scholarly journals Anti-Inflammatory Activity ofLactobacilluson Carrageenan-Induced Paw Edema in Male Wistar Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Sarika Amdekar ◽  
Purabi Roy ◽  
Vinod Singh ◽  
Avnish Kumar ◽  
Rambir Singh ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Male Wistar Rats ◽  
Anti Inflammatory

scholarly journals Evaluation of analgesic and anti-inflammatory activity of ethanolic extract of Enhydra fluctuans on male wistar rats

2021 ◽  
Vol 9 (1) ◽  
pp. 1-7
Author(s):  
Kishor Kumar Roy ◽  
Md. Kabirul Islam Mollah ◽  
Md. Masud Reja ◽  
Dibyendu Shil ◽  
Ranjan Kumar Maji
Keyword(s):  
Wistar Rats ◽  
Pain Threshold ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Hot Plate ◽  
Plate Method ◽  
Traditional System ◽  
Male Wistar Rats ◽  
Anti Inflammatory

Enhydra fluctuations an edible semi-aquatic vegetable plant are widely used in the traditional system of medicine. Ethanolic extract of Enhydra fluctuans was screened for analgesic & anti-inflammatory activity. Analgesic activity was evaluated by the hot plate method and anti-inflammatory activity was evaluated by formalin induce paw edema in Wistar rats (male). Ethanolic extract dose of 300 mg/kg reduce formalin induce paw inflammation and also increased the pain threshold in rats evidenced by hot plate method. The experimental results concluded that Enhydra fluctuans have significant analgesic and anti-inflammatory activity may due to flavonoid and phenolic compound content.

scholarly journals Evaluation of analgesic and anti-inflammatory activity of alcoholic extract of leaves of Malachra Capitata in male Wistar rats

2014 ◽  
Vol 01 (03) ◽  
pp. 85-90
Author(s):  
Premalatha Sundararajan ◽  
Ranjith K Rajendranb ◽  
Suresh Arumugamc ◽  
Varalakshmi Jayaramdoss
Keyword(s):  
Wistar Rats ◽  
Inflammatory Activity ◽  
Alcoholic Extract ◽  
Male Wistar Rats ◽  
Anti Inflammatory

Anti-Inflammatory activity of seeds extract of datura stramonium against carrageenan induced paw edema on albino wistar rats

2019 ◽  
Vol 7 (1) ◽  
pp. 41-46
Author(s):  
Vivek Asati ◽  
Rishika Agarwal ◽  
Ravi Gupta ◽  
Rajesh Yadav ◽  
Jagdish Chandra Rathi
Keyword(s):  
Wistar Rats ◽  
Datura Stramonium ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Anti Inflammatory

scholarly journals ANTI-INFLAMMATORY PROPERTIES OF ZANTHOXYLUM OVALIFOLIUM WEIGHT METHANOLIC EXTRACT ON ALBINO WISTAR RATS

2019 ◽  
pp. 274-277 ◽  
Author(s):  
PAVANI P ◽  
RAJA NAIKA
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Statistical Significance ◽  
Saline Group ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Standard Drug ◽  
Group I ◽  
Anti Inflammatory

Objective: The object of the present study, the methanolic leaf extract of Zanthoxylum ovalifolium was examined for anti-inflammatory activity and tested using carrageenan-induced paw edema in albino Wistar rats. Materials and Methods: The rats were grouped into five, each group consisting of six animals, Group I (negative control) received 1 ml of saline, Group II (standard) received 10 mg/kg p. o. of indomethacin, and remaining three groups received three different doses (100, 200, and 400 mg/kg p. o.) of the methanolic leaf extract after 1 h 0.1 ml of 1% carrageenan injection. The result of anti-inflammatory activity was set up to be dose-dependent in the carrageenan-induced paw edema model. Results: The methanolic leaf extract has shown significant (p<0.001) inhibition of paw edema, 66%, 66.03%, and 69.29% on the 3rd h at the doses of 100, 200, and 400 mg/kg, p. o., respectively. The results were expressed as the Mean±standard error of mean and statistical significance was analyzed by ANOVA followed by Dunnett’s test. The methanolic leaf of Z. ovalifolium extract showed significant anti-inflammatory activity compared with the standard drug indomethacin. Conclusion: Methanolic leaf extract of Z.ovalifolium showed excellent results in the anti-inflammatory experiment so, the plant can be explored as a potential medicine in suppressing inflammation.

scholarly journals POTENTIAL ANTI-INFLAMMATORY ACTIVITY OF PLUMBAGO ZEYLANICA

2017 ◽  
Vol 10 (10) ◽  
pp. 372
Author(s):  
Vetriselvan Subramaniyan ◽  
Velmurugan Paramasivam
Keyword(s):  
Test Dose ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Control Group ◽  
Paw Edema ◽  
Plumbago Zeylanica ◽  
Male Wistar Rats ◽  
Anti Inflammatory

