether acculturation status and age are significantly associated with hypertension among AAW.Methods: Acculturation status, age, and HTN were analyzed using data from the listening to our voices study (LOVS), a population-based observational study of 294 AAW conducted throughout Florida. LOVS was promoted via African American women research assistants trained to inform and recruit AAW living in Ft. Lauderdale, Jacksonville, Miami, and Tampa.Results: Findings demonstrate that AAW held traditional values regardless of age. Moreover, AAW of younger ages had higher average acculturation scores compared with older AAW indicating stronger agreement with traditional values, practices and beliefs. Acculturation subscale scores were not associated with HTN. AAW with HTN scored higher on the traditional food subscale compared to AAW without HTN.Conclusions: These findings indicate the significance of considering the beliefs, values, and practices of AAW when developing health interventions. Health interventions developed should be tailored toward AAW of varying ages to incorporate activities relevant to their cultural beliefs, values and practices.

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