  Objective: To determine the anti-inflammatory activity of dichloromethane extract of Plumbago zeylanica (DMEPZ), and its possible mechanism of action.Methods: Male Wistar rats (180-200 g) under controlled standard conditions (24±1°C, 55-58 humidity and 12 hrs light/dark cycle). The groups were divided into 5 groups (n=6/group) and assigned as positive control, negative control, and standard and two different test dose groups of P. zeylanica. Paw edema induced by subplantar injection of 0.1 mL of carrageenan (suspended in 1% carboxymethyl cellulose) into the right hind paw in all groups except negative control group. Granuloma induced by cotton pellets (10±1 mg) were implanted into groin region of each rat. The groups were divided into 4 groups (n=6/group) and assigned as possitive control, two different test dose groups of P. zeylanica and standard.Results: Oral administration of DMEPZ shown a significant (p<0.05) dose-dependent protection against carrageenan-induced paw edema. At 1st hr, P. zeylanica shown an inhibition effect of edema in the different doses of 250 mg/kg and 500 mg/kg were found to be 28.57 and 31.79%, respectively. At 3rd hrs, the paw edema inhibition was found to be 30.70 and 40.15%, respectively. Diclofenac (25 mg/kg) had effect of 34.10 and 41.73% (p<0.001) inhibition of paw edema at in 1 and 3 hrs. P. zeylanica 500 mg/kg showed percentage inhibition of wet and dry cotton pellet granuloma in rats 55.84% and 47.92%, respectively.Conclusion: Thus, the present study revealed that the DMEPZ offered significant protection against inflammation.

scholarly journals Anti-Inflammatulatory Activity of Hydro-Ethanolic Bark Extracts of Piliostigma reticulatum Hochst (Caesalpiniaceae) and Analysis by HPLC-DAD and HPLC-MS of its Methanol Fraction

2020 ◽  
Vol 10 (3) ◽  
pp. 97-106
Author(s):  
Serigne Ibra Mbacke Dieng ◽  
Céline Mathieu ◽  
Madièye Séne ◽  
Kady Badji-Diatta ◽  
Abdou Sarr ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Condensed Tannin ◽  
Chemical Study ◽  
Inflammatory Activity ◽  
Bark Extract ◽  
Paw Edema ◽  
Methanol Fraction ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract ◽  
Piliostigma Reticulatum

Use of plants as remedies dates back to the time of the oldest civilizations. Among these active ingredients, polyphenols play an important role. Piliostigma reticulatum, a plant whose barks are rich in condensed tannin is often used as an anti-inflammatory. The purpose of this work was to correlate the anti-inflammatory activity of extracts with their chemical composition through chromatography fractionation analyses (HPLC-DAD and HPLC-MS). The barks were extracted by moderate hydroethanol decoction followed by silica gel splitting with successively ethyl acetate, methanol and water. Anti-inflammatory activity was evaluated by the method of carrageenan induced hind paw edema in Wistar rats.  The chemical study was carried out by HPLC-DAD and HPLC-MS after isolation of the compounds by fractionation on Sephadex LH-20 gel. The bark hydroethanolic extract had shown ability to inhibit significantly the inflammation induced by carraghenan. Among the hydroethanolic bark extract fractions that methanol fraction had the best activity at 10 mg/kg with inhibition percentages similar to those of acetylsalicylic acid with 48.51% ± 2.26; 54.71% ± 5.13; 64.19% ± 6.70 vs. 54.69% ± 7.23; 57.83% ± 9; 65.13% ± 8.44 respectively. The HPLC-DAD analysis showed that the SF5 sub-fraction presented the best chromatogram with several peaks, three of which were high intensity. The latter would correspond to monomer, dimer and trimer of catechin according to the weights [M-H] + m / z: 291.07; 579.18; 867.27 obtained by HPLC-MS. The compounds responsible for anti-inflammatory activity would be condensed tannins. The latter would consist mainly of catechin oligomers.  Keys words: Piliostigma reticulatum, bark, anti-inflammatory activity, HPLC-DAD, HPLC-MS

scholarly journals Evaluation of anti-inflammatory activity of ethanolic extract of Gmelina arborea in experimental acute and sub-acute inflammatory models in wistar rats

2018 ◽  
Vol 8 (1) ◽  
pp. 128
Author(s):  
Priya Gandigawad ◽  
Basavaraj Poojar ◽  
Nandan Hodlur ◽  
Ravi K. Sori
Keyword(s):  
Wistar Rats ◽  
Acute Inflammation ◽  
Inflammatory Activity ◽  
High Dose ◽  
Root Extract ◽  
Paw Edema ◽  
Gmelina Arborea ◽  
Standard Drug ◽  
Inflammatory Models ◽  
Anti Inflammatory

Background: Inflammation is a complex reaction to various injurious agents such as infections, trauma, foreign bodies, tissue necrosis, physical and chemical agents, that consists of vascular responses, migration and activation of leukocytes and systemic reactions. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are currently the most commonly prescribed drugs for treating pain and inflammation. The traditional NSAIDs usually cause various adverse effects on long term use. Gmelina arborea Linn (Gambhari) belongs to family Verbenaceae. The roots, leaves, flowers, fruits and bark are used for treating different ailments as anthelmintic, analgesic, anti-pyretic, antidiabetic, antimicrobial, diuretic and other common disorders.Methods: The study was carried out by using inflammatory models in wistar rats. The anti-inflammatory activity of G. arborea was compared with standard drug aspirin. The study parameters for acute inflammation was assessment of reduction in inflammation & the percentage inhibition of the paw edema. The parameter for the sub-acute inflammation was percentage inhibition of the dry granuloma weight.Results: The low and high dose of G. arborea root extract significantly showed the anti-inflammatory activity when compared to control group. The high dose of G. arborea extract showed comparable results in parameters like reducing inflammation, percentage inhibition of paw edema and dry granuloma weight in acute carrageenan paw edema and sub-acute inflammation cotton pellet granuloma models with standard aspirin treated group.Conclusions: Since G. arborea root extract was having all the qualities required for anti-inflammatory drug. However, no clear inference can be drawn at this stage and hence we consider the work for further extensive research.

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